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NMN: A Ray of Hope the Battle Against Physical Decline and Poor Sleep in Elderly
New Clinical Trial Sheds Light on the Potential of NMN to Keep Our Elders Sprightly and Well-Rested The wise Bachchan ji said in the movie "Piku," "Motion se hi emotion." (well, he was talking about another kind of motion). But, indeed, movement is emotion, and for our elderly, maintaining that motion is crucial for a happy life. More Than Just a Walk in the Park In India, where respect for elders is deeply ingrained in our culture, we often overlook the subtle signs of aging. One such sign is the slowing of our elders' gait. However, science offers us a chance to slow down this process. The Indian Scenario A study published in the esteemed Indian Journal of Medical Research has shed light on a concerning trend among our elders. The research reveals a significant decline in walking speed as age increases, a phenomenon observed across both rural and urban landscapes of our diverse nation. The gradual reduction in walking speed serves as a crucial barometer of overall health in our aging population. It's not just a number on a calendar; it's a reflection of how gracefully—or challengingly—we're navigating the golden years. Indeed, this seemingly simple measure of steps and seconds tells a profound story. It speaks volumes about muscle strength, joint health, cardiovascular fitness, and even cognitive function. When our elders slow down, it's not just their feet that are affected—it's their independence, their ability to engage with the world, and ultimately, the richness of their daily experiences. By understanding and addressing this decline in walking speed, we're not just helping our elders move faster—we're paving the way for them to lead fuller, more active, and more satisfying lives well into their twilight years. It's about ensuring that the wisdom and experience they carry can continue to enrich our families and communities for years to come. Sleep: The Unsung Hero of Health Alarming research published in BMC Public Health has pulled back the curtain on a startling reality: over 60% of elderly individuals in India grapple with poor sleep quality. This statistic isn't just a number; it's a silent epidemic affecting millions of our respected elders. The implications stretch far beyond morning grogginess or afternoon fatigue. Poor sleep quality in the elderly is intricately linked to a cascade of health issues, including increased risk of falls, cognitive decline, cardiovascular problems, and a weakened immune system. The causes of this sleep crisis are multifaceted, ranging from chronic health conditions prevalent in older adults to the stresses of changing family dynamics in modern India. Nutritional deficiencies, common in our elderly population, further exacerbate sleep issues. Moreover, the lack of awareness about the importance of sleep hygiene and the dismissal of sleep problems as an inevitable part of aging contribute to the problem's persistence. Addressing this sleep crisis requires a holistic approach. It calls for increased awareness, better healthcare access, and innovative solutions that respect our cultural norms while embracing modern sleep science. From creating sleep-friendly environments in multigenerational homes to incorporating traditional practices like yoga and meditation for better sleep, there are numerous avenues to explore. Enter NMN: The Potential Game-Changer A recent clinical trial has shed light on the potential benefits of NMN supplementation, particularly for older adults. This study, which has caught the attention of researchers worldwide, focused on two critical aspects of healthy aging: mobility and sleep quality. Study Design The trial involved a group of older adults. Participants were randomly divided into two groups: The NMN group: Received 250 mg of NMN daily The placebo group: Received a placebo pill The study ran for 12 weeks, during which researchers meticulously monitored changes in walking speed and sleep quality. Remarkable Results Walking Speed NMN Group: Participants maintained their walking speed throughout the 12-week period. This is significant because it suggests that NMN might help combat the natural decline in mobility that often comes with aging. Placebo Group: In contrast, these participants showed a noticeable decline in walking speed over the same period, aligning with the typical age-related slowdown. Sleep Quality NMN Group: Remarkably, these participants reported improved sleep quality. This enhancement in sleep is crucial, considering the widespread sleep issues among India's elderly population. Placebo Group: Unfortunately, this group experienced a worsening in sleep quality, a common trend in aging populations. Implications for India's Elderly These results are particularly exciting when we consider the challenges facing India's aging population. The maintenance of walking speed suggests that NMN could help our elders retain their independence and mobility for longer. This is not just about physical health; it's about preserving dignity and quality of life. The improvement in sleep quality is equally significant. Given that over 60% of India's elderly struggle with poor sleep, as revealed by the BMC Public Health study, NMN could offer a new avenue for addressing this pervasive issue. Conclusion As we look to the future, NMN offers hope in our quest to ensure our elders age gracefully. It's not just about adding years to life, but life to years. To quote the legendary Dr. B.R. Ambedkar: "Life should be big, not long." With advancements like NMN, we're one step closer to making that a reality for our beloved elders. Always consult a healthcare provider before starting any new supplement regimen.
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The Hope of Caloric Restriction in India's Obesity Crisis: Contemplating a Healthier and Longer Life
Is Caloric Restriction The Answer? The desire for a healthier and longer life, free from the common ailments associated with aging, is a shared aspiration worldwide, including among the people of India. However, the nation is currently grappling with a significant challenge in the form of an escalating obesity crisis, as highlighted by recent data from the National Family Health Survey (NFHS). The concerning rise of obesity among Indian women and men, particularly in the age group of 15-49, indicates that approximately a quarter of young women and just over a fifth of men in India are above the normal body weight. This poses a serious concern, especially among women and those in better economic conditions, demanding urgent attention for the nation's wellbeing. Delving into the World of Caloric Restriction In the quest to combat aging-related ailments and enhance longevity, caloric restriction (CR) has emerged as a necessary subject of scientific research. Studies involving various organisms, ranging from yeast to mice, have consistently demonstrated the potential of CR to promote longevity and mitigate the effects of aging. Groundbreaking Studies At the forefront of this groundbreaking research lies the esteemed University of Aberdeen in Scotland. In a recent study published in The Journal of Gerontology, scientists from the university explored the effects of different levels of caloric restriction on lifespan and body composition in mice. Their findings have offered valuable insights into the potential of caloric restriction to extend life and improve overall health. To investigate further, the researchers divided the mice into four distinct groups, each subjected to varying degrees of caloric restriction: 10%, 20%, 30%, and 40% caloric deficit. Additionally, a separate control group had unrestricted access to food for 12 hours each day (12AL group). The caloric restriction started when the mice were 5 months old in human terms and continued until they were 24 months old in human terms.Among the 64 mice that underwent the caloric restriction intervention, 33 mice survived the entire 19-month period. Notably, the group with a 40% caloric deficit exhibited the most significant improvement in survival, boasting an increase in lifespan by 47.6% compared to the control group. Surprisingly, the groups with a 10% caloric deficit did not fare as well as the control group, suggesting that an extreme restriction might not be the optimal approach for everyone. Unraveling the Connection: Caloric Deficit and Weight Loss During the study, the researchers sought to understand the link between caloric deficit and weight loss. An intriguing observation was made - after approximately 30 days of caloric restriction, the mice's body mass stabilized. This stabilization was attributed to the loss of both fat and muscle mass. Moreover, the researchers noted that the benefits of weight loss seemed to plateau after this initial period, implying that prolonged extreme restriction might not be necessary to achieve positive outcomes. Insights from Human Studies Human studies exploring the potential benefits of caloric restriction have also shown promise, with intermittent fasting and similar approaches yielding positive results. For instance, intermittent fasting has been associated with lower blood pressure and improved insulin resistance in obese individuals. Furthermore, reducing calorie intake by certain percentages over time has been linked to various health benefits, including reduced inflammation, a decreased risk of mortality, and slower biological aging. Adopting a Balanced Approach to a Healthier Future While caloric restriction demonstrates remarkable potential for human health, it is essential to exercise caution. An extreme 40% caloric deficit may not be necessary to achieve positive outcomes. Moderation and personalized approaches should be considered when making dietary changes to improve health. Therefore, consulting healthcare professionals is of utmost importance to determine the most suitable approach for each individual. In the face of India's obesity crisis and global health challenges, embracing a balanced and heart-healthy diet, combined with moderate caloric restriction, can significantly promote overall health and potentially increase longevity. By incorporating healthy lifestyle habits into our daily routines, we can harness the potential benefits of caloric restriction and pave the way for a longer, healthier future. So, why not start making small, manageable changes today? Together, let's work towards a healthier, more mindful existence!
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Everything You need To Know About Apigenin
Introduction Apigenin, also called 4’,5,7-trihydroxyflavone is a plant flavonoid that normally occurs in herbs like parsley, celery, chamomile, spinach, red onions and green chillies, among other vegetables. It is found in very minute quantities in the food we eat but is pretty effective anyway. Apigenin has been known for a long time by biologists and chemists (from the early 1900s) but only now is it being studied in detail. Preclinical studies have shown promising results for the most part, which is why now its usage as a dietary supplement that promotes health is booming. Apigenin is needed in very small amounts and it has a largely inhibitory effect on the muscles and brain- which means it promotes relaxation in general. What Are The Benefits Of Apigenin Supplement? Apigenin’s main strength lies in its ability to regulate NAD+ levels in the body. NAD+ levels drop by large amounts as one ages, but it is a crucial molecule that helps cells perform all their functions with elan. NAD+ levels drop due to greater need for cellular maintenance as you age. Levels drop because of one glycoprotein called CD38, which plays a significant role in inflammation, consumes NAD+ molecules to maintain its level of activity. Apigenin works to cut down on the amounts of CD38 being produced in the body, thus helping NAD+ levels remain stable. Apigenin also interacts with specific inhibitory neurotransmitter receptors in the brain- which means it helps you sleep better. When Should You Take Apigenin For Best Results? Apigenin should be taken at night ideally, as it promotes muscular relaxation on a large scale- something that happens when you go to sleep. Apigenin helps modulate GABA (gamma amino butyric acid) levels in the brain, helping you feel less stressed. It's best if you take it right before bedtime. Apigenin Benefits For Inflammation And Immune Health Apigenin has potent anti-inflammatory activity as studies have shown that it can help regulate pro-inflammatory cytokines like TNF-alpha AND IL-1 beta, T-cells and macrophages and can also help cells stay protected from oxidative damage. Apigenin by itself may also have antimicrobial activity as research has shown. Since it promotes relaxation, it will help improve sleep quality and reduce stress- two important aspects that will in turn help improve your performance at work the next day. Some research suggests that apigenin may help increase testosterone levels by inhibiting enzymes that break down testosterone, potentially leading to higher levels of the hormone in the body. Apigenin is also small enough to be able to cross the blood brain barrier- so you can expect it to show some effect in the brain. A 50 mg capsule of apigenin is more than enough to help improve your sleep schedule and positively impact your day, everyday. FAQs 1. What is Apigenin and where does it come from?Apigenin is a plant based flavonoid found in many herbs that are commonly used to season food. It can be found in coriander, cabbage, chamomile, thyme, greens, tomatoes, in tea, wine etc. Apigenin has the unique property to help the body retain its NAD+ reserves, as it works to reduce CD38 levels. High CD38 levels are associated with lower NAD+ levels. 2. Can Apigenin help reduce anxiety or improve sleep quality?Yes, apigenin is good for helping muscles relax, which is the first step towards being able to sleep properly, while also helping regulate inhibitory GABA. Low levels of GABA can lead to poor sleep quality. Chamomile tea is very well known for its calming effects and this is due to apigenin. Apigenin helps in increasing synthesis of BDNF, while also regulating inflammatory cytokines. Apigenin is also known to help with serotonin regulation. Collectively, all these molecules help you sleep and prevent mood swings. 3. Are there any potential side effects of taking Apigenin?If you take too much, then you risk falling asleep much sooner. No other side effects have been observed. 4. Can Apigenin interact with other medications or supplements?Apigenin can interact with certain chemotherapy drugs, antibiotics, antiviral drugs, hormone replacement therapy drugs etc. but studies need to be done to understand more about these interactions. Consult a health specialist before starting Apigenin supplementation. 5. Is Apigenin safe for pregnant or breastfeeding women?Apigenin is generally safe enough to be consumed by everyone but if you are pregnant, it is best you talk to your doctor about supplementing with any substance in general
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Benefits Of Peptides For Skin
Introduction Peptides are the building blocks of proteins- as they are composed of various combinations of amino acids that can be then used to synthesize super crucial proteins like keratin, collagen or elastin. These proteins are the ones that actually give skin its soft, elastic and bouncy texture when present in the right amounts. Our body makes these proteins by itself very efficiently all the time, so when you add peptide containing products to your skincare routine, you are just helping nudge the process along- a lot faster. If you have seen a lot of products with peptides, it is for this very reason- and they are very good for your skin too. How Do Peptides Improve Skin Health? Peptides help your skin make more protein. You may then wonder why using the proteins themselves doesn’t work. The reason is simple- they are too large and don’t pass through the pores that easily. Instead, when you apply peptides which are much smaller in size, you allow the raw materials to penetrate through the pores with ease- thus helping your skin make more protein with less effort. How do they do that though? Peptides move quickly and tell your skin cells to make more collagen and elastin- so think of them as delivery agents which can get the job done really well. Let us look at different ways in which peptides are useful- They can help reduce the number of noticeable wrinkles- as they help smoothen them out. Collagen production picks up when you use peptides- which is good for this purpose. Elastin is a protein that gives skin its much coveted elastic properties- so your skin will look firm and taut- thanks to this tiny miracle worker protein. Peptides are gentle on your skin- so they can help you if you have sensitive skin related issues- like redness, inflammation or sun-damaged skin. If you get overzealous with your skincare routine, then you risk damaging the integrity of the skin barrier. Peptides help repair your skin layers effectively, if you have exfoliated too hard, or spend too long under the sun, if you are a poor sleeper or if you are exposed to pollutants on a regular basis. We know- those traffic jams and work commutes can be nightmares. Peptides can also be used if you have zits, they can be clubbed with other skincare products- but NOT all of them. Example- DON’T use AHA with peptides. Do Peptides Help With Acne And Scars? Yes, they can! Some peptides kill bacteria very effectively, so they won’t give these critters a chance to infect your pores. Also, we know how lush a post-workout glow can look like, but please remember to wash up ok? Peptides vs Retinol For Anti-Aging Peptides are a newer alternative to retinol which has been the anti-aging darling that we all know of. But, retinol is not suitable for everyone and can cause some major side effects initially- like shedding, dryness, itchy skin or even redness and it takes some getting used to. Peptides however are not like that- they are good for sensitive skin, but don’t give you quick results like retinol can. Should You Use Peptides With Vitamin C? Yes, they are a great combination that can help you achieve glass skin goals, or whatever else you have in mind. Vitamin C is a great antioxidant- and so can help reduce damage and brighten skin. Peptides are all rounders- so they will help with this concern too. But you should learn to layer them in the right way- Layer on some Vitamin C serum first, then follow with peptide. Ideally, you should be using a serum or a moisturiser- which means the product will be in contact for longer hours than just a cleanser for example- which you will wash off. Conclusion Peptides are pretty expensive though, so they may not be very economical at times. The best time to use peptides for skin care is both- in your AM and PM routine. This way they will help you all day. Just make sure you put it on before using makeup or SPF in the morning, while you can dab some on at night after cleansing and before bedtime. Peptides are gentle products- so they will not give you dramatic results right away. They are the very definition of ‘trusting the process’ in that way! FAQs 1. What are peptides, and how do they benefit the skin?They are short chains of amino acids (2-100 in number) that help your body make proteins like collagen, elastin and keratin- all of which are present on your skin and help it work well and look even better. 2. How do peptides compare to other skincare ingredients like retinol or hyaluronic acid?Peptides are gentle like hyaluronic acid- so they can help with repair and brightening, and also take care of hydration concerns by keeping the skin barrier intact. But, it is not going to give you quick results like retinol does. Retinol goes to work by making your skin cells multiply way faster than usual- which is how your old skin cells will slough off, while allowing new ones to form under. 3. How long does it take to see visible results from using peptides?You can expect to see some results in a couple months after consistent usage. Remember- peptides work slowly but surely! 4. Can peptides be used on sensitive skin or with other skincare ingredients?Yes, they are great for sensitive skincare enthusiasts too. 5. Are there any side effects or risks of using peptides in skincare?Some of you may be allergic to a few peptides- so make sure to do a patch test before you use them full time. Signs to watch for include redness, swelling or even itching but these are very rare.
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Everything You Need To Know About Betaine-TMG
Introduction TriMethylGlycine or Betaine TMG is a simple molecule but can get a lot done in your body. It is basically glycine, which has 3 methyl groups attached to it, which makes it an excellent methyl donor. Methyl groups are a necessity for hundreds of cellular reactions to occur. Notable among them are DNA modifications, transcription and translation of proteins, to assist the liver so it can function better in the detoxification department and as a crucial inhibitory neurotransmitter in the brain. Successful methylation also helps in the production of other neurotransmitters like dopamine. What Are The Benefits Of Betaine TMG Supplement? Betaine TMG’s main strength lies in its ability to donate methyl groups which help regulate lots of processes in the body. The addition of methyl groups is done by a process called methylation, while removing methyl groups is called demethylation. The addition of methyl groups is a highly planned process as excessive methylation or undermethylation- both can be problematic. Studies have shown that DNA is tagged with multiple methyl groups - which help regulate its expression When methylation does not occur normally, a person is more susceptible to certain kinds of cancers, immunity issues and heart disease. All of these have been linked to higher levels of homocysteine, though the exact mechanism is not understood. TMG is also good for increased endurance, as this was evident in a study conducted on football players. When they were given 2 grams of TMG everyday, they noticed better running speed and muscular strength, with them performing especially well with repeated sprints. This is because TMG helps the cells produce more creatine - which is fuel for muscle cells. It also helps reduce insulin resistance, when taken with choline. It also influences fat metabolism in positive ways. TMG can also be used for people who have depression or anxiety due to low levels of dopamine in their brain, while also reducing homocysteine levels (high levels of which have been associated with depression too). Who Should Take Betaine TMG Daily? People who have high levels of homocysteine in their system due to faulty genes, have heart disease or liver disease and want to improve their metabolism should talk to their doctor before supplementing with TMG. TMG also helps cells regulate hydration levels, which can be good if you are a fitness enthusiast. Its effects on muscular performance and health cannot be denied either. Should You Take Betaine TMG With Or Without Food? You should always take it AFTER a meal to get the maximum benefits from this supplement. The main advantage of TMG is that there is nothing artificial about it and it is readily synthesised and broken down in our body in normal conditions. The methyl groups can be taken away and used for a variety of chemical reactions, most of which centre around DNA maintenance and regulation, in detoxification of certain compounds by the liver and in making important neurotransmitters that help improve brain function and mood. T + N = L + P: TMG Works great with NMN. When NAD+ is boosted, your body might get depleted of methyl groups. TMG restores the methyl groups. Pair with NMN for optimal longevity and performance benefits. Finally, glycine by itself is a neurotransmitter and the smallest amino acid molecule that can help you sleep better and for longer. FAQs 1. What is Betaine TMG, and how does it work in the body?Betaine trimethylglycine (TMG) is a compound that contains 3 methyl groups- which are extensively used for all sorts of cellular functions and synthesis related processes. It helps the heart especially, by lowering levels of homocysteine (an amino acid that has been linked to increased incidence of heart disease), by ensuring that all cells in the body have enough fluids in them, while also helping the liver and pancreas metabolise food better. 2. How does Betaine TMG support heart health and lower homocysteine levels?Betaine gives away its methyl groups, which the body can then use to convert homocysteine to methionine, which does not cause any harm. High homocysteine levels in the blood are a marker of heart disease and possible issues later on. 3. When is the best time to take Betaine TMG—morning or night?You should take TMG supplements after breakfast. If better sleep is your priority, then TMG can be taken at night too, 30 minutes before bedtime. Once the methyl groups get donated, glycine amino acid remains. It is an inhibitory neurotransmitter which asks your brain to relax, so that you can wind down for the night and fall asleep. 4. Are there any side effects or risks associated with Betaine TMG?If you take too much of TMG, then you risk having very high levels of methionine in the blood, which is not good for you. Otherwise, some people may be allergic to it and develop rashes or have diarrhoea and stomach pain. But these occur in very rare cases. 5. Can Betaine TMG be taken with other supplements like creatine or choline?Yes, betaine helps in making more creatine - both of which help regulate homocysteine levels in the body. Taking both choline and TMG can help you reduce your chances of suffering from cancer, according to a few studies.
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Is Your Biological Age The Same As Your Age?
Introduction We don’t think twice before giving our age for official purposes or otherwise. This is because we know when we were born - i.e. the Date of birth (DoB) and just calculate how old we could be. Though your age can be a simple number, there are a lot of factors that actually determine if you are as old as that or not. Case in point- some people look much younger than their age, while others may look a lot more mature or older and tired. Why do you think that happens? This is where the concept of ‘chronological age’ vs. ‘biological age’ comes in - where someone who is much older but fitter may have a lower ‘biological age’, when compared to someone who is much younger but leads a very sedentary lifestyle and makes poor dietary choices on a daily basis. Aging is ascertained by looking at certain biomarkers- which are indicators of cell function. How To Calculate Biological Age Accurately?Just like how we may require certain details to calculate the age of a person- their birth date, calculating biological age is dependent on a bunch of important factors. Aging at a cellular level is called ‘senescence’, and we have an in-built mechanism to get rid of very old and dying cells - as they don’t function well and also influence their neighbours in adverse ways. So, biological age in simpler terms just means to measure how much damage your cells have undergone, over a period of time- mostly in years, though some people may seem to age faster if they are highly stressed. The term ‘biological age’ was coined in the last century by an English physician called Alex Comfort.This concept has further been developed to explain DNA epigenetic markers. Our DNA sequence is very long- so long that if stretched from end to end, it can go to the moon and back several times, with probably some more left in the strand. We can’t have all that genetic material just floating around right? This is why it is packaged in a highly specific manner using particular proteins called histones. They are further spooled in to form the 4-armed chromosomes that we all associate with cell division. The chromosome has different regions in it- the tail end or the part away from the center is called the telomere. You can think of the telomere as a cap or protective sheath that shortens every time you age, but your DNA is still retained for the most part. If telomere loss is extreme, then it is a marker for aging. Wherever the DNA has been exposed, there are certain molecules that are added or removed- mostly methyl groups. This ‘methylation’ of DNA is what determines how we all have the same genes, but still end up looking really different from each other. Though there is a genetic component to aging for sure, what really matters is how your cells are functioning at the present moment- which genes are on, which genes are being switched off and which are maintained throughout. This is the first component used to calculate biological age- ‘Methylation of DNA- epigenetic changes’. In general, a lesser number of methyl groups mean that you are older in age. Since, the methylation observed has been super specific in a number of cases, the age of a person can be easily determined from just a tissue sample. All of these can be studied in detail using specially designed genetic tests- which check for epigenetic markers, telomere length, blood pressure, blood cells and populations, thyroid function tests and other hormones that help you stay healthy. They are said to be simple - provide a blood sample and you will then receive a report with all details of how you are doing at a cellular level. Biological Age vs. Chronological Age Calculation-Biological age is calculated based on the expression of certain genes in cells present in the blood. If there is chronic inflammation in some form, then those genes are expressed more than necessary. Measuring how much your DNA methylation has reduced can give researchers a good estimate of what your biological age is. You can think of biological age as the number of rings a tree can have- which is a closer approximation of its age, compared to just its appearance and how lush its foliage is. Chronological aging measurement is pretty no-nonsense- you just need to know the date of birth or the year they were born in and you know their present age, by subtracting it from 2024. This number is also called calendar age too. Conclusion Simple blood tests these days will give you the biological age of a person. If the number is higher, it means your cells and organs are having a hard time working, while any lesser values will show that cellular performance is more than optimum. Being mindful of what you eat, how much you eat, exercise and sleep- while also remembering to not get stressed out can greatly help you feel younger and better- and this will reflect as a lower biological age value. In fact, if you exercise regularly- like 40 minutes for 5-6 days a week, your biological age will be lower by 9 years on an average, while it is the opposite if you sit and work for 10 hours a day. You decide whether you want to live just longer, or if you really want to live well. FAQs 1. What is biological age, and how is it different from chronological age?Biological age is a method used to calculate how old your cells really are metabolically speaking. This is determined by looking at certain DNA related markers like methylation in various cell types, some inflammatory markers and others. Chronological age is literally how old you are and it is determined by looking at your date of birth. 2. How can I calculate my biological age at home?You can give your blood sample to check for actual biological age- where it will be checked for telomere shortening, DNA methylation and other parameters. There are online calculators too, based on detailed questionnaires, but we are not sure how accurate they are, as the questions are pretty general. 3. Does DNA methylation play a role in calculating biological age?Yes, more methylation means you are younger in age, while the inverse is true if you are older. 4. Are online biological age calculators accurate?These applications rely on a set questionnaire with a few possibilities for answers. If you choose the right ones, your biological age will be a smaller value than if you are actually pretty honest about it. We are not sure of the formula they use and there is no certain way to tell you how old you are, unless some tissue sample from your body is tested thoroughly. 5. How does lifestyle affect biological age?If you eat well and exercise regularly, get enough sleep every night and find ways to destress regularly, then you will generally be better than someone who is pretty stressed and doesn’t have time to exercise or meal prep and doesn’t sleep well.
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Grape Seed Extract - Benefits Explained
Introduction We all know what grapes are- especially the varieties that are turned into delicious wines. But did you know that there are hundreds of different grape cultivars- some of which are seedless, while others contain seeds in them? The parent cultivar is called Vitis vinifera, from which grape seed extracts are normally prepared. Grape flesh is good obviously, but most of us prefer eating the seedless varieties for textural purposes. Grape seeds however are great storehouses for high quality compounds called proanthocyanidins, which have potent antioxidant activity and help regulate hundreds of cellular processes in the body. What Are The Benefits Of Grape Seed Extract? Grape seeds are rich in plenty of compounds like epicatechin, procyanidin-B1, B2, B3 and B respectively, along with catechins, epicatechin gallate, protocatechic acid, procyanidins, pro- delphinidins, etc. Grape seed extract is hence great for the cardiovascular system- the proanthocyanidins present help in various ways- like producing nitric oxide so that blood vessels relax and helps lower blood pressure, helps in regulating LDL levels, is good at keeping platelets inactive unless absolutely needed- thus helping the immune system work better. Proanthocyanidins are also very good at removing superoxide radicals- this protects cells from oxidative damage. In diabetic models, some studies have shown promise- grape seed extract can help cells improve glucose sensitivity. They also help wounds heal better- which is why it is such a great additive in skincare products. Grape seed extract is also great for the skin as it promotes collagen production. It helps bones mineralise better and prevents immune cells from attacking bone (so it is good if you have rheumatoid arthritis for example). Grape Seed Benefits For Brain And Memory Since circulation as a whole is benefitted, it is easy to understand why grape seed extract is good for the brain. The brain is a major energy hog and consumes about 20% of the total oxygen that you breathe in. Since the brain is super metabolically active almost always, high oxygen demand can only be fulfilled by good circulation. Any clots or related issues can hence leave the brain starving and cause a stroke or something more drastic than that. Studies have shown that people with Alzheimer’s disease are benefitted when they supplement with grape seed extract regularly, as it has gallic acid- which does not allow beta-amyloid plaques to form. Grape Seed Extract Benefits For Liver Health The liver is the largest organ in the body, as you know. It is also very metabolically active and is mainly responsible for breaking down all sorts of compounds in the body- toxic or not, into absorbable by-products. The liver can get affected severely if you drink too much, eat a poorly designed diet. This shows up as inflammation, high levels of alanine aminotransferase (ALT) in blood, excessive fat deposition in the liver etc. Grape seed extract has shown to actively help reduce ALT levels- lowering hepatotoxicity. Since free radicals are produced in large amounts, it actively removes them and keeps cells safe from oxidative stress. Conclusion Grape seed extract has shown a lot of potential in treating all sorts of conditions- acute, chronic or otherwise. Though it is mostly very well tolerated by the majority of the population, if you are allergic to grapes- then stay away from it. If you have too much of it, you may have to deal with issues like an itchy scalp, feel faint and have bad headaches. It is also great for skincare- and can help improve texture and elasticity- if used at a 2% concentration for topical application. Grape seed extract in general is a super achiever in the health department and you should talk to your doctor about including it in your routine from today! FAQs1. What is grape seed extract, and how is it different from whole grapes?Literally, grape seed extract means taking all the potent compounds from the seeds alone and leaving the fruit. The seeds have a different biochemical profile, when compared to the fleshy parts of the fruit. Grape seed extract is rich in proanthocyanidins- which are highly potent antioxidants. 2. Can grape seed extract improve skin health and slow aging?Since they are rich in antioxidants, they help skin feel and look better, behave better and work better. They help prevent skin damage due to pollutants and increase collagen production- making your skin feel softer and keeping it wrinkle free for longer, or you will develop wrinkles at a much slower rate- if we are being realistic. 3. Is grape seed extract effective for reducing inflammation and boosting immunity?Yes, grape seed extract can help reduce inflammation by working on the circulatory system, by helping wounds heal better and help reduce the production of inflammatory cytokines- which can help regulate the immune system. 4. How does grape seed extract benefit hair growth and scalp health?Grape seed oil is rich in procyanidins- which is a good antioxidant by itself. It also has a lot of Vitamin E, flavonoids- all of which come from the seeds themselves. Hair follicle health improves with regular usage- leading to better hair growth and texture in the long term. 5. Are there any side effects or risks of taking grape seed extract?Some people may be allergic to the seeds and may develop symptoms like headaches, dizziness, nausea, diarrhoea, sore throat etc. Always remember to talk to your doctor about taking any health supplements- especially if you are on any other medication.
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When Should You Use Trans-Resveratrol? Uses And Benefits Explained
Introduction Trans-Resveratrol is a compound that plants normally synthesize when they are attacked by some infectious pathogens- think of it as an immunity protector for our photosynthesising friends. But, this multifaceted compound can do so much more for us all, as its main strength lies in helping improve cellular function, reducing free radical production, preventing DNA damage and keeping cells healthy in the long run. It also helps improve mitochondrial function, helping our cells produce more energy, more efficiently. Many preclinical studies show that it is a super promising compound that can be used as a supplement safely, so let us understand why it is so. What Are The Benefits Of Trans-Resveratrol? Trans-Resveratrol or 3,5,4′-trihydroxy-trans-stilbene (if you remember chemical nomenclature rules) is a stilbene produced by lots of plants. Since they are found in such minute amounts in peanuts, grapes and berries, it is not possible for you to be able to get the required amounts of trans-resveratrol from your diet. A good example is this- you will need to eat about 10 kg of grapes if you need say 50 grams of it per day. The concentrations tend to vary when you look at different grape cultivars. Let us look at some of the most pronounced effects this compound has, on cellular function in our body- It is obviously great for the heart- studies have shown that it can help lower blood pressure- both systolic and diastolic when taken regularly. It can also help lower LDL levels and increase HDL levels- thus helping your circulatory system in the whole scheme of things. Resveratrol is good for the body as a whole as it helps improve circulation- which means all cells in the body get nutrients as they need. Trans-resveratrol helps reduce inflammatory cytokines in the body- like TNF-alpha or factors like NF-KB- that work upstream of many pathways. Trans-resveratrol helps cells remove superoxide radicals by being a great scavenger, while also helping them activate proteins like sirtuins- SIRT1 to be more specific. This means there is lesser oxidative stress systemically- which means lesser inflammation and better health in the long run. SIRT-1 has a global effect on the production of multiple enzymes that regulate oxidative pathways- like catalases, dismutases, peroxidases. This is how translate-resveratrol boosts mitochondrial function too. It has been shown to improve brain health and cerebral blood flow too. Other organs also benefit immensely with trans–resveratrol- like the liver, the kidneys, the pancreas (the beta cells that produce insulin are especially vulnerable to superoxides) due to its antioxidative properties. They also change how fat cells or adipocytes function- by reducing lipid accumulation in them. This means your metabolism is also improved. How Does Trans-Resveratrol Improve Longevity? By helping boost SIRT-1 production in the body, trans-resveratrol helps in a host of ways- all of which culminate in helping you reduce biological age and improve longevity. When there is less inflammation and oxidative stress- the metabolism of an organism begins to improve. This mimics the effects of ‘fasting’ or restricting calories- that can lead to better cellular repair of any damage caused due to normal wear and tear, or due to some other issue. As mitochondrial function improves, cellular energy levels increase- which means you have more energy to get through the day- without having to worry about a mid-day slump. Conclusion Trans-resveratrol is a very beneficial compound that will help your body function better- so that you feel superb! Trans-resveratrol is a pretty safe compound for regular consumption too- which means you can incorporate it into your routine, without any fear. Just talk to your doctor if you have any doubts or are on certain medications for comorbidities. FAQs 1. What is trans-resveratrol, and how does it benefit health?It is a polyphenol that is normally produced by plants to counteract an infectious agent. Various preclinical studies have shown promising results for reducing chronic inflammation, activating sirtuins in the body and helping cellular repair mechanisms work better in general. 2. When should I take trans-resveratrol for the best results?Ideally, you should be taking the supplement after breakfast. This way, you will have lots of energy throughout the day. Remember to chase it down with some water. 3. Can trans-resveratrol support brain function and cognitive health?Yes, recent studies have shown that older folk and menopausal women who supplement with trans-resveratrol show that it can help improve blood flow to the brain - which can greatly help when there is poor circulation due to advancing age. 4. What are the potential side effects or risks of taking trans-resveratrol?High amounts of trans-resveratrol are generally well tolerated by most individuals, but you should watch out for side effects like nausea, vomiting, diarrhoea, higher heart rate, body aches etc. Consult a health specialist before starting this supplement. 5. How does trans-resveratrol compare to other antioxidants like quercetin?Both trans-resveratrol and quercetin are powerful antioxidants in their own right, but their mechanism of action is slightly different. Also, quercetin is more abundantly found in food sources than trans-resveratrol. Both are especially helpful in reducing chronic inflammation in adipocytes- fat cells in the body.
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Can The Superhero Supplement NMN Fight Depression?
Imagine if there was a supplement that could turn you from a sad person into a social butterfly faster than Clark Kent changes into Superman. We’re being a bit dramatic, don’t take this timeline seriously. According to recent research, nicotinamide mononucleotide (NMN) is that mood-boosting superhero we've been waiting for! The Mouse Experiment To model depression in mice, scientists used a "social defeat stress experiment"! This is a simple exercise where they make a small mouse face a much bigger and more aggressive mouse. Scientists often use this setup to study stress and depression in animals. In this experiment, the small mouse gets bullied by the big mouse for 10 days in a row. As you might guess, this makes the small mouse very stressed and sad. It starts acting in ways that look like depression in humans. Here's the interesting part: Some mice were given NMN every day for three weeks before meeting the big mouse. These mice seemed to handle the stress much better. It was like they had an invisible shield against feeling sad! Three Tests for the Mice The scientists then gave the mice three challenges: 1.The Friendship Test: Would the mouse go near another mouse, or stay away? 2. The Sugar Water Test: Would the mouse still enjoy sweet drinks, or had stress made everything seem less fun? 3. The Hanging Test: How long would the mouse keep trying to escape when hung by its tail? The mice that got NMN did better on all these tests. They were more social, enjoyed sweet things more, and didn't give up as quickly when things got tough. The Mitochondrial Connection: It's Not Just About Serotonin Anymore For years, we thought depression was all about a lack of feel-good chemicals like serotonin in the brain. But plot twist! It turns out our cellular powerhouses, the mitochondria, might be the real MVPs in the fight against the blues. Our brain cells need energy to keep swinging against depression. That's where NMN comes in, boosting levels of NAD+ and potentially giving our mitochondria the pep talk they need to produce more cellular energy. NMN: The Benjamin Button of Brain Health? Could taking NMN in your younger years be like investing in a 401k for your brain? Some scientists think so! Early- and mid-life depression have been linked to a higher risk of dementia later on. By potentially nipping depression in the bud, NMN might help keep your brain young and spry well into your golden years. Of course, we're not quite ready to call NMN the fountain of happiness just yet. We're gonna need more human studies - before we can make any definitive claims on depression. A Quick Spotlight on India's Mental Health Landscape The Numbers Don't Lie (But They Might Make You Anxious) According to the World Health Organization, nearly 15% of Indian adults need mental health intervention. That's more people than the entire population of Mumbai! Even more concerning, one in 20 Indians is grappling with depression. If you thought the pandemic was just about masks and social distancing, think again. A 2021 Lancet study showed a whopping 35% increase in anxiety disorders in India during the COVID-19 pandemic. Remember how we talked about stress affecting our little mouse friends? Well, humans aren't faring much better. The 2023 GOQii India Fit Report reveals that 26% of Indians are stressed due to work. That's right – over a quarter of the population is feeling the heat at the office! Several studies also show that Gen Z and Millennials are experiencing higher levels of stress and anxiety. Between academic pressure, career competition, and the constant comparison game on social media The Bottom Line: A New Hope for Mental Health? While we can't all be superheroes, it seems NMN might give us a fighting chance against the villainous duo of depression and stress. This is especially relevant in a country like India where a majority of the population is grappling with stress and depression. As we wait for more research, keep your chin up and maybe consider adding a little NMN to your daily routine. Who knows? It might just be the sidekick your mood has been waiting for. Remember, though, that while this research is exciting, it's important to consult with a healthcare professional before starting any new supplement regimen.
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