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Magnesium Aspartate with Threonate - Benefits Explained
Introduction Magnesium is a super important mineral that is needed by the body to perform well- to help muscles work well, to help with blood glucose regulation, to ensure that nerves fire well, to help the gut absorb more water, as a crucial cofactor in hundreds of reactions that take place in the body, to help the heart beat normally and assist the brain in synthesising neurotransmitters- and more. A major deficiency can even leave you feeling depressed or anxious too. Why Take Magnesium Aspartate With Threonate? Magnesium aspartate is readily bioavailable, so your gut can absorb it with minimal effort. Magnesium threonate meanwhile is the only one of the magnesium salts to be able to enter the brain via the blood brain barrier (BBB)- where it can help in the production of neurotransmitters. This is what really helps neurons work better by improving synaptic density. The neurotransmitters produced also help improve your mood, memory and cognition in general. The positive effects of magnesium threonate is mainly due to the increase in GABA and glutamate in the brain- both of which are inhibitory neurotransmitters, which force the brain to slow down and relax better. Lower cortisol levels are also reported due to magnesium threonate supplementation. All of this culminates in you sleeping better and then having a better day altogether. Is Magnesium Aspartate With Threonate Good For Heart Health? Magnesium in general is good for the heart as a deficiency can cause changes in heart rate and lead to greater incidence of damage or heart disease. Magnesium aspartate along with threonate have also been seen to help the mitochondria produce more ATP in an efficient manner. Can Magnesium Aspartate With Threonate Help With Muscle Recovery? Yes! Definitely! This mineral does a lot of good for the muscles- by helping reduce lactic acid levels and increasing rate of recovery, to help produce more energy so that muscles can contract better, to help regulate calcium ion entry into muscles and to ensure that muscles get enough glucose to perform well, as they are metabolically very active cells, respectively. One thing you should remember is- you will expend more magnesium if you exercise a lot, when compared to someone who is not very physically active. Conclusion Both magnesium aspartate and magnesium threonate are two important magnesium based salts that can be broken down with ease, so that magnesium can be absorbed as needed. Though there are tens of different kinds of magnesium salts that come as supplements, only magnesium threonate has the capacity to enter the brain as it is a lot smaller in size. Magnesium in general has a lot of uses in the body. It is an all-rounder and can help regulate hundreds of reactions. But, not everyone can take this supplement. If you have kidney disease or heart issues, you shouldn’t be including too much magnesium in your diet as it can make your symptoms worse. So, talk to your doctor first and then decide if supplementing is worth all the effort, or if you get enough magnesium from your diet alone, you don’t need to worry much at all. FAQs1. What is Magnesium Aspartate with Threonate, and how does it work? They are two magnesium salts that are given together as supplements - magnesium aspartate can be easily absorbed by the gut, leading to an increase in magnesium levels in the body, while magnesium threonate can cross the heavily guarded blood-brain-barrier and enter the brain to work its magic. 2. What are the key benefits of Magnesium Aspartate with Threonate for brain health? Magnesium aspartate generally helps increase levels of magnesium as it is broken down into the mineral and aspartic acid. Magnesium threonate crosses the BBB to help increase GABA levels and leaves you feeling a little less stressed and helps you sleep better. 3. Can Magnesium Aspartate with Threonate improve sleep and reduce anxiety? Yes, Gamma amino butyric acid (GABA) is a neurotransmitter that the brain makes to reduce stress and help you calm down. When you are relaxed, it is easier to fall asleep too. 4. When is the best time to take Magnesium Aspartate with Threonate morning or night? You can take it in the morning if good energy levels and a less stressful day are on your agenda. But, if getting a night of restful sleep is the primary aim, you can have it at night too. 5. Who should consider taking Magnesium Aspartate with Threonate, and who should avoid it? Anyone with kidney disease should talk to a doctor and then take it, because magnesium is mostly processed there. If you have a deficiency, then you could take it, but if you don’t have a deficiency, it is better to not supplement at all. Too much magnesium is bad for the kidneys, heart and the gut. You could also have breathing issues and go into shock in rare cases.
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How Do Astronauts Protect Their Bone Health While In Space?
IntroductionSunita Williams is back! She has spent close to 9 long months aboard the ISS- which is a long time by Earth standards, but even longer by space standards! This is because space has NO gravity- which means the way our bodies function change drastically. How Do Astronauts Prevent Bone Loss In Space? With no gravity to hold them down, or provide resistance and weight for the bones and muscles, astronauts literally do not need to put any effort in moving around- they just tend to randomly zoom or float around to their destination. Since they are not using their muscles and bones in the normal way, they can suffer from accelerated bone mass and muscle loss. Thankfully though, the two astronauts in question had to embark on a space walk where they had to get some repairs done, but otherwise, with them being cooped up in the ISS where space is at a massive premium, it does beg the question- how are they staying strong and healthy? How are their bones and muscles working normally? In a recent interview that one of the astronauts gave (she is the well known Sunita Williams)- she joked that she had almost forgotten how to walk around, as floating about has been the norm for the last 235 days. Why Do Astronauts Lose Bone Mass In Space? The earth has gravity, which is continuously acting on us- even if we don’t consciously feel it. This means the muscles of the lower half of the body and the back are in constant use- working hard to keep us upright. This is how we maintain our posture all day- while sitting, standing, eating, walking, running, jogging or whatever else we may be doing. But, since there is no gravity in space, there is no need to use any effort at all- with respect to moving around or staying upright. With muscles and bones- it is literally ‘use it or lose it’. When you keep using your muscles and bones in the right way, your body keeps making new bone cells, while also relegating resources for continuous maintenance and breaking down as needed. But, in microgravity, the breaking down or resorption rate is higher than the formation of new bone- resulting in a net loss in bone density. Astronauts lose almost 1-2% of their bone mass every month due to atrophy. If it continues unabated, it can lead to brittle bones and fractures, along with other issues like osteoporosis (which are normally associated with aging and normal wear and tear or tissue). To check for changes in bone densitometry values closely, NASA has a Human Health and Performance Directorate’s Bone and Mineral Laboratory- where astronauts need to get dual energy X-ray absorptiometry- (DXA) before and after a stint in space. Muscles also show less expression of growth and metabolism related genes when astronauts are in space. Ways Astronauts Stay Healthy In Space Weight bearing and resistance are the two primary factors that determine how strong and functional bones and muscles will be. Since both of them are virtually absent in space, astronauts find it really hard to exercise. This is why they are asked to follow a highly specific set of exercises and workouts- for over 2 hours everyday. Most of us hate the idea of working out everyday, let alone a couple hours. The non-existent conditions and poor motivation can make life worse for astronauts- which is why they work out using VR goggles to make things more interesting. Astronauts use a treadmill called TVIS which allows them to work out with small amounts of gravitational resistance, along with a well designed tether that keeps them on the machine- mimicking gravity. Another component they need to include everyday is weightlifting- which is done with the help of the Advanced Resistive Exercise Device (ARED). Some studies want to check the difference between astronauts who use and don’t use the treadmill everyday, and instead exercise without any equipment. Conclusion Astronauts undergo a very rigorous pre-flight training regimen, just like athletes do. When they continue to work out for two hours or more everyday, and eat well - they can limit the side effects of microgravity on bone loss, muscle strain and other factors. Myostatin inhibitors are certain specialised drugs used to treat osteoporosis on earth and scientists are trying to figure out if they will be good for astronauts in space. All of this research is being done in an effort to help them recover soon and prevent debilitating muscle atrophy and brittle bones from affecting them long term, once they are home. FAQs 1.How do astronauts protect their bone health while in space?Astronauts need to exercise 15 hours a week (2.5 hours, 6 days), while also eating foods rich in vitamin D and calcium. To help them combat microgravity related tissue loss, they also take bisphosphonates - to help them increase bone mass and reduce the chance of developing brittle bones. They also get bone densitometry scans done regularly - before and after a mission and once every 3 years afterwards, even if they have not flown to space. 2. How much bone loss do astronauts experience in space?They lose about 1-2% of bone mass every month- which is mostly pronounced in the hip, spine and knees-mall regions that help you maintain posture. 3. What exercises do astronauts do to maintain bone health in space?They do aerobic exercises, run on a treadmill with a tether, lift weights, do spacewalks, use stationary bikes, etc. 4. Do astronauts take calcium supplements in space?Astronauts consume about 1000-1200 mg calcium per day, along with Vitamin D supplements. They also need to drink plenty of water to ensure they don’t get kidney stones. 5. How do astronauts' bones adapt after long-duration space missions?Their bones demineralise - meaning lose their capacity to bear weight, causing brittle bones and leaving them more susceptible to fractures, muscular atrophy and osteoporosis.
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All About Vitamin B12- Your Questions Answered
IntroductionVitamin B12, also called methylcobalamin is derived from cyanocobalamin - which is what is mostly found in fortified foods or supplements. But, Vitamin B12 in general is a water soluble protein, as we all know and it has plenty of functions to fulfil in the body. Some of the most crucial functions are to ensure that normal red blood cells are produced in the bone marrow, to help neurons function well and in DNA synthesis itself. Vitamin B12 is also a part of many enzymatic complexes, to protect eyes from degenerative disease and is very much necessary for energy production. It is the last quirk that determines when this supplement should be taken in a day. Let us look at the 5 major concerns regarding regular supplementation with Vitamin B12, below-Concern No. 1- How to take Vitamin B12 for best absorption? You should ideally be getting Vitamin B12 from food sources, but if you have been asked to supplement, then try doing so first thing in the morning, with just water. This way, there is better absorption and you will also notice an uptick in your energy levels after a few days. Concern No. 2- Is it better to take B12 with or without food? If you are worried about timing your supplements right, then you can try eating them 30 minutes to an hour BEFORE a meal, or at least a couple hours AFTER one. But, like we said, on an empty stomach is cool too. Concern No. 3- Should B12 tablets be taken daily or weekly? Tablets can be taken everyday and the dosages normally available include 500 mcg to 1000 mcg- and you may be asked to take them twice a day. Tablets are normally NOT recommended on a weekly basis. Instead, you may be given a B12 injection or shot- to help raise levels, if you are very deficient or are highly symptomatic. Concern No. 4- How long does it take for B12 tablets to work? This mainly depends on what levels you were at, before starting with supplements. If your B12 levels were very low, then you could take longer to see results, but in general, it takes about 2 weeks or slightly longer for you to see any major improvement. If you take tablets after an injection, it is much quicker. Concern No. 5- B12 tablets for vegans and vegetarians- Vitamin B212 is abundantly found in animal based foods like meat, shellfish, fish, daily products, nutritional yeast etc.. and is rarely found in plant based foods. So, you may be deficient, especially if you are vegan or vegetarian in a few cases. Some foods are fortified- like cereals or plant milks, but not so often here in India. You can hence supplement with Vitamin B12 after you talk to a doctor. Conclusion Vitamin B1 is very important for multiple bodily processes to occur seamlessly- like blood cell formation, prevention of anemia, for producing energy in a consistent manner, for good neuronal and brain health, for the eyes and for various other enzymes to work normally. Vitamin B12 is also good for your skin by helping it retain moisture. Most importantly, it helps in DNA synthesis, in protein metabolism and breakdown of fatty acids. If you face issues like muscle weakness, numbness, a tingly feeling in the limbs, have heart issues, unexplained weight loss and related symptoms, then you should talk to a doctor and see if you have some deficiency that needs to be dealt with, ASAP! FAQs1. What is the best time of day to take B12 tablets—morning or night?Taking Vitamin B12 in the morning is your best shot at getting all the goodness for the day and to keep you going. This is because it is necessary for energy production in the body. Plus, having it with water on an empty stomach is best to kickstart absorption. 2. Can I take B12 tablets along with other vitamins and supplements?Don’t take Vitamin B12 with Vitamin C- which is another water soluble vitamin. They can compete with each other. Instead, take some VItamin C after a couple hours, to get the maximum results from both. 3. Does taking B12 at night affect sleep or energy levels?Taking B12 at night may disrupt melatonin levels- leaving you feeling restless and not being able to sleep properly. So, take the capsule in the morning. 4. Are there specific conditions where B12 intake should be adjusted?Yes, B12 is found in foods of animal origin- so if you are vegan or vegetarian- you could be deficient. If you have had gastric bypass surgery or have a chronic gut condition like Crohn’s, IBS, etc. absorption may be affected- leading to low reserves of Vitamin B12 in the body. Also, having pernicious anemia can mean that your stomach won’t be able to produce the required intrinsic factor that will help with B12 absorption in the gut. 5. Is it safe to take B12 supplements long-term?Vitamin B12 is water soluble, which means it is not stored in the body and is excreted via urine with ease. This is why reserves need to be replenished continuously. But, if you keep supplementing with B12 alone, you may get deficient with the other vitamins in the B group. Instead, taking a B-complex - which contains all B group vitamins is a better option.
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Top 5 Supplements for Brain Health and Longevity
Introduction There are plenty of supplements that promise everything- from improving vitality to making you look youthful. It is however a basic concept that eating well and drinking lots of water will help way more than popping just these supplements alone. The brain needs a lot of good quality nutrition and energy to perform at its peak. Since these cells work always - even during sleep, they produce a lot of metabolic waste and other byproducts which can be damaging in some aspects. These cells are particularly more susceptible to oxidative damage. So, nutrients or compounds that can decrease the rate of oxidative damage and improve circulation to the blood are the best ones for your consideration. What Supplements Help Maintain Brain Health As You Age With a greater incidence in the occurrence of chronic illnesses like diabetes, hypertension, neurodegenerative disease and poor lifestyle choices, circulation to the brain gets affected- which means that the brain won’t get as many nutrients as needed. So, one approach that scientists are researching on extensively is how to improve circulation and also provide enough nutrition, so both goals are achieved in one go. The main issue with drugs and supplements is that they need to cross the blood brain barrier- a thick layer of cells and vasculature that function like the gatekeepers of the brain. They allow only certain small sized molecules to enter and exit the brain. This is also why it is important to choose the right kinds of supplements, as all molecules cannot gain entry into the brain. That said, the ones that do work well have been covered below- Vitamins D, C and E- They show potent antioxidant activity. Studies have shown that people with depression, dementia etc. have low levels of Vitamin D, though the clear link between these 2 factors has still not been established yet. Vitamins C and E help reduce oxidative damage to cells in the brain. The B group of vitamins is also very essential for good cellular function and red blood cell health. Good quality blood cells means they have the capacity to bind to oxygen and nutrients better, which is how the brain will get the resources to work well. Choline especially, which is Vitamin B4 is good for blood circulation and improves cognition and memory, according to few studies. Zinc is an important mineral, like selenium and magnesium for brain health. But research is a little fragmented- supplementing with zinc helps improve spatial memory, attention span and thinking in kids, but not as much in adults. Apigenin, resveratrol and trimethylglycine (TMG) are supplements that reduce inflammation and promote better cellular function. They also help reduce brain fog related symptoms, helping you perform better at work. They also help promote better sleep quality, reduce stress and help you feel better overall. Trans-resveratrol is the more active form of resveratrol that can enter cells better and work its magic and studies have shown that it is super helpful for menopausal women. Omega-3 fatty acids help fight against dementia- and studies have shown that people with Alzheimer’s disease benefit the most with supplementation. You can also get them from your diet, but you need to consume good quality fats like fish, soybeans, edamame and nuts. These are all natural supplements for brain longevity and mental clarity. Nootropics are brain friendly compounds that are synthesised chemically, or can be derived from natural sources. The most effective nootropics for brain health and longevity which are well known include caffeine, adderall, ritalin, choline, amino acids like tyrosine and L-theanine and ginseng respectively. They have been used for many decades by health enthusiasts, while some of them are prescription meds. Conclusion Nootropics and brain supplements are good for people who want to sleep better, think better and improve their daily quality of life. The dosage of all of thes ec compounds has been studied, but not as extensively. Safe doses have however been ascertained and they are present as easy to consume capsules or gummies. It is always a good idea for you to first try the lowest dosage if possible- just to see how you react to it. Some of them are addictive too, so you may need to stop them and then start taking them again after a break. Nootropics are a sensible choice if you are above your 30s and find that life is hectic and becoming more and more unmanageable. Remember this though- all nootropics are not equal and you need to think long and hard before you start taking them. FAQs 1. What are the top supplements recommended for enhancing brain health? Supplements that prevent cell death due to oxidation, or reduce the activation of such pathways, molecules or compounds that are found in the cellular membranes of cells in the brain and vitamins or mineral supplements are good choices. Fish oil, Vitamins B9, B12, B6, zinc, magnesium, choline, serine, resveratrol, TMG and apigenin are all well known supplements in this regard. 2. Are there specific supplements that are particularly effective for older adults? Older adults need a lot of Vitamin D, A, B group, E and omega-3 fatty acids. These help cells perform better and reduce oxidative damage. Magnesium and creatine are also good for better energy and mood enhancement. 3. How often should I take supplements for brain health? Most of these supplements have to be taken everyday. You can choose when to take them or talk to your doctor about it. 4. Are there any potential side effects of taking brain health supplements? Some people may be allergic to the ingredient or active compound in the supplement and develop issues like hives, rapid heart beat, breathing issues and skin rashes, diarrhoea etc. among other conditions. The right dosage also matters. 5. How long does it take to see the effects of brain health supplements? Doctors will tell you that there is no quick fix with supplements. You need to eat well and take these pills or capsules for at least 3 months, to be able to notice any positive change in your day or routine. It may take longer if you are already deficient in a few of these vitamins or minerals.
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What Is The Importance Of A Balanced Diet For The Body?
Introduction The basic definition of a ‘balanced diet’ is pretty well known- the dietary choices you make on a daily basis need to nourish your body and mind. So, nourishment essentially means eating good quality food that will help your body and mind grow well. But how many of us actually care enough to think twice about what we put into our bodies? We come up with different excuses- one more creative than the last one- busy day, need a good drama to watch or I can’t eat, I have no time to eat a meal and the most ridiculous one yet- all food options seem too healthy. Diet culture now is so bad that eating a properly planned meal means you are ‘dieting’, while eating tasty junk is the new normal! Why Is A Balanced Diet Important For Health? This question is literally a no-brainer, in our opinion. Good food means more nutrients, which translates to your cells and bodily functions working well. Now, what’s not to like about the whole process? Except, nutritious food is not that easy to come by these days. It is like the popular saying ‘Eat anything that comes from a plant, not something that is MADE at a plant’. As for answering the no-brainer- it is simple. Your body needs a variety of nutrients for it to function well- vitamins, minerals, energy resources in the form of carbohydrates and fats, protein to help with healing and regeneration and fiber, along with water to make everything move smoothly within the gut. We have hundreds of cell types- each performing highly specialised functions, which means their nutritional needs are also going to be very specific. But, generally speaking, they get all they need from the food we eat- and that is only if we consume a large variety of foods, often. Eating a varied, well planned diet has a number of advantages, some of which have been listed below- To combat brittleness in bones and to make them strong, yet flexible. To help improve your ability to stay infection free To help your brain perform well- and it does a lot everyday! To prevent brain fog, fatigue and general meh-ness, you need to eat everyday. That is how a balanced diet improves mental health in the long run. To help your heart beat well and regularly- and to ensure that blood supply is good in the body. To ensure that your bone marrow has enough resources to make blood- which is a life giving fluid. To help your skin stay elastic and maintain its barrier function exceptionally, while looking plump and dewy. To help your cells get energy from the food you eat, and to help the gut derive proper nutrition by absorption. To allow your body time and space to heal from wounds or any other inflammatory situations, provided they are not very chronic in nature. For your joints to move well and to stay lubricated and strong For men and women- fertility and wellness is a big priority and good food can help you achieve serious health goals. Food is good for your lungs- as they keep working from the day you are born till you die. Don’t you want to keep them functioning well enough always? Your liver is the major organ tasked with detoxification and breaking down of a lot of components in the body- some harmful but most benign. Since it is a stressful job, providing good resources from healthy food can help your cells regenerate better and work well. How To Maintain A Balanced Diet Daily- The mantra is simple- like Mark Twain once said- “The only way to keep your health is to eat what you don't want, drink what you don't like, and do what you'd rather not.” This means if you don’t like your veggies and fruits- make a conscious effort to include them everyday. If you love your hyper-sweet coffee or chai, then go sugar free or replace it with just water or buttermilk. We have a small but super practical hack for you- imagine your plate has 4 quadrants- NOT equally sized. That is important. The largest quadrant (about 2 halves) should have all your veggies - poriyal,salads, vegetable curry, a quarter of your plate should have whole grains or a carbohydrate source which will keep you feeling full for longer than usual, so you don’t succumb to hunger pangs in between. The third quadrant should contain any protein of your choice- egg, lean meat, tofu, paneer (be judicious with this one as it is pretty fatty too), while the last one should be a dairy product, though if you’d like to go dairy free, it is fine too. You just need the calcium and Vitamin D from an alternative source. Also, never forget good quality fats as your heart needs them to function well. Some examples include ghee, some butter or oils like sesame oil, mustard oil, coconut oil etc. Another thing you could do- is to add lots of veggies of different colours- at least 3 different ones, per meal. Don’t forget your fresh fruits too. They have good fiber and a lot, which is good for your gut and will not let you get hungry soon. Conclusion As to why a balanced diet is key to long-term health- your body has millions of cells busily working away and producing a lot of harmful components in the process- like super oxide molecules or other by-products which can be harmful. These can actively damage DNA in your cells or cause long ranging mutations, leading you to age quicker than usual. A good meal which is especially colourful and fresh can give your body enough antioxidants and anti-inflammatory goodness- to allow your cells to fight the good fight always! FAQs- 1.What is a balanced diet, and why is it important?A balanced diet is one where you include variety in terms of sources of carbohydrates, proteins and fats and have plenty of fiber, vitamins and minerals which are normally found in fresh fruits and vegetables everyday. Drinking enough water everyday should also be a priority. 2.What are the main food groups that should be included in a balanced diet?Proteins, carbohydrates, water, fibre, healthy fats and dairy products should be on your radar, if eating well is your goal. 3.How does a balanced diet affect mental health?A good diet will include plenty of vitamins and minerals- especially the Vitamin B group that the brain needs in decent amounts so it can work well. If your food is not nutritious, then you may have to deal with brain fog and related issues. Antioxidant rich foods are great in helping the brain repair itself. 4.What happens if I don't eat a balanced diet?You will have to deal with a; lot of chronic illnesses like diabetes, hypertension, obesity, feel tired almost always, poor immunity and weight management related issues, among other concerns. 5.How can a balanced diet help with weight management?A well planned meal can help you feel full for longer so that you won’t snack in between.
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Proven Tips to Live a Longer, Healthier Life
Introduction A healthy long life requires the addition of a few choice ingredients and many other spices and condiments- which can essentially help enhance the quality of your life on a daily basis. The well known basic ingredients include diet, dealing with stress, getting enough sleep and exercising on a regular basis- switching between moderate and high intensity workouts to get the maximum benefits. But the so-called spice of life is how you deal with other people- how stable your relationships are, how your finances are and how much time you spend on yourself. So, let us look at the top hacks to improve the quality of your life- and to help you live longer and healthier, starting today! Top Tips For A Long And Healthy Life- The different aspects you can work on, to improve your healthspan, lifespan and dail quality of life have been listed below- Be picky about what you put into your body- in the form of drinks or foods. This means you should take some time out every week and go grocery shopping, plan meals out and eat them on time. What this exercise will help you achieve is- better blood glucose levels and insulin sensitivity, the joy of having cooked yourself a meal and is a guaranteed mental exercise in planning and strategic decision making. Eat a lot of veggies, fruits and nuts everyday- they are chock full of antioxidants, vitamins and minerals- all of which are good for your body. It is time to stop being a couch potato- because, hey, long hours at work make you just that. Don’t repeat the same routine once you are home! Go for a walk, run a bit, play with your little one, go for a swim or do something that you enjoy- like yoga and gossip with friends, dance with a group of like minded individuals and join aerobics classes. Annoy your friends to join you in these shenanigans- better results and more fun all around! This also has the added advantage of letting you de-stress properly. You get to maintain your weight and can greatly reduce the risk of having to deal with a chronic condition like diabetes, hypertension, hypercholesterolemia etc. Talk to your friends about going to places which serve good food and not just a lot of alcohol. Getting drunk on a regular basis can sound like a lot of fun, but your liver is in a world of pain and you do know that hangovers suck, right? Same goes for smoking- if you are a chain smoker, then try to stop gradually but be firm about this decision. Smoking and drinking incessantly can introduce a lot of toxic substances into your body and cause the DNA in your cells to act in weird ways. Plus, you age faster this way and this is not what you want. Love pulling all nighters, catching up on lost time and trying to finish a tonne of stuff? Don’t! Just go to bed and make sure to sleep well. This can greatly impact your mental and physical health in myriad ways. Also, you won’t be as grumpy or annoyed with life if you have slept enough. Less sleep can up your physiological stress levels and cause cortisol levels to build up in your blood. This means you will constantly be in the fight or flight mode and will never feel settled and at ease. More sleep is also bad for you, so try to maintain a good balance. Conclusion These are some essential daily tips for enhancing health and longevity. Granted, longevity and aging are highly dependent on genes, there are plenty of epigenetic factors that can influence them in positive or negative ways. Being consistent with these habits can take you to places, literally and figuratively. These days, getting good quality food can be slightly problematic- what with the advent of aggressive marketing and production of hyper processed junk food. It totally makes sense to turn to supplements in this case- to help your body thrive. Supplements you should ask your doctor about include NMN, taurine, Trimethylglycine, apigenin, resveratrol, creatine, multivitamins etc., though there are thousands of other potent candidates. It is time to be overzealous about healthy habits - because you do want to live for long, don’t you? FAQs 1. What are the most important daily habits to live a longer life? The best things you can do are eat well, eat on time, exercise everyday, sleep well, drink enough water, not drink or smoke too much and ensure that you deal with stress in the right way, you are setting yourself up mostly for a long life, unless you have inherited faulty genes which may cause chronic illnesses or something else happens. 2. Can regular exercise really help extend my life? What type of exercise is best? Exercise in general is good- about 150 minutes every week or more, or 30 minutes per day minimum. You should do aerobic exercises, balance improving exercises and strength training regularly- lift weights. This is good for your heart, helps you prevent depression and you also get to manage your weight effectively. 3. What role does mental health play in living a longer life? If you are not depressed or anxious or have any other psychiatric disorder, then your quality of life is generally way better than someone who has a related condition. You will also not be as stressed, nor will your body have to deal with high levels of inflammation on a chronic basis either. If you have a positive outlook in general, then you also will bounce back if something bad happens. 4. How much sleep do I need to optimize my health and longevity? You need 7-9 hours of sleep every night, if you are an adult, though young children need much more. If you sleep longer than 8 hours, or for less than hours, then you may be in trouble and your body will find it harder to work normally. 5. Are there any proven supplements that contribute to a longer, healthier life? Some well known longevity promoting supplements include curcumin, taurine, resveratrol, apigenin, trimethylglycine, NMN, creatine, magnesium and Vitamin B complex. They work by reducing inflammation, have anti-oxidative properties and can also help cells work better.
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The Science Behind Longevity: What You Need to Know
Introduction A long life span is dependent on many overlapping factors, most of which are not really in our control. But, what about those factors that we can control? We should technically be able to influence them, in subtle ways which can help us live healthier, longer lives. Research shows that some of those factors include lifestyle and the environment a person lives in. Most of the traits related to aging have been decided beforehand, because it is heavily dependent on genes which dictate all cellular processes. What Research Says About Living Longer Aging is a process that involves the genes heavily, so if you have won good genes in the genetic lottery, you are more likely to live healthier for longer, as compared to someone who may suffer from a chronic illness and pass on those mutated genes to their progeny. The easiest way to understand how much the landscape of aging has changed over the last half century is to look at the lifespan of people all over the world- it has increased drastically from the late 40s to over 65 years of age. This has been attributed to nations being at peace, not having wars and having enough resources for food, research and healthcare respectively. Humans in general can live for about 120 years of age, and this is the maximum number according to the information our genes give us. Some people have probably lived for longer but they may have been exceptional in a few ways. The focus now is on how to age better, while understanding epigenetic cues. A good example is this- most of us have genes for hypertension or prediabetes, but if you follow a relatively active lifestyle and don't eat too much of junk, then you are at lower risk of developing such chronic conditions. This is the epigenetics theory- where other influences are thought to be just as important as genes themselves. Latest scientific findings on life extension have shown that if we can try to find some way for telomerases to act slower than usual, the telomere of chromosomes stay on for longer and a person is able to age better. Telomeres naturally have the tendency to get shorter as we age, but with a poor lifestyle and too much stress, we can accelerate this process. The DNA present in all cells undergoes major changes- called mutations that are no longer repaired or taken care of properly- causing the aging process to move forward quickly. Research has shown that there are 9 hallmarks of aging that are known- each of these hallmarks are specific pathways or processes that regulate the process of aging altogether. Older populations present in blue zones have also been studied in detail and scientists have been able to pinpoint to a few genes which determine longevity. What we hope to do is tweak these longevity genes by working on making proper lifestyle choices- this itself is enough for improving healthspan and consecutive lifespan of an individual. Conclusion Extensive research on longevity has shown that eating healthy foods, exercising regularly, prioritising sleep and de-stressing regularly can greatly help kick start recovery pathways in the body. Intermittent fasting increases the activity of guardian proteins called sirtuins- which help cells stay healthy in the long term. Eating less means more sirtuin activation, which can also be achieved by taking specific supplements designed for this very purpose. Sirtuins get activated mainly during times of stress- like starvation, extreme weather and similar instances. The bottom line is- if you focus on 3 main areas- diet, exercise and reducing stress, you can influence the hallmarks of aging enough to slow them down. FAQs 1. What are the key scientific factors that contribute to longevity? Not exposing yourself to harmful substances like alcohol and tobacco, eating a variety of fresh fruits and vegetables, whole grains, pulses, spices and other components on a daily basis, getting some exercise everyday and sleeping for at least 8 hours a night are the requisites for longevity and health. 2. How do genetics play a role in how long we live? A quarter of how we age is heavily dependent on our genes- those which we inherit from our parents. Next comes environmental factors and what you are exposed to or have to deal with in life and the last is lifestyle related components like sanitation, if you have access to medical care and what your standard of living is. 3. What recent scientific breakthroughs have been made in extending human lifespan? The current lifespan for a seemingly normal individual is 71 years old, which is the global average. In India, it is about 68-70 years old. Senolytics are being studied extensively for their ability to influence aging related processes and increase healthspan and lifespan. Gene therapy is also being studied to help people deal with diseases caused by point mutations. 4. What role does diet play in scientific studies on longevity? A healthy diet rich in colourful, fresh fruits and vegetables means you will get plenty of antioxidants and other anti-inflammatory compounds into your system. Fibre is good for the gut and to keep things moving. Fibre also helps in regulating blood glucose levels, which means it also helps you metabolically in the long term. Good sources of fats and carbohydrates help provide energy perpetually to the cells working day and night in your body. Protein helps in repair and in various synthetic reactions. All of these when taken together help cells age better, work better and improve health expectations. Such foods are commonly called ‘superfoods’. 5. What are the common traits of populations that live the longest? If you mostly eat a lot of plant based products and fermented items, eat good quality meat and protein, ghee and get other fats from proper sources which have NOT been ultra-processed, exercise everyday and if you drink or smoke very less, manage to sleep well most nights and like hanging out with other human beings, you will generally live longer than an average human being who does not eat well, sleep well and drinks or smokes a lot.
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Best Healthy-Aging Supplements You Should Be Taking
Introduction Our skin is a remarkable organ- it is the largest one in terms of coverage and size and it performs so many functions- the most well known of which are to sweat, to help regulate body temperature, to feel sensations of various kinds, to basically function as a protective barrier and keep pathogens and other nasties away and finally, it is the site for Vitamin D synthesis, when you are exposed to sunlight. Since there is no way you can stop aging, it is better to look for foods and supplements and ways to slow down aging related processes, or promote healthy aging. Taking care of your skin can help you look and feel your best and also help improve your chances of staying safe from infections and other related issues. Let us look at some scientifically proven anti-aging supplements, or rather compounds which promote healthy aging. What Supplements Help Maintain Youthful Skin? We have a list of super cool compounds listed below, which help your skin function better, while also helping you look your best. The first one is Vitamin C- this is a no-brainer. It has the unique ability to reduce or even stop the production of melanin- which is why it is great for treating hyperpigmentation and brightening your skin. Since it has potent antioxidant activity, it also helps skin cells make more collagen. Vitamin E also has a similar effect and can be taken as a supplement. Collagen is a protein that is found in your skin, hair and many other organs. It is a structural protein and its main function is to protect. Collagen production naturally decreases as someone ages, which is why eating collagen rich foods or protein rich foods can help a lot. You can also supplement with collagen itself. If you take biotin along with collagen, then you will notice an improvement in hair texture and health too! Curcumin found in our beloved Indian spice- turmeric is a great antioxidant. It also boosts immunity because it has antipathogenic activity. Using turmeric in food is a great way to get the curcumin goodness, but if you want a golden glow on your face, just apply some paste too. Why do you think we celebrate Haldi during weddings? It is to help the bride and groom stay infection free for the most part, while also improving their glow for the other events to follow. Curcumin supplements have a high concentration of the active compound and are hence good for you. Hyaluronic acid (HA) is a humectant- meaning it is a sugar molecule that can hold on to a lot of moisture. Applying it as a serum or having it as a supplement can help improve the barrier function of the skin by reinforcing moisture within. Look for products that have different sized HA molecules for best results. Oral supplements of HA contain hyaluronan which is an effective compound with respect to dealing with dry skin and wrinkles. Resveratrol is a plant based polyphenol that helps in improving blood circulation and has potent antioxidative activity. This is what is good for the skin- collagen production is maintained and skin texture and structure are also good. Conclusion Most supplements available in the market promise too much- that they can stop aging and make you look youthful in a couple days. Nothing could be farther from the truth. It is important for you to understand that supplements by themselves can do very little, but if you combine them with a healthy diet and a good lifestyle, their positive effects get magnified many times over. The same approach needs to go for skincare too- what you put in your body is what will show on the outside as healthy skin. So, hydrate really well, eat your veggies and fruits, get enough protein and wholesome foods and then supplement with these badass compounds- we are very sure you won’t be disappointed with the results! FAQs 1. How do anti-aging supplements work to improve skin health? Anti-aging skin friendly supplements need to help reduce oxidative damage and inflammation caused by exposure to UV rays and other pollutants. They also need to help increase reserves of collagen and other proteins like keratin. So, look for products which can help you achieve all these goals. 2. Which vitamins are most effective for anti-aging? Vitamins C, E, D and alpha lipoic acid, Coenzyme Q10, trans-resveratrol and omega-3 fatty acids respectively, for better skin health and anti-aging. 3. Can anti-aging supplements help with fine lines and wrinkles? If you supplement with collagen, it can help with fine lines and wrinkles as these signs appear due to collagen deficiency attributed to advancing age. 4. How long does it take to see results from anti-aging supplements? You should notice a definite improvement in skin texture and health in a few weeks or months, after committed usage, everyday. Plus, how fast you respond also depends on what kind of product you use- oral pills or creams and lotions. 5. Can I take anti-aging supplements if I have specific health conditions or am on medication? Most of the supplements are of compounds that are naturally synthesised in your body, but you may still be allergic to some part of the formulation. So, do a patch test and check with your doctor about whether any of the supplements on your mind have unnecessary drug interactions that you need to be aware of.
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NMN Could Be An Effective Supplement To Take If Weight Loss Is Your Primary Health Goal
Introduction India has long been labelled the soon to become diabetes capital or nation of the world, with incidence rates just below China. Over 77 million people suffer from Type 2 diabetes while less than 30 million are prediabetic, which means it is only a matter of time before they become diabetic too, unless they make serious changes to their lifestyle and manage to delay it somehow. Ozempic is a well known therapeutic drug that is used to treat Type 2 Diabetes and is produced by Novo Nordisk, a Danish pharmaceutical company. More recently though, this drug which is a type of semaglutide- which means it helps the pancreas release insulin as needed, helps food digest slowly and also regulates glucose release by the liver - has been used to help individuals treat obesity, as it assists in weight loss. However, the brand names are different. Recent studies have shown that taking liraglutide, which is structurally quite similar to semaglutide can help reduce blood glucose levels, improve bone formation and mass and lead to weight loss. What Drugs Like Liraglutide Or Ozempic Can Do Liraglutide or semaglutide- both are classes of drugs called GLP-1 (Glucagon like Protein-1) agonists- which means they mimic the action of the GLP1 receptor. People who suffer from Type 2 Diabetes have enough insulin being made, but it is not able to enter cells effectively, as there is some issue with the number of GLP1 receptors on cells. Normally, GLP-1 helps sense glucose levels in blood and will signal to the pancreas to increase insulin production, while also helping reduce glucagon (a protein that helps blood glucose levels increase) activity at the same time. But, in Type 2 diabetes, this mechanism is messed up, leading to high blood glucose levels, less satiety and blood glucose spikes, among other issues. Liraglutide works in almost the same way as a semaglutide, except it needs to be taken everyday, while a semaglutide can be taken once a week. It also has the additional ability to reduce chronic inflammation by using SIRT-1 controlled pathways in cells. SIRT-1 is a well known sirtuin protein- a class of 7 proteins labelled from SIRT-1-7 respectively, which help in cellular repair and are protective in nature. Sirtuins need plenty of NAD+ to work their magic- and levels of NAD+ begin to reduce with increasing age. The Experiment Chinese researchers conducted experiments on diabetic mice models, which were then treated with 0.2mg/kg liraglutide, for a duration of 12 weeks. This helped reduce their blood glucose levels and body weight too. It was also observed that liraglutide helped increase bone mass and formation, and this was confirmed with tests that showed bone breakdown markers were lower than before. This happened mainly due to an increase in SIRT-1 activity. Now, the researchers genetically modified the mice to NOT produce SIRT1 protein at all, but continued treating them with liraglutide injections as before. They noticed that without SIRT-1 activation, there were greater levels of oxidative stress and inflammation- which directly impacted bone mass and formation. This helped them confirm that SIRT-1 was indeed being activated by liraglutide. What Happens With NMN Supplementation With that experimental result in mind, let us explore one more concept- how NAD+ from NMN helps regulate all of this and increases longevity related markers in cells. Nicotinamide Mononucleotide, shortened to NMN is a compound that acts like a precursor to NAD+ - which is the energy currency of the mitochondria. If more NAD+ is present, the mitochondria works very efficiently and helps provide enough energy to run all cellular processes in real time. But, as someone ages, their NAD+ levels begin to drop, and they feel fatigued and suffer from chronic illnesses more often than not. Sirtuin activation also plummets as they are highly dependent on NAD+ for their energy needs. So, if we supplement liraglutide or semaglutide therapy with NMN, then there could be weight loss and better blood glucose control because of the liraglutide, while other chronic inflammatory and aging related markers can be downregulated (or reduced) due to better activation of sirtuins by ample NAD+ derived from NMN. Though this drug combination still needs to be experimented with, it is not too hard to postulate what may happen- as research has definitively shown that NMN supplementation helps increase sirtuin activation in the body and that NMN can be combined with sirtuin activator drugs themselves for an additive therapeutic effect. Conclusion The renowned Australian aging researcher Dr. David Sinclair says this “I believe that aging is a disease. I believe it is treatable. I believe we can treat it within our lifetimes. And in doing so, I believe, everything we know about human health will be fundamentally changed.’ Though, all of us want to live long lives, we may not be able to do that because of the concerted effects of aging related pathways in the body. The use of liraglutide and semaglutide for treatment of obesity and diabetes is now well known. Quick weight loss can be stressful for the body and so supplementing with NMN may help offset some of these issues. With improvement in blood glucose levels and lower chronic inflammation, the person may also feel better than ever. So, what do you think would happen if sirtuin activators, NMN and liraglutide or semaglutide were used in combination to treat diabetes or obesity?
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