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Is Your Biological Age The Same As Your Age?
Introduction We don’t think twice before giving our age for official purposes or otherwise. This is because we know when we were born - i.e. the Date of birth (DoB) and just calculate how old we could be. Though your age can be a simple number, there are a lot of factors that actually determine if you are as old as that or not. Case in point- some people look much younger than their age, while others may look a lot more mature or older and tired. Why do you think that happens? This is where the concept of ‘chronological age’ vs. ‘biological age’ comes in - where someone who is much older but fitter may have a lower ‘biological age’, when compared to someone who is much younger but leads a very sedentary lifestyle and makes poor dietary choices on a daily basis. Aging is ascertained by looking at certain biomarkers- which are indicators of cell function. How To Calculate Biological Age Accurately?Just like how we may require certain details to calculate the age of a person- their birth date, calculating biological age is dependent on a bunch of important factors. Aging at a cellular level is called ‘senescence’, and we have an in-built mechanism to get rid of very old and dying cells - as they don’t function well and also influence their neighbours in adverse ways. So, biological age in simpler terms just means to measure how much damage your cells have undergone, over a period of time- mostly in years, though some people may seem to age faster if they are highly stressed. The term ‘biological age’ was coined in the last century by an English physician called Alex Comfort.This concept has further been developed to explain DNA epigenetic markers. Our DNA sequence is very long- so long that if stretched from end to end, it can go to the moon and back several times, with probably some more left in the strand. We can’t have all that genetic material just floating around right? This is why it is packaged in a highly specific manner using particular proteins called histones. They are further spooled in to form the 4-armed chromosomes that we all associate with cell division. The chromosome has different regions in it- the tail end or the part away from the center is called the telomere. You can think of the telomere as a cap or protective sheath that shortens every time you age, but your DNA is still retained for the most part. If telomere loss is extreme, then it is a marker for aging. Wherever the DNA has been exposed, there are certain molecules that are added or removed- mostly methyl groups. This ‘methylation’ of DNA is what determines how we all have the same genes, but still end up looking really different from each other. Though there is a genetic component to aging for sure, what really matters is how your cells are functioning at the present moment- which genes are on, which genes are being switched off and which are maintained throughout. This is the first component used to calculate biological age- ‘Methylation of DNA- epigenetic changes’. In general, a lesser number of methyl groups mean that you are older in age. Since, the methylation observed has been super specific in a number of cases, the age of a person can be easily determined from just a tissue sample. All of these can be studied in detail using specially designed genetic tests- which check for epigenetic markers, telomere length, blood pressure, blood cells and populations, thyroid function tests and other hormones that help you stay healthy. They are said to be simple - provide a blood sample and you will then receive a report with all details of how you are doing at a cellular level. Biological Age vs. Chronological Age Calculation-Biological age is calculated based on the expression of certain genes in cells present in the blood. If there is chronic inflammation in some form, then those genes are expressed more than necessary. Measuring how much your DNA methylation has reduced can give researchers a good estimate of what your biological age is. You can think of biological age as the number of rings a tree can have- which is a closer approximation of its age, compared to just its appearance and how lush its foliage is. Chronological aging measurement is pretty no-nonsense- you just need to know the date of birth or the year they were born in and you know their present age, by subtracting it from 2024. This number is also called calendar age too. Conclusion Simple blood tests these days will give you the biological age of a person. If the number is higher, it means your cells and organs are having a hard time working, while any lesser values will show that cellular performance is more than optimum. Being mindful of what you eat, how much you eat, exercise and sleep- while also remembering to not get stressed out can greatly help you feel younger and better- and this will reflect as a lower biological age value. In fact, if you exercise regularly- like 40 minutes for 5-6 days a week, your biological age will be lower by 9 years on an average, while it is the opposite if you sit and work for 10 hours a day. You decide whether you want to live just longer, or if you really want to live well. FAQs 1. What is biological age, and how is it different from chronological age?Biological age is a method used to calculate how old your cells really are metabolically speaking. This is determined by looking at certain DNA related markers like methylation in various cell types, some inflammatory markers and others. Chronological age is literally how old you are and it is determined by looking at your date of birth. 2. How can I calculate my biological age at home?You can give your blood sample to check for actual biological age- where it will be checked for telomere shortening, DNA methylation and other parameters. There are online calculators too, based on detailed questionnaires, but we are not sure how accurate they are, as the questions are pretty general. 3. Does DNA methylation play a role in calculating biological age?Yes, more methylation means you are younger in age, while the inverse is true if you are older. 4. Are online biological age calculators accurate?These applications rely on a set questionnaire with a few possibilities for answers. If you choose the right ones, your biological age will be a smaller value than if you are actually pretty honest about it. We are not sure of the formula they use and there is no certain way to tell you how old you are, unless some tissue sample from your body is tested thoroughly. 5. How does lifestyle affect biological age?If you eat well and exercise regularly, get enough sleep every night and find ways to destress regularly, then you will generally be better than someone who is pretty stressed and doesn’t have time to exercise or meal prep and doesn’t sleep well.
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Grape Seed Extract - Benefits Explained
Introduction We all know what grapes are- especially the varieties that are turned into delicious wines. But did you know that there are hundreds of different grape cultivars- some of which are seedless, while others contain seeds in them? The parent cultivar is called Vitis vinifera, from which grape seed extracts are normally prepared. Grape flesh is good obviously, but most of us prefer eating the seedless varieties for textural purposes. Grape seeds however are great storehouses for high quality compounds called proanthocyanidins, which have potent antioxidant activity and help regulate hundreds of cellular processes in the body. What Are The Benefits Of Grape Seed Extract? Grape seeds are rich in plenty of compounds like epicatechin, procyanidin-B1, B2, B3 and B respectively, along with catechins, epicatechin gallate, protocatechic acid, procyanidins, pro- delphinidins, etc. Grape seed extract is hence great for the cardiovascular system- the proanthocyanidins present help in various ways- like producing nitric oxide so that blood vessels relax and helps lower blood pressure, helps in regulating LDL levels, is good at keeping platelets inactive unless absolutely needed- thus helping the immune system work better. Proanthocyanidins are also very good at removing superoxide radicals- this protects cells from oxidative damage. In diabetic models, some studies have shown promise- grape seed extract can help cells improve glucose sensitivity. They also help wounds heal better- which is why it is such a great additive in skincare products. Grape seed extract is also great for the skin as it promotes collagen production. It helps bones mineralise better and prevents immune cells from attacking bone (so it is good if you have rheumatoid arthritis for example). Grape Seed Benefits For Brain And Memory Since circulation as a whole is benefitted, it is easy to understand why grape seed extract is good for the brain. The brain is a major energy hog and consumes about 20% of the total oxygen that you breathe in. Since the brain is super metabolically active almost always, high oxygen demand can only be fulfilled by good circulation. Any clots or related issues can hence leave the brain starving and cause a stroke or something more drastic than that. Studies have shown that people with Alzheimer’s disease are benefitted when they supplement with grape seed extract regularly, as it has gallic acid- which does not allow beta-amyloid plaques to form. Grape Seed Extract Benefits For Liver Health The liver is the largest organ in the body, as you know. It is also very metabolically active and is mainly responsible for breaking down all sorts of compounds in the body- toxic or not, into absorbable by-products. The liver can get affected severely if you drink too much, eat a poorly designed diet. This shows up as inflammation, high levels of alanine aminotransferase (ALT) in blood, excessive fat deposition in the liver etc. Grape seed extract has shown to actively help reduce ALT levels- lowering hepatotoxicity. Since free radicals are produced in large amounts, it actively removes them and keeps cells safe from oxidative stress. Conclusion Grape seed extract has shown a lot of potential in treating all sorts of conditions- acute, chronic or otherwise. Though it is mostly very well tolerated by the majority of the population, if you are allergic to grapes- then stay away from it. If you have too much of it, you may have to deal with issues like an itchy scalp, feel faint and have bad headaches. It is also great for skincare- and can help improve texture and elasticity- if used at a 2% concentration for topical application. Grape seed extract in general is a super achiever in the health department and you should talk to your doctor about including it in your routine from today! FAQs1. What is grape seed extract, and how is it different from whole grapes?Literally, grape seed extract means taking all the potent compounds from the seeds alone and leaving the fruit. The seeds have a different biochemical profile, when compared to the fleshy parts of the fruit. Grape seed extract is rich in proanthocyanidins- which are highly potent antioxidants. 2. Can grape seed extract improve skin health and slow aging?Since they are rich in antioxidants, they help skin feel and look better, behave better and work better. They help prevent skin damage due to pollutants and increase collagen production- making your skin feel softer and keeping it wrinkle free for longer, or you will develop wrinkles at a much slower rate- if we are being realistic. 3. Is grape seed extract effective for reducing inflammation and boosting immunity?Yes, grape seed extract can help reduce inflammation by working on the circulatory system, by helping wounds heal better and help reduce the production of inflammatory cytokines- which can help regulate the immune system. 4. How does grape seed extract benefit hair growth and scalp health?Grape seed oil is rich in procyanidins- which is a good antioxidant by itself. It also has a lot of Vitamin E, flavonoids- all of which come from the seeds themselves. Hair follicle health improves with regular usage- leading to better hair growth and texture in the long term. 5. Are there any side effects or risks of taking grape seed extract?Some people may be allergic to the seeds and may develop symptoms like headaches, dizziness, nausea, diarrhoea, sore throat etc. Always remember to talk to your doctor about taking any health supplements- especially if you are on any other medication.
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When Should You Use Trans-Resveratrol? Uses And Benefits Explained
Introduction Trans-Resveratrol is a compound that plants normally synthesize when they are attacked by some infectious pathogens- think of it as an immunity protector for our photosynthesising friends. But, this multifaceted compound can do so much more for us all, as its main strength lies in helping improve cellular function, reducing free radical production, preventing DNA damage and keeping cells healthy in the long run. It also helps improve mitochondrial function, helping our cells produce more energy, more efficiently. Many preclinical studies show that it is a super promising compound that can be used as a supplement safely, so let us understand why it is so. What Are The Benefits Of Trans-Resveratrol? Trans-Resveratrol or 3,5,4′-trihydroxy-trans-stilbene (if you remember chemical nomenclature rules) is a stilbene produced by lots of plants. Since they are found in such minute amounts in peanuts, grapes and berries, it is not possible for you to be able to get the required amounts of trans-resveratrol from your diet. A good example is this- you will need to eat about 10 kg of grapes if you need say 50 grams of it per day. The concentrations tend to vary when you look at different grape cultivars. Let us look at some of the most pronounced effects this compound has, on cellular function in our body- It is obviously great for the heart- studies have shown that it can help lower blood pressure- both systolic and diastolic when taken regularly. It can also help lower LDL levels and increase HDL levels- thus helping your circulatory system in the whole scheme of things. Resveratrol is good for the body as a whole as it helps improve circulation- which means all cells in the body get nutrients as they need. Trans-resveratrol helps reduce inflammatory cytokines in the body- like TNF-alpha or factors like NF-KB- that work upstream of many pathways. Trans-resveratrol helps cells remove superoxide radicals by being a great scavenger, while also helping them activate proteins like sirtuins- SIRT1 to be more specific. This means there is lesser oxidative stress systemically- which means lesser inflammation and better health in the long run. SIRT-1 has a global effect on the production of multiple enzymes that regulate oxidative pathways- like catalases, dismutases, peroxidases. This is how translate-resveratrol boosts mitochondrial function too. It has been shown to improve brain health and cerebral blood flow too. Other organs also benefit immensely with trans–resveratrol- like the liver, the kidneys, the pancreas (the beta cells that produce insulin are especially vulnerable to superoxides) due to its antioxidative properties. They also change how fat cells or adipocytes function- by reducing lipid accumulation in them. This means your metabolism is also improved. How Does Trans-Resveratrol Improve Longevity? By helping boost SIRT-1 production in the body, trans-resveratrol helps in a host of ways- all of which culminate in helping you reduce biological age and improve longevity. When there is less inflammation and oxidative stress- the metabolism of an organism begins to improve. This mimics the effects of ‘fasting’ or restricting calories- that can lead to better cellular repair of any damage caused due to normal wear and tear, or due to some other issue. As mitochondrial function improves, cellular energy levels increase- which means you have more energy to get through the day- without having to worry about a mid-day slump. Conclusion Trans-resveratrol is a very beneficial compound that will help your body function better- so that you feel superb! Trans-resveratrol is a pretty safe compound for regular consumption too- which means you can incorporate it into your routine, without any fear. Just talk to your doctor if you have any doubts or are on certain medications for comorbidities. FAQs 1. What is trans-resveratrol, and how does it benefit health?It is a polyphenol that is normally produced by plants to counteract an infectious agent. Various preclinical studies have shown promising results for reducing chronic inflammation, activating sirtuins in the body and helping cellular repair mechanisms work better in general. 2. When should I take trans-resveratrol for the best results?Ideally, you should be taking the supplement after breakfast. This way, you will have lots of energy throughout the day. Remember to chase it down with some water. 3. Can trans-resveratrol support brain function and cognitive health?Yes, recent studies have shown that older folk and menopausal women who supplement with trans-resveratrol show that it can help improve blood flow to the brain - which can greatly help when there is poor circulation due to advancing age. 4. What are the potential side effects or risks of taking trans-resveratrol?High amounts of trans-resveratrol are generally well tolerated by most individuals, but you should watch out for side effects like nausea, vomiting, diarrhoea, higher heart rate, body aches etc. Consult a health specialist before starting this supplement. 5. How does trans-resveratrol compare to other antioxidants like quercetin?Both trans-resveratrol and quercetin are powerful antioxidants in their own right, but their mechanism of action is slightly different. Also, quercetin is more abundantly found in food sources than trans-resveratrol. Both are especially helpful in reducing chronic inflammation in adipocytes- fat cells in the body.
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Can The Superhero Supplement NMN Fight Depression?
Imagine if there was a supplement that could turn you from a sad person into a social butterfly faster than Clark Kent changes into Superman. We’re being a bit dramatic, don’t take this timeline seriously. According to recent research, nicotinamide mononucleotide (NMN) is that mood-boosting superhero we've been waiting for! The Mouse Experiment To model depression in mice, scientists used a "social defeat stress experiment"! This is a simple exercise where they make a small mouse face a much bigger and more aggressive mouse. Scientists often use this setup to study stress and depression in animals. In this experiment, the small mouse gets bullied by the big mouse for 10 days in a row. As you might guess, this makes the small mouse very stressed and sad. It starts acting in ways that look like depression in humans. Here's the interesting part: Some mice were given NMN every day for three weeks before meeting the big mouse. These mice seemed to handle the stress much better. It was like they had an invisible shield against feeling sad! Three Tests for the Mice The scientists then gave the mice three challenges: 1.The Friendship Test: Would the mouse go near another mouse, or stay away? 2. The Sugar Water Test: Would the mouse still enjoy sweet drinks, or had stress made everything seem less fun? 3. The Hanging Test: How long would the mouse keep trying to escape when hung by its tail? The mice that got NMN did better on all these tests. They were more social, enjoyed sweet things more, and didn't give up as quickly when things got tough. The Mitochondrial Connection: It's Not Just About Serotonin Anymore For years, we thought depression was all about a lack of feel-good chemicals like serotonin in the brain. But plot twist! It turns out our cellular powerhouses, the mitochondria, might be the real MVPs in the fight against the blues. Our brain cells need energy to keep swinging against depression. That's where NMN comes in, boosting levels of NAD+ and potentially giving our mitochondria the pep talk they need to produce more cellular energy. NMN: The Benjamin Button of Brain Health? Could taking NMN in your younger years be like investing in a 401k for your brain? Some scientists think so! Early- and mid-life depression have been linked to a higher risk of dementia later on. By potentially nipping depression in the bud, NMN might help keep your brain young and spry well into your golden years. Of course, we're not quite ready to call NMN the fountain of happiness just yet. We're gonna need more human studies - before we can make any definitive claims on depression. A Quick Spotlight on India's Mental Health Landscape The Numbers Don't Lie (But They Might Make You Anxious) According to the World Health Organization, nearly 15% of Indian adults need mental health intervention. That's more people than the entire population of Mumbai! Even more concerning, one in 20 Indians is grappling with depression. If you thought the pandemic was just about masks and social distancing, think again. A 2021 Lancet study showed a whopping 35% increase in anxiety disorders in India during the COVID-19 pandemic. Remember how we talked about stress affecting our little mouse friends? Well, humans aren't faring much better. The 2023 GOQii India Fit Report reveals that 26% of Indians are stressed due to work. That's right – over a quarter of the population is feeling the heat at the office! Several studies also show that Gen Z and Millennials are experiencing higher levels of stress and anxiety. Between academic pressure, career competition, and the constant comparison game on social media The Bottom Line: A New Hope for Mental Health? While we can't all be superheroes, it seems NMN might give us a fighting chance against the villainous duo of depression and stress. This is especially relevant in a country like India where a majority of the population is grappling with stress and depression. As we wait for more research, keep your chin up and maybe consider adding a little NMN to your daily routine. Who knows? It might just be the sidekick your mood has been waiting for. Remember, though, that while this research is exciting, it's important to consult with a healthcare professional before starting any new supplement regimen.
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Unlocking the Secrets of Dr. David Sinclair's Anti-Aging Regimen
In the realm of anti-aging supplements, few have garnered as much attention in recent years as Nicotinamide Mononucleotide (NMN). This unassuming precursor to the vital pro-longevity molecule Nicotinamide Adenine Dinucleotide (NAD+) has been the subject of numerous human trials over the past three years, all with one common and reassuring theme - safety. Let's delve into the extensive research that confirms NMN's safety profile. NMN's Safety: A Pillar of Confidence A cornerstone of NMN's journey as a potential anti-aging supplement is its impeccable safety record. Extensive human trials have been conducted to ascertain the safety of NMN, and the results have been resoundingly positive. The very first study, conducted at Keio University in Japan in 2016, set the tone. Male participants consumed varying doses of NMN, and for five subsequent hours, researchers meticulously monitored them. The outcome? No harmful effects, changes in blood pressure, heart rate, blood oxygen saturation, or body temperature were observed. This initial study unequivocally established that NMN, at doses of up to 500 mg, is safe and well-tolerated. Since that groundbreaking study, seven additional human trials, each testing safety parameters with varying NMN doses, have been conducted. In the most robust of these trials, conducted at Harvard, participants were administered a whopping 1,000 mg of NMN twice daily for 14 days. The result? No adverse side effects, further cementing NMN's safety credentials. Crucially, these studies have also dispelled concerns regarding NMN's potential to induce cancer, putting to rest any lingering doubts. NMN's Remarkable Impact on Aging While the safety of NMN has been unequivocally established, its real allure lies in its potential to combat the aging process. Recent human trials have begun to unlock the vast potential of NMN in this regard, with a specific focus on age-related physical decline. Aging and NAD+ Levels As individuals age, their NAD+ levels naturally decline. Researchers have long hypothesized that increasing NAD+ levels with precursors like NMN could protect against age-related organ deterioration. This hypothesis has spurred a surge in NMN supplementation, with the global NMN market projected to reach a staggering $385.7 million by 2027. NMN's Impact on Physical Performance Human trials have started to yield promising results regarding NMN's impact on physical performance in aging adults. Igarashi and colleagues found that NMN improved muscle motility, walking speed, grip strength, and the frequency of standing and sitting down in aged individuals. Liao and colleagues reported significant improvements in aerobic capacity among trained runners supplemented with NMN, as measured by blood oxygen consumption. Another study demonstrated that NMN enhanced walking endurance in middle-aged and older adults. These findings suggest that NMN has the potential to enhance exercise capacity, a crucial factor in combating age-related physical decline. Metabolic Benefits of NMN NMN's potential extends beyond physical performance. In a study involving postmenopausal women who were overweight or obese, NMN was found to increase muscle insulin sensitivity by about 25% and improve insulin signaling. These results imply that NMN can offer metabolic benefits, particularly for individuals with prediabetes. NMN and Hearing Age-related hearing loss is a common concern among the elderly. Research by Igarashi and colleagues indicated that NMN supplementation could improve hearing capabilities in older men, offering a glimmer of hope for those grappling with this age-related decline. Telomere Lengthening: A Molecular Anti-Aging Effect Telomeres, the protective caps at the ends of chromosomes, shorten with age, serving as a biological marker of aging. A study by Niu and colleagues found that daily supplementation with 300 mg of NMN nearly doubled telomere lengths in blood cells within just 90 days of treatment. This remarkable result suggests that NMN may exert an anti-aging effect at the molecular level. Unanswered Questions and Future Prospects While human trials with NMN have showcased its potential in improving physical function, metabolism, telomere length, and even hearing capabilities during aging, crucial questions remain unanswered. The limited duration of these studies, with none lasting more than three months, raises concerns about whether NMN can provide its full range of benefits in the long term. Additionally, the question of whether NMN confers the same benefits on multiple organ systems in humans as it does in rodents remains an area of intrigue and uncertainty. The FDA's recent decision to exclude the sale of NMN as a supplement has ignited debates about the molecule's potential. While it may not pose safety risks, the decision raises questions about the motives behind suppressing access to NMN. The fact that NMN is under investigation as a new drug further underscores its potential as an anti-aging molecule, leaving many hopeful for its future. In conclusion, NMN has emerged as a fascinating candidate in the quest for anti-aging solutions. Extensive research has underscored its safety and revealed its potential to combat age-related physical decline, metabolic issues, and even hearing loss. However, many mysteries surrounding its effects on various organ systems in humans and its long-term implications remain unsolved. As NMN continues to captivate the scientific community and consumers alike, ongoing human trials will provide the answers we seek, shedding light on this promising anti-aging supplement's true potential.
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Inflammaging and Your Body's Largest Organ
The real question is: "Mirror, Mirror on the Wall, Who's the Most Inflamed of Them All?" Imagine your skin is like a magic mirror from Snow White! But instead of just showing you how you look, it's telling a story about what's happening inside your body. In this story, there's a sneaky villain called "inflammaging". It's not as dramatic as an evil queen, but it can cause trouble as we get older. Inflammaging is: A type of low-level inflammation Something that happens naturally as we age Affects our whole body, including our skin Here's the key part: Your skin doesn't just show the effects of inflammaging - it actually plays a role in your overall health. It's like the mirror in the fairy tale came to life and started influencing the story! By taking care of your skin, you might be helping your whole body stay healthier as you age. It's a simple idea, but it could make a big difference in how you look and feel over time. What's the Deal with Skin Inflammaging? As we get older, our skin changes in a few ways: We get "Zombie" cells: Old cells that should die but stick around and cause trouble. Energy problems: The parts of our cells that make energy (mitochondria) start to slow down. Sun damage: Too much sun exposure over the years can hurt our skin. These changes can make our skin look older and less healthy. The Skin-Body Connection "As above, so below" isn't just for mystics anymore. Scientists are quickly discovering that your skin's health could be driving your overall health and aging process. Think about dry, cracked hands in winter. It's not just uncomfortable - it might actually be bad for your overall health. When your skin is damaged, it can cause: 1. Inflammation throughout your body 2. Weakening of muscles and bones 3. Possible effects on brain health As your skin gets unhealthy, it might make the rest of your body age faster too. Your skin doesn't just show signs of aging - it might actually be causing some of it. Taking care of your skin might be more important than we thought. It's not just about looking good - it could help you stay healthier overall as you get older. Next time you put on moisturizer or sunscreen, you're not just helping your skin. You might be helping your whole body stay healthier. How to Fight Inflammaging Here are some simple steps to fight inflammaging: 1. Sun's Out, Guns Out: Always protect yourself from the sun with the right SPF. 2. Eat Like You Love Yourself: "Consume more veggies, fruits, lean proteins, whole grains, and probiotic foods." Think of your plate as a superhero team - each food group has its own power to fight inflammaging. 3. Move It or Lose It: Exercise isn't just for influencers. So,spend at least 20 mins on quality exercise. 4. Beauty Sleep Isn't a Myth: Sleeping Beauty had the right idea. Quality sleep is your skin's time to regenerate. 5. Simplify Your Skincare: Channel your inner Marie Kondo and keep only what brings joy (and scientific backing) to your skin. 6. Avoid the Dark Side: Cigarette smoke and pollution are the Darth Vaders of skin health. Don't join the dark side! New Science for Better Skin In addition to a healthy lifestyle, scientists have discovered something called Urolithin A, which may help: Renew skin cells Reduce wrinkles Protect against sun damage Boost collagen (which keeps skin firm) The Big Picture Taking care of your skin isn't just about looking good - it's about staying healthy overall. By following these simple steps and using effective skincare products, you can help keep both your skin and your body in good shape as you age. Remember, it's never too late to start taking better care of your skin. Every little bit helps!
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You are unique: Your Supplement Plan Should Be Unique Too!
Almost everyone I speak to these days tells me the same thing, like it is a rehearsed answer! “I’m taking Vitamin D, B and C supplements.” While these supplements have proven to have long-term benefits, a one-size-fits-all approach to nutrition and supplementation is not only inadequate, but can also be detrimental. If you take your health and longevity seriously and are not driven solely but health trends, this concept may not be foreign to you. But, for the rest of the world this may come as a shocker. Good nutrition is the foundation for good health. About 70% of your overall health comes from what you put into your body… i.e.… what you eat and drink! Supplementation can only add to that, yet people spend thousands of Rupees on generic over-the-counter supplements every year! Innovations in personalized supplementation aim to address this gap. For instance, a popular company focused on creating individualized supplement plans based on comprehensive biomarker data and lifestyle factors has demonstrated notable success. This company initially catered to a niche market with high-cost services but has since expanded to a global audience with more accessible options. They offer two main products: a premium service that uses blood biomarker data for highly tailored supplement plans and a more affordable option based on AI and user questionnaires. Each formulation is unique and continuously updated to reflect changes in an individual's health status and goals. How to Mimic Personalized Supplementation in Your Daily Routine Now, a key question that you as an Indian may have is, how can I as an Indian with a limited budget personalize my supplementation plan? Don’t worry, I’ve got you covered with a step-by-step approach to solve this! You can adopt a personalized approach to supplementation and wellness by incorporating the following steps into your daily routine: Get Comprehensive Health Assessments: Blood Tests: Start with a thorough blood test to assess key biomarkers such as vitamin levels, mineral deficiencies, and other crucial health indicators. Many clinics and health services offer these tests, which can provide insights into specific nutrient imbalances. Health Questionnaires: You can take authentic online questionnaires to gather information about your lifestyle, diet, exercise habits, and health goals. Analyze Your Results: Consult Health Professionals: Review your test results with a healthcare provider or a nutritionist who can interpret the data and identify any deficiencies or imbalances. They can provide guidance on what specific nutrients you may need to adjust. Identify Patterns: Look for patterns in your health data that might indicate areas of concern. For instance, low levels of certain vitamins could be linked to fatigue or immune system issues. Personalize Your Supplement Regimen: Tailor Your Supplements: Based on your analysis, select supplements that address your specific deficiencies. Choose products that match your unique needs rather than relying on generic, one-size-fits-all supplements Consider Lifestyle Factors: Factor in your age, activity level, and health goals when choosing supplements. For instance, athletes may need higher levels of certain nutrients compared to sedentary individuals. Monitor and Adjust: Regular Follow-Ups: Schedule regular follow-up tests and consultations to monitor changes in your health and adjust your supplement regimen as needed. This ensures that your supplementation remains aligned with your evolving health needs. Track Your Progress: Keep a log of any changes in your health, such as improvements in energy levels, sleep quality, or overall well-being, to assess the effectiveness of your personalized regimen. Integrate Holistic Wellness Practices: Exercise and Diet: Complement your personalized supplementation with a balanced diet and regular exercise. These foundational practices are essential for optimal health and should work in tandem with your supplementation strategy. Sleep and Stress Management: Ensure adequate sleep and manage stress, as these factors significantly impact overall health and can influence how effectively your body utilizes nutrients. You don’t need to spend thousands of Rupees on these personalized supplementation plans, all you need to do is follow these steps to create your very own personalized supplementation and wellness plan, similar to the tailored solutions offered by specialized services. This method not only helps address specific health needs but also supports long-term health and vitality.
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New Study Demonstrates Plant-Derived Molecule Berberine’s Potential to Inhibit Cancer Cell Growth
Berberine; A New Hope, in the Battle Against Colorectal Cancer Colorectal cancer also known as CRC is a health issue. Ranks as the fourth most prevalent form of cancer. Unfortunately, the survival rate for cancer within five years is 64%, which is quite disheartening. The current treatments available, such as surgery, radiotherapy, chemotherapy, and immunotherapy are not expensive but also come with financial burdens and the ongoing risk of mortality. As a result, there is a quest to find approaches that can effectively combat colorectal cancer by stopping its growth and progression. Global Disparities in Colorectal Cancer Prevalence Colorectal cancer shows disparities in prevalence with most cases occurring in developed countries. In contrast to this trend countries like India report an incidence of CRC at 87 cases per 100,000 individuals over five years. These variations can be attributed to differences in habits, lifestyles, and the prevalence of obesity – a known risk factor for developing CRC. Additionally, age plays a role since colorectal cancer tends to be more common, among individuals. Berberine; A Beacon of Hope In a study recently published in the journal Molecules scientists, from the University of Jordan have revealed a breakthrough in the fight against colorectal cancer. They have discovered that berberine, a compound has the potential to be a game changer. Their research shows that when colorectal cancer cells are exposed to berberine it not only slows down their growth but also triggers cell death. Additionally, berberine treatment inhibits the movement of cancer cells, which is crucial in preventing the spread of cancer throughout the body. Berberine Promotes Cancer Cell Death and Impairs Movement To assess how berberine affects the proliferation of cancer cells researchers conducted controlled laboratory experiments using three lines of colorectal cancer cells. The results were remarkable – high doses of berberine led to more than a four reduction in cell viability, for all three types of colorectal cancer cells effectively stopping their uncontrolled growth. Lower doses of berberine showed promise by reducing cell viability to a lesser extent. This discovery highlights that berberine can impede cancer cell proliferation in a dose manner; higher doses yield stronger inhibitory effects. To further understand how berberine achieves its proliferative effects scientists examined the treated cancer cells under a microscope. What they observed were signs that indicate apoptosis, a process of programmed cell death. These findings strengthen the belief that berberine can halt the growth of cancer cells by triggering apoptosis, which is an encouraging development, in our efforts to fight this disease. Moreover, the researchers investigated whether berberines' ability to inhibit cell migration, a factor in cancer metastasis played a role in its proliferative effects. Using a membrane that simulates the wall of a blood vessel they evaluated how well berberine-treated colorectal cancer cells could migrate. The results were berberine reduced migration by at least five-fold in all three colorectal cancer cell lines indicating a significant disruption in their ability to spread. As cancer cells can enter the bloodstream and initiate metastasis berberine suppression of cell migration suggests its potential to impede the invasion of tissues through the blood. Berberine as a Preventive Measure Although this study did not involve trials with patients suffering from cancer these promising results open up numerous possibilities. Given the costs associated with treatments for colorectal cancer and persistently high mortality rates, the potential use of berberine supplementation offers hope, for better outcomes. Furthermore, there is a possibility that berberine could be used as a measure to halt the progression of colorectal cancer by inhibiting the growth and spread of cells as observed in laboratory experiments. Berberines Availability and Affordability One aspect that makes berberine particularly appealing as a treatment or preventative option is its accessibility and affordability. Berberine supplements are easily obtainable, with prices ranging from $20 to $50 for a month's supply. Moreover, berberine can also be naturally sourced from sources like grapes and turmeric making it an attractive choice for those looking for approaches to their well-being. A Supplement with Potential Longevity Benefits Interestingly another study found that supplementing with berberine increased the lifespan of aging mice by 16%. This does not highlight the potential of berberine as a supplement that promotes longevity. Also adds an extra layer of fascination to its diverse range of benefits. Colorectal cancer represents a challenge. Ranks among the most prevalent and deadly types of cancer. However, the emergence of berberine as a treatment and preventative measure provides hope in our fight against this disease. While further research and clinical trials are necessary to validate berberine's effectiveness, in patients its accessibility and affordability make it an appealing choice. In our unwavering dedication, to reducing the impact of cancer and improving survival rates berberine emerges as an ally. It shows promise not only in treatment but in potentially preventing this destructive disease. As we delve deeper into its possibilities berberine could become a weapon in the battle against cancer bringing us closer to a time when this illness no longer poses a significant risk, to our overall health and well-being.
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Discovering the Magic of Youthful Skin and Hair: Your Exciting Journey into the World of NMN
Greetings, my intelligent, skincare loving friend! Ever wondered if reversing gray hair or slowing skin aging is actually possible? Today, we dive deep into the exciting science behind youthful skin, vibrant hair, and one molecule that’s changing everything: NMN. Get ready for a journey into the future of longevity, beauty, and inner vitality. Let’s go! Chapter 1: Why Does Hair Turn Gray, and Is It Reversible? Picture this: you're brushing your hair one morning and suddenly notice a few unexpected gray strands. Surprising, right? The secret lies in melanin, the pigment responsible for the color of our hair and skin, produced by tiny cells called melanocytes at the base of each hair follicle. When we're stressed or have certain health conditions, we may temporarily lose hair and along with it, melanin. But here’s the hopeful part: if those melanocytes survive, the color can return once your stress is reduced. It’s not magic. It’s biology in motion. Curious fact: Some people have seen their gray hair repigmented after lifestyle changes. Fascinating, isn’t it? Chapter 2: How Aging Starts, and Where It Hits First Let’s explore why aging happens at the cellular level. It’s more fascinating than you might think. Our cells contain mitochondria, the energy powerhouses that keep everything running smoothly. As we age, mitochondrial function declines, and this impacts the health of our melanocytes (remember those guys?). Then there are telomeres - protective caps on our chromosomes that shorten each time our cells divide. You’re beginning to get bored, aren’t you! Hang in there, we’re getting to it. When they get too short, cells stop dividing and turn into senescent cells, which are old, inactive cells that contribute to signs of aging like wrinkles and gray hair. So yes, aging begins inside the cell, long before we see it on our face or scalp. Chapter 3: Meet NAD+, Your Body’s Inner Fuel Source Now for the exciting part: NAD+ (nicotinamide adenine dinucleotide). Think of it as your body’s energy currency. It fuels over 300 enzymatic reactions, including mitochondrial health, DNA repair, and cell regeneration. But NAD+ levels decline with age. That’s where NMN (nicotinamide mononucleotide) steps in. As a precursor to NAD+, NMN helps restore those energy levels, potentially rejuvenating your cells from the inside out. Even more promising, early studies suggest it may help maintain telomere length, a key to staying youthful longer. In short: More NMN means more NAD+, which can lead to more energy, better skin, and possibly fewer gray hairs. Chapter 4: Can NMN Really Reverse Gray Hair? Here's What People Are Saying Science is still catching up, but early adopters of NMN are sharing intriguing stories. Many report a reduction in gray hairs and increased hair vitality after supplementing with NMN. It’s not yet a proven cure, but it’s promising and definitely worth paying attention to. Real people. Real stories. Real transformations. “My hair was almost all white in my early 60s when I started taking NMN a year ago. After 3 months, it was slightly more blonde. Noticeably more blonde after 6 months - enough for my wife to see it. After a year, my hair color is about the same as when I was in my 50s. Mostly blond with white-blond temples. My hair is also fuller. I didn't take NMN to change my hair color, but it is a daily reminder that the cells throughout my body must be getting healthier, too.” – A 60-year-old NMN user Yes, we know this is anecdotal and we are not saying that the science is settled, but it’s getting there. Chapter 5: The Secret to Glowing Skin Isn’t in a Bottle Skincare is more than creams and serums. It’s a reflection of what’s happening inside your body. Over time, sun exposure, pollutants, and oxidative stress wear down our collagen and elastin, causing skin to sag and wrinkle. That’s where NMN shows its magic again. By boosting NAD+ levels, NMN helps support collagen production internally. This gives your skin a natural, radiant lift from within. It’s not just about looking younger. It’s about aging better. Pro tip: Pair NMN with antioxidants and hydration for maximum glow. Your Journey Begins Here You, my smart and ambitious friend, have the power to make remarkable choices for your body and your future. You’re not just surviving time. You’re mastering it. With science on your side and NMN in your wellness toolkit, you’re one step closer to radiant skin, revitalized hair, and a more youthful you. So stay curious, stay radiant, and remember: The fountain of youth might not be a myth after all. Until next time,Team Gataca- Backed by science. Inspired by you.
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