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Can Supplements Really Help You Age Better?

Can Supplements Really Help You Age Better?

by Pooja Ramakrishnan in News

Introduction

David Sinclair is a very well known scientist who has been studying all about aging and its intricate mechanisms on the body. He recommends that taking supplements will greatly help you in the fight against aging. But is it really necessary to think of aging as a disease? Every cell has its own time limit etched within the DNA and forcing cells to live forever doesn’t really sound very realistic. However, if we think of aging as a phenomenon which can be controlled if we make the right choices everyday, then what is stopping you from enjoying what you do even after you retire? Let us try to understand why aging is an important part of life and that aging in the right way matters more than just racking up the years. 

Which Vitamins And Minerals Boost Longevity?

Vitamins and minerals are easy to come by in your diet, if you tend to include a lot of variety with respect to fruits, vegetables and protein sources. Whole grains are good carbohydrate sources and they provide you with some vitamins and minerals too. You need all of them for your body to function well, but if longevity is your major health goal, then vitamins and minerals that help reduce oxidative damage and help regulate antiinflammatory pathways are the ones you should go for. Examples include the B group of vitamins, C, E, D, Magnesium, Calcium, iron, iodine, and zinc respectively. 

How Supplements Can Boost Energy And Slow Aging

Aging is a collection of processes that involve damage to DNA, the shortening of the arms of the chromosomes (telomeres), the accumulation of mutations in DNA that cause it to be transcribed in the wrong way and other cellular pathways not working quite like they are supposed to. But, aging is inevitable and the only thing you can do is to try to age better- by ensuring that your cells stay healthy for longer. Making sustainable changes to your daily routine is one sure fire way to go about doing that, but when you do decide to add supplements, do so smartly. Adding those which help you improve energy levels, reduce oxidation and also aid your immune system in regulating inflammation will hence be useful. One sure fire way that works all the time is to go for supplements that mimic calorie restriction like resveratrol and also fasting in real life, few times in a month. 

Other supplements like epigallocatechin gallate (EGCG), curcumin from turmeric, collagen, CoQ10 which has antioxidant properties, NAD+ precursors and resveratrol have all been studied for their ability to promote healthy aging in cells.

Does Taking NAD+ Supplements Help With Aging?

NAD+ levels tend to decrease sharply once you are in your 30s. NAD+ is an important molecule that cells need to function well. But, NAD+ cannot be taken as a supplement all by itself because it is a huge molecule that cannot enter cells easily. Taking precursor molecules as supplements makes much more sense as cells like to make NAD+ from scratch- which is why NMN and NR are great options. 

Conclusion

The supplement industry is a huge one with billions being invested into it. While most supplements can be helpful if taken in the right doses at the right times, there is no way they can prevent aging itself from occurring. So, instead of looking for magical solutions which won’t ever work, it is time you start paying attention to your daily routine and the food you eat. Supplements can be an assistive device but should never be used as a crutch for you to get through life. When you do want to include supplements to your routine, make sure you do your research- so you understand how they align with your specific health goals and then talk to your doctor about them. 

FAQs

1. Do anti-aging supplements actually work?
Supplements in general cannot help you stop aging but if you take them, eat proper meals, get enough exercise and focus on getting a night’s sleep, then you are setting yourself up for better health and living for long. 

2. Can collagen supplements really reduce wrinkles and improve skin elasticity?
Yes, studies have shown that hydration of skin gets better, along with other parameters like elasticity, wrinkling and better texture. Collagen is also good for the muscles and joints. 

3. How do NMN and resveratrol help with longevity?
Both supplements help in increasing NAD+ levels in the body, which means more sirtuins get activated. SIRT1 is an important protein that helps cells in the body regulate aging, cell death and autophagy related pathways. They can work together and are generally well tolerated by most of the population. 

4. Can taking antioxidants reverse signs of aging?
Antioxidants in general help reduce DNA damage caused by the production of superoxide molecules- which are normal but toxic byproducts of metabolism. With respect to skin cells, there is an improvement in skin texture, hydration and elasticity and also protect them from damage caused due to sunlight and pollutants. Some common examples include carotenoids or those molecules that are responsible for giving vegetables and fruits their vivid colours, polyphenols and Vitamin C respectively. 

5. Are there any risks or side effects of taking anti-aging supplements?
You should always talk to your doctor about taking them in the right doses as high amounts can cause issues or interact unnecessarily with drugs you take on a regular basis.

Tags: Cognitive Performance Metabolism and Weight NAD+ updates

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Guava Seeds Benefits

Guava Seeds Benefits

Introduction Guavas have generally been considered great snackage in India- especially when sold by street hawkers. The fruits are sliced in an appealing manner, and then seasoned with a heady chilli powder and salt mix- that just brings out the sweeter and nuttier profiles of the fruit to life. They are also consumed in the form of jams, jellies, candies, for flavourful and savoury cocktails and mocktails and as fruit butters. Though the fruits themselves have long been known to be great sources of dietary fiber, vitamins and minerals- the seeds themselves cannot be ignored as something that provides the gritty texture profile to the fruit. The seeds are chock full of nutrients too, and eating some everyday is very good for you. Since they spoil rather quickly as table fruit, they are more readily processed into other edible forms as mentioned above. With the processing comes the wastage- about a metric ton of guavas will give you less than 100 kg of waste by-products- most of which are the seeds and the peel. Using the seeds again means there is less wastage of resources.  Are Guava Seeds Good For Health? Yes, totally! Guava seeds are storehouses of proteins, lipids, polysaccharides, minerals, vitamins, carotenoids, phenolic compounds and fiber, along with anti-nutrients - which are present in minute amounts. When eaten in moderation, they are a fantastic nutritive source of goodness for the body. But, many people may face issues like bloating or indigestion due to the high amounts of fiber- which can lead to diarrhoea. It is also pretty high in potassium- which means people with kidney disease should be especially careful when eating them. Some of the most prominent health benefits include the following- They are super rich in Vitamin C- one guava will give you as much Vitamin C as two oranges. This vitamin is well known as an antioxidant and helps the immune system function better. Vitamin C is obviously great for the skin as well. They are high in fibre, low in calories and are pretty nutritious- which means they will be a great addition to your daily diet. It can also help you with your weight loss goals. The soluble dietary fiber found in the seeds and the fruit can help relieve your constipation or any other gut related issues, while also helping you regulate blood glucose levels by keeping you feeling fuller for longer. For women who deal with severe cramps every month, guava seeds are said to help lessen the degree of pain - as it is gut friendly in general. Since guava seeds are rich in potassium, cardiovascular health can be improved. Blood glucose levels go down, HDL cholesterol levels increase and LDL cholesterol levels decrease- all of which are signs of a properly working heart and circulatory system. Nutritional Value Of Guava Seeds- Guava seeds are a very good source of protein as they contain almost all amino acids, except for lysine. With respect to minerals- they are rich in magnesium, phosphorus, sodium, potassium, calcium, zinc, copper, manganese and iron respectively. These seeds also contain lots of essential fatty acids like palmitic acid, linoleic acid and oleic acid., They are rich in quercetin and resveratrol- both of which are prized for their anti-aging properties. They help protect cellular function and reduce biological age by increasing the concentration of sirtuins- which are guardian proteins that take care of longevity related processes in the body. Since, Vitamin C is present in high amounts too, the anti-inflammatory properties cannot be understated. Eating them without processing them in any way is the best way for you to get all the goodness- without any filter or loss.  Do Guava Seeds Have Antioxidants? Definitely! Let us go into more detail about the antioxidant properties in this section. Guava seeds are good reserves of flavonoids, carotenoids, polyphenols, vanillin and vanillic acid. They also help in reducing the production of oxidized intermediaries and the production of free radicals. The last two compounds have excellent neuroprotective, anti-cancer and anti-aging properties- all of which help cells age better and slower.  Conclusion Guava seeds are powerhouses of nutrients - as they are rich in Vitamin C, a variety of polyphenols and essential fatty acids, many vitamins and minerals and so much more. They have a host of health improving benefits- better heart health, kidney and gut health, along with a systemic effect in helping all cells function better. This is done with the help of anti-senolytic or anti-apoptotic effects that are conferred by specific bioactives like catechin, gallic acid, quercetin, resveratrol, chlorogenic acid, avicularin, apigenin, myricetin, hyperin etc. Most of these are potent antioxidants too, in their own right and are actually more active than the Vitamin C itself, that is abundantly found in the fruit and seeds. So, what are you waiting for? It is time you include guava seeds in some form daily- as they are plain great for you!  FAQs 1. Are guava seeds safe to eat?Yes, they are super safe for regular consumption- in fact, daily is good too. They are not harmful unless you are allergic to the fruit.  2. Do guava seeds help with digestion?Definitely! Guava seeds have high amounts of fibre in them, which means you will feel fuller for longer. You will also not get constipated as they can help bulk your stool. The fats, vitamins and minerals found in the fruit are good for your body as a whole.  3. Are guava seeds good for skin health?The seeds have oil in them which can help moisturise your skin, if applied externally or used as an exfoliating pack. The fruit and seeds themselves are rich in antioxidants, so your skin cells stay protected. Some compounds are also anti-microbial in nature, which means you may not have as much acne either.  4. Do guava seeds help regulate blood sugar levels?Yes, firstly because the fruit itself is low in sugar content, second- due to its high fibre - both of which means there won’t be any glucose spikes in the blood. You won’t feel hungry very soon either, so it is a good option to snack on.  5. How can guava seeds be consumed for maximum benefits?Each fruit has hundreds of seeds in it, depending on the size and it is pretty impossible for you to remove them all. Instead, you can just chop them up and eat them or you make them into juices and smoothies. Guava seeds alone are available these days, so you can toast them and use them as a topping of sorts for salads or into fruit yoghurt.

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Why You Need To Care About Sleep Deprivation

Why You Need To Care About Sleep Deprivation

IntroductionSleep is a biological imperative for a lot of organisms. Though much about sleep is shrouded in mystery, one thing is clear- it is very restorative and good for the body and the mind. A good night’s sleep can do wonders for tiredness, your lousy mood and help your body recover from a long day at work or school. Sleep is a finely regulated phenomenon- with the production of certain hormones and neurotransmitters that are made at specific times in the day. Melatonin is a very well known molecule that is produced by the pineal gland located deep in your forehead. It uses information from the eyes to check how much light is present and then synthesises melatonin accordingly. More is made at night in the absence of light, when compared to the day. This crucial hormone helps the brain synchronize its internal clock. Glycine is an amino acid that tells the brain to relax, along with GABA. When these molecules are not produced in the right amounts at the right time, you incur a sleep debt. Sleeping poorly can affect you systemically, so let’s look at 4 concerns in detail. How Does Sleep Deprivation Affect The Brain?Pulling all nighters regularly can get you closer to that promotion sooner but it is bad for your brain in the long run. The brain is always active, even when you are asleep- some areas in fact begin to work only when you are in deep sleep. Sleep is necessary for you to form new memories and to help you sharpen your problem solving skills. If you don’t sleep enough, you won’t be able to focus on work and you may not be able to exercise your decision making skills that accurately either. You will also feel annoyed and take that frustration out on others-which means your social skills are also impaired. Can Sleep Deprivation Lead To Poor Immunity?Yes, high levels of stress hormones can lead to greater chronic inflammation in the body. The immune system has to work overtime to take care of you in this case. This situation gets markedly worse when you don’t sleep enough.  Can Sleep Deprivation Cause High Blood Pressure?Dealing with sleepless nights can leave you feeling more stressed than usual. This means you will have way more cortisol than is necessary, which can increase blood pressure. If you are always stressed, then you will probably have to deal with hypertension in the future. How Does Sleep Deprivation Affect Metabolism?Not sleeping at night can mean you will feel hungry at odd hours- more snackage than needed. Your blood glucose levels are not well regulated in such a scenario and this can lead to chronic inflammation. This is also how diabetes may begin. Changes in metabolism can cause the fat cells in your body to behave differently. You may have to deal with a dreaded ‘paunch’ too because your brain processes hunger cues more urgently. More of the ‘hunger’ hormone leptin is made and you don’t feel full as well, even if you have eaten properly. ConclusionThe lack of sleep and its impact on work performance has been well documented in many industries. For some. Loss of sleep is a genuine medical condition, in which case getting it treated immediately must be a priority. Some of you may have issues like sleep apnea, insomnia, eating disorders or may need to work at odd hours. All of this can contribute to massive changes in your daily routine. FAQs1. What are the immediate effects of not getting enough sleep?Your mood may be in the toilet, you can feel super tired and you may not be able to focus on work. Concentration may not be that great, so if you need to keep looking at minute details often, you may miss some. You will be a lot slower when you have to come up with solutions and you may not be able to exercise your decision making skills well. 2. How does sleep deprivation affect brain function and memory?You could forget more than before and you may not be able to process information like normal. Plus, being stressed about not getting enough sleep can ruin your mood for the day and make you feel pretty antisocial too.  3. Can lack of sleep cause weight gain or affect metabolism?Sleep deprivation can mess your hormones up big time, causing you to binge eat or snack at odd hours. Both of these factors need to be well within control and range for you to be able to have a decent metabolism and manage weight. 4. Can lack of sleep contribute to serious conditions like stroke or dementia?Dementia means to forget stuff and not sleeping enough can cause memories to not form properly, or even if they are present, you may not be able to retrieve them at the right time. Stroke risk is also higher in people who don’t sleep enough or sleep too much. So, sleeping just right needs to be on your agenda every night. 5. 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Plant-Based Senolytic Flavonoids Are Linked to Slower Aging: New Study

Plant-Based Senolytic Flavonoids Are Linked to Slower Aging: New Study

Unveiling the Secrets of a Youthful Diet: The Role of Flavonoids in Retarding Aging The quest for the fountain of perpetual youth has captivated humanity for centuries. While the elixir of eternal life remains elusive, recent research provides an intriguing glimpse into the potential of certain dietary choices to decelerate the aging process. In this article, we delve into the captivating realm of flavonoids and their function in fostering youthful biological ages, as unveiled by a groundbreaking study published in the Journal of Translational Medicine. Nature's Anti-Aging Elixirs Flavonoids are compounds found in plants, and they are notably abundant in the fruits and vegetables that form the bedrock of the Mediterranean diet. These natural substances possess remarkable antioxidative and anti-inflammatory attributes, rendering them formidable allies in the struggle against the ravages of time. 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Aging with Grace: The Ideal Candidates While the overarching findings are encouraging, the study also endeavored to pinpoint the specific factors and practices that may contribute to the advantages of a flavonoid-abundant diet against aging. • Age Plays a Vital Role: The advantages of a high-flavonoid diet were most pronounced in individuals aged 60 and beyond. • Smoking and Alcohol Consumption: Individuals who refrained from smoking and imbibed alcohol in moderation experienced more pronounced reductions in biological age. • Physical Activity Matters: Participants who engaged in regular physical activity also reaped more substantial benefits from flavonoid consumption. In essence, older individuals who abstain from smoking, consume alcohol in moderation, and adhere to an active lifestyle appear to derive the most substantial anti-aging advantages from a diet rich in flavonoids. Glimpsing the Future: Advancing our Understanding of Flavonoids While this study offers compelling insights into the potential anti-aging effects of flavonoids, it is imperative to acknowledge its constraints. The evaluation of biological age was solely predicated on blood markers, which may not encompass the entire intricacy of the aging process. Other advanced methodologies, such as telomere length and DNA methylation, might furnish a more holistic comprehension of biological age. Another notable limitation is the study's omission of the potential impact of medication utilization on the blood markers employed to assess aging. Given that a higher proportion of individuals aged 60 and over utilize medications, this element might have influenced the observed advantages in this age category. Furthermore, it is imperative to underscore that this study establishes a correlation between flavonoid consumption and a decelerated aging process, rather than establishing causation. To affirm the role of high dietary flavonoid consumption in retarding aging, forthcoming research should endeavor to eliminate the potential effects of medication utilization, employ more advanced techniques for assessing biological age, and probe deeper into the mechanisms via which flavonoids exert their anti-aging effects. Nurturing Youthfulness with Flavonoids  As we continue our quest to unveil the mysteries of aging gracefully, the significance of our dietary selections cannot be overstated. Chen and his colleagues' research suggests that a diet replete with flavonoids, a hallmark of the Mediterranean diet, may indeed possess the key to slowing down the aging process. While additional investigations are indispensable to validate causation and probe the underlying mechanisms, the evidence is compelling: a diet rich in flavonoids can culminate in biological ages that defy the relentless march of time. Therefore, if you aspire to rewind the clock and bask in a healthier, more youthful existence, contemplate embracing the potency of flavonoids. Integrate an assortment of fruits, vegetables, whole grains, legumes, nuts, fish, and olive oil into your daily nourishment. Fuse this dietary transformation with a smoke-free lifestyle, restrained alcohol consumption, and consistent physical activity, particularly if you find yourself beyond the age of 60. You may very well unearth the elusive fountain of youth right on your plate. While the quest for everlasting youthfulness persists, one thing remains crystal clear: the gifts bestowed upon us by nature, embodied in the form of flavonoids, are treasures well worth savoring on your odyssey to a healthier, more vivacious version of yourself.

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