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What to Stack With NMN for Results?
NMN Dosage by Weight Unlike a one-size-fits-all pill, NMN dosing requires a little more thought, because body weight, age, and lifestyle can influence how much is enough. While human trials have tested doses ranging from 250 mg to 1200 mg daily without major safety concerns, most experts now suggest a sweet spot of 500 mg to 1000 mg for those seeking longevity benefits, and here is where personal context matters the most. A person weighing 55 kg who leads a moderately active life may respond well to 400 or 500 mg, whereas someone closer to 75 or 80 kg, or someone dealing with higher oxidative stress from pollution, late nights, or metabolic concerns, might benefit from 800 mg or even 1000 mg per day. Should NMN Be Taken With Food? Picture NMN as a sprinter primed for the starting blocks- on an empty stomach it can dash straight into circulation, somewhat like an express train, quietly raising NAD+ levels without digestive friction, yet in the Indian context where every morning has its own culinary choreography of chai or coffee, paratha or pesarattu, and gentle spicing, sometimes a light breakfast or a smear of ghee gives the stomach what it needs to hold steady while NMN carries out its cellular mission. So the real trick is personalised timing: try it before the first sip of tea and see how your energy hums, or take it with your breakfast to see if your tummy prefers a softer drop. Best Supplements to Stack With NMN for Longevity NMN is the soloist, but the best routines are orchestras- and when it comes to longevity, several supporting agents help NMN shine: Resveratrol - the famed longevity polyphenol, activates sirtuins and makes NMN- driven NAD+ work harder and smarter; Quercetin and Fisetin - natural flavonoids from foods like onions and strawberries act as cleanup crew, clearing out cellular debris so NMN can dispatch maintenance crews more efficiently; Curcumin- a potent antioxidant and anti-inflammatory star found in turmeric, supports NAD+ pathways and soothes the body’s internal rhythm. NMN Stack for Boosting NAD+ Naturally Supplements may start the conversation, but your lifestyle writes the main story; elevating NAD+ requires habitual harmony: intermittent fasting- common in Indian households when meals run late or breakfast is delayed- naturally raises NAD+ and makes NMN’s impact smoother; daily movement- whether temple-going walks or yoga salutations- activates mitochondrial function; sleep aligned with your inner clock, resisting the urge for late-night screen binges - these activities ensure that NAD+ cycles in sync with natural rhythms. Lastly, it makes sense to eat NAD+ buddies like beans, avocado, broccoli, and leafy greens to support coenzyme synthesis overall, in the body. Conclusion Stacking NMN is not about complexity or chasing the most expensive bottle- it’s about thoughtful companionship and chemistry: NMN leads the NAD+ charge, while resveratrol, antioxidants, and supportive foods create a welcoming environment. Your lifestyle meanwhile- (fasting, movement, sleep, diet), is the conductor that ensures everything comes together in rhythm. So, start gently, feel deeply, and refine continuously, because aging gracefully is a dance, not a sprint, and NMN deserves to move with elegance, balance, and a touch of some very well known Indian sensibility. FAQs- 1.What to mix NMN powder with? The simplest option is water, as it ensures quick absorption, but many prefer to mix NMN powder into juices such as orange or amla to mask its slightly bitter taste. The key is to avoid very hot drinks, since heat may degrade NMN. 2.Can you take NMN and glutathione together? Yes, NMN and glutathione complement one another beautifully, because while NMN boosts NAD+ to improve energy metabolism and repair pathways, glutathione acts as a master antioxidant, clearing cellular waste and oxidative stress. Together they strengthen immunity, slow visible aging, and support skin clarity. 3.Can I mix NMN with coffee? You technically can, since NMN is water-soluble and coffee is a common morning ritual, but it is wise to test carefully. Start by taking NMN separately on an empty stomach, then if your system feels comfortable, try combining it with your morning coffee to suit your personal rhythm. 4.Can I take vitamin C with NMN? Absolutely, vitamin C adds an extra layer of defence by reducing oxidative stress, supporting collagen production, and boosting immunity, while NMN enhances NAD+ to fuel cellular repair. This combination is particularly useful for skin health and overall vitality, acting like a double shield against stressors. Taken together, they work as partners in wellness, and because both are safe and well-tolerated, many Indians include them in their daily stack. 5.Does NMN increase triglycerides? No evidence currently suggests that NMN raises triglycerides. In fact, some studies have shown that NMN may support better metabolic health, improve insulin sensitivity, and help regulate lipid profiles. Elevated triglycerides are often linked to poor diet, lack of exercise, and genetic factors, not to NMN itself.
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Nicotinamide vs. Niacinamide- Two Different Coins Or Are They One And The Same?
Introduction If you are a skincare enthusiast, then hunting for good products that work will take a lot of your time. This is because it was normal for us all to say - ‘I do skincare but my skin does NOT care’. Though it is more of a joke, it is important to understand that not all products work on everyone- and this is exactly illustrated by that skincare and skin DON’T care quote. Among all the options available in the skincare universe, none is more celebrated than niacinamide. Structurally similar to its sibling nicotinamide- both are derivatives of Vitamin B3- and they play different but highly specific roles within the body. These terms may appear more often than you realise in the ingredients list of your favourite skincare products. But, if they are structurally almost the same, why and how are they different? If this question bugs you pretty often, then we are here to help you decide once and for all- that both are good for you. No confusion needed at all! Nicotinamide or Niacinamide- Should I Really Overthink?Yep, totally. This is because structurally they are the same! It is a simple, water-soluble amide of Niacin (Vitamin B3). But with respect to usage for different aspects- the naming changes. When skincare is the point of focus- it is called niacinamide. When longevity and better health are major concerns- it is termed nicotinamide. This compound can be derived from niacin- which is Vitamin B3 (the parent compound). This is why it is important to understand that both niacin and niacinamide are different from each other. Niacin has been used to treat skin conditions like dermatitis or pellagra, from many centuries but an unfortunate side effect is present- excessive flushing of the skin is observed. This is why it is not such a great option for most people. Nicotinamide is a derivative of niacin sure, but it is not often used in skincare products because its role is more tailored to helping cells maintain their metabolism, while also providing them with energy in the form of NAD+ - which is a compound that all cells need to survive and function flawlessly. NAD+ levels plummet when someone gets older- so, it is in the interest of healthcare buffs to try to replenish reserves and to maintain health in the long run. However, it can be used in skincare too, as it will NOT give you the annoying flush. The principle here is that if you improve cellular health, you are improving your appearance and skin texture eventually, Niacinamide is another derivative of Vitamin B3 or niacin but is more commonly used in skincare products because it is oh-so-good for you! It is an excellent compound that will help your skin feel more lush and hydrated, works diligently on fine lines and wrinkles and is also great for treating acne breakouts- as it can calm your skin down due to its anti-inflammatory properties. It also works on dark spots or uneven skin tone and can work on redness and irritation. It helps protect against pollution and damage due to sun exposure as it has anti-oxidative properties. You could try creams or serums with 2-10% of nicotinamide or niacinamide in them. You don’t have to change any part of your skincare routine either, when you use this product, as it is not going to interfere much in any way at all. But, if you go any higher, you risk having to deal with unpleasant side effects like irritation. Another major positive with niacinamide is it is NOT like retinoids- which means it can be used during pregnancy or while breastfeeding too. Don’t Worry, It Is All Good For You! As we mentioned before, the different names may seem a little confusing, but you don’t need to overthink at all. This Vitamin B3 derivative is good for sensitive skin and can help retain or improve the skin barrier function, because of its pronounced anti-inflammatory and anti-oxidative properties. Be confident when you see ingredient labels with different terms.They will offer the same benefits as niacinamide containing products - because remember this- they are literally the SAME! If you are still worried, it makes sense to get serums or products that have a low percentage of the active ingredient present in them- like 2% which is the lowest. You can slowly build it up to 5 and 10% later, if you notice good results. Conclusion Niacinamide or nicotinamide is a celebrated ingredient in the skincare universe as it can help with a variety of concerns- like fine lines, wrinkles, hyperpigmentation, acne, and hydration, while strengthening the skin barrier by reinforcing collagen production. Thousand’s of studies have shown how efficient nicotinamide is for skincare- plus it does NOT give you the dreaded niacin flush just like its sibling niacinamide. It is not nicotinamide’s fault that it is used for other aspects of healthcare right? So, the next time you see a good deal on a nicotinamide based product, why don’t you try it out and see the goodness for yourself? Let us know if you loved it, liked it, hated it or just couldn’t be bothered with it- with some constructive feedback here! FAQs1. Is niacinamide the same as nicotinamide?Yes, they are the same type of Vitamin B3 derivative with different names. Niacinamide has been used in popular culture for skincare, while nicotinamide is used when the same vitamin is used for health and longevity related needs. 2. Is niacinamide a form of vitamin B3?Yes, they are the same- derived from Vitamin B3 or niacin. It is a versatile molecule that finds use in many sectors- skincare and healthcare especially. It is easily found in fruits and vegetables and animal based products, but when applied topically or taken as supplements in slightly higher percentages, it is very beneficial as it helps cells regain their functionality soon. 3. Does niacinamide cause skin flushing like niacin?Niacin can cause your skin to look red or flushed if applied topically as it is not well tolerated by most folk. But niacinamide has a different structure which makes it easier for your skin to absorb - and it is great for sensitive skin too. 4. Is nicotinamide better than niacin for health benefits?Nicotinamide is better for skin and the eyes as it is easily absorbed, when compared to niacin itself. Since Nicotinamide is needed to make NAD, your body handles it better than niacin alone. 5. Are there any side effects of using niacinamide in skincare?Some people may be allergic to it or react poorly if the active ingredient is present at a high percentage. You can also take it as a capsule - if better health is your goal.
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Can Supplements Really Help You Age Better?
Introduction David Sinclair is a very well known scientist who has been studying all about aging and its intricate mechanisms on the body. He recommends that taking supplements will greatly help you in the fight against aging. But is it really necessary to think of aging as a disease? Every cell has its own time limit etched within the DNA and forcing cells to live forever doesn’t really sound very realistic. However, if we think of aging as a phenomenon which can be controlled if we make the right choices everyday, then what is stopping you from enjoying what you do even after you retire? Let us try to understand why aging is an important part of life and that aging in the right way matters more than just racking up the years. Which Vitamins And Minerals Boost Longevity? Vitamins and minerals are easy to come by in your diet, if you tend to include a lot of variety with respect to fruits, vegetables and protein sources. Whole grains are good carbohydrate sources and they provide you with some vitamins and minerals too. You need all of them for your body to function well, but if longevity is your major health goal, then vitamins and minerals that help reduce oxidative damage and help regulate antiinflammatory pathways are the ones you should go for. Examples include the B group of vitamins, C, E, D, Magnesium, Calcium, iron, iodine, and zinc respectively. How Supplements Can Boost Energy And Slow Aging Aging is a collection of processes that involve damage to DNA, the shortening of the arms of the chromosomes (telomeres), the accumulation of mutations in DNA that cause it to be transcribed in the wrong way and other cellular pathways not working quite like they are supposed to. But, aging is inevitable and the only thing you can do is to try to age better- by ensuring that your cells stay healthy for longer. Making sustainable changes to your daily routine is one sure fire way to go about doing that, but when you do decide to add supplements, do so smartly. Adding those which help you improve energy levels, reduce oxidation and also aid your immune system in regulating inflammation will hence be useful. One sure fire way that works all the time is to go for supplements that mimic calorie restriction like resveratrol and also fasting in real life, few times in a month. Other supplements like epigallocatechin gallate (EGCG), curcumin from turmeric, collagen, CoQ10 which has antioxidant properties, NAD+ precursors and resveratrol have all been studied for their ability to promote healthy aging in cells. Does Taking NAD+ Supplements Help With Aging? NAD+ levels tend to decrease sharply once you are in your 30s. NAD+ is an important molecule that cells need to function well. But, NAD+ cannot be taken as a supplement all by itself because it is a huge molecule that cannot enter cells easily. Taking precursor molecules as supplements makes much more sense as cells like to make NAD+ from scratch- which is why NMN and NR are great options. Conclusion The supplement industry is a huge one with billions being invested into it. While most supplements can be helpful if taken in the right doses at the right times, there is no way they can prevent aging itself from occurring. So, instead of looking for magical solutions which won’t ever work, it is time you start paying attention to your daily routine and the food you eat. Supplements can be an assistive device but should never be used as a crutch for you to get through life. When you do want to include supplements to your routine, make sure you do your research- so you understand how they align with your specific health goals and then talk to your doctor about them. FAQs 1. Do anti-aging supplements actually work?Supplements in general cannot help you stop aging but if you take them, eat proper meals, get enough exercise and focus on getting a night’s sleep, then you are setting yourself up for better health and living for long. 2. Can collagen supplements really reduce wrinkles and improve skin elasticity?Yes, studies have shown that hydration of skin gets better, along with other parameters like elasticity, wrinkling and better texture. Collagen is also good for the muscles and joints. 3. How do NMN and resveratrol help with longevity?Both supplements help in increasing NAD+ levels in the body, which means more sirtuins get activated. SIRT1 is an important protein that helps cells in the body regulate aging, cell death and autophagy related pathways. They can work together and are generally well tolerated by most of the population. 4. Can taking antioxidants reverse signs of aging?Antioxidants in general help reduce DNA damage caused by the production of superoxide molecules- which are normal but toxic byproducts of metabolism. With respect to skin cells, there is an improvement in skin texture, hydration and elasticity and also protect them from damage caused due to sunlight and pollutants. Some common examples include carotenoids or those molecules that are responsible for giving vegetables and fruits their vivid colours, polyphenols and Vitamin C respectively. 5. Are there any risks or side effects of taking anti-aging supplements?You should always talk to your doctor about taking them in the right doses as high amounts can cause issues or interact unnecessarily with drugs you take on a regular basis.
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Why You Need To Care About Sleep Deprivation
IntroductionSleep is a biological imperative for a lot of organisms. Though much about sleep is shrouded in mystery, one thing is clear- it is very restorative and good for the body and the mind. A good night’s sleep can do wonders for tiredness, your lousy mood and help your body recover from a long day at work or school. Sleep is a finely regulated phenomenon- with the production of certain hormones and neurotransmitters that are made at specific times in the day. Melatonin is a very well known molecule that is produced by the pineal gland located deep in your forehead. It uses information from the eyes to check how much light is present and then synthesises melatonin accordingly. More is made at night in the absence of light, when compared to the day. This crucial hormone helps the brain synchronize its internal clock. Glycine is an amino acid that tells the brain to relax, along with GABA. When these molecules are not produced in the right amounts at the right time, you incur a sleep debt. Sleeping poorly can affect you systemically, so let’s look at 4 concerns in detail. How Does Sleep Deprivation Affect The Brain?Pulling all nighters regularly can get you closer to that promotion sooner but it is bad for your brain in the long run. The brain is always active, even when you are asleep- some areas in fact begin to work only when you are in deep sleep. Sleep is necessary for you to form new memories and to help you sharpen your problem solving skills. If you don’t sleep enough, you won’t be able to focus on work and you may not be able to exercise your decision making skills that accurately either. You will also feel annoyed and take that frustration out on others-which means your social skills are also impaired. Can Sleep Deprivation Lead To Poor Immunity?Yes, high levels of stress hormones can lead to greater chronic inflammation in the body. The immune system has to work overtime to take care of you in this case. This situation gets markedly worse when you don’t sleep enough. Can Sleep Deprivation Cause High Blood Pressure?Dealing with sleepless nights can leave you feeling more stressed than usual. This means you will have way more cortisol than is necessary, which can increase blood pressure. If you are always stressed, then you will probably have to deal with hypertension in the future. How Does Sleep Deprivation Affect Metabolism?Not sleeping at night can mean you will feel hungry at odd hours- more snackage than needed. Your blood glucose levels are not well regulated in such a scenario and this can lead to chronic inflammation. This is also how diabetes may begin. Changes in metabolism can cause the fat cells in your body to behave differently. You may have to deal with a dreaded ‘paunch’ too because your brain processes hunger cues more urgently. More of the ‘hunger’ hormone leptin is made and you don’t feel full as well, even if you have eaten properly. ConclusionThe lack of sleep and its impact on work performance has been well documented in many industries. For some. Loss of sleep is a genuine medical condition, in which case getting it treated immediately must be a priority. Some of you may have issues like sleep apnea, insomnia, eating disorders or may need to work at odd hours. All of this can contribute to massive changes in your daily routine. FAQs1. What are the immediate effects of not getting enough sleep?Your mood may be in the toilet, you can feel super tired and you may not be able to focus on work. Concentration may not be that great, so if you need to keep looking at minute details often, you may miss some. You will be a lot slower when you have to come up with solutions and you may not be able to exercise your decision making skills well. 2. How does sleep deprivation affect brain function and memory?You could forget more than before and you may not be able to process information like normal. Plus, being stressed about not getting enough sleep can ruin your mood for the day and make you feel pretty antisocial too. 3. Can lack of sleep cause weight gain or affect metabolism?Sleep deprivation can mess your hormones up big time, causing you to binge eat or snack at odd hours. Both of these factors need to be well within control and range for you to be able to have a decent metabolism and manage weight. 4. Can lack of sleep contribute to serious conditions like stroke or dementia?Dementia means to forget stuff and not sleeping enough can cause memories to not form properly, or even if they are present, you may not be able to retrieve them at the right time. Stroke risk is also higher in people who don’t sleep enough or sleep too much. So, sleeping just right needs to be on your agenda every night. 5. What are the best ways to recover from sleep debt and improve sleep quality?You should try to be super consistent about bedtime and wake up at the same time too every morning. You should try not to nap, use dim lights in the evening and eat well before sleeping, so you don’t stay up due to a full tummy. For melatonin to be produced, you need to get enough sunlight into your eyes, and try not to use your laptop or phone more than needed.
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Exploring NMN Human Trial Advancements
Unlocking the Potential of NMN: Is it the Anti-Aging Elixir We've Been Waiting For? NMN: The Fountain of Youth or Just Another Fad? In a world obsessed with staying youthful and vibrant, the quest for the elusive elixir of life has led us to some intriguing places. One such destination on this journey is Nicotinamide Mononucleotide (NMN). Over the past three years, NMN has been the subject of extensive human trials, and the results are nothing short of fascinating. These trials have not only confirmed its safety but have also unearthed its potential as an anti-aging supplement. Safety First: NMN's Clean Bill of Health One of the primary concerns when it comes to any supplement is safety. Can we trust it not to harm our bodies? Well, if the past three years of NMN trials are any indication, we can breathe a sigh of relief. NMN, the precursor to the essential NAD+ molecule, has undergone rigorous testing, and not once has it triggered adverse physiological effects. This verdict comes from a series of human trials, painting a reassuring picture of NMN's safety profile. NMN: A Beacon of Hope for Aging Bodies Now that we've established NMN's safety, let's dive into what truly sets it apart. The human trials have unveiled its remarkable benefits, particularly for aging adults. NMN seems to possess the power to enhance insulin sensitivity, an essential factor in maintaining stable blood sugar levels. This alone can be a game-changer for those battling age-related metabolic challenges. But that's not all NMN has up its sleeve. These trials also highlight its ability to bolster physical capacity in older individuals. The aging process often takes a toll on our muscles and overall physical performance, but NMN seems to push back against this decline. For those looking to stay active and vital as they age, this is welcome news indeed FDA Scrutiny and the Ongoing NMN Controversy While NMN's potential is captivating, it's important to address the elephant in the room: the FDA's stance on NMN. As of November 2022, the FDA authorized NMN for investigation as a new drug, effectively excluding its sale as a dietary supplement. However, this decision has not halted the fervent interest in NMN, with sales continuing unabated. For those who continue to purchase and consume NMN despite the FDA's ruling, as well as those waiting for a prescription, the question remains: what do the published NMN trials say about its safety and effectiveness as an anti-aging supplement? Let's take a closer look at the research that's shedding light on this enigmatic molecule. NMN Human Trials: A Closer Look A pivotal study published in Advances in Nutrition by Yang and colleagues from Hangzhou Normal University in China delves into the currently available data from NMN human trials. Their aim? To scrutinize NMN's safety and effectiveness, especially in combatting physiological deterioration during aging. The findings from these human trials paint a promising picture. NMN appears to confer a range of physical and metabolic benefits, particularly in older adults. However, a critical question remains unanswered: do the numerous advantages observed in aging rodents also apply to humans? While NMN's potential as an anti-aging therapeutic is evident, more extensive research is required to bridge the gap between rodent and human studies. The Safety Assurance: Keio University's Pioneering Study To understand why NMN has gained such momentum, we must revisit its safety profile. The journey began in 2016 when researchers at Keio University in Japan conducted the first study evaluating NMN's safety. Male participants were administered 100, 250, or 500 mg of NMN in the morning and closely monitored for five subsequent hours. The outcome was nothing short of reassuring. No harmful effects were observed, and crucial parameters like blood pressure, heart rate, blood oxygen saturation, and body temperature remained stable. Based on these results, Keio University researchers concluded that NMN, even at doses as high as 500 mg, is safe and well-tolerated. Building Confidence: Subsequent Human Trials Since the groundbreaking study at Keio University, seven other human trials, testing NMN's safety parameters with varying doses, have been carried out. The highest oral dose, a substantial 1,000 mg twice daily for 14 days, was administered in a Harvard study - all without any adverse side effects. These trials collectively send a resounding message: NMN is not only safe but also well-tolerated. NMN's Impact on Physical Performance Now, let's delve deeper into NMN's ability to enhance physical performance. Rodent studies have indicated positive findings related to physical capabilities, brain function, metabolism, and more. These promising results prompted researchers to explore whether NMN could counteract age-related physical decline in humans. The study led by Igarashi and colleagues demonstrated that NMN improves muscle motility, walking speed, grip strength, and the frequency of movements like standing and sitting in aged individuals. This data strongly suggests that NMN can significantly enhance physical performance in older adults. Another noteworthy study conducted by Liao and colleagues focused on trained runners. The results were equally impressive. NMN substantially improved aerobic capacity, a crucial factor for endurance athletes, as evidenced by increased blood oxygen consumption during exercise. Additionally, Huang and colleagues explored NMN's impact on walking endurance in adults aged 40 to 65 years. Using a six-minute walking endurance test, they discovered that NMN led to a sustained improvement. This finding underscores NMN's potential to enhance exercise capacity, even in middle-aged and older individuals. NMN and Metabolic Benefits NMN's benefits extend beyond physical performance. In one study involving postmenopausal women who were overweight or obese, NMN demonstrated its potential to combat prediabetes. The results indicated a substantial increase in muscle insulin sensitivity, along with improvements in insulin signaling. These findings suggest that NMN holds metabolic benefits, particularly for women dealing with prediabetes. The Sound of Youth: NMN and Hearing Capabilities Aging often takes a toll on our senses, including our hearing. NMN, however, may have something to say about that. Igarashi and colleagues found that NMN supplementation improved hearing capabilities in older men, particularly in the right ear. These findings provide a glimmer of hope that NMN could potentially restore hearing abilities in the elderly. Telomeres: The Key to Longevity? The ends of our chromosomes, known as telomeres, shorten with age, serving as a biological marker of the aging process. Niu and colleagues conducted a study that could hold the key to longevity. By supplementing with 300 mg of NMN per day, they nearly doubled telomere lengths in blood cells within just 90 days. These results suggest that NMN might exert its anti-aging effects at the molecular level. The Road Ahead: More Questions, More Research While NMN's potential is undeniable, there are still many unanswered questions. Do its benefits extend consistently across multiple organ systems in aging humans as they do in rodents? The relatively short durations of the studies, none lasting longer than three months, leave us wondering if NMN's effects are maximized over time and if there are any long-term side effects to consider. NMN and the FDA: An Ongoing Controversy Despite the FDA's decision to exclude NMN from the dietary supplement market, the molecule seems to hold significant promise. Human trials have not raised any red flags regarding its safety, and there is growing evidence of its potential anti-aging benefits. The fact that NMN is under investigation as a new drug underscores its potential as a game-changer in the world of anti-aging. In conclusion, NMN is a captivating molecule that has the potential to transform the way we age. It has cleared the safety hurdle with flying colors and has shown remarkable promise in improving physical performance, metabolic health, and even hearing capabilities in aging individuals. However, there is still much to uncover about its effects on multiple organ systems and its long-term implications. As research continues, NMN may yet prove to be the elixir of youth we've been searching for, challenging the controversy surrounding its accessibility and unlocking its true potential for humanity.
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Can The Superhero Supplement NMN Fight Depression?
Imagine if there was a supplement that could turn you from a sad person into a social butterfly faster than Clark Kent changes into Superman. We’re being a bit dramatic, don’t take this timeline seriously. According to recent research, nicotinamide mononucleotide (NMN) is that mood-boosting superhero we've been waiting for! The Mouse Experiment To model depression in mice, scientists used a "social defeat stress experiment"! This is a simple exercise where they make a small mouse face a much bigger and more aggressive mouse. Scientists often use this setup to study stress and depression in animals. In this experiment, the small mouse gets bullied by the big mouse for 10 days in a row. As you might guess, this makes the small mouse very stressed and sad. It starts acting in ways that look like depression in humans. Here's the interesting part: Some mice were given NMN every day for three weeks before meeting the big mouse. These mice seemed to handle the stress much better. It was like they had an invisible shield against feeling sad! Three Tests for the Mice The scientists then gave the mice three challenges: 1.The Friendship Test: Would the mouse go near another mouse, or stay away? 2. The Sugar Water Test: Would the mouse still enjoy sweet drinks, or had stress made everything seem less fun? 3. The Hanging Test: How long would the mouse keep trying to escape when hung by its tail? The mice that got NMN did better on all these tests. They were more social, enjoyed sweet things more, and didn't give up as quickly when things got tough. The Mitochondrial Connection: It's Not Just About Serotonin Anymore For years, we thought depression was all about a lack of feel-good chemicals like serotonin in the brain. But plot twist! It turns out our cellular powerhouses, the mitochondria, might be the real MVPs in the fight against the blues. Our brain cells need energy to keep swinging against depression. That's where NMN comes in, boosting levels of NAD+ and potentially giving our mitochondria the pep talk they need to produce more cellular energy. NMN: The Benjamin Button of Brain Health? Could taking NMN in your younger years be like investing in a 401k for your brain? Some scientists think so! Early- and mid-life depression have been linked to a higher risk of dementia later on. By potentially nipping depression in the bud, NMN might help keep your brain young and spry well into your golden years. Of course, we're not quite ready to call NMN the fountain of happiness just yet. We're gonna need more human studies - before we can make any definitive claims on depression. A Quick Spotlight on India's Mental Health Landscape The Numbers Don't Lie (But They Might Make You Anxious) According to the World Health Organization, nearly 15% of Indian adults need mental health intervention. That's more people than the entire population of Mumbai! Even more concerning, one in 20 Indians is grappling with depression. If you thought the pandemic was just about masks and social distancing, think again. A 2021 Lancet study showed a whopping 35% increase in anxiety disorders in India during the COVID-19 pandemic. Remember how we talked about stress affecting our little mouse friends? Well, humans aren't faring much better. The 2023 GOQii India Fit Report reveals that 26% of Indians are stressed due to work. That's right – over a quarter of the population is feeling the heat at the office! Several studies also show that Gen Z and Millennials are experiencing higher levels of stress and anxiety. Between academic pressure, career competition, and the constant comparison game on social media The Bottom Line: A New Hope for Mental Health? While we can't all be superheroes, it seems NMN might give us a fighting chance against the villainous duo of depression and stress. This is especially relevant in a country like India where a majority of the population is grappling with stress and depression. As we wait for more research, keep your chin up and maybe consider adding a little NMN to your daily routine. Who knows? It might just be the sidekick your mood has been waiting for. Remember, though, that while this research is exciting, it's important to consult with a healthcare professional before starting any new supplement regimen.
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Discovering the Magic of Youthful Skin and Hair: Your Exciting Journey into the World of NMN
Greetings, my intelligent, skincare loving friend! Ever wondered if reversing gray hair or slowing skin aging is actually possible? Today, we dive deep into the exciting science behind youthful skin, vibrant hair, and one molecule that’s changing everything: NMN. Get ready for a journey into the future of longevity, beauty, and inner vitality. Let’s go! Chapter 1: Why Does Hair Turn Gray, and Is It Reversible? Picture this: you're brushing your hair one morning and suddenly notice a few unexpected gray strands. Surprising, right? The secret lies in melanin, the pigment responsible for the color of our hair and skin, produced by tiny cells called melanocytes at the base of each hair follicle. When we're stressed or have certain health conditions, we may temporarily lose hair and along with it, melanin. But here’s the hopeful part: if those melanocytes survive, the color can return once your stress is reduced. It’s not magic. It’s biology in motion. Curious fact: Some people have seen their gray hair repigmented after lifestyle changes. Fascinating, isn’t it? Chapter 2: How Aging Starts, and Where It Hits First Let’s explore why aging happens at the cellular level. It’s more fascinating than you might think. Our cells contain mitochondria, the energy powerhouses that keep everything running smoothly. As we age, mitochondrial function declines, and this impacts the health of our melanocytes (remember those guys?). Then there are telomeres - protective caps on our chromosomes that shorten each time our cells divide. You’re beginning to get bored, aren’t you! Hang in there, we’re getting to it. When they get too short, cells stop dividing and turn into senescent cells, which are old, inactive cells that contribute to signs of aging like wrinkles and gray hair. So yes, aging begins inside the cell, long before we see it on our face or scalp. Chapter 3: Meet NAD+, Your Body’s Inner Fuel Source Now for the exciting part: NAD+ (nicotinamide adenine dinucleotide). Think of it as your body’s energy currency. It fuels over 300 enzymatic reactions, including mitochondrial health, DNA repair, and cell regeneration. But NAD+ levels decline with age. That’s where NMN (nicotinamide mononucleotide) steps in. As a precursor to NAD+, NMN helps restore those energy levels, potentially rejuvenating your cells from the inside out. Even more promising, early studies suggest it may help maintain telomere length, a key to staying youthful longer. In short: More NMN means more NAD+, which can lead to more energy, better skin, and possibly fewer gray hairs. Chapter 4: Can NMN Really Reverse Gray Hair? Here's What People Are Saying Science is still catching up, but early adopters of NMN are sharing intriguing stories. Many report a reduction in gray hairs and increased hair vitality after supplementing with NMN. It’s not yet a proven cure, but it’s promising and definitely worth paying attention to. Real people. Real stories. Real transformations. “My hair was almost all white in my early 60s when I started taking NMN a year ago. After 3 months, it was slightly more blonde. Noticeably more blonde after 6 months - enough for my wife to see it. After a year, my hair color is about the same as when I was in my 50s. Mostly blond with white-blond temples. My hair is also fuller. I didn't take NMN to change my hair color, but it is a daily reminder that the cells throughout my body must be getting healthier, too.” – A 60-year-old NMN user Yes, we know this is anecdotal and we are not saying that the science is settled, but it’s getting there. Chapter 5: The Secret to Glowing Skin Isn’t in a Bottle Skincare is more than creams and serums. It’s a reflection of what’s happening inside your body. Over time, sun exposure, pollutants, and oxidative stress wear down our collagen and elastin, causing skin to sag and wrinkle. That’s where NMN shows its magic again. By boosting NAD+ levels, NMN helps support collagen production internally. This gives your skin a natural, radiant lift from within. It’s not just about looking younger. It’s about aging better. Pro tip: Pair NMN with antioxidants and hydration for maximum glow. Your Journey Begins Here You, my smart and ambitious friend, have the power to make remarkable choices for your body and your future. You’re not just surviving time. You’re mastering it. With science on your side and NMN in your wellness toolkit, you’re one step closer to radiant skin, revitalized hair, and a more youthful you. So stay curious, stay radiant, and remember: The fountain of youth might not be a myth after all. Until next time,Team Gataca- Backed by science. Inspired by you.
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Indian Foods That Contain NMN
In India, many people are looking to enhance their NMN levels through dietary choices in order to lead healthier and longer lives. The remarkable benefits associated with NMN have piqued their interest, including increased energy, improved focus, enhanced fitness levels, weight loss, and the potential for extended life expectancy. However, supplements of NMN in India can be expensive, with prices reaching 1500 INR or more per bottle. As a result, individuals are considering whether incorporating NMN-rich foods into their diets can produce similar effects, providing a more affordable approach. NMN is naturally present in all living things and can be obtained from specific whole foods. NMN, a ribonucleotide and consists of a nicotinamide group, a ribose group, and a phosphate group. It serves as a direct precursor to nicotinamide adenine dinucleotide (NAD+), a vital molecule that plays a crucial role in supporting essential bodily functions such as cellular energy, DNA repair, and metabolic processes. Enzymes in mitochondria and sirtuins rely on NAD+ to maintain the proper functioning of these systems. With age, NAD+ levels decline, causing these systems to slow down and eventually cease functioning. This age-related NAD+ depletion occurs because our bodies struggle to produce enough NAD+ while simultaneously increasing their consumption to repair the wear and tear associated with aging. Boosting NAD+ levels in the body has the potential to slow down the aging process. While clinical evidence suggests that NMN supplements can promote the biosynthesis of NAD+ and combat the effects of aging. Taking supplements of NMN in India does not require a leap of faith due to their substantial benefits and efficacy, however, the costs can be prohibitive. Therefore, individuals are wondering if modifying their diet alone can yield similar results. Thankfully, NMN-rich foods can be found in a variety of fruits and vegetables that are part of the Indian dietFoods such as cabbage, cucumbers, avocados, broccoli, and edamame can give NMN levels a modest boost when incorporated into daily meals. However, it's important to note that the NMN levels in supplements are significantly higher than what can be obtained from a natural diet alone. Relying solely on a diet may not be sufficient to replicate the effects of NMN supplements To bridge the gap caused by age-related NAD+ decline, which often begins by the age of 40 with levels already reduced by half, relying solely on a diet may not be sufficient to replicate the effects of supplements. Consuming the right NMN-rich foods can still have a cumulative impact on NAD+ levels, slowing down the rate of decline and providing some minimal anti-aging effects. Among the NMN-rich foods, a 2016 study reported the following NMN levels: Cucumbers and cabbage: 0.25-1.88mg of NMN per 100g Fruits like avocado and tomato: 0.26 to 1.60mg per 100g Raw beef, meat, and shrimp: Approximately 0.06 to 0.42mg per 100g To clarify, to get a 500mg daily dose of NMN, you would need to eat a minimum of 26Kgs of Cucumber & cabbage 31 Kgs of avocado or tomato 119 Kgs of raw beef, meat, and shrimp Incorporating these foods into the diet can certainly boost NAD+ levels and help combat the effects of aging. However, it's essential to remember that maintaining a healthy diet provides numerous additional benefits that contribute to overall well-being and promote a youthful appearance. For a more significant impact, combining a balanced diet with regular exercise is recommended. This combination not only enhances NAD+ levels but also improves overall health and reduces vulnerability to various health risks that NMN aims to address. When considering NMN supplements, it's crucial to exercise caution. Most supplements contain between 100mg to 300mg of NMN per tablet, providing a significantly higher NMN intake than what can be achieved through diet alone. However, it's important to be aware that not all supplements of NMN in India are of equal quality. Due to the high cost, counterfeit or low-quality products may be present in the market, which could contain additional ingredients that are potentially harmful to health. If opting for the supplement route, it is wise to choose products with a proven track record and demonstrated effectiveness through independent studies. Nevertheless, maintaining a healthy diet with NMN-rich foods, particularly cabbage and cucumber which are commonly found in Indian cuisine, can help replenish NMN levels. For a substantial boost, combining a regular course of NMN supplements with a nutritious diet may be an effective approach, considering Indian sensibilities and preferences.
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NMN Reduces Weight, Cholesterol, and Blood Pressure in Overweight Adults: Harvard Study
Obesity has emerged as a global health crisis, affecting millions of people and increasing the risk of various chronic diseases. In India, the prevalence of obesity has been skyrocketing, with over 135 million individuals now considered obese. This alarming trend has spurred researchers to explore innovative solutions to tackle obesity and its associated health complications. In this quest for effective weight loss options, Human studies have shown that NMN (Nicotinamide Mononucleotide) supplementation has gained attention for its potential in boosting blood NAD+ levels in overweight or obese adults. NAD+ is a vital molecule involved in cellular energy production and plays a crucial role in metabolic processes. While previous studies have shown that NMN can increase NAD+ levels, the actual physiological benefits of this increase have been mixed and inconclusive. Enter Harvard Medical School researchers who sought to delve deeper into the potential benefits of NMN beyond just weight loss. Their groundbreaking study focused on a specific formulation of NMN called MIB-626 and its impact on overweight or obese adults. The findings of this study, published in the Journal of Clinical Endocrinology and Metabolism, shed new light on the potential of NMN as a metabolic stabilizer and cardiovascular health promoter. NMN Supplementation: More Than Just Weight Loss The study led by Bhasin and colleagues administered 1,000 mg of NMN twice daily to middle-aged and older overweight or obese adults for a duration of 28 days. The results were astonishing. Participants who received NMN experienced a significant decrease in body weight, averaging over 6 lbs., compared to those who did not receive NMN. This suggests that NMN supplementation indeed offers metabolic benefits, as reflected in the substantial reduction in body weight. But that's not all! The researchers went a step further to examine the effects of NMN on cardiovascular health. The results were equally promising. NMN supplementation led to a decrease in total cholesterol levels, including the notorious "bad" LDL cholesterol, known for its association with heart-related issues. Furthermore, NMN was found to have a positive impact on blood pressure, specifically reducing diastolic blood pressure, which is a critical factor in hypertension. Extending NMN Supplementation: Fighting Obesity Effectively While the results of this study are promising, it is essential to acknowledge its limitations. The relatively short duration of the study and the small number of participants (21 individuals) who received NMN warrant caution in drawing definitive conclusions. To truly understand the potential of NMN in reversing obesity and metabolic dysfunction, future clinical trials with larger sample sizes and longer durations are necessary. With India facing a growing obesity epidemic and associated cardiovascular risks, NMN supplementation could hold the key to combatting these challenges. Longer-term studies may uncover even more impressive anti-obesity effects of NMN and greater reductions in cholesterol and blood pressure levels. Additionally, exploring NMN's potential to enhance muscle performance when combined with exercise could revolutionize fitness approaches for overweight and obese individuals. India's Battle with Obesity and Cholesterol: A Wake-Up Call The obesity epidemic in India is reaching alarming levels, with approximately one in 16 women and one in 25 men now classified as obese. Obesity is a known risk factor for type 2 diabetes and cardiovascular diseases, making it a significant public health concern. Adding to the worrisome scenario, 6 out of 10 Indians exhibit abnormal levels of bad cholesterol, significantly contributing to heart disease risk. Genetic factors, sedentary lifestyles, and suboptimal dietary habits are some of the culprits behind this prevalent cholesterol problem. The Need for a Holistic Approach The promising findings from the study on NMN supplementation provide hope for those seeking effective weight loss solutions and improved cardiovascular health. However, it is crucial to recognize that NMN is not a magic bullet and a holistic approach to combating obesity and cholesterol issues is essential. Encouraging physical activity, adopting a balanced diet, and promoting lifestyle changes are integral to achieving long-term health goals. NMN supplementation, when combined with a comprehensive wellness plan, could pave the way for transformative results in the fight against obesity and cardiovascular disease. In conclusion, the study conducted by Harvard Medical School researchers highlights the remarkable potential of NMN supplementation in reducing body weight and improving cardiovascular health. While the results are encouraging, there is still much to explore in terms of the optimal dosing regimens and long-term effects of NMN. As India grapples with a growing obesity epidemic and cholesterol-related health risks, innovative solutions like NMN offer hope in shaping a healthier future. By embracing a holistic approach to wellness and furthering research in this area, we can unlock the full potential of NMN and transform the lives of millions.
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