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Why You're Still Tired After 8 Hours of Sleep
Why Am I Still Tired After 8 Hours Of Sleep? Let’s get one thing straight. If you’ve slept for a solid 8 (or 10) hours and still wake up feeling tired, you’re not lazy, broken or overdramatic; you’re just in the company of millions of people whose bodies are technically horizontal at night but never truly resting. It’s not about how long you sleep, it’s about what your brain and body are doing while you’re out cold. If your sleep cycles are shallow, fragmented or constantly yanked out of rhythm - thanks to stress, caffeine, scrolling or snoring, your body never hits the deep, slow-wave and REM stages it needs to fully reboot. Think of it like recharging your phone on a dodgy USB cable: it lights up, but it’s not really filling up. And then there’s sleep inertia, a.k.a that cursed fog that makes your brain feel like it’s booting up on Windows 98 while the world runs on fibre broadband, and that groggy mess is often caused by waking up during the wrong stage of your sleep cycle. Not to mention the sneaky suspects: sleep apnea, iron or B12 deficiencies, underactive thyroid, or low magnesium levels - pretty common in Indian diets, especially if you’re vegetarian or skipping out on whole foods in favour of yet another dosa + filter coffee situation. In short: You’re sleeping. But you’re not recovering. And that’s a problem you can absolutely fix. How To Stop Feeling Tired After Sleeping First, let’s drop the idea that more sleep equals more energy. You could sleep 12 hours and still wake up feeling like a rickshaw with a flat tyre if your sleep quality is trash. Here’s where you get smart about your recovery game. Fix your sleep hygiene, not just by changing your bedsheets (though, yes, please do that too), but by reworking the entire vibe of your nights. Your body loves consistency, and that means going to bed and waking up at roughly the same time every day, and yes, Sundays too! Next, protect your circadian rhythm like it’s your Spotify Discover playlist: personal, essential, and wrecked if tampered with too much. Your body runs on light cues, so if you’re waking up to darkness, working indoors all day, and binging on reels till 2 AM, your internal clock is basically in a different time zone. Here’s where supplements can help. Your body’s little energy factories (called mitochondria) don’t just run on vibes; they need actual fuel, and if your diet’s not delivering, smart supplementation is your shortcut to try. Some great options to try are apigenin, melatonin - all of which are natural. Apigenin is a plant based compound that helps keep your blood pressure on track- keeping your heart and brain working better than ever. Sleep Hacks To Feel Energised Let’s break down some practical, no-fluff hacks that can turn your sleep from “meh” to “miraculously restorative”. Chill before you crash Give yourself a wind-down hour. That means: no screens, no emails, no revenge-scrolling. Do some light stretching, journaling or breathwork. And if your brain is still racing, take a dose of magnesium glycinate or TMG Betaine. You could also try calming adaptogens, which help switch off the cortisol party and let melatonin take the wheel. Track it to hack it Your sleep may feel decent, but you could still be tossing, turning or waking up multiple times without knowing it. Use a tracker to see how much time you're actually spending in deep or REM sleep. It’ll tell you more than guesswork ever will. Support your mitochondria If you’re tired even after decent sleep, your body’s energy production is likely lagging. NMN, Apigenin, TMG, CoQ10 and alpha-lipoic acid aren’t just trending, they’re well-researched mitochondrial support compounds that help your body make more energy, more efficiently. Think of it as cellular caffeine, without the crash. What’s better- they are great for cellular health in the long term and help them age better too. Conclusion Look, waking up tired isn’t just annoying. It’s disorienting. You start questioning your life choices, your mattress, your career, and your ancestors. But here’s the thing- it’s not you. It’s your recovery game that needs a glow-up. You can’t out-sleep bad habits, or poor nutrient levels, or chronic stress. But you can get smarter about how you rest, how you fuel, and how you supplement. When you pair quality sleep with smart cellular support like Gataca’s NMN, you’re not just surviving mornings, you’re owning them. And that Hyderabad traffic you dread at 9 AM? You’ll be ready to stare it down with a grin, a podcast, and a pulse that says, “I’ve slept. I’ve recovered. Now, let’s go.” FAQs- 1. Can sleep apnea make me tired even after a full night’s sleep? Yes, sleep apnea causes multiple interruptions in breathing during the night. This prevents your body from entering deep restorative sleep, leaving you tired even if you were in bed for 8 hours or more. 2. What are signs of poor sleep quality? Waking up frequently, vivid dreams, sweating, feeling groggy in the morning, and needing caffeine right after waking are common signs. Even if you sleep for a long duration, these indicate that your body isn't getting restful, deep sleep. 3. Does screen time affect sleep even if I get 8 hours? Absolutely. Exposure to blue light just before bed time suppresses melatonin production. This can delay sleep onset, reduce deep sleep stages, and result in waking up feeling haggard, despite clocking in enough hours. 4. Can stress or anxiety ruin my sleep quality? Yes. Chronic stress or even unresolved worry can prevent your brain from fully winding down. This leads to fragmented or shallow sleep, often without you realising it, and leaves you feeling exhausted throughout. 5. What medical conditions cause constant fatigue? Thyroid disorders, diabetes, anaemia, vitamin B12 deficiency, chronic fatigue syndrome and depression are some conditions that can cause persistent tiredness. If fatigue continues despite good sleep, consult a doctor for a full evaluation.
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How Apigenin Blocks Cortisol and Improves Deep Sleep Cycles
How Apigenin Blocks Cortisol And Improves Deep Sleep Cycles While you might be trying to sleep, your body- specifically, your hypothalamic-pituitary-adrenal (HPA) axis- is still convinced there’s a tiger in the bushes, or a deadline on your neck, or at the very least, an Instagram reel you haven’t seen yet. This means cortisol- your body’s favourite stress hormone, continues to party in your bloodstream long after the day is over, leaving you feeling wired, tired, and utterly confused as to why eight hours in bed still feel like a nap taken inside a blender. Apigenin, however, knows exactly where the party’s happening- at the level of your cortisol production and your GABA receptors- and what it does, in its gentle, nerdy way, is reduce the output of that late-night cortisol while simultaneously whispering sweet nothings to your GABA pathways, which are like your brain’s natural brakes, the ones that say, “Shh now, enough thinking, let’s rest.” Apigenin For Deep Sleep What makes apigenin particularly seductive in the realm of sleep science is its uncanny ability to increase the availability of gamma-aminobutyric acid, which, in the most poetic sense, acts as your brain’s lullaby molecule, lowering neuron firing, slowing down your internal monologue, and luring you into the quiet, dark cocoon of slow-wave sleep where the real restoration begins- the kind where your body repairs tissues, rebalances hormones, files away memories, and gently erases the day’s chaos without needing your permission. Reduce Nighttime Cortisol Naturally If your cortisol is high at night, think of it as having a power drill running in the background while you’re trying to meditate- you can try, but your nervous system will still be on alert. Normally, cortisol- your body’s main stress hormone- should rise in the morning like the sun, powering your get-up-and-go, and slowly taper off in the evening like a soft dimmer switch. But modern life with its constant notifications, late-night meals, endless doomscrolling, and pressure to be "on" at all hours, has completely hijacked that cycle. So, Apigenin doesn’t just wait passively in a corner, it steps in and modulates the very enzymes that drive cortisol production. And the beauty is, it doesn’t crash your system or leave you feeling foggy; it simply helps you slide out of the overdrive gear and into neutral, which is exactly where your body needs to be when you’re getting ready to sleep. Apigenin And Stress Relief It’s not just sleep apigenin is interested in. No, what this little compound offers, in its own subtle way, is a form of neuroprotection - calming down the oxidative stress in your brain and easing neuroinflammation, which has been linked to everything from anxiety to brain fog to why you walked into the kitchen and immediately forgot why you were there. How Does Apigenin Compare To Melatonin For Sleep? While melatonin is a hormone your brain naturally produces in response to changes in light exposure, signalling your body that it’s time to wind down, taking it as a supplement can sometimes feel like turning off the lights too suddenly. You may fall asleep, but you might also wake up feeling like someone hit “eject” before the credits rolled. Apigenin, on the other hand, plays a longer, smoother game, works through the GABAergic system, enhances the quality and depth of sleep without forcing it to happen - more like setting the stage than just pushing the actors on. Conclusion In a world where burnout is romanticised, rest is undervalued, and stress is practically a badge of honour, apigenin arrives like a soft rebellion. It is a plant-derived, non-sedative compound and is a quietly effective answer to sleepless nights, chronic overthinking, and cortisol levels that refuse to mind their business. It offers not just sleep, but the right kind of sleep- the kind where your nervous system is no longer dancing on high alert, your brain is finally safe to relax, and your body gets to restore itself without fighting through stress signals. Think of it as nature’s way of saying, “You don’t have to try so hard- just let go, close your eyes, and I’ll take it from here.” FAQs- 1. What is apigenin and how does it work in the body? Apigenin is a plant flavone commonly found in chamomile and parsley. It interacts with GABA receptors to calm brain activity and modulates the stress axis to lower cortisol levels, supporting deeper sleep cycles and nervous system balance naturally. 2. Why does apigenin make you sleepy? It promotes sleep by enhancing GABA signalling, which slows neural firing, and by reducing cortisol, which inhibits deep sleep. The combined effect leads to easier onset of relaxation and improved time spent in slow-wave sleep. 3. What does apigenin do for the brain? It supports neuroprotection by reducing oxidative stress, balances neurotransmitters to ease anxiety, and improves sleep architecture. Over time these benefits help preserve cognitive clarity, emotional resilience and healthy memory function. 4. What’s the best time to take apigenin for sleep support? The ideal time is about forty-five to sixty minutes before bed. This allows the compound to take effect by lowering morning cortisol signalling and engaging GABA pathways just as you begin your wind-down. 5. Can apigenin help with anxiety or nervous tension? Yes, it can. Apigenin reduces stress by calming the HPA axis and enhancing GABAergic tone. It has been shown in studies to reduce markers of generalised anxiety and physiological tension, making it useful for calming a busy mind before rest.
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The Natural Compound That Calms Your Brain and Protects It - Apigenin
How Apigenin Calms The Brain Naturally If your brain often feels like a music festival with too many DJs playing at once and none of them seem to be agreeing on the same tracklist, apigenin might just be the manager who steps in quietly and brings everyone into harmony. Found in plants like chamomile, parsley and even celery, this naturally occurring flavonoid interacts with your nervous system in a way that feels more like a gentle hand on your shoulder than a hammer knocking you out cold, and it does this by connecting with your GABA receptors- those players in your brain that know how to say “relax, we’ve got this” when the world feels like it’s spiralling. Just because it works with your natural systems instead of bulldozing through them, the calmness it creates doesn’t feel artificial or heavy; instead, it feels like your mind has finally closed the 100 open tabs and decided to just focus on one thing at a time, which, as anyone who has lain awake at night replaying conversations from five years ago will tell you, is a huge win. Apigenin For Cognitive Support And Mental Clarity Studies suggest that apigenin may even help your brain grow new neurons, a process called neurogenesis, which is as exciting as it sounds because it’s the biological equivalent of upgrading your old laptop to a brand-new model without having to throw the old one away. For you, this means sharper focus, better memory and fewer moments where you walk into a room and immediately forget why you’re there, which, let’s be honest, is something all of us can get behind. When To Take Apigenin? If we’re being real, the perfect time to take apigenin is an hour before bedtime, when your brain has officially hit its “I’m done with this day” quota, but your nervous system is still over there acting like it just chugged three shots of espresso. Here’s the thing: apigenin doesn’t come in with a mallet and knock you out cold like some sketchy sleeping pill, it’s more like that chill friend who shows up at 10 p.m., puts your phone on silent, throws on a lo-fi playlist and convinces your mind to stop overthinking for once. Apigenin Dosage For Testosterone Now let’s talk dosage and why apigenin is kind of a hormonal ninja because aside from making your brain chill, it also helps you maintain healthier testosterone levels by slowing down the aromatase enzyme, which is the little troublemaker that keeps converting testosterone into oestrogen for no good reason. While most studies throw around numbers like 50 to 150 mg a day, here’s the truth, your body is not a copy-paste template and the smart move is to talk to your doctor or nutrition pro who actually knows your vibe and can help you figure out how much you need because overdosing on supplements is not the flex you think it is. Conclusion Apigenin is not the kind of supplement that’s going to slap you with instant results or make your life feel like a luxury wellness retreat in Goa overnight, but it will help your nervous system stop spiralling, keep your hormones from throwing tantrums and basically make it easier for you to not feel like you’re permanently running on 3% battery. And the best part is you can get it in small doses through foods like chamomile tea if you’re into that soft aesthetic or you can go full send with a quality supplement that actually gives you enough to make a difference, because being the version of yourself who wakes up ready to handle the day is the biggest power move you can make! FAQs- 1. What is apigenin and how does it affect the brain? Apigenin is a natural flavonoid found in plants like chamomile, parsley, and celery. It binds to GABA receptors in the brain, helping to reduce overactive brain activity and promote calmness. It may also support neurogenesis and reduce oxidative stress, making it a valuable compound for overall brain health. 2. Is apigenin effective for anxiety and stress relief? Yes, apigenin’s interaction with GABA receptors can reduce anxious feelings and help the body relax naturally. Unlike pharmaceutical sedatives, it works subtly, allowing your brain to calm down without feeling sedated. Regular use may help you better manage everyday stress and improve sleep quality. 3. Which foods are high in apigenin naturally? Apigenin is abundant in chamomile tea, parsley, celery, onions, and oranges. Indian diets often include coriander and basil, which also contain small amounts. While these foods contribute to overall intake, supplements may be considered for therapeutic benefits, as natural dietary sources often provide smaller doses. 4. What is the ideal apigenin dosage for brain health? Although research is still emerging, most studies suggest 50–150 mg daily is a safe range for adults using apigenin supplements. The right dosage may vary depending on your health status and goals, so consult your doctor before starting to ensure it’s appropriate for you. 5. Is apigenin safe to take daily as a supplement? Yes, when taken in recommended doses, apigenin is generally considered safe for long-term use. It’s a natural plant compound and well tolerated by most people. However, those on prescription medications or with health conditions should check with a doctor before beginning supplementation.
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Can Supplements Really Help You Age Better?
Introduction David Sinclair is a very well known scientist who has been studying all about aging and its intricate mechanisms on the body. He recommends that taking supplements will greatly help you in the fight against aging. But is it really necessary to think of aging as a disease? Every cell has its own time limit etched within the DNA and forcing cells to live forever doesn’t really sound very realistic. However, if we think of aging as a phenomenon which can be controlled if we make the right choices everyday, then what is stopping you from enjoying what you do even after you retire? Let us try to understand why aging is an important part of life and that aging in the right way matters more than just racking up the years. Which Vitamins And Minerals Boost Longevity? Vitamins and minerals are easy to come by in your diet, if you tend to include a lot of variety with respect to fruits, vegetables and protein sources. Whole grains are good carbohydrate sources and they provide you with some vitamins and minerals too. You need all of them for your body to function well, but if longevity is your major health goal, then vitamins and minerals that help reduce oxidative damage and help regulate antiinflammatory pathways are the ones you should go for. Examples include the B group of vitamins, C, E, D, Magnesium, Calcium, iron, iodine, and zinc respectively. How Supplements Can Boost Energy And Slow Aging Aging is a collection of processes that involve damage to DNA, the shortening of the arms of the chromosomes (telomeres), the accumulation of mutations in DNA that cause it to be transcribed in the wrong way and other cellular pathways not working quite like they are supposed to. But, aging is inevitable and the only thing you can do is to try to age better- by ensuring that your cells stay healthy for longer. Making sustainable changes to your daily routine is one sure fire way to go about doing that, but when you do decide to add supplements, do so smartly. Adding those which help you improve energy levels, reduce oxidation and also aid your immune system in regulating inflammation will hence be useful. One sure fire way that works all the time is to go for supplements that mimic calorie restriction like resveratrol and also fasting in real life, few times in a month. Other supplements like epigallocatechin gallate (EGCG), curcumin from turmeric, collagen, CoQ10 which has antioxidant properties, NAD+ precursors and resveratrol have all been studied for their ability to promote healthy aging in cells. Does Taking NAD+ Supplements Help With Aging? NAD+ levels tend to decrease sharply once you are in your 30s. NAD+ is an important molecule that cells need to function well. But, NAD+ cannot be taken as a supplement all by itself because it is a huge molecule that cannot enter cells easily. Taking precursor molecules as supplements makes much more sense as cells like to make NAD+ from scratch- which is why NMN and NR are great options. Conclusion The supplement industry is a huge one with billions being invested into it. While most supplements can be helpful if taken in the right doses at the right times, there is no way they can prevent aging itself from occurring. So, instead of looking for magical solutions which won’t ever work, it is time you start paying attention to your daily routine and the food you eat. Supplements can be an assistive device but should never be used as a crutch for you to get through life. When you do want to include supplements to your routine, make sure you do your research- so you understand how they align with your specific health goals and then talk to your doctor about them. FAQs 1. Do anti-aging supplements actually work?Supplements in general cannot help you stop aging but if you take them, eat proper meals, get enough exercise and focus on getting a night’s sleep, then you are setting yourself up for better health and living for long. 2. Can collagen supplements really reduce wrinkles and improve skin elasticity?Yes, studies have shown that hydration of skin gets better, along with other parameters like elasticity, wrinkling and better texture. Collagen is also good for the muscles and joints. 3. How do NMN and resveratrol help with longevity?Both supplements help in increasing NAD+ levels in the body, which means more sirtuins get activated. SIRT1 is an important protein that helps cells in the body regulate aging, cell death and autophagy related pathways. They can work together and are generally well tolerated by most of the population. 4. Can taking antioxidants reverse signs of aging?Antioxidants in general help reduce DNA damage caused by the production of superoxide molecules- which are normal but toxic byproducts of metabolism. With respect to skin cells, there is an improvement in skin texture, hydration and elasticity and also protect them from damage caused due to sunlight and pollutants. Some common examples include carotenoids or those molecules that are responsible for giving vegetables and fruits their vivid colours, polyphenols and Vitamin C respectively. 5. Are there any risks or side effects of taking anti-aging supplements?You should always talk to your doctor about taking them in the right doses as high amounts can cause issues or interact unnecessarily with drugs you take on a regular basis.
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Guava Seeds Benefits
Introduction Guavas have generally been considered great snackage in India- especially when sold by street hawkers. The fruits are sliced in an appealing manner, and then seasoned with a heady chilli powder and salt mix- that just brings out the sweeter and nuttier profiles of the fruit to life. They are also consumed in the form of jams, jellies, candies, for flavourful and savoury cocktails and mocktails and as fruit butters. Though the fruits themselves have long been known to be great sources of dietary fiber, vitamins and minerals- the seeds themselves cannot be ignored as something that provides the gritty texture profile to the fruit. The seeds are chock full of nutrients too, and eating some everyday is very good for you. Since they spoil rather quickly as table fruit, they are more readily processed into other edible forms as mentioned above. With the processing comes the wastage- about a metric ton of guavas will give you less than 100 kg of waste by-products- most of which are the seeds and the peel. Using the seeds again means there is less wastage of resources. Are Guava Seeds Good For Health? Yes, totally! Guava seeds are storehouses of proteins, lipids, polysaccharides, minerals, vitamins, carotenoids, phenolic compounds and fiber, along with anti-nutrients - which are present in minute amounts. When eaten in moderation, they are a fantastic nutritive source of goodness for the body. But, many people may face issues like bloating or indigestion due to the high amounts of fiber- which can lead to diarrhoea. It is also pretty high in potassium- which means people with kidney disease should be especially careful when eating them. Some of the most prominent health benefits include the following- They are super rich in Vitamin C- one guava will give you as much Vitamin C as two oranges. This vitamin is well known as an antioxidant and helps the immune system function better. Vitamin C is obviously great for the skin as well. They are high in fibre, low in calories and are pretty nutritious- which means they will be a great addition to your daily diet. It can also help you with your weight loss goals. The soluble dietary fiber found in the seeds and the fruit can help relieve your constipation or any other gut related issues, while also helping you regulate blood glucose levels by keeping you feeling fuller for longer. For women who deal with severe cramps every month, guava seeds are said to help lessen the degree of pain - as it is gut friendly in general. Since guava seeds are rich in potassium, cardiovascular health can be improved. Blood glucose levels go down, HDL cholesterol levels increase and LDL cholesterol levels decrease- all of which are signs of a properly working heart and circulatory system. Nutritional Value Of Guava Seeds- Guava seeds are a very good source of protein as they contain almost all amino acids, except for lysine. With respect to minerals- they are rich in magnesium, phosphorus, sodium, potassium, calcium, zinc, copper, manganese and iron respectively. These seeds also contain lots of essential fatty acids like palmitic acid, linoleic acid and oleic acid., They are rich in quercetin and resveratrol- both of which are prized for their anti-aging properties. They help protect cellular function and reduce biological age by increasing the concentration of sirtuins- which are guardian proteins that take care of longevity related processes in the body. Since, Vitamin C is present in high amounts too, the anti-inflammatory properties cannot be understated. Eating them without processing them in any way is the best way for you to get all the goodness- without any filter or loss. Do Guava Seeds Have Antioxidants? Definitely! Let us go into more detail about the antioxidant properties in this section. Guava seeds are good reserves of flavonoids, carotenoids, polyphenols, vanillin and vanillic acid. They also help in reducing the production of oxidized intermediaries and the production of free radicals. The last two compounds have excellent neuroprotective, anti-cancer and anti-aging properties- all of which help cells age better and slower. Conclusion Guava seeds are powerhouses of nutrients - as they are rich in Vitamin C, a variety of polyphenols and essential fatty acids, many vitamins and minerals and so much more. They have a host of health improving benefits- better heart health, kidney and gut health, along with a systemic effect in helping all cells function better. This is done with the help of anti-senolytic or anti-apoptotic effects that are conferred by specific bioactives like catechin, gallic acid, quercetin, resveratrol, chlorogenic acid, avicularin, apigenin, myricetin, hyperin etc. Most of these are potent antioxidants too, in their own right and are actually more active than the Vitamin C itself, that is abundantly found in the fruit and seeds. So, what are you waiting for? It is time you include guava seeds in some form daily- as they are plain great for you! FAQs 1. Are guava seeds safe to eat?Yes, they are super safe for regular consumption- in fact, daily is good too. They are not harmful unless you are allergic to the fruit. 2. Do guava seeds help with digestion?Definitely! Guava seeds have high amounts of fibre in them, which means you will feel fuller for longer. You will also not get constipated as they can help bulk your stool. The fats, vitamins and minerals found in the fruit are good for your body as a whole. 3. Are guava seeds good for skin health?The seeds have oil in them which can help moisturise your skin, if applied externally or used as an exfoliating pack. The fruit and seeds themselves are rich in antioxidants, so your skin cells stay protected. Some compounds are also anti-microbial in nature, which means you may not have as much acne either. 4. Do guava seeds help regulate blood sugar levels?Yes, firstly because the fruit itself is low in sugar content, second- due to its high fibre - both of which means there won’t be any glucose spikes in the blood. You won’t feel hungry very soon either, so it is a good option to snack on. 5. How can guava seeds be consumed for maximum benefits?Each fruit has hundreds of seeds in it, depending on the size and it is pretty impossible for you to remove them all. Instead, you can just chop them up and eat them or you make them into juices and smoothies. Guava seeds alone are available these days, so you can toast them and use them as a topping of sorts for salads or into fruit yoghurt.
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Urolithin A: A Promising Breakthrough in Alzheimer's Research
Introduction Recent research has uncovered exciting potential in urolithin A (UA) as a treatment for Alzheimer's disease (AD). A study published in Alzheimer's & Dementia reveals that UA may enhance cognitive function and reduce key AD markers in mice. What is Alzheimer's Disease? Alzheimer's disease is a devastating neurodegenerative disorder affecting millions worldwide. It progressively impairs memory, cognitive abilities, and daily functioning. Key features of AD include: Buildup of toxic amyloid beta proteins Formation of neurofibrillary tangles Brain inflammation Mitochondrial dysfunction Understanding Urolithin A Sources and Production UA is a natural compound found in foods like: Pomegranates Berries Nuts While the human body can produce UA, many people lack sufficient gut bacteria to make adequate amounts. Known Benefits Previous research has shown that UA may: Enhance physical performance in overweight adults Delay muscle aging in mice Increase levels of NAD+, an important molecule for cellular health Stimulate mitophagy (clearance of damaged mitochondria) The New Study: UA's Effects on Alzheimer's Researchers from the National Institute on Aging and Tongji University conducted a study on mice with an Alzheimer's-like condition. Here's what they found: Improved Cognitive Function Mice treated with UA for six months showed: Better spatial learning and memory Improved working memory Enhanced recognition memory Remarkably, these benefits persisted even after treatment ended. Reduced Alzheimer's Markers UA treatment led to: Fewer amyloid beta plaques in the prefrontal cortex Decreased levels of phosphorylated tau Decreased Brain Inflammation The study observed: Lower levels of inflammatory molecules (IL-1B and TNF-a) Reduced activity of inflammatory brain cells (microglia and astrocytes) Enhanced Mitochondrial Health UA supplementation: Increased levels of mitophagy-related proteins (PINK1 and Parkin) Potentially protected against AD progression by removing damaged mitochondria What This Means for Humans While these results are promising, it's important to note: The study was conducted on mice, not humans Further research is needed to determine UA's effects in people Consult a doctor before starting any new supplement regimen Conclusion Urolithin A shows potential as a therapeutic agent for Alzheimer's disease. By improving cognitive function, reducing AD markers, decreasing inflammation, and enhancing mitochondrial health, UA offers a multi-faceted approach to combating this devastating condition. As research continues, we may gain more insights into how UA could benefit human patients with Alzheimer's disease.
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Can AI Help Combat Dementia and Cognitive Decline?
A word that can send shivers down your spine and make you hold on to dear life is - Dementia. Anyone who has had a dear one affected by it will know how debilitating it really is! And my guess is that you or someone you know probably have it too! In fact, a recent study by the National Institutes of Health (NIH) estimated that 7.4% of adults aged 60 and above, roughly 8.8 million Indians, are living with dementia. This figure is significantly higher than previous estimates, meaning we need to find innovative solutions to tackle this crippling challenge in the country. India's population is aging rapidly, and the number of people aged 60 and above projected to reach 319 million by 2050. This only means the number of dementia cases in the country is expected to rise significantly. Despite huge investments and efforts in drug research, progress has been incredibly slow, with no breakthrough treatments on the horizon. Artificial Intelligence (AI) solutions have the potential to make a significant impact by leveraging capabilities in data analysis, pattern recognition, and predictive modeling. The Brain Bio-Digital Twin NTT Data, a strategic consulting firm that specializes in leading-edge technology has collaborated with the National Center for Neurology and Psychiatry (NCNP) to work on a new technology called the Brain Bio-Digital Twin. This technology gathers significant amounts of data on brain-related diseases and converts it into digital data. It then maps it virtually as a digital model of the brain. With the data collected and digitized, AI and ML can then be used to study the brain and its functions. Goals and Benefits The primary goal of this research program is to create a digital version of a person's brain that can be studied instead of the actual patient. The hope is that this will lead to fewer invasive tests for patients. This kind of technology could also prove to be cheaper, simpler, and better. The prototype model is scheduled to come out this year. This technology may also help with better prediction of medication side effects, and detect & prevent disease earlier. Collaboration with NCNP National Center for Neurology and Psychiatry (NCNP), a Tokyo-based organization that offers treatments and research on prevention and therapy for various disorders, is contributing important data to the Brain Bio Digital Twin. This includes PET (Positron Emission Tomography) scans, bio-samples (blood, cerebrospinal fluid, tissue samples, genetic information), and medical interpretation of the results obtained through AI and ML processing. Digital Avatars for Dementia Patients NTT DATA work is also advancing research into combating dementia by using AI and deepfake technology to build digital avatars to communicate with dementia patients and stimulate them through dialogue. AI for Detecting Cognitive Decline in Elderly Drivers NTT DATA new AI system could prove to be invaluable in detecting cognitive decline among elderly drivers. The company has started working with Kokusai Motorcars on this project, scheduled to run until the end of June. The system will analyze driving speed, acceleration and deceleration, among other driving data to assess whether drivers are experiencing a decline in cognitive brain activity, such as the ability to make quick judgments and pay attention. Kokusai Motorcars will collect a large amount of driving data from several taxis whose drivers are 65 years old or older, which will be fed to NTT DATA to develop AI algorithms and verify the accuracy of driver judgments. Future Applications NTT DATA aims to launch the system as a cloud-based service within the next couple of years, targeting the taxi and logistics industries in particular, where the average age of drivers is steadily increasing. The system will also be made available to general drivers in the future, and NTT DATA is considering building a specific version for insurance companies to incorporate as a function of their insurance products. With the prevalence of dementia in India significantly higher than previous estimates, and the country's rapidly aging population, AI solutions like those developed by NTT DATA have the potential to transform the detection, prevention, and management of dementia and cognitive decline in the country. From the Brain Bio-Digital Twin to digital avatars and AI-powered driving analysis, these innovative approaches show us the powerful role AI can play in addressing one of India's most pressing healthcare challenges. So, what do you think? Can AI really help combat cognitive decline and a scary demon like dementia? Does this give you hope? Let us know.
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One-Time Injection Enhances Brain Function In Monkeys
Unlocking Cognitive Enhancement: The Promise of Klotho Protein for Aging Minds In a groundbreaking discovery, researchers hailing from the Yale School of Medicine and the University of California, San Francisco (UCSF) have uncovered a potential key to reversing cognitive decline in the elderly. Through a singular injection of the longevity factor known as klotho, these scientists achieved remarkable improvements in the memory and cognitive function of aging non-human primates, offering a glimmer of hope for aging populations worldwide. The newly published research in Nature Aging offers a revealing glimpse into the captivating possibilities of klotho as a therapeutic solution in combatting cognitive decline linked to aging. Klotho: A Glimpse into the Fountain of Youth The tale of klotho began with a significant revelation in klotho-deficient mice, which displayed symptoms akin to human premature aging. This discovery set the stage for a cascade of research revealing the multifaceted roles of klotho in various molecular signaling pathways and diseases. This remarkable protein presents an impressive spectrum of characteristics, encompassing anti-aging qualities, the ability to extend lifespan, cognitive improvement impacts, antioxidative strengths, anti-inflammatory potentials, and even properties that counteract tumor development.Klotho's potential to bolster cognitive function has been spotlighted through acute peripheral administration in mice. The elevation of systemic klotho levels in these animals demonstrated tangible improvements in synaptic plasticity, cognitive prowess, and neural resilience against aging and neurodegenerative afflictions like Alzheimer's and Parkinson's disease. Buoyed by these discoveries, researchers redirected their focus toward investigating the feasibility of reproducing these cognitive improvements in aging non-human primates. Unraveling the Cognitive Benefits of Klotho in Aging Primates The primary objective of the study was elegantly simple: to ascertain whether aging rhesus macaques could experience cognitive improvements akin to their rodent counterparts when exposed to klotho. Aging rhesus macaques, much like humans, suffer from cognitive decline as they grow older. Yet, unlike humans, cognitive decay stems from synaptic changes rather than significant neuronal loss. Led by Stacy A. Castner from Graham V. Williams' lab at Yale School of Medicine, the research team embarked on a journey to replicate the cognitive enhancements of klotho through a single subcutaneous injection in aged rhesus macaques. These macaques, with an average age equivalent to 65 human years, were administered klotho doses that matched natural levels observed in humans and mice subjected to cognitive enhancements. The cognitive evaluations revolved around a spatial delayed response (SDR) task, focusing on the intricate interplay of fronto-temporal circuits and brain regions like the hippocampus and prefrontal cortex. This task scrutinized working and spatial memory under both low and high memory loads. The Remarkable Findings The results were nothing short of extraordinary. A single injection of 10 g/kg klotho led to a rapid improvement in high-memory-load (HML) performance in rhesus macaques, mirroring the swift cognitive enhancement witnessed in mice. These enhancements persisted even after two weeks, with improvements evident in both high and low memory load scenarios. Notably, there was no discernible difference in klotho-mediated improvements between male and female subjects. Additionally, the researchers examined the dose-dependent nature of klotho's benefits. Surprisingly, administering higher doses of klotho failed to yield further improvements, and in no way hindered cognitive function. While certain investigations have emphasized a robust link between klotho and kidney function, divergent outcomes indicate that relying on klotho as a dependable substitute biomarker in cases of chronic kidney disease might be questionable. Pioneering a New Frontier: Klotho in Clinical Trials The potential of klotho doesn't just reside in the realm of experimental research. Concrete evidence of age-dependent changes in soluble klotho levels among healthy individuals was documented in a study over a decade ago. However, human clinical trials involving klotho protein as a therapeutic agent are scarce. Over twenty clinical trials have either concluded or are in progress, exploring klotho as a biomarker for aging and various diseases. For instance, the FIT-AGING clinical trial examined different exercise modalities' effects on klotho protein and the physiological consequences of activating the klotho gene in sedentary individuals. The CHANGE clinical trial, completed in March 2020, delved into the influence of a low-calorie diet on klotho levels, brain stem cells, and cognitive abilities. Another ongoing clinical trial aims to determine whether klotho serum levels could serve as a biomarker for peripheral artery disease progression. A Glimpse into the Future While the horizon appears promising for klotho as an aging treatment and diagnostic biomarker, not all published research aligns with klotho's relevance in aging-related diseases, particularly those affecting the kidneys. Although some studies have highlighted a strong connection between klotho and kidney function, conflicting results suggest that klotho might not be a reliable surrogate biomarker in chronic kidney disease. This underscores the pressing need for comprehensive research to ascertain klotho's clinical significance in these scenarios. As our understanding of klotho continues to deepen, the potential for therapeutic interventions that harness its benefits grows more tangible. The tantalizing prospect of klotho-boosting treatments may well become a reality, unlocking a new chapter in our quest to enhance cognitive vitality and extend healthy aging.
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Newest Study Indicates NMN Reduces Inflammation and Restores Cognitive Function
Our immune system, the shield that protects us from infections, is a marvel of nature. It tirelessly battles pathogens, keeping us healthy and safe. Yet, sometimes, this protective mechanism can become overly zealous or unbalanced, mistakenly attacking our own organs, and leading to severe damage. Even our precious brain, the core of our identity and intelligence, is not immune to these potential hazards. When inflammation takes over the brain, it can cause cognitive impairments, affecting our memory and learning abilities.But hold on to hope! In a groundbreaking research discovery from the Naval Medical University in China, scientists have unearthed a remarkable solution to combat this memory-hindering brain inflammation. Meet NMN (nicotinamide mononucleotide), an extraordinary compound showing great promise in counteracting brain inflammation and enhancing cognitive function. The Connection Between NMN and Brain Inflammation Published in the esteemed scientific journal Redox Biology, a study led by Li and colleagues delved into the interplay between NMN and the immune system's inflammatory response. The researchers unveiled NMN's ability to activate a critical enzyme called SIRT1, playing a pivotal role in regulating the immune system's response to inflammation and oxidative stress.In a series of experiments on mice afflicted with a life-threatening infection known as sepsis, the team observed that NMN brought about increased levels of NAD+ and SIRT1 in a crucial brain region called the hippocampus. This finding is of paramount importance as the hippocampus governs memory and learning processes. Putting NMN to the Test To gauge the cognitive abilities of the septic mice, the scientists employed the Morris water maze test. In this challenging test, the infected mice faced navigation hurdles, exhibiting memory deficits by taking longer to find an escape platform and making more errors compared to their healthy counterparts. Yet, when NMN was administered to the septic mice, their cognitive performance underwent a remarkable improvement, indicating NMN's potential to enhance cognition. NMN: Easing Inflammation and Oxidative Stress Delving deeper into NMN's effects on the septic mice's cognition, the researchers examined inflammation and oxidative stress levels in the hippocampus. Oxidative stress arises when harmful reactive oxygen species (ROS) accumulate, causing damage to cellular components like proteins, lipids, and DNA. Importantly, inflammation is a known trigger of oxidative stress.In the septic mice, the hippocampus showed elevated levels of proinflammatory molecules, including the notorious IL-6, alongside ROS. Nevertheless, NMN administration led to a significant reduction in both inflammatory molecules and ROS, highlighting NMN's prowess in effectively countering inflammation and oxidative stress in the brain. SIRT1: The Longevity-Boosting Enzyme Aiding NMN's potent effects, SIRT1 acts like an engine fueled by a molecule called NAD+. Sufficient NAD+ supply, generated through NMN metabolism, sets SIRT1 in motion, initiating a cascade of processes associated with longevity and overall health. Interestingly, previous studies have demonstrated that over-activating SIRT1 in the brain can extend the lifespan of mice.To solidify the connection between NMN and SIRT1 in alleviating brain inflammation, the researchers performed additional experiments by blocking SIRT1 using a specific drug. The results were clear: inhibiting SIRT1 undermined NMN's cognitive-enhancing, anti-oxidative, and anti-inflammatory effects in the septic mice, underscoring that NMN's benefits stem from its activation of SIRT1. NMN is a Potent Anti-Inflammatory Agent The impact of this research extends beyond sepsis-induced inflammation, with NMN demonstrating potential in various inflammation-related conditions, including aging and chronic diseases such as neurodegenerative and cardiovascular disorders. Inflammation can be triggered by factors like injury, aging, and even certain foods or environmental toxins.NMN's positive influence goes beyond the brain, as it exhibits anti-inflammatory properties in other organs like the skin, gut, lungs, and fat tissue, as seen in animal studies. NMN's activation of SIRT1 and subsequent increase in NAD+ levels enhance the health of cellular powerhouses known as mitochondria, reducing harmful ROS production. Additionally, elevated NAD+ levels in immune cells contribute to restoring balance in a dysregulated immune system, effectively reducing inflammation.The exciting discoveries emerging from the Naval Medical University's research shed a beacon of light on NMN's immense potential in combating brain inflammation and enhancing cognitive function. This extraordinary compound, through its activation of the longevity-promoting enzyme SIRT1, offers a promising path toward addressing inflammation-induced memory impairments.The wonders of NMN extend far beyond the brain, presenting a holistic impact on overall health by taming inflammation in multiple organs. As researchers continue their journey, we might witness NMN emerging as a powerful ally in the battle against inflammation-related health challenges, fostering hope for a brighter future of improved cognitive function and enhanced well-being. Let us remain eager as the quest for better brain health and longevity unfolds before our eyes.
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