News
Magnesium Aspartate with Threonate - Benefits Explained
Introduction Magnesium is a super important mineral that is needed by the body to perform well- to help muscles work well, to help with blood glucose regulation, to ensure that nerves fire well, to help the gut absorb more water, as a crucial cofactor in hundreds of reactions that take place in the body, to help the heart beat normally and assist the brain in synthesising neurotransmitters- and more. A major deficiency can even leave you feeling depressed or anxious too. Why Take Magnesium Aspartate With Threonate? Magnesium aspartate is readily bioavailable, so your gut can absorb it with minimal effort. Magnesium threonate meanwhile is the only one of the magnesium salts to be able to enter the brain via the blood brain barrier (BBB)- where it can help in the production of neurotransmitters. This is what really helps neurons work better by improving synaptic density. The neurotransmitters produced also help improve your mood, memory and cognition in general. The positive effects of magnesium threonate is mainly due to the increase in GABA and glutamate in the brain- both of which are inhibitory neurotransmitters, which force the brain to slow down and relax better. Lower cortisol levels are also reported due to magnesium threonate supplementation. All of this culminates in you sleeping better and then having a better day altogether. Is Magnesium Aspartate With Threonate Good For Heart Health? Magnesium in general is good for the heart as a deficiency can cause changes in heart rate and lead to greater incidence of damage or heart disease. Magnesium aspartate along with threonate have also been seen to help the mitochondria produce more ATP in an efficient manner. Can Magnesium Aspartate With Threonate Help With Muscle Recovery? Yes! Definitely! This mineral does a lot of good for the muscles- by helping reduce lactic acid levels and increasing rate of recovery, to help produce more energy so that muscles can contract better, to help regulate calcium ion entry into muscles and to ensure that muscles get enough glucose to perform well, as they are metabolically very active cells, respectively. One thing you should remember is- you will expend more magnesium if you exercise a lot, when compared to someone who is not very physically active. Conclusion Both magnesium aspartate and magnesium threonate are two important magnesium based salts that can be broken down with ease, so that magnesium can be absorbed as needed. Though there are tens of different kinds of magnesium salts that come as supplements, only magnesium threonate has the capacity to enter the brain as it is a lot smaller in size. Magnesium in general has a lot of uses in the body. It is an all-rounder and can help regulate hundreds of reactions. But, not everyone can take this supplement. If you have kidney disease or heart issues, you shouldn’t be including too much magnesium in your diet as it can make your symptoms worse. So, talk to your doctor first and then decide if supplementing is worth all the effort, or if you get enough magnesium from your diet alone, you don’t need to worry much at all. FAQs 1. What is Magnesium Aspartate with Threonate, and how does it work? They are two magnesium salts that are given together as supplements - magnesium aspartate can be easily absorbed by the gut, leading to an increase in magnesium levels in the body, while magnesium threonate can cross the heavily guarded blood-brain-barrier and enter the brain to work its magic. 2. What are the key benefits of Magnesium Aspartate with Threonate for brain health? Magnesium aspartate generally helps increase levels of magnesium as it is broken down into the mineral and aspartic acid. Magnesium threonate crosses the BBB to help increase GABA levels and leaves you feeling a little less stressed and helps you sleep better. 3. Can Magnesium Aspartate with Threonate improve sleep and reduce anxiety? Yes, Gamma amino butyric acid (GABA) is a neurotransmitter that the brain makes to reduce stress and help you calm down. When you are relaxed, it is easier to fall asleep too. 4. When is the best time to take Magnesium Aspartate with Threonate morning or night? You can take it in the morning if good energy levels and a less stressful day are on your agenda. But, if getting a night of restful sleep is the primary aim, you can have it at night too. 5. Who should consider taking Magnesium Aspartate with Threonate, and who should avoid it? Anyone with kidney disease should talk to a doctor and then take it, because magnesium is mostly processed there. If you have a deficiency, then you could take it, but if you don’t have a deficiency, it is better to not supplement at all. Too much magnesium is bad for the kidneys, heart and the gut. You could also have breathing issues and go into shock in rare cases.
Learn more
Top 5 Supplements for Brain Health and Longevity
Introduction There are plenty of supplements that promise everything- from improving vitality to making you look youthful. It is however a basic concept that eating well and drinking lots of water will help way more than popping just these supplements alone. The brain needs a lot of good quality nutrition and energy to perform at its peak. Since these cells work always - even during sleep, they produce a lot of metabolic waste and other byproducts which can be damaging in some aspects. These cells are particularly more susceptible to oxidative damage. So, nutrients or compounds that can decrease the rate of oxidative damage and improve circulation to the blood are the best ones for your consideration. What Supplements Help Maintain Brain Health As You Age With a greater incidence in the occurrence of chronic illnesses like diabetes, hypertension, neurodegenerative disease and poor lifestyle choices, circulation to the brain gets affected- which means that the brain won’t get as many nutrients as needed. So, one approach that scientists are researching on extensively is how to improve circulation and also provide enough nutrition, so both goals are achieved in one go. The main issue with drugs and supplements is that they need to cross the blood brain barrier- a thick layer of cells and vasculature that function like the gatekeepers of the brain. They allow only certain small sized molecules to enter and exit the brain. This is also why it is important to choose the right kinds of supplements, as all molecules cannot gain entry into the brain. That said, the ones that do work well have been covered below- Vitamins D, C and E- They show potent antioxidant activity. Studies have shown that people with depression, dementia etc. have low levels of Vitamin D, though the clear link between these 2 factors has still not been established yet. Vitamins C and E help reduce oxidative damage to cells in the brain. The B group of vitamins is also very essential for good cellular function and red blood cell health. Good quality blood cells means they have the capacity to bind to oxygen and nutrients better, which is how the brain will get the resources to work well. Choline especially, which is Vitamin B4 is good for blood circulation and improves cognition and memory, according to few studies. Zinc is an important mineral, like selenium and magnesium for brain health. But research is a little fragmented- supplementing with zinc helps improve spatial memory, attention span and thinking in kids, but not as much in adults. Apigenin, resveratrol and trimethylglycine (TMG) are supplements that reduce inflammation and promote better cellular function. They also help reduce brain fog related symptoms, helping you perform better at work. They also help promote better sleep quality, reduce stress and help you feel better overall. Trans-resveratrol is the more active form of resveratrol that can enter cells better and work its magic and studies have shown that it is super helpful for menopausal women. Omega-3 fatty acids help fight against dementia- and studies have shown that people with Alzheimer’s disease benefit the most with supplementation. You can also get them from your diet, but you need to consume good quality fats like fish, soybeans, edamame and nuts. These are all natural supplements for brain longevity and mental clarity. Nootropics are brain friendly compounds that are synthesised chemically, or can be derived from natural sources. The most effective nootropics for brain health and longevity which are well known include caffeine, adderall, ritalin, choline, amino acids like tyrosine and L-theanine and ginseng respectively. They have been used for many decades by health enthusiasts, while some of them are prescription meds. Conclusion Nootropics and brain supplements are good for people who want to sleep better, think better and improve their daily quality of life. The dosage of all of thes ec compounds has been studied, but not as extensively. Safe doses have however been ascertained and they are present as easy to consume capsules or gummies. It is always a good idea for you to first try the lowest dosage if possible- just to see how you react to it. Some of them are addictive too, so you may need to stop them and then start taking them again after a break. Nootropics are a sensible choice if you are above your 30s and find that life is hectic and becoming more and more unmanageable. Remember this though- all nootropics are not equal and you need to think long and hard before you start taking them. FAQs 1. What are the top supplements recommended for enhancing brain health? Supplements that prevent cell death due to oxidation, or reduce the activation of such pathways, molecules or compounds that are found in the cellular membranes of cells in the brain and vitamins or mineral supplements are good choices. Fish oil, Vitamins B9, B12, B6, zinc, magnesium, choline, serine, resveratrol, TMG and apigenin are all well known supplements in this regard. 2. Are there specific supplements that are particularly effective for older adults? Older adults need a lot of Vitamin D, A, B group, E and omega-3 fatty acids. These help cells perform better and reduce oxidative damage. Magnesium and creatine are also good for better energy and mood enhancement. 3. How often should I take supplements for brain health? Most of these supplements have to be taken everyday. You can choose when to take them or talk to your doctor about it. 4. Are there any potential side effects of taking brain health supplements? Some people may be allergic to the ingredient or active compound in the supplement and develop issues like hives, rapid heart beat, breathing issues and skin rashes, diarrhoea etc. among other conditions. The right dosage also matters. 5. How long does it take to see the effects of brain health supplements? Doctors will tell you that there is no quick fix with supplements. You need to eat well and take these pills or capsules for at least 3 months, to be able to notice any positive change in your day or routine. It may take longer if you are already deficient in a few of these vitamins or minerals.
Learn more
Why You're Still Tired After 8 Hours of Sleep
Why Am I Still Tired After 8 Hours Of Sleep? Let’s get one thing straight. If you’ve slept for a solid 8 (or 10) hours and still wake up feeling tired, you’re not lazy, broken or overdramatic; you’re just in the company of millions of people whose bodies are technically horizontal at night but never truly resting. It’s not about how long you sleep, it’s about what your brain and body are doing while you’re out cold. If your sleep cycles are shallow, fragmented or constantly yanked out of rhythm - thanks to stress, caffeine, scrolling or snoring, your body never hits the deep, slow-wave and REM stages it needs to fully reboot. Think of it like recharging your phone on a dodgy USB cable: it lights up, but it’s not really filling up. And then there’s sleep inertia, a.k.a that cursed fog that makes your brain feel like it’s booting up on Windows 98 while the world runs on fibre broadband, and that groggy mess is often caused by waking up during the wrong stage of your sleep cycle. Not to mention the sneaky suspects: sleep apnea, iron or B12 deficiencies, underactive thyroid, or low magnesium levels - pretty common in Indian diets, especially if you’re vegetarian or skipping out on whole foods in favour of yet another dosa + filter coffee situation. In short: You’re sleeping. But you’re not recovering. And that’s a problem you can absolutely fix. How To Stop Feeling Tired After Sleeping First, let’s drop the idea that more sleep equals more energy. You could sleep 12 hours and still wake up feeling like a rickshaw with a flat tyre if your sleep quality is trash. Here’s where you get smart about your recovery game. Fix your sleep hygiene, not just by changing your bedsheets (though, yes, please do that too), but by reworking the entire vibe of your nights. Your body loves consistency, and that means going to bed and waking up at roughly the same time every day, and yes, Sundays too! Next, protect your circadian rhythm like it’s your Spotify Discover playlist: personal, essential, and wrecked if tampered with too much. Your body runs on light cues, so if you’re waking up to darkness, working indoors all day, and binging on reels till 2 AM, your internal clock is basically in a different time zone. Here’s where supplements can help. Your body’s little energy factories (called mitochondria) don’t just run on vibes; they need actual fuel, and if your diet’s not delivering, smart supplementation is your shortcut to try. Some great options to try are apigenin, melatonin - all of which are natural. Apigenin is a plant based compound that helps keep your blood pressure on track- keeping your heart and brain working better than ever. Sleep Hacks To Feel Energised Let’s break down some practical, no-fluff hacks that can turn your sleep from “meh” to “miraculously restorative”. Chill before you crash Give yourself a wind-down hour. That means: no screens, no emails, no revenge-scrolling. Do some light stretching, journaling or breathwork. And if your brain is still racing, take a dose of magnesium glycinate or TMG Betaine. You could also try calming adaptogens, which help switch off the cortisol party and let melatonin take the wheel. Track it to hack it Your sleep may feel decent, but you could still be tossing, turning or waking up multiple times without knowing it. Use a tracker to see how much time you're actually spending in deep or REM sleep. It’ll tell you more than guesswork ever will. Support your mitochondria If you’re tired even after decent sleep, your body’s energy production is likely lagging. NMN, Apigenin, TMG, CoQ10 and alpha-lipoic acid aren’t just trending, they’re well-researched mitochondrial support compounds that help your body make more energy, more efficiently. Think of it as cellular caffeine, without the crash. What’s better- they are great for cellular health in the long term and help them age better too. Conclusion Look, waking up tired isn’t just annoying. It’s disorienting. You start questioning your life choices, your mattress, your career, and your ancestors. But here’s the thing- it’s not you. It’s your recovery game that needs a glow-up. You can’t out-sleep bad habits, or poor nutrient levels, or chronic stress. But you can get smarter about how you rest, how you fuel, and how you supplement. When you pair quality sleep with smart cellular support like Gataca’s NMN, you’re not just surviving mornings, you’re owning them. And that Hyderabad traffic you dread at 9 AM? You’ll be ready to stare it down with a grin, a podcast, and a pulse that says, “I’ve slept. I’ve recovered. Now, let’s go.” FAQs- 1. Can sleep apnea make me tired even after a full night’s sleep? Yes, sleep apnea causes multiple interruptions in breathing during the night. This prevents your body from entering deep restorative sleep, leaving you tired even if you were in bed for 8 hours or more. 2. What are signs of poor sleep quality? Waking up frequently, vivid dreams, sweating, feeling groggy in the morning, and needing caffeine right after waking are common signs. Even if you sleep for a long duration, these indicate that your body isn't getting restful, deep sleep. 3. Does screen time affect sleep even if I get 8 hours? Absolutely. Exposure to blue light just before bed time suppresses melatonin production. This can delay sleep onset, reduce deep sleep stages, and result in waking up feeling haggard, despite clocking in enough hours. 4. Can stress or anxiety ruin my sleep quality? Yes. Chronic stress or even unresolved worry can prevent your brain from fully winding down. This leads to fragmented or shallow sleep, often without you realising it, and leaves you feeling exhausted throughout. 5. What medical conditions cause constant fatigue? Thyroid disorders, diabetes, anaemia, vitamin B12 deficiency, chronic fatigue syndrome and depression are some conditions that can cause persistent tiredness. If fatigue continues despite good sleep, consult a doctor for a full evaluation.
Learn more
How Apigenin Blocks Cortisol and Improves Deep Sleep Cycles
How Apigenin Blocks Cortisol And Improves Deep Sleep Cycles While you might be trying to sleep, your body- specifically, your hypothalamic-pituitary-adrenal (HPA) axis- is still convinced there’s a tiger in the bushes, or a deadline on your neck, or at the very least, an Instagram reel you haven’t seen yet. This means cortisol- your body’s favourite stress hormone, continues to party in your bloodstream long after the day is over, leaving you feeling wired, tired, and utterly confused as to why eight hours in bed still feel like a nap taken inside a blender. Apigenin, however, knows exactly where the party’s happening- at the level of your cortisol production and your GABA receptors- and what it does, in its gentle, nerdy way, is reduce the output of that late-night cortisol while simultaneously whispering sweet nothings to your GABA pathways, which are like your brain’s natural brakes, the ones that say, “Shh now, enough thinking, let’s rest.” Apigenin For Deep Sleep What makes apigenin particularly seductive in the realm of sleep science is its uncanny ability to increase the availability of gamma-aminobutyric acid, which, in the most poetic sense, acts as your brain’s lullaby molecule, lowering neuron firing, slowing down your internal monologue, and luring you into the quiet, dark cocoon of slow-wave sleep where the real restoration begins- the kind where your body repairs tissues, rebalances hormones, files away memories, and gently erases the day’s chaos without needing your permission. Reduce Nighttime Cortisol Naturally If your cortisol is high at night, think of it as having a power drill running in the background while you’re trying to meditate- you can try, but your nervous system will still be on alert. Normally, cortisol- your body’s main stress hormone- should rise in the morning like the sun, powering your get-up-and-go, and slowly taper off in the evening like a soft dimmer switch. But modern life with its constant notifications, late-night meals, endless doomscrolling, and pressure to be "on" at all hours, has completely hijacked that cycle. So, Apigenin doesn’t just wait passively in a corner, it steps in and modulates the very enzymes that drive cortisol production. And the beauty is, it doesn’t crash your system or leave you feeling foggy; it simply helps you slide out of the overdrive gear and into neutral, which is exactly where your body needs to be when you’re getting ready to sleep. Apigenin And Stress Relief It’s not just sleep apigenin is interested in. No, what this little compound offers, in its own subtle way, is a form of neuroprotection - calming down the oxidative stress in your brain and easing neuroinflammation, which has been linked to everything from anxiety to brain fog to why you walked into the kitchen and immediately forgot why you were there. How Does Apigenin Compare To Melatonin For Sleep? While melatonin is a hormone your brain naturally produces in response to changes in light exposure, signalling your body that it’s time to wind down, taking it as a supplement can sometimes feel like turning off the lights too suddenly. You may fall asleep, but you might also wake up feeling like someone hit “eject” before the credits rolled. Apigenin, on the other hand, plays a longer, smoother game, works through the GABAergic system, enhances the quality and depth of sleep without forcing it to happen - more like setting the stage than just pushing the actors on. Conclusion In a world where burnout is romanticised, rest is undervalued, and stress is practically a badge of honour, apigenin arrives like a soft rebellion. It is a plant-derived, non-sedative compound and is a quietly effective answer to sleepless nights, chronic overthinking, and cortisol levels that refuse to mind their business. It offers not just sleep, but the right kind of sleep- the kind where your nervous system is no longer dancing on high alert, your brain is finally safe to relax, and your body gets to restore itself without fighting through stress signals. Think of it as nature’s way of saying, “You don’t have to try so hard- just let go, close your eyes, and I’ll take it from here.” FAQs- 1. What is apigenin and how does it work in the body? Apigenin is a plant flavone commonly found in chamomile and parsley. It interacts with GABA receptors to calm brain activity and modulates the stress axis to lower cortisol levels, supporting deeper sleep cycles and nervous system balance naturally. 2. Why does apigenin make you sleepy? It promotes sleep by enhancing GABA signalling, which slows neural firing, and by reducing cortisol, which inhibits deep sleep. The combined effect leads to easier onset of relaxation and improved time spent in slow-wave sleep. 3. What does apigenin do for the brain? It supports neuroprotection by reducing oxidative stress, balances neurotransmitters to ease anxiety, and improves sleep architecture. Over time these benefits help preserve cognitive clarity, emotional resilience and healthy memory function. 4. What’s the best time to take apigenin for sleep support? The ideal time is about forty-five to sixty minutes before bed. This allows the compound to take effect by lowering morning cortisol signalling and engaging GABA pathways just as you begin your wind-down. 5. Can apigenin help with anxiety or nervous tension? Yes, it can. Apigenin reduces stress by calming the HPA axis and enhancing GABAergic tone. It has been shown in studies to reduce markers of generalised anxiety and physiological tension, making it useful for calming a busy mind before rest.
Learn more
The Natural Compound That Calms Your Brain and Protects It - Apigenin
How Apigenin Calms The Brain Naturally If your brain often feels like a music festival with too many DJs playing at once and none of them seem to be agreeing on the same tracklist, apigenin might just be the manager who steps in quietly and brings everyone into harmony. Found in plants like chamomile, parsley and even celery, this naturally occurring flavonoid interacts with your nervous system in a way that feels more like a gentle hand on your shoulder than a hammer knocking you out cold, and it does this by connecting with your GABA receptors- those players in your brain that know how to say “relax, we’ve got this” when the world feels like it’s spiralling. Just because it works with your natural systems instead of bulldozing through them, the calmness it creates doesn’t feel artificial or heavy; instead, it feels like your mind has finally closed the 100 open tabs and decided to just focus on one thing at a time, which, as anyone who has lain awake at night replaying conversations from five years ago will tell you, is a huge win. Apigenin For Cognitive Support And Mental Clarity Studies suggest that apigenin may even help your brain grow new neurons, a process called neurogenesis, which is as exciting as it sounds because it’s the biological equivalent of upgrading your old laptop to a brand-new model without having to throw the old one away. For you, this means sharper focus, better memory and fewer moments where you walk into a room and immediately forget why you’re there, which, let’s be honest, is something all of us can get behind. When To Take Apigenin? If we’re being real, the perfect time to take apigenin is an hour before bedtime, when your brain has officially hit its “I’m done with this day” quota, but your nervous system is still over there acting like it just chugged three shots of espresso. Here’s the thing: apigenin doesn’t come in with a mallet and knock you out cold like some sketchy sleeping pill, it’s more like that chill friend who shows up at 10 p.m., puts your phone on silent, throws on a lo-fi playlist and convinces your mind to stop overthinking for once. Apigenin Dosage For Testosterone Now let’s talk dosage and why apigenin is kind of a hormonal ninja because aside from making your brain chill, it also helps you maintain healthier testosterone levels by slowing down the aromatase enzyme, which is the little troublemaker that keeps converting testosterone into oestrogen for no good reason. While most studies throw around numbers like 50 to 150 mg a day, here’s the truth, your body is not a copy-paste template and the smart move is to talk to your doctor or nutrition pro who actually knows your vibe and can help you figure out how much you need because overdosing on supplements is not the flex you think it is. Conclusion Apigenin is not the kind of supplement that’s going to slap you with instant results or make your life feel like a luxury wellness retreat in Goa overnight, but it will help your nervous system stop spiralling, keep your hormones from throwing tantrums and basically make it easier for you to not feel like you’re permanently running on 3% battery. And the best part is you can get it in small doses through foods like chamomile tea if you’re into that soft aesthetic or you can go full send with a quality supplement that actually gives you enough to make a difference, because being the version of yourself who wakes up ready to handle the day is the biggest power move you can make! FAQs- 1. What is apigenin and how does it affect the brain? Apigenin is a natural flavonoid found in plants like chamomile, parsley, and celery. It binds to GABA receptors in the brain, helping to reduce overactive brain activity and promote calmness. It may also support neurogenesis and reduce oxidative stress, making it a valuable compound for overall brain health. 2. Is apigenin effective for anxiety and stress relief? Yes, apigenin’s interaction with GABA receptors can reduce anxious feelings and help the body relax naturally. Unlike pharmaceutical sedatives, it works subtly, allowing your brain to calm down without feeling sedated. Regular use may help you better manage everyday stress and improve sleep quality. 3. Which foods are high in apigenin naturally? Apigenin is abundant in chamomile tea, parsley, celery, onions, and oranges. Indian diets often include coriander and basil, which also contain small amounts. While these foods contribute to overall intake, supplements may be considered for therapeutic benefits, as natural dietary sources often provide smaller doses. 4. What is the ideal apigenin dosage for brain health? Although research is still emerging, most studies suggest 50–150 mg daily is a safe range for adults using apigenin supplements. The right dosage may vary depending on your health status and goals, so consult your doctor before starting to ensure it’s appropriate for you. 5. Is apigenin safe to take daily as a supplement? Yes, when taken in recommended doses, apigenin is generally considered safe for long-term use. It’s a natural plant compound and well tolerated by most people. However, those on prescription medications or with health conditions should check with a doctor before beginning supplementation.
Learn more
Can Supplements Really Help You Age Better?
Introduction David Sinclair is a very well known scientist who has been studying all about aging and its intricate mechanisms on the body. He recommends that taking supplements will greatly help you in the fight against aging. But is it really necessary to think of aging as a disease? Every cell has its own time limit etched within the DNA and forcing cells to live forever doesn’t really sound very realistic. However, if we think of aging as a phenomenon which can be controlled if we make the right choices everyday, then what is stopping you from enjoying what you do even after you retire? Let us try to understand why aging is an important part of life and that aging in the right way matters more than just racking up the years. Which Vitamins And Minerals Boost Longevity? Vitamins and minerals are easy to come by in your diet, if you tend to include a lot of variety with respect to fruits, vegetables and protein sources. Whole grains are good carbohydrate sources and they provide you with some vitamins and minerals too. You need all of them for your body to function well, but if longevity is your major health goal, then vitamins and minerals that help reduce oxidative damage and help regulate antiinflammatory pathways are the ones you should go for. Examples include the B group of vitamins, C, E, D, Magnesium, Calcium, iron, iodine, and zinc respectively. How Supplements Can Boost Energy And Slow Aging Aging is a collection of processes that involve damage to DNA, the shortening of the arms of the chromosomes (telomeres), the accumulation of mutations in DNA that cause it to be transcribed in the wrong way and other cellular pathways not working quite like they are supposed to. But, aging is inevitable and the only thing you can do is to try to age better- by ensuring that your cells stay healthy for longer. Making sustainable changes to your daily routine is one sure fire way to go about doing that, but when you do decide to add supplements, do so smartly. Adding those which help you improve energy levels, reduce oxidation and also aid your immune system in regulating inflammation will hence be useful. One sure fire way that works all the time is to go for supplements that mimic calorie restriction like resveratrol and also fasting in real life, few times in a month. Other supplements like epigallocatechin gallate (EGCG), curcumin from turmeric, collagen, CoQ10 which has antioxidant properties, NAD+ precursors and resveratrol have all been studied for their ability to promote healthy aging in cells. Does Taking NAD+ Supplements Help With Aging? NAD+ levels tend to decrease sharply once you are in your 30s. NAD+ is an important molecule that cells need to function well. But, NAD+ cannot be taken as a supplement all by itself because it is a huge molecule that cannot enter cells easily. Taking precursor molecules as supplements makes much more sense as cells like to make NAD+ from scratch- which is why NMN and NR are great options. Conclusion The supplement industry is a huge one with billions being invested into it. While most supplements can be helpful if taken in the right doses at the right times, there is no way they can prevent aging itself from occurring. So, instead of looking for magical solutions which won’t ever work, it is time you start paying attention to your daily routine and the food you eat. Supplements can be an assistive device but should never be used as a crutch for you to get through life. When you do want to include supplements to your routine, make sure you do your research- so you understand how they align with your specific health goals and then talk to your doctor about them. FAQs 1. Do anti-aging supplements actually work?Supplements in general cannot help you stop aging but if you take them, eat proper meals, get enough exercise and focus on getting a night’s sleep, then you are setting yourself up for better health and living for long. 2. Can collagen supplements really reduce wrinkles and improve skin elasticity?Yes, studies have shown that hydration of skin gets better, along with other parameters like elasticity, wrinkling and better texture. Collagen is also good for the muscles and joints. 3. How do NMN and resveratrol help with longevity?Both supplements help in increasing NAD+ levels in the body, which means more sirtuins get activated. SIRT1 is an important protein that helps cells in the body regulate aging, cell death and autophagy related pathways. They can work together and are generally well tolerated by most of the population. 4. Can taking antioxidants reverse signs of aging?Antioxidants in general help reduce DNA damage caused by the production of superoxide molecules- which are normal but toxic byproducts of metabolism. With respect to skin cells, there is an improvement in skin texture, hydration and elasticity and also protect them from damage caused due to sunlight and pollutants. Some common examples include carotenoids or those molecules that are responsible for giving vegetables and fruits their vivid colours, polyphenols and Vitamin C respectively. 5. Are there any risks or side effects of taking anti-aging supplements?You should always talk to your doctor about taking them in the right doses as high amounts can cause issues or interact unnecessarily with drugs you take on a regular basis.
Learn more
Guava Seeds Benefits
Overview Guava seeds are nutrient-dense edible seeds found inside guava fruit.They are beneficial for people looking to improve digestion, heart health, and immunity naturally. Many people discard guava seeds without realizing their high fiber and antioxidant content.Regular, moderate consumption supports gut health, metabolic balance, and cellular protection. Primary Answer: Are Guava Seeds Good for Health? Yes, guava seeds are good for health when eaten in moderation. They are rich in dietary fiber, vitamin C, essential fatty acids, minerals, and antioxidants. Guava seeds support digestion, heart health, blood sugar control, and immunity. Their polyphenols help reduce inflammation and protect cells from oxidative damage. Introduction Guavas have generally been considered great snackage in India- especially when sold by street hawkers. The fruit is consumed raw, ripe and can be processed into a lot of different products too.. Though the fruits themselves have long been known to be great sources of dietary fiber, vitamins and minerals, the seeds cannot be ignored either. Guava seeds are chock full of nutrients too, and eating some everyday is very good for you. So, let us look at a few prominent guava seeds benefits in this blog. Are Guava Seeds Good For Health? Yes, totally! Guava seeds are storehouses of proteins, lipids, polysaccharides, minerals, vitamins, carotenoids, phenolic compounds and fiber, along with anti-nutrients - which are present in minute amounts. When eaten in moderation, they are a fantastic nutritive source of goodness for the body. But, many people may face issues like bloating or indigestion due to the high amounts of fiber- which can lead to diarrhoea. It is also pretty high in potassium- which means people with kidney disease should be especially careful when eating them. Some of the most prominent health benefits include the following- They are super rich in Vitamin C- one guava will give you as much Vitamin C as two oranges. This vitamin is well known as an antioxidant and helps the immune system function better. Vitamin C is obviously great for the skin as well. They are high in fibre, low in calories and are pretty nutritious- which means they will be a great addition to your daily diet. It can also help you with your weight loss goals. The soluble dietary fiber found in the seeds and the fruit can help relieve your constipation or any other gut related issues, while also helping you regulate blood glucose levels by keeping you feeling fuller for longer. For women who deal with severe cramps every month, guava seeds are said to help lessen the degree of pain - as it is gut friendly in general. Since guava seeds are rich in potassium, cardiovascular health can be improved. Blood glucose levels go down, HDL cholesterol levels increase and LDL cholesterol levels decrease- all of which are signs of a properly working heart and circulatory system. Nutritional Value Of Guava Seeds Guava seeds are a very good source of protein as they contain almost all amino acids, except for lysine. With respect to minerals- they are rich in magnesium, phosphorus, sodium, potassium, calcium, zinc, copper, manganese and iron respectively. These seeds also contain lots of essential fatty acids like palmitic acid, linoleic acid and oleic acid., They are rich in quercetin and resveratrol- both of which are prized for their anti-aging properties. They help protect cellular function and reduce biological age by increasing the concentration of sirtuins- which are guardian proteins that take care of longevity related processes in the body. Since, Vitamin C is present in high amounts too, the anti-inflammatory properties cannot be understated. Eating them without processing them in any way is the best way for you to get all the goodness- without any filter or loss. Do Guava Seeds Have Antioxidants? Definitely! Let us go into more detail about the antioxidant properties in this section. Guava seeds are good reserves of flavonoids, carotenoids, polyphenols, vanillin and vanillic acid. They also help in reducing the production of oxidized intermediaries and the production of free radicals. The last two compounds have excellent neuroprotective, anti-cancer and anti-aging properties- all of which help cells age better and slower. Conclusion Conclusion- Guava seeds are powerhouses of nutrients - they are rich in fiber, vitamin C, essential fatty acids and antioxidants.They have a host of health improving benefits- better heart health, kidney and gut health, along with a systemic effect in helping all cells function better. This is done with the help of anti-senolytic or anti-apoptotic effects that are conferred by specific bioactives like catechin, gallic acid, quercetin, resveratrol, chlorogenic acid, avicularin, apigenin, myricetin, hyperin etc. Most of these are potent antioxidants too, in their own right and are actually more active than the Vitamin C itself, that is abundantly found in the fruit and seeds. So, what are you waiting for? It is time you include guava seeds in some form daily- as they are great for you! FAQs 1. Are guava seeds safe to eat? Yes, they are super safe for regular consumption- in fact, daily is good too. They are not harmful unless you are allergic to the fruit. 2. Do guava seeds help with digestion? Definitely! Guava seeds have high amounts of fibre in them, which means you will feel fuller for longer. You will also not get constipated as they can help bulk your stool. The fats, vitamins and minerals found in the fruit are good for your body as a whole. 3. Are guava seeds good for skin health? The seeds have oil in them which can help moisturise your skin, if applied externally or used as an exfoliating pack. The fruit and seeds themselves are rich in antioxidants, so your skin cells stay protected. Some compounds are also anti-microbial in nature, which means you may not have as much acne either. 4. Do guava seeds help regulate blood sugar levels? Yes, firstly because the fruit itself is low in sugar content, second- due to its high fibre - both of which means there won’t be any glucose spikes in the blood. You won’t feel hungry very soon either, so it is a good option to snack on. 5. How can guava seeds be consumed for maximum benefits? Each fruit has hundreds of seeds in it, depending on the size and it is pretty impossible for you to remove them all. Instead, you can just chop them up and eat them or you make them into juices and smoothies. Guava seeds alone are available these days, so you can toast them and use them as a topping of sorts for salads or into fruit yoghurt.
Learn more
Urolithin A: A Promising Breakthrough in Alzheimer's Research
Introduction Recent research has uncovered exciting potential in urolithin A (UA) as a treatment for Alzheimer's disease (AD). A study published in Alzheimer's & Dementia reveals that UA may enhance cognitive function and reduce key AD markers in mice. What is Alzheimer's Disease? Alzheimer's disease is a devastating neurodegenerative disorder affecting millions worldwide. It progressively impairs memory, cognitive abilities, and daily functioning. Key features of AD include: Buildup of toxic amyloid beta proteins Formation of neurofibrillary tangles Brain inflammation Mitochondrial dysfunction Understanding Urolithin A Sources and Production UA is a natural compound found in foods like: Pomegranates Berries Nuts While the human body can produce UA, many people lack sufficient gut bacteria to make adequate amounts. Known Benefits Previous research has shown that UA may: Enhance physical performance in overweight adults Delay muscle aging in mice Increase levels of NAD+, an important molecule for cellular health Stimulate mitophagy (clearance of damaged mitochondria) The New Study: UA's Effects on Alzheimer's Researchers from the National Institute on Aging and Tongji University conducted a study on mice with an Alzheimer's-like condition. Here's what they found: Improved Cognitive Function Mice treated with UA for six months showed: Better spatial learning and memory Improved working memory Enhanced recognition memory Remarkably, these benefits persisted even after treatment ended. Reduced Alzheimer's Markers UA treatment led to: Fewer amyloid beta plaques in the prefrontal cortex Decreased levels of phosphorylated tau Decreased Brain Inflammation The study observed: Lower levels of inflammatory molecules (IL-1B and TNF-a) Reduced activity of inflammatory brain cells (microglia and astrocytes) Enhanced Mitochondrial Health UA supplementation: Increased levels of mitophagy-related proteins (PINK1 and Parkin) Potentially protected against AD progression by removing damaged mitochondria What This Means for Humans While these results are promising, it's important to note: The study was conducted on mice, not humans Further research is needed to determine UA's effects in people Consult a doctor before starting any new supplement regimen Conclusion Urolithin A shows potential as a therapeutic agent for Alzheimer's disease. By improving cognitive function, reducing AD markers, decreasing inflammation, and enhancing mitochondrial health, UA offers a multi-faceted approach to combating this devastating condition. As research continues, we may gain more insights into how UA could benefit human patients with Alzheimer's disease.
Learn more
Can AI Help Combat Dementia and Cognitive Decline?
A word that can send shivers down your spine and make you hold on to dear life is - Dementia. Anyone who has had a dear one affected by it will know how debilitating it really is! And my guess is that you or someone you know probably have it too! In fact, a recent study by the National Institutes of Health (NIH) estimated that 7.4% of adults aged 60 and above, roughly 8.8 million Indians, are living with dementia. This figure is significantly higher than previous estimates, meaning we need to find innovative solutions to tackle this crippling challenge in the country. India's population is aging rapidly, and the number of people aged 60 and above projected to reach 319 million by 2050. This only means the number of dementia cases in the country is expected to rise significantly. Despite huge investments and efforts in drug research, progress has been incredibly slow, with no breakthrough treatments on the horizon. Artificial Intelligence (AI) solutions have the potential to make a significant impact by leveraging capabilities in data analysis, pattern recognition, and predictive modeling. The Brain Bio-Digital Twin NTT Data, a strategic consulting firm that specializes in leading-edge technology has collaborated with the National Center for Neurology and Psychiatry (NCNP) to work on a new technology called the Brain Bio-Digital Twin. This technology gathers significant amounts of data on brain-related diseases and converts it into digital data. It then maps it virtually as a digital model of the brain. With the data collected and digitized, AI and ML can then be used to study the brain and its functions. Goals and Benefits The primary goal of this research program is to create a digital version of a person's brain that can be studied instead of the actual patient. The hope is that this will lead to fewer invasive tests for patients. This kind of technology could also prove to be cheaper, simpler, and better. The prototype model is scheduled to come out this year. This technology may also help with better prediction of medication side effects, and detect & prevent disease earlier. Collaboration with NCNP National Center for Neurology and Psychiatry (NCNP), a Tokyo-based organization that offers treatments and research on prevention and therapy for various disorders, is contributing important data to the Brain Bio Digital Twin. This includes PET (Positron Emission Tomography) scans, bio-samples (blood, cerebrospinal fluid, tissue samples, genetic information), and medical interpretation of the results obtained through AI and ML processing. Digital Avatars for Dementia Patients NTT DATA work is also advancing research into combating dementia by using AI and deepfake technology to build digital avatars to communicate with dementia patients and stimulate them through dialogue. AI for Detecting Cognitive Decline in Elderly Drivers NTT DATA new AI system could prove to be invaluable in detecting cognitive decline among elderly drivers. The company has started working with Kokusai Motorcars on this project, scheduled to run until the end of June. The system will analyze driving speed, acceleration and deceleration, among other driving data to assess whether drivers are experiencing a decline in cognitive brain activity, such as the ability to make quick judgments and pay attention. Kokusai Motorcars will collect a large amount of driving data from several taxis whose drivers are 65 years old or older, which will be fed to NTT DATA to develop AI algorithms and verify the accuracy of driver judgments. Future Applications NTT DATA aims to launch the system as a cloud-based service within the next couple of years, targeting the taxi and logistics industries in particular, where the average age of drivers is steadily increasing. The system will also be made available to general drivers in the future, and NTT DATA is considering building a specific version for insurance companies to incorporate as a function of their insurance products. With the prevalence of dementia in India significantly higher than previous estimates, and the country's rapidly aging population, AI solutions like those developed by NTT DATA have the potential to transform the detection, prevention, and management of dementia and cognitive decline in the country. From the Brain Bio-Digital Twin to digital avatars and AI-powered driving analysis, these innovative approaches show us the powerful role AI can play in addressing one of India's most pressing healthcare challenges. So, what do you think? Can AI really help combat cognitive decline and a scary demon like dementia? Does this give you hope? Let us know.
Learn more