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Are We Facing a Silent Epidemic? Understanding and Addressing Inflammaging in an Aging World
As the global population continues to age, we face new challenges in maintaining health and quality of life for older adults. One of the most significant yet often overlooked issues is "inflammaging" - a chronic, low-grade inflammation associated with aging. This article explores the concept of inflammaging, its impact on health, and strategies to combat it. The Aging Population - A Global Phenomenon Before delving into inflammaging, it's crucial to understand the context of our rapidly aging world: - The current elderly population (aged 60 and above) of 153 million is expected to reach 347 million by 2050. - In India alone, the 2011 Census reported 104 million older people (60+ years), constituting 8.6% of the total population. - By 2030, it's estimated that 34 nations will have over 20% of their population above 65 years. These statistics highlight the urgent need to address age-related health issues, including inflammaging. What is Inflammaging? Inflammaging refers to the chronic, low-grade inflammation that occurs as we age. It's not just an elevation of inflammatory markers but a complex interplay of genetic predispositions, lifestyle factors, and physiological alterations that collectively tip the balance toward chronic inflammation over time. The Double-Edged Sword of Inflammation Inflammation is a crucial response to injury and infection. It: - Lays the foundation for cell repair - Prevents the spread of damage - Removes cell debris However, while acute inflammation serves a protective function, chronic inflammation poses significant health risks. The Impact of Inflammaging Inflammaging is linked to several age-related diseases and conditions, including: - Type 2 diabetes - Cancer - Dementia - Cardiovascular disease - Metabolic syndrome According to recent data from India: - 101 million people have diabetes - 136 million have pre-diabetes - 315 million have high blood pressure - 254 million have generalized obesity - 351 million have abdominal obesity - 213 million have hypercholesterolemia These statistics underscore the potential link between inflammaging and widespread health issues in aging populations. The Mechanisms of Inflammaging Inflammaging accelerates the aging process by: - Promoting cellular damage - Weakening tissue function - Contributing to chronic conditions It's often a silent contributor to age-related decline and disease, making it crucial to address proactively. Strategies to Combat Inflammaging Addressing inflammaging requires a multifaceted approach that encompasses both lifestyle modifications and targeted treatments. 1. Exercise Regularly Physical activity has been shown to reduce inflammation and improve overall health in older adults. 2. Adopt an Anti-Inflammatory Diet Focus on a diet rich in: - Fruits and vegetables - Whole grains - Healthy fats Minimize consumption of: - Processed foods - Sugary snacks The Mediterranean diet is often recommended for its anti-inflammatory properties. 3. Consider Nutritional Supplements Some supplements that may help combat inflammaging include: - Turmeric - N-acetylcysteine (NAC) - Quercetin These ingredients have demonstrated impacts on key cellular mechanisms driving inflammation. 4. Manage Stress Chronic stress can contribute to inflammation. Implement stress-reduction techniques such as meditation, yoga, or deep breathing exercises. 5. Prioritize Sleep Adequate, quality sleep is crucial for reducing inflammation and promoting overall health. 6. Stay Socially Active Social isolation can contribute to inflammation. Maintain social connections and engage in community activities. The Future of Inflammaging Research Scientists worldwide are researching inflammaging, seeking to understand its mechanisms and develop effective interventions. As our knowledge grows, we may see more targeted approaches to combating this aspect of aging. Conclusion Inflammaging represents a significant challenge in our aging world, but it's one we can address through a combination of lifestyle changes, targeted interventions, and ongoing research. By taking a proactive approach to inflammaging, we can work towards improving healthspan and quality of life for older adults globally.
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Exploring NMN Human Trial Advancements
Unlocking the Potential of NMN: Is it the Anti-Aging Elixir We've Been Waiting For? NMN: The Fountain of Youth or Just Another Fad? In a world obsessed with staying youthful and vibrant, the quest for the elusive elixir of life has led us to some intriguing places. One such destination on this journey is Nicotinamide Mononucleotide (NMN). Over the past three years, NMN has been the subject of extensive human trials, and the results are nothing short of fascinating. These trials have not only confirmed its safety but have also unearthed its potential as an anti-aging supplement. Safety First: NMN's Clean Bill of Health One of the primary concerns when it comes to any supplement is safety. Can we trust it not to harm our bodies? Well, if the past three years of NMN trials are any indication, we can breathe a sigh of relief. NMN, the precursor to the essential NAD+ molecule, has undergone rigorous testing, and not once has it triggered adverse physiological effects. This verdict comes from a series of human trials, painting a reassuring picture of NMN's safety profile. NMN: A Beacon of Hope for Aging Bodies Now that we've established NMN's safety, let's dive into what truly sets it apart. The human trials have unveiled its remarkable benefits, particularly for aging adults. NMN seems to possess the power to enhance insulin sensitivity, an essential factor in maintaining stable blood sugar levels. This alone can be a game-changer for those battling age-related metabolic challenges. But that's not all NMN has up its sleeve. These trials also highlight its ability to bolster physical capacity in older individuals. The aging process often takes a toll on our muscles and overall physical performance, but NMN seems to push back against this decline. For those looking to stay active and vital as they age, this is welcome news indeed FDA Scrutiny and the Ongoing NMN Controversy While NMN's potential is captivating, it's important to address the elephant in the room: the FDA's stance on NMN. As of November 2022, the FDA authorized NMN for investigation as a new drug, effectively excluding its sale as a dietary supplement. However, this decision has not halted the fervent interest in NMN, with sales continuing unabated. For those who continue to purchase and consume NMN despite the FDA's ruling, as well as those waiting for a prescription, the question remains: what do the published NMN trials say about its safety and effectiveness as an anti-aging supplement? Let's take a closer look at the research that's shedding light on this enigmatic molecule. NMN Human Trials: A Closer Look A pivotal study published in Advances in Nutrition by Yang and colleagues from Hangzhou Normal University in China delves into the currently available data from NMN human trials. Their aim? To scrutinize NMN's safety and effectiveness, especially in combatting physiological deterioration during aging. The findings from these human trials paint a promising picture. NMN appears to confer a range of physical and metabolic benefits, particularly in older adults. However, a critical question remains unanswered: do the numerous advantages observed in aging rodents also apply to humans? While NMN's potential as an anti-aging therapeutic is evident, more extensive research is required to bridge the gap between rodent and human studies. The Safety Assurance: Keio University's Pioneering Study To understand why NMN has gained such momentum, we must revisit its safety profile. The journey began in 2016 when researchers at Keio University in Japan conducted the first study evaluating NMN's safety. Male participants were administered 100, 250, or 500 mg of NMN in the morning and closely monitored for five subsequent hours. The outcome was nothing short of reassuring. No harmful effects were observed, and crucial parameters like blood pressure, heart rate, blood oxygen saturation, and body temperature remained stable. Based on these results, Keio University researchers concluded that NMN, even at doses as high as 500 mg, is safe and well-tolerated. Building Confidence: Subsequent Human Trials Since the groundbreaking study at Keio University, seven other human trials, testing NMN's safety parameters with varying doses, have been carried out. The highest oral dose, a substantial 1,000 mg twice daily for 14 days, was administered in a Harvard study - all without any adverse side effects. These trials collectively send a resounding message: NMN is not only safe but also well-tolerated. NMN's Impact on Physical Performance Now, let's delve deeper into NMN's ability to enhance physical performance. Rodent studies have indicated positive findings related to physical capabilities, brain function, metabolism, and more. These promising results prompted researchers to explore whether NMN could counteract age-related physical decline in humans. The study led by Igarashi and colleagues demonstrated that NMN improves muscle motility, walking speed, grip strength, and the frequency of movements like standing and sitting in aged individuals. This data strongly suggests that NMN can significantly enhance physical performance in older adults. Another noteworthy study conducted by Liao and colleagues focused on trained runners. The results were equally impressive. NMN substantially improved aerobic capacity, a crucial factor for endurance athletes, as evidenced by increased blood oxygen consumption during exercise. Additionally, Huang and colleagues explored NMN's impact on walking endurance in adults aged 40 to 65 years. Using a six-minute walking endurance test, they discovered that NMN led to a sustained improvement. This finding underscores NMN's potential to enhance exercise capacity, even in middle-aged and older individuals. NMN and Metabolic Benefits NMN's benefits extend beyond physical performance. In one study involving postmenopausal women who were overweight or obese, NMN demonstrated its potential to combat prediabetes. The results indicated a substantial increase in muscle insulin sensitivity, along with improvements in insulin signaling. These findings suggest that NMN holds metabolic benefits, particularly for women dealing with prediabetes. The Sound of Youth: NMN and Hearing Capabilities Aging often takes a toll on our senses, including our hearing. NMN, however, may have something to say about that. Igarashi and colleagues found that NMN supplementation improved hearing capabilities in older men, particularly in the right ear. These findings provide a glimmer of hope that NMN could potentially restore hearing abilities in the elderly. Telomeres: The Key to Longevity? The ends of our chromosomes, known as telomeres, shorten with age, serving as a biological marker of the aging process. Niu and colleagues conducted a study that could hold the key to longevity. By supplementing with 300 mg of NMN per day, they nearly doubled telomere lengths in blood cells within just 90 days. These results suggest that NMN might exert its anti-aging effects at the molecular level. The Road Ahead: More Questions, More Research While NMN's potential is undeniable, there are still many unanswered questions. Do its benefits extend consistently across multiple organ systems in aging humans as they do in rodents? The relatively short durations of the studies, none lasting longer than three months, leave us wondering if NMN's effects are maximized over time and if there are any long-term side effects to consider. NMN and the FDA: An Ongoing Controversy Despite the FDA's decision to exclude NMN from the dietary supplement market, the molecule seems to hold significant promise. Human trials have not raised any red flags regarding its safety, and there is growing evidence of its potential anti-aging benefits. The fact that NMN is under investigation as a new drug underscores its potential as a game-changer in the world of anti-aging. In conclusion, NMN is a captivating molecule that has the potential to transform the way we age. It has cleared the safety hurdle with flying colors and has shown remarkable promise in improving physical performance, metabolic health, and even hearing capabilities in aging individuals. However, there is still much to uncover about its effects on multiple organ systems and its long-term implications. As research continues, NMN may yet prove to be the elixir of youth we've been searching for, challenging the controversy surrounding its accessibility and unlocking its true potential for humanity.
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Unveiling the Secrets of Sirtuin 6: A Key to Healthy Aging
What is Sirtuin 6? In maintaining good health as we age, Sirtuin supplements have emerged as potential allies. These supplements are centered around a group of proteins known as sirtuins, which play a pivotal role in regulating cellular processes like inflammation and metabolism. In this exploration, we delve into the specifics of one such protein—Sirtuin 6 or SIRT6—and how supplements can activate its potent benefits. The Basics of Sirtuin 6 Sirtuin 6 is a critical player in regulating cellular processes such as DNA repair, metabolism, and inflammation. Belonging to the sirtuin family, SIRT6 operates by modifying other proteins, particularly histones. By removing a small chemical group called "acetyl" from histones, Sirtuin 6 positively influences gene expression. This modification of histones impacts how genes are expressed, ultimately influencing cell function and behavior. How Do Supplements Activate Sirtuin 6? Unlocking the potential of Sirtuin 6 has brought about a groundbreaking shift in addressing various diseases like cancer, diabetes, and neurodegenerative conditions. Think of Sirtuin 6 as a superhero inside your body – it plays a crucial role in fixing damaged DNA, which is like repairing the blueprint of your cells. When it comes to cancer, activating Sirtuin 6 acts like a shield, preventing abnormal cell growth and the spread of cancerous cells. It's like having a superhero power that stops the bad guys (mutations) from taking over. In the world of metabolic disorders, especially diabetes, Sirtuin 6 is like a metabolic maestro. It helps regulate insulin (the blood sugar manager), improves how cells take up glucose for energy, and manages the production of fats. This makes it a potential hero in the fight against type 2 diabetes and obesity. But Sirtuin 6 isn't just a one-trick hero. It also steps up to protect your brain, making it a contender in the battle against neurodegenerative diseases like Alzheimer's. By keeping the genetic stability in your brain intact, Sirtuin 6 shows promise in slowing down age-related degeneration. The cool thing about Sirtuin 6 is its versatility. It's like having a superhero with multiple powers – capable of addressing a variety of health challenges. Whether it's cancer, diabetes, or issues with your brain health, Sirtuin 6 is the superhero that stands at the forefront of potential treatments for a range of diseases. Notably, SIRT6 activators can enhance the activity of other sirtuins, offering many health benefits. However, not all activators are created equal, making it crucial to choose a reliable supplement. SIRT6 Activator Supplements Sirtuin 6 activator supplements are derived from various natural sources, one of which includes a specific strain of seaweed, Fucus Vesiculosus. Rigorous testing is essential to ensure the effectiveness of these activators, given the variable nature of Fucus Vesiculosus found globally. Countries with high seaweed consumption, such as Japan and South Korea, boast impressive life expectancies, emphasizing the potential health benefits of seaweed. Sirtuin 6 Benefits SIRT6 Has Anti-aging Properties SIRT6's involvement in critical aging processes, such as DNA repair and inflammation, positions it as a potent anti-aging agent. Studies on mice treated with a SIRT6 activator showcased extended and healthier lifespans compared to untreated counterparts. Improved Glucose and Lipid Metabolism Sirtuin 6 plays a crucial role in regulating insulin sensitivity, glucose uptake, and lipid synthesis. By increasing insulin secretion and activating key regulators of energy metabolism, Sirtuin 6 aids in preventing metabolic disorders like type 2 diabetes and obesity. Sirtuin 6 Improves Cardiovascular Function Positive effects on cardiovascular health include the promotion of new blood vessel growth, relaxation of existing vessels, and enhanced heart contractions. SIRT6's protective mechanisms also extend to reducing the risk of heart failure by improving cardiac function and reducing fibrosis. Sirtuin 6 Plays a Role in Cancer Prevention By managing the activity of the protein HIF-1 alpha, SIRT6 lowers the risk of cancer development. Ongoing human trials aim to demonstrate the preventive potential of SIRT6 Activator against cancer recurrence. Sirtuin 6 Supplement Studies Studies on mice deficient in Sirtuin 6 revealed abnormalities resembling aging-associated degenerative processes, emphasizing the protein's role in promoting normal DNA repair. Clinical Trials and Future Prospects Several clinical trials are underway to explore the potential of SIRT6 activators in treating age-related diseases like Alzheimer's and metabolic disorders such as diabetes. The future may see Sirtuin 6 activators as natural alternatives to traditional anti-aging treatments. Conclusion on Sirtuin 6 Activator Supplements In conclusion, Sirtuin 6, particularly through activator supplements, emerges as a key player in promoting healthy aging. By activating Sirtuin 6, these supplements showcase benefits ranging from anti-aging properties to improved glucose and lipid metabolism, cardiovascular function, and cancer prevention. The meticulous testing and curation process ensure the efficacy of these products, setting them apart as trustworthy choices for those seeking to enhance their health and lifespan naturally. As we navigate the complexities of aging, Sirtuin 6 stands as a beacon of promise in the realm of cellular health. Choose wisely to unlock the potential benefits of Sirtuin 6 activation.
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NMN: A Ray of Hope the Battle Against Physical Decline and Poor Sleep in Elderly
New Clinical Trial Sheds Light on the Potential of NMN to Keep Our Elders Sprightly and Well-Rested The wise Bachchan ji said in the movie "Piku," "Motion se hi emotion." (well, he was talking about another kind of motion). But, indeed, movement is emotion, and for our elderly, maintaining that motion is crucial for a happy life. More Than Just a Walk in the Park In India, where respect for elders is deeply ingrained in our culture, we often overlook the subtle signs of aging. One such sign is the slowing of our elders' gait. However, science offers us a chance to slow down this process. The Indian Scenario A study published in the esteemed Indian Journal of Medical Research has shed light on a concerning trend among our elders. The research reveals a significant decline in walking speed as age increases, a phenomenon observed across both rural and urban landscapes of our diverse nation. The gradual reduction in walking speed serves as a crucial barometer of overall health in our aging population. It's not just a number on a calendar; it's a reflection of how gracefully—or challengingly—we're navigating the golden years. Indeed, this seemingly simple measure of steps and seconds tells a profound story. It speaks volumes about muscle strength, joint health, cardiovascular fitness, and even cognitive function. When our elders slow down, it's not just their feet that are affected—it's their independence, their ability to engage with the world, and ultimately, the richness of their daily experiences. By understanding and addressing this decline in walking speed, we're not just helping our elders move faster—we're paving the way for them to lead fuller, more active, and more satisfying lives well into their twilight years. It's about ensuring that the wisdom and experience they carry can continue to enrich our families and communities for years to come. Sleep: The Unsung Hero of Health Alarming research published in BMC Public Health has pulled back the curtain on a startling reality: over 60% of elderly individuals in India grapple with poor sleep quality. This statistic isn't just a number; it's a silent epidemic affecting millions of our respected elders. The implications stretch far beyond morning grogginess or afternoon fatigue. Poor sleep quality in the elderly is intricately linked to a cascade of health issues, including increased risk of falls, cognitive decline, cardiovascular problems, and a weakened immune system. The causes of this sleep crisis are multifaceted, ranging from chronic health conditions prevalent in older adults to the stresses of changing family dynamics in modern India. Nutritional deficiencies, common in our elderly population, further exacerbate sleep issues. Moreover, the lack of awareness about the importance of sleep hygiene and the dismissal of sleep problems as an inevitable part of aging contribute to the problem's persistence. Addressing this sleep crisis requires a holistic approach. It calls for increased awareness, better healthcare access, and innovative solutions that respect our cultural norms while embracing modern sleep science. From creating sleep-friendly environments in multigenerational homes to incorporating traditional practices like yoga and meditation for better sleep, there are numerous avenues to explore. Enter NMN: The Potential Game-Changer A recent clinical trial has shed light on the potential benefits of NMN supplementation, particularly for older adults. This study, which has caught the attention of researchers worldwide, focused on two critical aspects of healthy aging: mobility and sleep quality. Study Design The trial involved a group of older adults. Participants were randomly divided into two groups: The NMN group: Received 250 mg of NMN daily The placebo group: Received a placebo pill The study ran for 12 weeks, during which researchers meticulously monitored changes in walking speed and sleep quality. Remarkable Results Walking Speed NMN Group: Participants maintained their walking speed throughout the 12-week period. This is significant because it suggests that NMN might help combat the natural decline in mobility that often comes with aging. Placebo Group: In contrast, these participants showed a noticeable decline in walking speed over the same period, aligning with the typical age-related slowdown. Sleep Quality NMN Group: Remarkably, these participants reported improved sleep quality. This enhancement in sleep is crucial, considering the widespread sleep issues among India's elderly population. Placebo Group: Unfortunately, this group experienced a worsening in sleep quality, a common trend in aging populations. Implications for India's Elderly These results are particularly exciting when we consider the challenges facing India's aging population. The maintenance of walking speed suggests that NMN could help our elders retain their independence and mobility for longer. This is not just about physical health; it's about preserving dignity and quality of life. The improvement in sleep quality is equally significant. Given that over 60% of India's elderly struggle with poor sleep, as revealed by the BMC Public Health study, NMN could offer a new avenue for addressing this pervasive issue. Conclusion As we look to the future, NMN offers hope in our quest to ensure our elders age gracefully. It's not just about adding years to life, but life to years. To quote the legendary Dr. B.R. Ambedkar: "Life should be big, not long." With advancements like NMN, we're one step closer to making that a reality for our beloved elders. Always consult a healthcare provider before starting any new supplement regimen.
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The Hope of Caloric Restriction in India's Obesity Crisis: Contemplating a Healthier and Longer Life
Is Caloric Restriction The Answer? The desire for a healthier and longer life, free from the common ailments associated with aging, is a shared aspiration worldwide, including among the people of India. However, the nation is currently grappling with a significant challenge in the form of an escalating obesity crisis, as highlighted by recent data from the National Family Health Survey (NFHS). The concerning rise of obesity among Indian women and men, particularly in the age group of 15-49, indicates that approximately a quarter of young women and just over a fifth of men in India are above the normal body weight. This poses a serious concern, especially among women and those in better economic conditions, demanding urgent attention for the nation's wellbeing. Delving into the World of Caloric Restriction In the quest to combat aging-related ailments and enhance longevity, caloric restriction (CR) has emerged as a necessary subject of scientific research. Studies involving various organisms, ranging from yeast to mice, have consistently demonstrated the potential of CR to promote longevity and mitigate the effects of aging. Groundbreaking Studies At the forefront of this groundbreaking research lies the esteemed University of Aberdeen in Scotland. In a recent study published in The Journal of Gerontology, scientists from the university explored the effects of different levels of caloric restriction on lifespan and body composition in mice. Their findings have offered valuable insights into the potential of caloric restriction to extend life and improve overall health. To investigate further, the researchers divided the mice into four distinct groups, each subjected to varying degrees of caloric restriction: 10%, 20%, 30%, and 40% caloric deficit. Additionally, a separate control group had unrestricted access to food for 12 hours each day (12AL group). The caloric restriction started when the mice were 5 months old in human terms and continued until they were 24 months old in human terms.Among the 64 mice that underwent the caloric restriction intervention, 33 mice survived the entire 19-month period. Notably, the group with a 40% caloric deficit exhibited the most significant improvement in survival, boasting an increase in lifespan by 47.6% compared to the control group. Surprisingly, the groups with a 10% caloric deficit did not fare as well as the control group, suggesting that an extreme restriction might not be the optimal approach for everyone. Unraveling the Connection: Caloric Deficit and Weight Loss During the study, the researchers sought to understand the link between caloric deficit and weight loss. An intriguing observation was made - after approximately 30 days of caloric restriction, the mice's body mass stabilized. This stabilization was attributed to the loss of both fat and muscle mass. Moreover, the researchers noted that the benefits of weight loss seemed to plateau after this initial period, implying that prolonged extreme restriction might not be necessary to achieve positive outcomes. Insights from Human Studies Human studies exploring the potential benefits of caloric restriction have also shown promise, with intermittent fasting and similar approaches yielding positive results. For instance, intermittent fasting has been associated with lower blood pressure and improved insulin resistance in obese individuals. Furthermore, reducing calorie intake by certain percentages over time has been linked to various health benefits, including reduced inflammation, a decreased risk of mortality, and slower biological aging. Adopting a Balanced Approach to a Healthier Future While caloric restriction demonstrates remarkable potential for human health, it is essential to exercise caution. An extreme 40% caloric deficit may not be necessary to achieve positive outcomes. Moderation and personalized approaches should be considered when making dietary changes to improve health. Therefore, consulting healthcare professionals is of utmost importance to determine the most suitable approach for each individual. In the face of India's obesity crisis and global health challenges, embracing a balanced and heart-healthy diet, combined with moderate caloric restriction, can significantly promote overall health and potentially increase longevity. By incorporating healthy lifestyle habits into our daily routines, we can harness the potential benefits of caloric restriction and pave the way for a longer, healthier future. So, why not start making small, manageable changes today? Together, let's work towards a healthier, more mindful existence!
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Everything You need To Know About Apigenin
Introduction Apigenin, also called 4’,5,7-trihydroxyflavone is a plant flavonoid that normally occurs in herbs like parsley, celery, chamomile, spinach, red onions and green chillies, among other vegetables. It is found in very minute quantities in the food we eat but is pretty effective anyway. Apigenin has been known for a long time by biologists and chemists (from the early 1900s) but only now is it being studied in detail. Preclinical studies have shown promising results for the most part, which is why now its usage as a dietary supplement that promotes health is booming. Apigenin is needed in very small amounts and it has a largely inhibitory effect on the muscles and brain- which means it promotes relaxation in general. What Are The Benefits Of Apigenin Supplement? Apigenin’s main strength lies in its ability to regulate NAD+ levels in the body. NAD+ levels drop by large amounts as one ages, but it is a crucial molecule that helps cells perform all their functions with elan. NAD+ levels drop due to greater need for cellular maintenance as you age. Levels drop because of one glycoprotein called CD38, which plays a significant role in inflammation, consumes NAD+ molecules to maintain its level of activity. Apigenin works to cut down on the amounts of CD38 being produced in the body, thus helping NAD+ levels remain stable. Apigenin also interacts with specific inhibitory neurotransmitter receptors in the brain- which means it helps you sleep better. When Should You Take Apigenin For Best Results? Apigenin should be taken at night ideally, as it promotes muscular relaxation on a large scale- something that happens when you go to sleep. Apigenin helps modulate GABA (gamma amino butyric acid) levels in the brain, helping you feel less stressed. It's best if you take it right before bedtime. Apigenin Benefits For Inflammation And Immune Health Apigenin has potent anti-inflammatory activity as studies have shown that it can help regulate pro-inflammatory cytokines like TNF-alpha AND IL-1 beta, T-cells and macrophages and can also help cells stay protected from oxidative damage. Apigenin by itself may also have antimicrobial activity as research has shown. Since it promotes relaxation, it will help improve sleep quality and reduce stress- two important aspects that will in turn help improve your performance at work the next day. Some research suggests that apigenin may help increase testosterone levels by inhibiting enzymes that break down testosterone, potentially leading to higher levels of the hormone in the body. Apigenin is also small enough to be able to cross the blood brain barrier- so you can expect it to show some effect in the brain. A 50 mg capsule of apigenin is more than enough to help improve your sleep schedule and positively impact your day, everyday. FAQs 1. What is Apigenin and where does it come from?Apigenin is a plant based flavonoid found in many herbs that are commonly used to season food. It can be found in coriander, cabbage, chamomile, thyme, greens, tomatoes, in tea, wine etc. Apigenin has the unique property to help the body retain its NAD+ reserves, as it works to reduce CD38 levels. High CD38 levels are associated with lower NAD+ levels. 2. Can Apigenin help reduce anxiety or improve sleep quality?Yes, apigenin is good for helping muscles relax, which is the first step towards being able to sleep properly, while also helping regulate inhibitory GABA. Low levels of GABA can lead to poor sleep quality. Chamomile tea is very well known for its calming effects and this is due to apigenin. Apigenin helps in increasing synthesis of BDNF, while also regulating inflammatory cytokines. Apigenin is also known to help with serotonin regulation. Collectively, all these molecules help you sleep and prevent mood swings. 3. Are there any potential side effects of taking Apigenin?If you take too much, then you risk falling asleep much sooner. No other side effects have been observed. 4. Can Apigenin interact with other medications or supplements?Apigenin can interact with certain chemotherapy drugs, antibiotics, antiviral drugs, hormone replacement therapy drugs etc. but studies need to be done to understand more about these interactions. Consult a health specialist before starting Apigenin supplementation. 5. Is Apigenin safe for pregnant or breastfeeding women?Apigenin is generally safe enough to be consumed by everyone but if you are pregnant, it is best you talk to your doctor about supplementing with any substance in general
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Benefits Of Peptides For Skin
Introduction Peptides are the building blocks of proteins- as they are composed of various combinations of amino acids that can be then used to synthesize super crucial proteins like keratin, collagen or elastin. These proteins are the ones that actually give skin its soft, elastic and bouncy texture when present in the right amounts. Our body makes these proteins by itself very efficiently all the time, so when you add peptide containing products to your skincare routine, you are just helping nudge the process along- a lot faster. If you have seen a lot of products with peptides, it is for this very reason- and they are very good for your skin too. How Do Peptides Improve Skin Health? Peptides help your skin make more protein. You may then wonder why using the proteins themselves doesn’t work. The reason is simple- they are too large and don’t pass through the pores that easily. Instead, when you apply peptides which are much smaller in size, you allow the raw materials to penetrate through the pores with ease- thus helping your skin make more protein with less effort. How do they do that though? Peptides move quickly and tell your skin cells to make more collagen and elastin- so think of them as delivery agents which can get the job done really well. Let us look at different ways in which peptides are useful- They can help reduce the number of noticeable wrinkles- as they help smoothen them out. Collagen production picks up when you use peptides- which is good for this purpose. Elastin is a protein that gives skin its much coveted elastic properties- so your skin will look firm and taut- thanks to this tiny miracle worker protein. Peptides are gentle on your skin- so they can help you if you have sensitive skin related issues- like redness, inflammation or sun-damaged skin. If you get overzealous with your skincare routine, then you risk damaging the integrity of the skin barrier. Peptides help repair your skin layers effectively, if you have exfoliated too hard, or spend too long under the sun, if you are a poor sleeper or if you are exposed to pollutants on a regular basis. We know- those traffic jams and work commutes can be nightmares. Peptides can also be used if you have zits, they can be clubbed with other skincare products- but NOT all of them. Example- DON’T use AHA with peptides. Do Peptides Help With Acne And Scars? Yes, they can! Some peptides kill bacteria very effectively, so they won’t give these critters a chance to infect your pores. Also, we know how lush a post-workout glow can look like, but please remember to wash up ok? Peptides vs Retinol For Anti-Aging Peptides are a newer alternative to retinol which has been the anti-aging darling that we all know of. But, retinol is not suitable for everyone and can cause some major side effects initially- like shedding, dryness, itchy skin or even redness and it takes some getting used to. Peptides however are not like that- they are good for sensitive skin, but don’t give you quick results like retinol can. Should You Use Peptides With Vitamin C? Yes, they are a great combination that can help you achieve glass skin goals, or whatever else you have in mind. Vitamin C is a great antioxidant- and so can help reduce damage and brighten skin. Peptides are all rounders- so they will help with this concern too. But you should learn to layer them in the right way- Layer on some Vitamin C serum first, then follow with peptide. Ideally, you should be using a serum or a moisturiser- which means the product will be in contact for longer hours than just a cleanser for example- which you will wash off. Conclusion Peptides are pretty expensive though, so they may not be very economical at times. The best time to use peptides for skin care is both- in your AM and PM routine. This way they will help you all day. Just make sure you put it on before using makeup or SPF in the morning, while you can dab some on at night after cleansing and before bedtime. Peptides are gentle products- so they will not give you dramatic results right away. They are the very definition of ‘trusting the process’ in that way! FAQs 1. What are peptides, and how do they benefit the skin?They are short chains of amino acids (2-100 in number) that help your body make proteins like collagen, elastin and keratin- all of which are present on your skin and help it work well and look even better. 2. How do peptides compare to other skincare ingredients like retinol or hyaluronic acid?Peptides are gentle like hyaluronic acid- so they can help with repair and brightening, and also take care of hydration concerns by keeping the skin barrier intact. But, it is not going to give you quick results like retinol does. Retinol goes to work by making your skin cells multiply way faster than usual- which is how your old skin cells will slough off, while allowing new ones to form under. 3. How long does it take to see visible results from using peptides?You can expect to see some results in a couple months after consistent usage. Remember- peptides work slowly but surely! 4. Can peptides be used on sensitive skin or with other skincare ingredients?Yes, they are great for sensitive skincare enthusiasts too. 5. Are there any side effects or risks of using peptides in skincare?Some of you may be allergic to a few peptides- so make sure to do a patch test before you use them full time. Signs to watch for include redness, swelling or even itching but these are very rare.
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Everything You Need To Know About Betaine-TMG
Introduction TriMethylGlycine or Betaine TMG is a simple molecule but can get a lot done in your body. It is basically glycine, which has 3 methyl groups attached to it, which makes it an excellent methyl donor. Methyl groups are a necessity for hundreds of cellular reactions to occur. Notable among them are DNA modifications, transcription and translation of proteins, to assist the liver so it can function better in the detoxification department and as a crucial inhibitory neurotransmitter in the brain. Successful methylation also helps in the production of other neurotransmitters like dopamine. What Are The Benefits Of Betaine TMG Supplement? Betaine TMG’s main strength lies in its ability to donate methyl groups which help regulate lots of processes in the body. The addition of methyl groups is done by a process called methylation, while removing methyl groups is called demethylation. The addition of methyl groups is a highly planned process as excessive methylation or undermethylation- both can be problematic. Studies have shown that DNA is tagged with multiple methyl groups - which help regulate its expression When methylation does not occur normally, a person is more susceptible to certain kinds of cancers, immunity issues and heart disease. All of these have been linked to higher levels of homocysteine, though the exact mechanism is not understood. TMG is also good for increased endurance, as this was evident in a study conducted on football players. When they were given 2 grams of TMG everyday, they noticed better running speed and muscular strength, with them performing especially well with repeated sprints. This is because TMG helps the cells produce more creatine - which is fuel for muscle cells. It also helps reduce insulin resistance, when taken with choline. It also influences fat metabolism in positive ways. TMG can also be used for people who have depression or anxiety due to low levels of dopamine in their brain, while also reducing homocysteine levels (high levels of which have been associated with depression too). Who Should Take Betaine TMG Daily? People who have high levels of homocysteine in their system due to faulty genes, have heart disease or liver disease and want to improve their metabolism should talk to their doctor before supplementing with TMG. TMG also helps cells regulate hydration levels, which can be good if you are a fitness enthusiast. Its effects on muscular performance and health cannot be denied either. Should You Take Betaine TMG With Or Without Food? You should always take it AFTER a meal to get the maximum benefits from this supplement. The main advantage of TMG is that there is nothing artificial about it and it is readily synthesised and broken down in our body in normal conditions. The methyl groups can be taken away and used for a variety of chemical reactions, most of which centre around DNA maintenance and regulation, in detoxification of certain compounds by the liver and in making important neurotransmitters that help improve brain function and mood. T + N = L + P: TMG Works great with NMN. When NAD+ is boosted, your body might get depleted of methyl groups. TMG restores the methyl groups. Pair with NMN for optimal longevity and performance benefits. Finally, glycine by itself is a neurotransmitter and the smallest amino acid molecule that can help you sleep better and for longer. FAQs 1. What is Betaine TMG, and how does it work in the body?Betaine trimethylglycine (TMG) is a compound that contains 3 methyl groups- which are extensively used for all sorts of cellular functions and synthesis related processes. It helps the heart especially, by lowering levels of homocysteine (an amino acid that has been linked to increased incidence of heart disease), by ensuring that all cells in the body have enough fluids in them, while also helping the liver and pancreas metabolise food better. 2. How does Betaine TMG support heart health and lower homocysteine levels?Betaine gives away its methyl groups, which the body can then use to convert homocysteine to methionine, which does not cause any harm. High homocysteine levels in the blood are a marker of heart disease and possible issues later on. 3. When is the best time to take Betaine TMG—morning or night?You should take TMG supplements after breakfast. If better sleep is your priority, then TMG can be taken at night too, 30 minutes before bedtime. Once the methyl groups get donated, glycine amino acid remains. It is an inhibitory neurotransmitter which asks your brain to relax, so that you can wind down for the night and fall asleep. 4. Are there any side effects or risks associated with Betaine TMG?If you take too much of TMG, then you risk having very high levels of methionine in the blood, which is not good for you. Otherwise, some people may be allergic to it and develop rashes or have diarrhoea and stomach pain. But these occur in very rare cases. 5. Can Betaine TMG be taken with other supplements like creatine or choline?Yes, betaine helps in making more creatine - both of which help regulate homocysteine levels in the body. Taking both choline and TMG can help you reduce your chances of suffering from cancer, according to a few studies.
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Is Your Biological Age The Same As Your Age?
Introduction We don’t think twice before giving our age for official purposes or otherwise. This is because we know when we were born - i.e. the Date of birth (DoB) and just calculate how old we could be. Though your age can be a simple number, there are a lot of factors that actually determine if you are as old as that or not. Case in point- some people look much younger than their age, while others may look a lot more mature or older and tired. Why do you think that happens? This is where the concept of ‘chronological age’ vs. ‘biological age’ comes in - where someone who is much older but fitter may have a lower ‘biological age’, when compared to someone who is much younger but leads a very sedentary lifestyle and makes poor dietary choices on a daily basis. Aging is ascertained by looking at certain biomarkers- which are indicators of cell function. How To Calculate Biological Age Accurately?Just like how we may require certain details to calculate the age of a person- their birth date, calculating biological age is dependent on a bunch of important factors. Aging at a cellular level is called ‘senescence’, and we have an in-built mechanism to get rid of very old and dying cells - as they don’t function well and also influence their neighbours in adverse ways. So, biological age in simpler terms just means to measure how much damage your cells have undergone, over a period of time- mostly in years, though some people may seem to age faster if they are highly stressed. The term ‘biological age’ was coined in the last century by an English physician called Alex Comfort.This concept has further been developed to explain DNA epigenetic markers. Our DNA sequence is very long- so long that if stretched from end to end, it can go to the moon and back several times, with probably some more left in the strand. We can’t have all that genetic material just floating around right? This is why it is packaged in a highly specific manner using particular proteins called histones. They are further spooled in to form the 4-armed chromosomes that we all associate with cell division. The chromosome has different regions in it- the tail end or the part away from the center is called the telomere. You can think of the telomere as a cap or protective sheath that shortens every time you age, but your DNA is still retained for the most part. If telomere loss is extreme, then it is a marker for aging. Wherever the DNA has been exposed, there are certain molecules that are added or removed- mostly methyl groups. This ‘methylation’ of DNA is what determines how we all have the same genes, but still end up looking really different from each other. Though there is a genetic component to aging for sure, what really matters is how your cells are functioning at the present moment- which genes are on, which genes are being switched off and which are maintained throughout. This is the first component used to calculate biological age- ‘Methylation of DNA- epigenetic changes’. In general, a lesser number of methyl groups mean that you are older in age. Since, the methylation observed has been super specific in a number of cases, the age of a person can be easily determined from just a tissue sample. All of these can be studied in detail using specially designed genetic tests- which check for epigenetic markers, telomere length, blood pressure, blood cells and populations, thyroid function tests and other hormones that help you stay healthy. They are said to be simple - provide a blood sample and you will then receive a report with all details of how you are doing at a cellular level. Biological Age vs. Chronological Age Calculation-Biological age is calculated based on the expression of certain genes in cells present in the blood. If there is chronic inflammation in some form, then those genes are expressed more than necessary. Measuring how much your DNA methylation has reduced can give researchers a good estimate of what your biological age is. You can think of biological age as the number of rings a tree can have- which is a closer approximation of its age, compared to just its appearance and how lush its foliage is. Chronological aging measurement is pretty no-nonsense- you just need to know the date of birth or the year they were born in and you know their present age, by subtracting it from 2024. This number is also called calendar age too. Conclusion Simple blood tests these days will give you the biological age of a person. If the number is higher, it means your cells and organs are having a hard time working, while any lesser values will show that cellular performance is more than optimum. Being mindful of what you eat, how much you eat, exercise and sleep- while also remembering to not get stressed out can greatly help you feel younger and better- and this will reflect as a lower biological age value. In fact, if you exercise regularly- like 40 minutes for 5-6 days a week, your biological age will be lower by 9 years on an average, while it is the opposite if you sit and work for 10 hours a day. You decide whether you want to live just longer, or if you really want to live well. FAQs 1. What is biological age, and how is it different from chronological age?Biological age is a method used to calculate how old your cells really are metabolically speaking. This is determined by looking at certain DNA related markers like methylation in various cell types, some inflammatory markers and others. Chronological age is literally how old you are and it is determined by looking at your date of birth. 2. How can I calculate my biological age at home?You can give your blood sample to check for actual biological age- where it will be checked for telomere shortening, DNA methylation and other parameters. There are online calculators too, based on detailed questionnaires, but we are not sure how accurate they are, as the questions are pretty general. 3. Does DNA methylation play a role in calculating biological age?Yes, more methylation means you are younger in age, while the inverse is true if you are older. 4. Are online biological age calculators accurate?These applications rely on a set questionnaire with a few possibilities for answers. If you choose the right ones, your biological age will be a smaller value than if you are actually pretty honest about it. We are not sure of the formula they use and there is no certain way to tell you how old you are, unless some tissue sample from your body is tested thoroughly. 5. How does lifestyle affect biological age?If you eat well and exercise regularly, get enough sleep every night and find ways to destress regularly, then you will generally be better than someone who is pretty stressed and doesn’t have time to exercise or meal prep and doesn’t sleep well.
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