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Can you lengthen your life? You can with these 7 (not-so) secrets
Live Longer and Age Gracefully with These 7 Secrets What do Rekha, Anil Kapoor, Suniel Shetty, and Hema Malini have in common? Well, yes. They’re all Bollywood stars, but also, they’ve aged extremely gracefully. And this is not the case with all-stars and celebrities. So, they must be doing something right. If you’ve ever wondered what their secrets are, then you’re in luck, because in this blog, we’re going to explore how to live longer, healthier, and more fulfilled lives. Challenges to Overall Health and Well-being in India In India, achieving longevity and aging gracefully is not just about extending the number of years lived, but also about enhancing the quality of those years. While the average life expectancy in India is 70.8 years, the healthy life expectancy is significantly lower, indicating that many people spend their later years dealing with health issues. Consider these stats: - Average Life Expectancy: 70.8 years (World Health Statistics 2023). - Healthy Life Expectancy: - Male: 65 years. - Female: 60 years. This gap between life expectancy and healthy life expectancy suggests that while people are living longer, many of those additional years are spent in poor health. Health Challenges 1. Infant Mortality Rate (IMR): Despite improvements, the IMR remains a concern, with 35 deaths per 1,000 births (2019-2021 data). 2. Communicable Diseases: Although decreasing, they still pose significant risks, especially in rural areas. 3. Non-Communicable Diseases (NCDs): The rise of NCDs such as heart disease, stroke, diabetes, chronic respiratory diseases, and cancers is alarming. These conditions are now the leading causes of death in India. Common Causes of Death - Ischemic Heart Disease (Heart Attack) - Chronic Obstructive Pulmonary Disease (COPD) - Stroke - Neonatal Conditions - Trachea, Bronchus, and Lung Cancers Addressing these challenges requires a comprehensive approach that includes preventive healthcare, and making healthy lifestyle choices. 7 Secrets to Combat Accelerated Aging and Unlock Longevity 1. Eat Less Research indicates that reducing daily calorie intake by 500 to 750 calories can significantly slow down the aging process. In the Indian context, this could mean cutting down on portion sizes of traditional meals and being mindful of calorie-dense foods like sweets and fried snacks. 2. Get Moving Exercise is crucial for reducing biological age. Loma Linda University researchers found that three HIIT sessions a week for a month could reduce biological age by over three years. Incorporate traditional Indian exercises like yoga or dance forms like Bharatanatyam to stay active. 3. Manage Stress Stress accelerates aging, but managing emotions effectively can counteract this. Mindfulness practices, meditation, and pranayama (breathing exercises), deeply rooted in Indian culture, can be highly effective in managing stress. 4. Sleep Smart Adequate sleep is essential for healthy aging. Aim for 6 to 8 hours of sleep each night. Traditional bedtime routines, such as drinking herbal teas like chamomile and avoiding screen time, can improve sleep quality. 5. Smoking Kills & You Already Know It! Smoking significantly accelerates aging. In India, where bidi and cigarette smoking are prevalent, quitting these habits can greatly improve your health and longevity. 6. Stay Hydrated Dehydration is linked to faster aging and higher disease risk. Drink plenty of water and consider traditional hydrating drinks like coconut water and buttermilk (chaas) to keep your body and skin healthy. 7. Supplement Smartly Research shows that Omega 3, Mg & NMN (Nicotinamide Mononucleotide) can help slow down aging. Consult with a healthcare provider to see if this supplement fits your dietary needs and lifestyle. Connecting the Dots for a Healthier You Adopting these habits can work wonders for your longevity and overall well-being. They’re interconnected exercising reduces stress, a balanced diet improves sleep, and staying hydrated boosts your energy. It’s about creating a positive feedback loop for your health. Remember, living well is about making smart, sustainable choices. Cheers to a healthier, younger you!
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How is NMN manufactured? Read this before you start taking NMN
I think we have you figured out. You are the kid that took apart your dad’s Walkman or your mom’s microwave to figure out how each of those worked. Putting it back together was another story. It was not that important, right? If you were brilliant enough to put them back together, you are at the right place, researching the right molecule to not only enhance your overall cognition but also reclaim your child-like energy. I am not going to get into the benefits of NMN, because that’s not what you’re here to read. You can find that here: The Benefits of NMN There are 3 methods that are used to manufacture NMN. 1. Chemical synthesis – Expensive & Not environmentally friendly 2. Enzymatic production – Expensive & Slow 3. Fermentation – Not as easy as beer Let’s get into it Fermentation: As I said, it’s not easy as throwing in a few ingredients and letting it sit. It’s not as easy as making beer. Not that making beer is easy, but I’m sure it’s easier than fermenting this panacea into existence. If you don’t know what fermentation is, look it up. The gist – it involves the breaking up of organic matter by bacteria or yeast or other microorganisms. One of the ways of producing NMN is by yeast fermentation. NMN produced using this method is of high quality. However, the raw ingredients needed for this process end up costing much more than the yield of the NMN. NMN is found in small quantities in several avocados, broccoli, cabbage, edamame, cucumbers, etc. However, the quantity of NMN found in these is very low and requires a large amount of raw material to produce usable amounts of NMN. Additionally, the product stability is quite low. Enzymatic process: Enzymes are proteins that act as catalysts in all living beings. They speed up processes that are essential for digestion, liver function, and a multitude of other pathways/reactions in your body. Enzymes require certain conditions to function optimally. Alternations in these conditions result in the failure of the pathway/reaction and the process will have to be restarted again. NMN is produced from NAM (nicotinamide) with the help of the NAMPT (nicotinamide phosphoribosyltransferase) enzyme, where NMN attaches a phosphate called PRPP (5’-phosphoribosyl-1-pyrophosphate). NMN with high purity can be obtained through this process along with a high yield. The final product has a small molecular structure, low density, poor fluidity, and can be absorbed quite easily. One more thing, the purity of the final product and the yield is directly proportional to the purity of the enzyme that is used. Chemical process: This process, in addition to the enzymatic process, produces NMN with the highest purity. Like all other chemical reactions, each of the steps is controlled to ensure a high yield. NMN is produced through Zincke’s reaction. N-(2,4- dinitrophenyl)-3-carbamoylpyridinium chloride (compound A) and 2′,3′- O-isopropylidene-α/β-D-ribofuranosylamine (compound B) are the main two compound that takes place in the reaction The raw ingredients used in this process are not entirely safe for the environment. This limits the reliance on chemical processes to produce high-yield and high-purity NMN. What does each company use to produce NMN · Uthever – Enzymatic process · Wonderfeel: Enzymatic process. · Donotage: Enzymatic process · Decode age* – Enzymatic process · Fitness Veda – Unknown · Zaaz NMN – Fermentation with yeast
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Transforming Gut Health: New Study Shows NMN Fosters Beneficial Bacteria Growth
Unlocking the Gut's Potential: How NMN Shapes Beneficial Bacteria Growth and Nurtures Gut Health Understanding the Microbial World Within Us Our gastrointestinal tract, often referred to as the "gut," houses a diverse community of bacteria that play a crucial role in our overall health. These microorganisms impact everything from our immune system to blood glucose levels. Recent research from the Jiangsu Academy of Agricultural Sciences in China sheds light on how Nicotinamide Mononucleotide (NMN) influences the growth of gut bacteria, particularly its role in promoting beneficial species. NMN's Impact on Gut Bacteria Diversity The study conducted by Tang and colleagues involved testing stool samples from nine healthy volunteers, aiming to mimic the conditions of human intestines. The addition of 500 mg of NMN to the simulated intestines led to a reduction in species diversity after 24 hours of fermentation. The results suggest that NMN inhibits the growth of certain gut bacteria during this period. NMN and Bacteroides: A Symbiotic Relationship Tang and colleagues' findings reveal a fascinating aspect of NMN's impact on gut bacteria. After 24 hours, NMN was observed to increase the growth of beneficial bacteria, particularly Bacteroides. This genus, along with others, contributes to the production of a beneficial fat called propionate, a key metabolite that supports normal gut function. The Science Behind NMN's Influence on Gut Bacteria Diving deeper into the specifics, the researchers identified changes in different genera of bacteria. NMN was found to elevate the levels of Bacteroides and other genera associated with propionate production, while harmful bacteria were reduced. These observations suggest that NMN selectively promotes the growth of beneficial gut bacteria, creating a more favorable microbial environment. NMN and Short-Chain Fatty Acids (SCFAs): Nourishing the Gut When our gut bacteria ferment undigested carbohydrates, they produce short-chain fatty acids (SCFAs), crucial for maintaining normal gut function. Tang and colleagues discovered that NMN treatment increased the concentration of SCFAs, particularly propionate, in the artificially digested human stool. This implies that NMN has the potential to enhance the production of beneficial SCFAs, contributing to overall gut health. The Indian Perspective: Foods that Support Gut Health In India, where diverse culinary traditions prevail, several foods have long been recognized for their positive impact on gut health: Buttermilk (Chhaach): Available in various flavors, this traditional Indian drink aids in maintaining the body's fluid and salt levels, contributing to a well-balanced gut environment. Idli: A staple in South Indian cuisine, idli is a fermented food rich in plant-based protein, fiber, and micronutrients. Its consumption aligns with the principles of fostering a healthy gut. Curd: A probiotic-rich food widely consumed in Indian households, curd regulates bowel movements and provides a defense mechanism against infections, promoting a resilient gut. Ginger: A common spice in Indian cooking, ginger possesses natural laxative properties that aid in relieving constipation, supporting digestive health. Kefir: Although not traditionally Indian, incorporating probiotic-rich kefir into the diet can positively impact digestion, preventing bloating and flatulence. Turmeric: Widely used in Indian spices, turmeric's antioxidant and anti-inflammatory properties contribute to improved digestion, reducing gut spasms and flatulence. Timing Matters: Addressing the Duration of NMN Exposure While the study provides valuable insights into NMN's impact on gut bacteria, there are considerations regarding the duration of exposure. Human digestion typically takes 6 to 8 hours, and the study exposed the bacteria to NMN for a full 24 hours. This raises questions about the likelihood of such extended exposure in real-life scenarios. Additionally, NMN remained almost entirely intact after 6 hours in the simulated intestines, suggesting rapid absorption. Implications for NMN Supplementation in Humans Despite the timing discrepancy, the study suggests that some effects observed in the artificial setting may translate to humans upon oral NMN supplementation. However, the effects are likely to be less pronounced. Future studies focusing on gut bacteria in individuals, especially across different age groups, after NMN supplementation could provide valuable insights into the real-world impact of this promising compound. Nurturing Gut Health with NMN and Traditional Foods In conclusion, NMN emerges as a potential player in shaping a healthier gut environment. By selectively promoting the growth of beneficial bacteria and elevating the levels of propionate, NMN holds promise for enhancing gut health. As science continues to unravel the mysteries of our microbial companions, NMN stands as a noteworthy candidate in the quest for optimal gut health, complemented by the longstanding wisdom of traditional Indian foods that have supported digestive wellness for generations.
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How Old Are You, Really? What Is Biological Age?
Dr. Kara Fitzgerald, an expert in epigenetics and aging, describes biological age as the pace at which our bodies age physically. It's distinct from our chronological age, which is simply the number of years we've spent on this planet. Unlike chronological age, biological age is not set in stone—it's a dynamic measure influenced by various factors. Determining Your Biological Age To get a precise measurement of your biological age, you need to look beyond conventional methods like online quizzes and calculators. The most accurate way to assess it is by studying your epigenetic data. Epigenetics explores how your behaviors and environment impact your genes. This involves analyzing DNA collected from samples such as saliva, blood, or other tissues. One of the pioneers in this field is Steve Horvath, a researcher at the University of California, Los Angeles, who developed the first reliable epigenetic clock in 2013. Horvath's research demonstrated that multiple tissue types can be used to calculate a person's biological age. In recent years, several at-home epigenetic tests have entered the market, with prices ranging from $75 to $500. Among them, myDNAge stands out as the only test based on Horvath's epigenetic age clock. These tests typically provide insights into your metabolic health, genetics, and other risk factors related to age-related diseases, making them a valuable starting point for those interested in their biological age. Influences on Biological Age Once you've determined your biological age, it's essential to understand the factors that can accelerate or decelerate the aging process. Emerging research suggests that aging can be influenced and, in some cases, even reversed. Several studies have shown varying degrees of success in reversing aging. For instance, a 2019 study demonstrated a biological age reversal of up to three years in humans. Another study focused on obese African Americans with vitamin D deficiency, revealing a reversal of 1.85 years in just 16 weeks through a supplement regimen. Dr. Fitzgerald emphasizes that our genes are not our destiny. While certain genetic conditions may be powerful, most of the influence on our genes comes from our lifestyle choices. Factors like diet, sleep, stress management, physical activity, relationships, and community engagement all play pivotal roles in shaping our genetic expression. Reversing Your Biological Age Dr. Fitzgerald's research team conducted an eight-week clinical trial to investigate the impact of diet and lifestyle interventions on biological age reversal. The results were astonishing—a 3.23-year reduction in biological age was associated with the treatment. Here's a breakdown of the regimen participants followed: 1. A Tailored Diet: This diet included a wide variety of colorful and cruciferous vegetables, low glycemic fruits, and select animal proteins like eggs and liver. These foods are rich in essential nutrients and polyphenols, such as cumin, turmeric, green tea, and mushrooms, known for their beneficial effects. 2. Hydration: Staying adequately hydrated is crucial for maintaining overall health. 3. Regular Exercise: Participants engaged in a minimum of 30 minutes of exercise per day, five days a week, at a moderate to high level of intensity. 4. Stress Management: The regimen incorporated meditation, breathing exercises, and other relaxation practices to manage stress effectively. 5. Adequate Sleep: Participants aimed for at least seven hours of sleep per night, emphasizing the importance of quality rest. 6. Supplements: The intervention included extra polyphenols and a simple probiotic to support DNA methylation and positive epigenetic changes. Dr. Fitzgerald underlines that initiating these lifestyle changes in your 30s is ideal since the aging process becomes more prominent in your 40s. Aging is a significant risk factor for both chronic and acute diseases, and by taking proactive steps to slow or reverse biological age, the possibilities for improving human health are extraordinary. Epigenetic Insights in India In India, individuals keen on exploring the realm of anti-aging and uncovering the secrets of their biological age can access a range of innovative products. AIWO's TruAge COMPLETE This test offers a comprehensive kit for those seeking a detailed assessment of their aging metrics and specific age-related biomarkers. This at-home test is convenient for users in India, with AIWO facilitating the delivery of samples to the processing lab in America. Meanwhile, DecodeAge Decodeage takes a revolutionary approach by harnessing the power of epigenetic science to deliver a DNA analysis that goes beyond conventional testing. This unique perspective on health and aging sets it apart in the market. Additionally, for those looking to optimize their health, the tools that have been trusted by Olympic gold medalists and emerging sports stars are now readily available through Decode BioAge. These products offer individuals in India valuable insights into their biological age and health, aligning with the growing interest in proactively managing the aging process and overall well-being. In conclusion, the quest to unlock the secrets of biological age is no longer confined to science fiction. With epigenetic tests becoming more accessible, and promising research on reversing aging, individuals in India and around the world have the opportunity to take control of their health and potentially turn back the clock on their biological age. By making mindful choices in lifestyle and embracing innovative approaches, we may indeed discover the fountain of youth within ourselves.
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Who is supplementing with NMN in India and Should You?
Unlocking the Potential of NMN: A New Age of Wellness in India In recent years, the world has witnessed a significant shift in the approach to health and wellness. India, too, has not remained untouched by this transformation. With the onset of the COVID-19 pandemic, the fitness industry in India underwent a complete makeover. As gyms closed and businesses digitized, a tech-driven fitness revolution emerged. Among the many innovations that gained traction, one intriguing compound began to draw attention: Nicotinamide Mononucleotide, or NMN. NMN is a precursor to NAD+, a molecule vital for various biological processes, and it has been linked to potential health benefits related to aging and cellular function. In this article, we delve into the new trend of NMN in India and explore how it may become a game-changer for health-conscious individuals. Seeking NAD+ Restoration: The Quest for Health and Longevity In the vibrant landscape of health and wellness in India, the relentless pursuit of health and longevity has taken a prominent role. With the age-related decline in Nicotinamide Adenine Dinucleotide (NAD+) levels becoming a growing concern, individuals across India are on a quest to restore and rejuvenate this essential molecule. NAD+, a linchpin in cellular processes, encompasses functions like energy production and DNA repair, but as the years progress, its levels diminish, potentially leading to organ dysfunction and metabolic issues. Amidst this quest, Nicotinamide Mononucleotide (NMN) emerges as a compelling solution. The Role of NMN in Age Prevention For those aged 35 and above, the quest for health and longevity often revolves around seeking ways to restore NAD+ levels. NAD+ (Nicotinamide Adenine Dinucleotide) plays a pivotal role in processes such as energy production and DNA repair. Unfortunately, as we age, NAD+ levels decline, leading to faltering organ function and metabolic problems. NMN has emerged as a potential solution to this problem, as it can boost NAD+ levels, offering hope for age prevention and overall health. The Pandemic-Driven Fitness Revolution The COVID-19 pandemic accelerated the adoption of technology in the fitness industry worldwide, and India was no exception. People started exploring new supplements, fitness apps, virtual workouts, and wellness counseling from the comfort of their homes. In this digital age of health and anti-aging, NMN has captured the attention of both fitness enthusiasts and those seeking age-related interventions. Understanding the NMN Enthusiasts in India Health, Fitness, Aging, Research, and Wellness Enthusiasts A significant portion of NMN enthusiasts in India falls under the category of health enthusiasts aged 35 and older. These proactive individuals are deeply invested in their well-being and often incorporate NMN into their wellness regimens. By increasing blood NAD+ levels, NMN helps them combat the effects of aging and maintain organ function. Age-Related Concerns People over 65 who are concerned about the challenges of aging form another group of potential NMN users. These individuals turn to NMN in the hope of staving off age-related frailty and organ decline. NMN's ability to restore NAD+ levels offers a promising strategy for maintaining health and vitality in their later years. Aging Fitness Buffs Aging fitness enthusiasts, who are keen on improving their endurance, muscle function, and recovery, are also showing interest in NMN. This supplement has found its way into the regimens of those who aim to enhance their physical fitness as they age. Avid Followers of Aging Research Trends The influence of prominent aging researchers like Harvard Professor David Sinclair has not gone unnoticed. NMN has garnered attention for its potential to extend health span—the number of years lived without disease. Those who closely follow such research trends are drawn to NMN as a means to counteract aging by increasing their blood NAD+ levels. Healthcare Practitioners and Wellness Professionals Healthcare practitioners and wellness professionals in India are increasingly recommending NMN to their clients and patients based on specific health goals. For instance, research suggests that NMN can improve insulin sensitivity in overweight adults with prediabetes, making it a valuable tool for those looking to improve their metabolic function and overall health. Potential Benefits Beyond Aging While the evidence is primarily anecdotal, there are studies suggesting that increasing NAD+ levels with NMN may alleviate cravings associated with addiction, as well as anxiety and depression. This opens up the possibility that individuals struggling with addiction or mood-related complications could also benefit from NMN, regardless of age or weight. However, further research is needed to confirm these potential benefits. Celebrities Embrace NMN In the world of celebrities, the use of NAD+ and NMN has gained prominence. Celebrities like Hailey Bieber, Kendall Jenner, Joe Rogan, and Andrew Huberman have openly discussed their use of NAD+ and NMN. Their endorsements have added to the growing interest in NMN as a means to combat aging and promote overall health. The rise of NMN in India in the health and wellness landscape signals a new era of proactive health maintenance. While NMN's potential as an anti-aging remedy is promising, it's important to remember that more research is needed to establish its long-term safety and efficacy. Nevertheless, the diverse group of NMN enthusiasts in India, spanning from health enthusiasts to aging fitness buffs and avid research followers, demonstrates the widespread curiosity and hope surrounding this intriguing compound. As the quest for health and longevity continues, NMN may play a significant role in shaping the future of wellness in India.
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The Anti-Aging Supplements Dr. David Sinclair Takes Besides NMN
Unlocking the Secrets of Dr. David Sinclair's Anti-Aging Regimen In the quest to extend the human lifespan, Harvard scientist Dr. David Sinclair stands as a prominent figure. He believes that we might already have individuals capable of living up to 150 years, thanks to the recent advances in anti-aging research. In a bid to slow down his own aging process, Dr. Sinclair has meticulously curated a daily supplement and drug regimen. He graciously shares this regimen, though without endorsing specific brands or offering personal advice. In this article, we will delve into Dr. Sinclair's regimen, exploring each component's potential anti-aging properties and the scientific evidence supporting their use. Resveratrol: Sipping from the Fountain of Youth Resveratrol, a polyphenol found in grapes, makes its appearance in Dr. Sinclair's daily regimen at a dosage of 1 gram. This compound activates sirtuin enzymes linked to longevity. Human studies have shown that resveratrol-enriched wine can reverse aging processes, hinting at its potential benefits for humans. In animal experiments, resveratrol has proven to delay heart and muscle aging, promote kidney health, and improve memory. https://gataca.in/products/trans-resveratrol Metformin: A Diabetes Drug Turned Anti-Aging Agent In the evening, Dr. Sinclair ingests 800 mg of Metformin, a drug primarily used to treat type 2 diabetes. Beyond its role in managing blood glucose, Metformin exhibits anti-aging properties. Animal studies have highlighted its ability to boost immune function, protect against organ deterioration, and even reverse intestinal aging. When combined with leucine, it prevents muscle atrophy, further emphasizing its potential in slowing down the aging process. Spermidine: Unveiling the Secrets of Wheat Germ Dr. Sinclair includes 1 mg of spermidine in his daily routine, a natural compound found in wheat germ and various foods. Spermidine induces autophagy, the body's cellular waste disposal system. In animals, spermidine has demonstrated benefits such as improved cardiovascular health, enhanced cancer immunity, reduced brain inflammation, and slowed liver aging. Amazon: https://tinyurl.com/bdfw2b4t Quercetin: The Senescence Fighter At 500 mg daily, quercetin takes a prominent spot in Dr. Sinclair's regimen. This polyphenol possesses senolytic properties, capable of removing senescent cells associated with aging. Studies often combine quercetin with dasatinib, a leukemia drug, for enhanced effects. Animal experiments have indicated potential benefits in muscle and bone regeneration, Alzheimer's treatment, heart function improvement, and blood sugar level reduction. Amazon: https://tinyurl.com/mr3be2tp Fisetin: The Lesser-Known Senolytic Fisetin, another polyphenol, makes its presence known with a daily dose of 500 mg. Like quercetin, fisetin has senolytic properties and can alleviate cognitive dysfunction, reduce depression-like behavior, and enhance kidney health. It also boosts muscle size and strength while extending lifespan in animal studies. Amazon: https://tinyurl.com/4mewc4p5 Vitamins D3 and K2: Building Stronger Bones and a Cancer Defense Dr. Sinclair adheres to recommended daily doses of 4,000 to 5,000 IUs of vitamin D3 and 180 to 360 mcg of vitamin K2. The combination of vitamin D3, omega-3s, and exercise has shown a 60% lower risk of cancer in older adults. Vitamin D3 activation of sirtuins is believed to slow colorectal cancer growth, and it also helps in arthritis management. Furthermore, vitamin D3 and K2 collaborate to enhance bone strength. Amazon: https://tinyurl.com/4sybkcej Low-Dose Aspirin: Balancing Cardiovascular Health Dr. Sinclair takes a daily dose of 83 mg of aspirin, a controversial choice for some. While the evidence on its cardiovascular benefits is mixed, Sinclair continues due to a perceived reduction in cancer risk. It's essential to note that aspirin's effectiveness in aging-related contexts remains a topic of ongoing research. Trimethylglycine (TMG): Safeguarding Methyl Groups To counteract the potential depletion of methyl groups caused by high nicotinamide levels, Dr. Sinclair includes 500 to 1,000 mg of TMG daily. Although he acknowledges uncertainty about its necessity, TMG provides a precautionary measure to replenish methyl groups, crucial for various bodily functions, including antioxidants. https://gataca.in/products/tmg-trimethylglycine Rapamycin: The Controversial Longevity Compound While Dr. Sinclair occasionally takes rapamycin, he hasn't disclosed the exact dosage. Rapamycin's effects are notable but come with caveats. It can extend the lifespan of animals significantly, reverse hair graying, prevent muscle weakness, and enhance immunity against the flu. However, taken too early in life, it may stunt growth and development. In closing, Dr. Sinclair's anti-aging regimen comprises a diverse array of compounds, each with unique potential benefits backed by scientific evidence. However, it's important to remember that most of these compounds have not undergone extensive testing in humans for their anti-aging effects. Dr. Sinclair's regimen serves as an intriguing experiment, a testament to the ongoing pursuit of longevity. While we await more robust human studies, it's wise to consult with a healthcare professional before embarking on a similar journey to unlock the secrets of a longer, healthier life. Nicotinamide Mononucleotide (NMN): The Elixir of Youth Dr. Sinclair starts his day with 1 gram of Nicotinamide Mononucleotide (NMN). NMN acts as a precursor to nicotinamide adenine dinucleotide (NAD+), a molecule vital for cellular energy production. Declining NAD+ levels are associated with aging, and NMN aims to counter this decline. Extensive clinical trials suggest NMN's potential to enhance physical performance, sleep quality, insulin sensitivity, and even skin aging. Furthermore, it exhibits positive effects on cardiovascular and neurological health, showcasing promise as a potent anti-aging compound. https://gataca.in/products/nmn-500-india-s-purest-nmn-anti-aging-supplement-for-enhanced-cellular-energy-dna-repair
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Best NMN Supplements In India: A Review Of The Top 7 - Aug 2023
Smarty pants! Good job on discovering the panacea that can help you live a long, long time. You must already know all the benefits of NMN and you are about to quickly scroll down to glance at the top 5 list before you make a decision. Do that! Cause I am going to write a little about NMN and its benefits etc, such that Google Baba will show my article on page 1. Go on, scroll down to the information you are here to read. Benefits of NMN: Are you still reading this? This will be a brief version of the benefits of NMN, you can click through our more detailed article for a breakdown on how NMN works and why you should start taking it. NMN was discovered in 1963 by Chambon, Weill, and Mandel who reported that it provided cellular energy for an important nuclear enzyme called PARP. PARP is implicated in several cellular processes such as DNA repair, programmed cell death, genomic stability, lifespan, and much more. NMN does this by increasing the NAD+ levels. NAD+ energizes PARP. PARP protects the genome. YOU LIVE LONGER! David Sinclair and his team, in 2014, demonstrated that NMN can extend the lifespan of mice. Since this discovery, NMN has been implicated to benefit a wide range of conditions. From increasing insulin sensitivity in diabetics to anecdotal demonstrations of improvement in fertility, NMN is truly a panacea. NMN can Improve brain function Restore blood vessel health Improve muscle function Promote heart health Protect against obesity Protect against diabetes Improve vision Improve organ health Improve fertility & much more What to look for when buying NMN The color should be light grey or white Should taste like burnt popcorn Ideally Manufactured under GMP (Good Manufacturing Processes) Reputable brand names The Top 7 Brands of NMN in India GATACA Of course we are going to put ours first. But hear us out! You will definitely prefer our product once you’ve read this and tried us out.A majority of the brands in India are using Uthever. Specifically for our NMN, we went another route. We’ve comprehensively tested suppliers and our manufacturer came out on top. We were surprised too! Our supplier is among the first to figure out the process of manufacturing NMN on a large scale and claims to supply to David Sinclair’s lab too! All of these put together made us pick this manufacturer. How they make it: Enzymatic Process Contains: NMN only Available Doses: 500 mg, 1000 mg Form: Capsules Claimed Purity: 99.9% GMP: Yes Manufacturer: Secret :) Website price: ₹1599 | ₹2999 Shipping: Free link: https://tinyurl.com/m4e3emh5 Decode Age Decode Age not only uses the same vendor as the market leader Do Not Age but has also established itself as the most reputable brand in India in a short period of time. While they offer NMN in India as a single ingredient, their marketing focus is primarily on their formulations Longevit, Sinevit, etc. which are severely underdosed with NMN. This is not a comment on the effectiveness of their formulations, merely an observation about the dosing of NMN in these formulations. The manufacturer of Decode Age, Uthever, uses the Enzymatic process to manufacture NMN. NMN as a single ingredient is offered in three doses on Decode Age. How they make it: Enzymatic Process Contains: NMN only Available Doses: 250 mg, 500 mg, 1000 mg Form: Capsules Claimed Purity: 99% GMP: Yes Manufacturer: Uthever Website price: ₹990 | ₹1800 | ₹3400 (subscribe to save) Amazon Price: ₹921 | ₹1674 | ₹3248 Shipping: Free Amazon link: https://tinyurl.com/2mt3uy2f Fitness Veda: The only company we found that makes NMN in India. If the “Make in India” tag is important to you, we highly recommend you buy your NMN for Fitness Veda. However, if you are looking for the best NMN in India, we are unable to comment on this as their manufacturing process is not listed on public sources of information. We have reached out to them to understand their manufacturing process but have not received any comment. How they make it: Unknown Contains: NMN Pro+ Available Doses: 300 mg | 600mg | 1000 mg Form: Capsules Claimed Purity: 99% GMP: Yes Manufacturer: Made In India Website price: ₹2475 | ₹3499 | ₹3999 Amazon Price: ₹2999 | ₹3999 | ₹4400 Shipping: Free Amazon link: https://tinyurl.com/3hfv4y2m Leap Life One of the newer entrants into the sales of NMN in India, Leap life has its pricing on point. One month's supply of NMN comes at a sticker price of ₹1699. Information about their manufacturing process and their supplier is sparse. They claim to be vegan if that’s important for you. How they make it: Unknown Contains: NMN Available Doses: 500 mg Form: Capsules Claimed Purity: Unknown GMP: Yes Manufacturer: Unknown Website price: ₹1699 Amazon Price: ₹1699 Shipping: Free Amazon link: https://tinyurl.com/2twvcxxv Nutrija NMN Another new entrant into the NMN supplements space in India, Nutrija NMN claims a purity of 99.8%. We honestly have not come across any manufacturer who claims this level of purity. Nutirja must have figured out a great supplier or a process. They claim to have their ingredients imported from the US while the origin of the NMN is India. How they make it: Special Unknown Process Contains: NMN Available Doses: 500 mg Form: Slow Release Capsules Claimed Purity: 99.8% GMP: Yes Manufacturer: Self Website price: ₹1250 Amazon Price: ₹2698 Shipping: Free Amazon link: https://tinyurl.com/5as4tnp2 ProHealth This is not an Indian company. Their NMN, seemingly, is distributed by the same company that launched Centrum in India. Prohealth offers NM in two forms, as capsules, and as lozenges. It is the only option for lozenges. The Price for both forms is too high. If you are looking for a cost-effective solution, this is not an option. However, if you are looking for lozenges, this is your only option as of now. By the way, they use the same manufacturer as Decode Age and Do Not Age. How they make it: Enzymatic Process Contains: NMN Only Available Doses: 250 mg | 300 mg | 500 mg | 1000 mg Form: Powder, Capsules & Lozenges Claimed Purity: 99% GMP: Yes Manufacturer: Uthever Website price: $29 - $115 (price varies on form) Amazon Price: ₹5000 (price varies on form) Shipping: Free from Amazon Amazon link: https://tinyurl.com/bwuhup6u Livest: Really! ₹999 for 100mg. This is the most expensive product/gram. We are guessing this product was either launched in a hurry to catch the NMN wave or was released before the NMN wave caught up in India. Livest does claim that their NMN has high bioavailability, however, they do not explain how they have achieved this. How they make it: Unknown Contains: NMN only Available Doses: 100 mg Form: Powder, Capsules Claimed Purity: Unknown GMP: Unknown Manufacturer: RGS Formulations Website price: ₹999 Amazon Price: ₹999 Shipping: Free Amazon link: https://tinyurl.com/4uaatu9z StemRx Biosciences This is a formulation of NMN and NAD. The only company that has NAD available in any form. NAD is not necessarily a better alternative to its precursors. The dosing is surprisingly lower than necessary. How they make it: Unknown Contains: NMN & NAD Available Doses: 150 mg Form: Powder, Capsules Claimed Purity: Unknown GMP: Yes Manufacturer: Vitagenics Lifesciences Website price: ₹3499 Amazon Price: ₹3299 Shipping: Free Amazon link: https://tinyurl.com/3rhfran9
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Longevity Revolution 2.0: Pursuing Health Spans, Not Just Longer Lifespans
“A rapidly aging population” is rarely viewed as a positive statement. But, it is the reality in many countries. Humans are living longer because of advances in the field of medicine. While this is good news, an unfortunate reality that grapples most countries is that the quality of life starts diminishing after the age of 60. Andrew Scott's new book The Longevity Imperative makes a compelling case that humanity must embrace an "evergreen agenda" to transform from simply aging societies into true longevity societies. So, are we on the cusp of the second longevity revolution? India's Graying Population India as a country is going to undergo a massive demographic shift! While we are currently a young Nation, our elderly population will soar in the next 20 years. According to the United Nations Population Fund India, the share of Indians over 60 years old is projected to nearly double from 10.5% in 2022 to 20.8% by 2050. This dramatic graying of the population is viewed as a looming socioeconomic burden. However, this aging trend represents a remarkable achievement - Indians are living much longer than previous generations. Data from the World Bank shows India's life expectancy at birth reached 70.8 years as of 2019. More Indians than ever can expect to live into advanced ages that were once extremely rare. Andrew Scott and The "Evergreen Society" Imperative In his book, economist Andrew Scott argues that this longevity revolution offers a huge opportunity - if and when coupled with radical societal reforms. He strongly advocates for the creation of "evergreen societies" designed from the ground up to support healthier, more productive, engaged lifespans. Rather than just extending lifespan, Scott says a profound second longevity revolution is needed - one that improves the quality and purpose of those extra years of life. This may require us to rethink state pensions, education, workplace policies, healthcare, finance, and culture as we know it. Historically, living to 90 was very rare so we didn't create systems for that. But now it can be common, so major shifts are needed. This includes a focus on preventative health over just treating disease, and governments investing in anti-aging treatments available to everyone. There are signs of progress in adjusting to longevity, but much more change is required. Governments are only now starting to see the economic importance of supporting healthy aging populations. For individuals, the author advises recognizing you'll likely live much longer than previous generations. So think about how to live differently to stay healthy, engaged, and financially secure into old age. A Challenge and Opportunity for India For India, transitioning to an evergreen, longevity society mindset represents a tremendous challenge given the lack of existing infrastructure and social norms to support healthy longevity. But it's also imperative to avoid being crushed under the weight of an unproductive, impoverished aging population. By making the radical changes needed to help Indians thrive across longer lifespans, the nation can turn a potential crisis into an opportunity for prolonged health, engagement, and prosperity. The longevity revolution has arrived - India must decide whether to embrace it or be overwhelmed by it. How do you think India will be able to face these challenges? And what changes will you make in your personal life to live more healthier lives in your later years? Let us know!
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Are we heading toward immortality?
Here's everything you need to know about Gene Therapy on mice! From demons in the Great Indian epics like Bhagavatam to contemporary scientists, immortality is a concept that has fascinated humans for centuries. But, nobody really cracked the code to it. Until NOW. What if I told you that we are getting close, I mean really close to well… not being immortal… But, at least extending lifespans significantly? A recent study conducted by researchers at Rejuvenate Bio, a San Diego-based biotech company, has revealed the potential of gene therapy to extend lifespan and reverse aging in mice. Pretty cool, huh? But, before we explore further, it is important to understand the complex and diverse nature of the Indian population and what therapies like this could mean for us in the long run. Challenges in Indian Healthcare India, a country with diverse cultures and traditions, also faces significant challenges when it comes to healthcare and longevity. While Indians have an average life expectancy of about 70.4 years, there are stark differences between states, with Kerala boasting the highest life expectancy at 73.9 years and Telangana at 62.4 years. (data may vary based on sources) These disparities shed light on the complex interplay of several socioeconomic factors, access to quality healthcare, and lifestyle choices that exist in our country. Chronic diseases like heart disease, stroke, diabetes, and chronic obstructive pulmonary disease (COPD) are major causes of death in India, accounting for over 50% of all deaths. Tobacco use, unhealthy diet habits, bad lifestyle choices, and physical inactivity are major contributors to the rising numbers of non-communicable diseases. Additionally, infectious diseases like TB, malaria, and dengue fever continue to claim lives, particularly among children and the elderly. Concurrently, malnutrition remains a pressing issue in the country, with undernutrition and micronutrient deficiencies affecting children and pregnant women. Stunted growth, weakened immune systems, and increased vulnerability to disease are among the consequences of malnutrition, highlighting the need for comprehensive interventions to address nutritional challenges. The Breakthrough Study Amidst these healthcare challenges, a recent scientific breakthrough offers significant hope. A study conducted by researchers at Rejuvenate Bio, a San Diego-based biotech company, has revealed the potential of gene therapy to extend lifespan and reverse aging in mice. This groundbreaking research demonstrated that a gene therapy technique called partial cellular reprogramming could dramatically prolong the remaining lifespan of aged mice by 109%, equivalent to about 18.9 years in humans. Moreover, the therapy alleviated age-related frailty and reversed aging in vital organs like the liver and heart. The Study in Detail The study, published in Cellular Reprogramming, highlights the mechanism behind partial cellular reprogramming. This technique involves the transient delivery of genetic material to make cells younger, producing proteins called Yamanaka factors. Unlike full cellular reprogramming, partial reprogramming rejuvenates cells without turning them into stem cells, preserving their niche function within organs. For the experiment, researchers used normal, 124-week-old mice, equivalent to about 77 years old in humans. Injecting aged mice with non-infectious viruses containing the OSK genes and inducing OSK activation extended their lifespan by 109%. Furthermore, gene therapy-treated mice exhibited reduced frailty and reversed aging in the liver and heart, as assessed by DNA molecular tagging patterns. Implications for India The implications of this study for the future of longevity research in India are profound. Could such breakthroughs offer a pathway to addressing healthcare disparities and improving health outcomes for millions in the country? As researchers explore the possibilities of gene therapy, pharmaceutical interventions, and holistic approaches to healthcare, the pursuit of immortality takes on a whole new meaning. This could not only mean personal longevity but also catapult the journey toward a healthier, more equitable society. Conclusion While immortality may remain elusive, the findings from Rejuvenate Bio's study offer a glimpse into the future of longevity research. The ability to extend lifespan and reverse aging in vital organs through gene therapy is a breakthrough that could transform the healthcare industry as we know it. As this technology continues to evolve, one can't help but wonder how it may impact India's diverse population. Could gene therapy provide a means to address the disparities in life expectancy across different states? Might it offer a solution to combat the rising burden of chronic diseases and the lasting effects of malnutrition? Moreover, the potential of such interventions to prolong healthspan, not just lifespan, is equally intriguing. Can you imagine a future where aging-related tiredness, frailty, and organ deterioration are no longer inevitable, and where individuals can maintain their quality of life well into their later years? We’re excited to see how this study will impact the future of healthcare! Are you? Let us know!
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