Free Shipping Over ₹1500
30 Day Return
Third Party Tested
The Longevity Molecule That Mimics Fasting

The Longevity Molecule That Mimics Fasting

by Pooja Ramakrishnan in News

Introduction

We have all heard of this line- move! Exercise! Get going or you will not age well. That is definitely true, but what about people who genuinely cannot move freely or suffer from neurodegenerative disorders like Parkinson’s or Alzheimer’s or have to deal with dementia- where they forget intricate, little details that make their whole day a normal, routine occurrence? Movement by itself is a massive effort and getting enough exercise on a regular basis can feel like an insurmountable trek to the summit of Mt. Everest. But, researchers have finally found a work-around for such folks- they are testing the viability of using a compound that amps up metabolism to a super high level, minus the dehydration and extreme physical exhaustion. This is LaKe- a compound that breaks down to form lactones and ketones in the blood and studies have shown that an increase in the level of both of these molecules can cause the body to rev up its metabolism- as it is super similar to engaging in intermittent fasting and strenuous exercise (like running for 10 km straight, without breaks on an empty stomach). 

What is LaKe?

Researchers at the Aarhus University in Denmark have developed LaKe- an ester-based compound that breaks down to give lactones and ketones in the body. With greater levels of both molecules in the blood, there is a marked downward shift in the production of ghrelin- a hormone that causes you to get hungry and can increase your appetite. With ghrelin mostly out of the picture, you don’t eat as much and your body assumes that you are fasting and begins to break down fat to use as fuel for energy. This directly translates to lesser amounts of free fatty acids in the blood and better heart health in the long term. 

How Can LaKe Help?

Three researchers- Thomas Poulsen, Professor Mogens Johannsen  and Thomas Poulsen, Professor Mogens Johannsen who have studied metabolism in great detail over the last decade decided to work together to synthesise a compound that would be a good supplement to take regularly, for people with weak hearts or who suffer from movement disorders. These individuals need exercise but cannot get it daily. Even a well managed diet can only give a very minute, finite amount of lactones and ketones for the body to work with. This concentration by itself is not enough for promoting better fat metabolism. 

The lactones themselves can also possibly help individuals who suffer from dementia or other neurodegenerative disorders- as a key feature is low cellular energy with such conditions. This can worsen forgetfulness or cognitive decline too over time. The lactones can break down to give lactate- which is a great alternative source of energy for the brain to use, instead of depending solely on glucose (whose levels begin to wobble because of poorer metabolism with advancing age).

Since LaKe breaks down to give ketones like beta-hydroxy butyrate, it can indirectly influence the NAD+/NADH ratio in cells and cause an increase in the amount of NAD+ available to cells for usage. This is also how LaKe simulates the positive effects of intermittent fasting. So, using LaKe may help in increasing NAD+ reserves in the body and promote better cellular healing and longevity related mechanisms too. 

Conclusion

Supplementing with LaKe can be a boon for folks who cannot exercise on a regular basis, but still need the regular movement to keep their heart and brain healthy. LaKe breaks down to give lactones and ketones and this can increase fat breakdown and reduce ghrelin production. The one crucial aspect of fasting is the increase in autophagy related pathways. Studies with LaKe on mice have been extremely promising, which is why human clinical trials have begun now. It hence remains to be seen how these human clinical trials with LaKe progress and if supplementing additionally with NMN can help magnify the positive effects of LaKe itself. While they won’t interact directly with each other, there is enough evidence to show that they can indirectly influence metabolism in a good way and that is what we ultimately want, right? 

FAQs

1. How does LaKe replicate the benefits of fasting?

LaKe breaks down to give lactones and ketones- which help reduce ghrelin production and increase lipolysis in the body- which is why it is so heart friendly and good for your metabolism too. 

2. What are the anti-ageing effects of LaKe?

Lactones can break down to give lactate- which is a good source of alternate fuel for the brain. Ketones like BHB can help increase NAD+ levels indirectly, by influencing the NAD+/NADH ratio. All of these translate to better cellular health and longevity for you. 

3. Does LaKe work without dietary changes?

LaKe can help increase lactone and ketone levels, which are otherwise present in very low amounts if you eat a balanced diet daily. Hence, there is no need for severe caloric reduction or prolonged fasting either, as these dietary restrictions don’t help older folk with chronic ailments. 

4. Who should consider LaKe for longevity and metabolic health?

Anyone who suffers from heart issues or has movement and neurodegenerative disorders may be an ideal candidate for regular supplementation with LaKe. But, please remember that this molecule is NOT presently available for usage by the general public. It is still being studied. 

5. Are fasting mimetics safe to take long-term?

You should talk to your doctor about taking any additional supplement. Plus, any substance that will influence your metabolism should NOT be taken long term and should be cycled appropriately. This is so that you don’t gain excessive weight when you are off it or your blood glucose levels don’t go all over the place and your body does NOT become overly dependent on it. 

 

Tags: Longevity

Related Posts

The Truth About Overtraining & Fatigue

The Truth About Overtraining & Fatigue

Signs Of Overtraining Fatigue There is plain exhaustion that follows a hard day, and then there is overtraining fatigue- which is more akin to your body issuing a distress call disguised in subtle symptoms like persistent muscular aches that refuse to fade despite rest, a relentless heaviness in the limbs that coffee cannot lift, or irritability that surprises you. The Indian fitness culture often glorifies training hard across seasons without listening for those early signals, and this is precisely where ambition collides with physiology because overdoing workouts without adequate recovery upsets the equilibrium that your muscles, nerves and immune system depend on. So what begins as grit may turn into a persistent fog that no amount of hard work can overcome until foundational rest and repair are reinstated. Overtraining And Hormone Imbalance Your hormonal milieu is like an orchestra conductor tuning the entire system for performance, recovery, growth and stress adaptation. Overtraining acts like a sudden cacophony that throws that conductor off balance by elevating cortisol for too long, suppressing restorative testosterone or progesterone, decreasing thyroid efficiency and interfering with sleep rhythms so profoundly that your circadian cues lose meaning making it difficult to recover even when your schedule allows for rest and a simple walk, thus creating a loop of fatigue that feels impossible to break. In India, many individuals train early in the morning before sunlight or late at night under artificial beams, making it easier to misalign daily hormone rhythms. Over time, elevated stress hormones rob the benefits of your efforts turning workouts into wear and tear sessions rather than it being geared towards growth and adaptation. This creates a feedback loop where the body gives more, asks for rest, does not get it and slips deeper into imbalance and perpetual exhaustion. How To Recover From Overtraining Think of recovery as tending to a garden- your body is the soil and workouts are seeds and if you plant too densely or water too aggressively without enough recuperation your garden will exhaust; behind the scenes even if it looks intense on trackers and mirror gains, recovery means creating breathing space where your mitochondria, your nervous system, your hormones and your immune cells have permission to reset their rebalance, grow stronger, and prepare you for smarter performance ahead. Recovery from overtraining is not a sprint but recalibration that demands several layers of attention. This can include reducing your training load, adjusting workout frequency and switching to gentler options such as brisk walking, yoga or cycling, increasing sleep quality by creating a wind‑down routine around consistent bedtimes, nourishing your body with whole foods rich in micronutrients, hydrating properly, and most importantly learning to read your own soft signals such as persistent soreness, poor motivation or mental fog as invitations to rest AND not treat them as a personal failure. Recovery Support Supplements While food, rest and moderation are foundational in healing overtraining fatigue, certain supplements can act as thoughtful partners when used strategically. This can be- including magnesium complex which supports relaxation, better sleep and muscle recovery, adaptogenic herbs like ashwagandha or rhodiola rosea which help modulate cortisol and bolster stress resilience, branched‑chain amino acids to support muscle repair when dietary protein is sub‑optimal, a good quality B‑complex for energy metabolism and better nerve function, omega‑3 fatty acids to reduce inflammation and support mood, or perhaps a full spectrum multivitamin targeting Indian dietary insufficiencies especially in vitamin D, zinc or iron which otherwise slow down recovery and adaptational potential. In India, where soil nutrient levels vary and processed dietary habits often miss key micronutrient support, supplements are not extra; they become recovery allies, especially when combined with better movement cues, routine breaks and sleep hygiene, giving your body the building blocks it requires to heal from overtraining rather than simply masking persistent fatigue. Conclusion  Excessive training without recovery does not make you stronger. It makes you vulnerable and when fatigue persists beyond a week’s rest it is a signal that overtraining is at play rather than laziness or lack of discipline, and understanding this helps you shift from pushing harder to recovering smarter from perceiving rest as failure to valuing it as strategic performance nutrition from honouring your body’s whispers instead of waiting for it to scream. For Indian audiences navigating busy routines, high expectations and wellness trends, it is vital to remember that fitness is not built in extremes but in consistency, balance and adaptation and that meaningful results come from listening to your body, not ignoring it by chasing daily targets that compromise repair. So train with purpose, rest with intention and recover with kindness because your body honours the care you give it more than the milestones it logs.  FAQs 1. Can overtraining cause extreme fatigue? Yes it can. Excessive training without adequate rest disrupts hormone balance, depletes energy reserves and weakens immunity leading to chronic fatigue that is not relieved by extra sleep or reduced effort. 2. Am I overtraining or just tired? If your exhaustion persists despite reduced workload, if your workouts feel harder, your mood dips, sleep is restless and recovery stalls, these are signs of overtraining rather than ordinary tiredness. 3. What is overtraining syndrome? It is a condition characterised by prolonged fatigue, performance decline, hormonal imbalance, suppressed immunity and decreased motivation that results after sustained stress exceeding recovery capacity. 4. How does overtraining impact the nervous system? Chronic overtraining activates sympathetic dominance causing persistent stress, poor sleep, impaired vagal tone and difficulty winding down even though the body craves rest. 5. What’s the difference between fatigue and overtraining? Fatigue is short lived and resolves with rest, whereas overtraining fatigue persists despite recovery efforts, is linked to performance decline, hormonal disruption and often requires strategic downtime to heal.

Learn more
What 10,000 Steps Don’t Tell You (But Your Mitochondria Will)

What 10,000 Steps Don’t Tell You (But Your Mitochondria Will)

Has Anyone Lost Weight Walking 10,000 Steps A Day? Walking 10,000 steps each day has become a celebrated benchmark in wellness culture, a milestone on digital trackers that feels like proof you are active, but the maths of weight loss simply does not add up in most cases- for example you may hike through bustling streets, step-counting zealously while scarfing down late evening samosas because the calories still outpace your modest burn, leaving you frustrated and stuck on the scale. What that popular 10k target does NOT communicate is that it rewards movement quantity but may fall short in stimulating the kind of cellular change necessary for real metabolic improvement. So if someone reports weight loss by hitting their step goal, it may often be tied to changes in diet or overall calorie reduction rather than step count alone. This is why coaches now stress that 10,000 steps will feel helpful, but will not tell you anything about whether your fat-burning engines are actually upgrading themselves behind the scenes. Exercise For Mitochondrial Health Let’s imagine your mitochondria as tiny personal trainers inside every cell, whispering “Keep going” as you climb stairs, jump, lift or resist gravity, and when you stick with merely gentle walking your mitochondria stay cozy but uninspired. Subtle shifts in your exercise routine that introduce zone 2 cardio, short bursts of exertion or resistance stimuli will challenge those mitochondria into making more copies of themselves, increasing density, improving resilience and elevating your basal metabolic rate without drama, pain or the need for intense marathon training. Deep Energy Optimisation Tips Now you might ask - how do I provide my mitochondria with the kind of nutritional, movement-related stimuli they love most-and not just in theory but amid long commutes, irregular meals and family chaos. So, here are deep optimisation tips that target cellular energy production rather than just surface‑level movement which are surprisingly feasible in Indian daily life, even with reasonable constraints. Prioritise nutrition rich in antioxidants and mitochondrial co‑factors, common in Indian diets like spinach, turmeric, ginger, lentils, small portions of fatty fish or eggs if non‑vegetarian, high‑fibre legumes and nuts on a daily basis and try to include most of these food groups in each meal. Nutrients such as CoQ10, magnesium, B‑group vitamins and polyphenols will support enzymatic reactions that help mitochondria generate ATP more efficiently, reducing fatigue and supporting slow metabolism reversal, without reliance on one‑dimensional step tracking and for that- you could think about taking good quality supplements (after your doctor gives you the okay, that is).  Functional Fitness For Energy Next let’s talk about functional fitness, a concept many Indians resonate with even if they haven’t heard the term- because functional movement is embedded in daily lives: bending to pick up a baby, hauling shopping bags, scrubbing floors or cycling through a market, and when these actions combine with resistance and variation they become mini strength training sessions that help your mitochondria thrive far more than repetitive treadmill steps could ever hope to. Functional fitness includes squats, pushing motions, carrying weight in varied postures, rotational movement and vertical engagement such as climbing or balancing. All of these actions fire multiple muscle groups and signal to your muscle cells that energy demand will be irregular- and that your mitochondria should prepare accordingly by building capacity, responsiveness and endurance, making energy production richer, cleaner and more sustainable in the long run.  Conclusion So here’s what 10,000 steps really tells you- it tells your device you moved your legs a lot, it gives you a quick dopamine hit, and it may make you feel virtuous, but if you truly want lasting energy, improved metabolism and resilience then your mitochondria must be your real focus. The reason is simple and incredibly fundamental- they hold the power to determine how well your body uses fuel, recovers from stress and prevents gradual metabolic decline. By thinking of mitochondria as mini engines needing care rather than defaulters giving passive mileage, you shift from counting to caring, from short-term points to sustainable potential, and from accidental movement to intentional, intelligent energy design.  So walk, yes, but walk with purpose. Move, yes, but move with depth. Support your mitochondria, because they are the unsung heroes of your daily vitality- and they speak the language steps can never even begin to accurately measure. FAQs 1. Can strength training improve mitochondrial density? Yes. Strength training involving resistance lifts or functional movements signals muscle cells to increase mitochondrial density, supporting greater energy production, improved recovery and elevated metabolic flexibility, especially effective when resistance is paired with endurance work. 2. What’s better: steps or zone 2 cardio for energy health? Zone 2 cardio, such as brisk walking or easy cycling at a moderate heart rate, triggers mitochondrial biogenesis more effectively than random step‑count alone. Steps count movement, but zone 2 improves cell energy production more deeply. 3. How can I optimize workouts for cellular health? Include a mix of moderate endurance, tempo or interval resistance, varied postures and recovery periods. Add nutrient‑rich whole foods, hydration, sleep and rest days so your mitochondria have signals and resources to build efficiently. 4. What are signs of poor mitochondrial function despite daily steps? Persistent fatigue, muscle weakness, difficulty recovering, brain fog, blood sugar swings or poor endurance indicate mitochondria are not efficient, even if you hit step goals regularly. 5. Can HIIT or resistance training enhance mitochondrial function? Absolutely. HIIT and resistance training stress mitochondria via short bursts that demand quick energy responses, prompting them to adapt by improving density and function beyond what steady walking alone can achieve.  

Learn more
You Age Daily. Your Supplement Stack Should Match That Energy!

You Age Daily. Your Supplement Stack Should Match That Energy!

Supplements To Slow Aging- Let’s stop pretending that aging shows up with a drumroll and grey hair on your fortieth birthday, because the truth is, it arrives like a quiet houseguest, slowly changing things in the background while you go about your business. It subtly drains your energy, slows your recovery, dulls your skin and invites a parade of small complaints that feel too minor to take on seriously, yet are too persistent to ignore. This is exactly why waiting for visible signs of decline before taking action is like fixing your roof only after the rain gets in. Supplements, especially those aimed at longevity, are not emergency tools that swoop in when the damage is done. They are more like quiet daily assistants, working in the background while your brain handles life’s bigger chaos. For us Indians juggling irregular schedules, nutrient-depleted produce, air that tastes like exhaust, and stress that comes pre-installed with adulthood, this becomes less about optimisation and more about basic upkeep. Daily NAD+ Support- The problem is that NAD+ doesn’t last forever, and by your late twenties, your natural levels begin to drop, slowly at first but eventually quite noticeably, especially if you are someone who is running on coffee, processed food, screens, sleep debt and general overcommitment, which, let’s be honest, describes most of us. NMN supplements act as precursors to NAD+, helping your body naturally produce more of it without reinventing the wheel. Unlike quick energy fixes that spike and crash, NMN fuels deeper cellular processes supporting everything from sharper brain focus to faster muscle recovery. Best Combination Of Vitamins To Take Daily- There is no shortage of flashy supplements trying to promise better skin, sharper brains or eternal youth, but the truth is, your body runs on the fundamentals, no matter how advanced your wellness routine may get. Add magnesium, preferably in glycinate or citrate form, because it supports over 300 enzymatic reactions in the body - including sleep, muscle recovery, hormone balance and stress regulation, yet most people remain chronically deficient without realising it until the symptoms show up as fatigue, irritability or poor recovery. Vitamin C supports more than just your immune system; it plays a role in collagen synthesis, skin health, wound healing and antioxidant protection, while omega-3 fatty acids help reduce inflammation, support cardiovascular function and keep your brain from feeling like a rusted processor at 3pm. Longevity Protocol For Energy- Longevity-driven energy comes from the mitochondria, the tiny powerhouses inside your cells that convert food into usable fuel. Like everything else, they slow down with age unless you give them specific support through nutrients like CoQ10, L-carnitine and alpha-lipoic acid. Hydration also plays a role, and while plain water is great, adding trace minerals or electrolytes can elevate your energy by improving cellular function, supporting nerve signalling and preventing the kind of low-grade fatigue that no amount of caffeine can fix. Especially in the Indian context, where modern living puts a strain on biology in ways we barely notice until it’s too loud to ignore, building a supplement stack that reflects your reality is one of the most intelligent forms of self-care you can practise, not because it’s trendy, but because it works. Conclusion You do not age once a year, you age every morning when your cells wake up and decide how well they’re going to handle today’s demands, and that decision is shaped not by your skincare or your gym streak but by the nutrients, molecules and compounds you give your body as tools to perform, repair and regenerate on its own timeline. If you understand this, then supplements stop being optional; they become daily instruments of self-respect, small choices that reinforce the idea that your future health is being built right now, meal by meal, scoop by scoop, moment by moment. You don’t need perfection, you don’t need to take twenty capsules a day or follow a Silicon Valley influencer’s protocol. You just need to choose wisely, stay consistent and listen to what your body is asking for before it gets too late.  FAQs- 1. Do you need supplements as you age? Yes. As you age, your body’s ability to absorb nutrients decreases while cellular wear and tear increases. Supplements help bridge nutritional gaps and support energy, cognition, immunity and recovery. 2. What supplement gives you the most energy? NAD+ precursors like NMN or NR, along with CoQ10 and magnesium, offer sustained energy by improving mitochondrial function. These help your body produce energy more efficiently rather than relying on stimulants. 3. Can I mix all my supplements together? It depends. Some supplements pair well together, like vitamin D3 and K2, while others may interfere with absorption. It's best to space out minerals like iron and calcium and consult a healthcare provider if unsure. 4. How does NAD+ support daily aging defenses? NAD+ fuels cellular repair, DNA protection and energy production. As NAD+ levels drop with age, replenishing it helps your body fight fatigue, inflammation and cognitive decline from the inside out. 5. What’s the ideal time to take longevity supplements each day? Morning is ideal for most energy-boosting supplements like NAD+ precursors and B vitamins, while magnesium, TMG, melatonin or adaptogens are better taken in the evening for rest and recovery.  

Learn more
Home Search Cart Products