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Discovering the Magic of Youthful Skin and Hair: Your Exciting Journey into the World of NMN
Greetings, my intelligent, skincare loving friend! Ever wondered if reversing gray hair or slowing skin aging is actually possible? Today, we dive deep into the exciting science behind youthful skin, vibrant hair, and one molecule that’s changing everything: NMN. Get ready for a journey into the future of longevity, beauty, and inner vitality. Let’s go! Chapter 1: Why Does Hair Turn Gray, and Is It Reversible? Picture this: you're brushing your hair one morning and suddenly notice a few unexpected gray strands. Surprising, right? The secret lies in melanin, the pigment responsible for the color of our hair and skin, produced by tiny cells called melanocytes at the base of each hair follicle. When we're stressed or have certain health conditions, we may temporarily lose hair and along with it, melanin. But here’s the hopeful part: if those melanocytes survive, the color can return once your stress is reduced. It’s not magic. It’s biology in motion. Curious fact: Some people have seen their gray hair repigmented after lifestyle changes. Fascinating, isn’t it? Chapter 2: How Aging Starts, and Where It Hits First Let’s explore why aging happens at the cellular level. It’s more fascinating than you might think. Our cells contain mitochondria, the energy powerhouses that keep everything running smoothly. As we age, mitochondrial function declines, and this impacts the health of our melanocytes (remember those guys?). Then there are telomeres - protective caps on our chromosomes that shorten each time our cells divide. You’re beginning to get bored, aren’t you! Hang in there, we’re getting to it. When they get too short, cells stop dividing and turn into senescent cells, which are old, inactive cells that contribute to signs of aging like wrinkles and gray hair. So yes, aging begins inside the cell, long before we see it on our face or scalp. Chapter 3: Meet NAD+, Your Body’s Inner Fuel Source Now for the exciting part: NAD+ (nicotinamide adenine dinucleotide). Think of it as your body’s energy currency. It fuels over 300 enzymatic reactions, including mitochondrial health, DNA repair, and cell regeneration. But NAD+ levels decline with age. That’s where NMN (nicotinamide mononucleotide) steps in. As a precursor to NAD+, NMN helps restore those energy levels, potentially rejuvenating your cells from the inside out. Even more promising, early studies suggest it may help maintain telomere length, a key to staying youthful longer. In short: More NMN means more NAD+, which can lead to more energy, better skin, and possibly fewer gray hairs. Chapter 4: Can NMN Really Reverse Gray Hair? Here's What People Are Saying Science is still catching up, but early adopters of NMN are sharing intriguing stories. Many report a reduction in gray hairs and increased hair vitality after supplementing with NMN. It’s not yet a proven cure, but it’s promising and definitely worth paying attention to. Real people. Real stories. Real transformations. “My hair was almost all white in my early 60s when I started taking NMN a year ago. After 3 months, it was slightly more blonde. Noticeably more blonde after 6 months - enough for my wife to see it. After a year, my hair color is about the same as when I was in my 50s. Mostly blond with white-blond temples. My hair is also fuller. I didn't take NMN to change my hair color, but it is a daily reminder that the cells throughout my body must be getting healthier, too.” – A 60-year-old NMN user Yes, we know this is anecdotal and we are not saying that the science is settled, but it’s getting there. Chapter 5: The Secret to Glowing Skin Isn’t in a Bottle Skincare is more than creams and serums. It’s a reflection of what’s happening inside your body. Over time, sun exposure, pollutants, and oxidative stress wear down our collagen and elastin, causing skin to sag and wrinkle. That’s where NMN shows its magic again. By boosting NAD+ levels, NMN helps support collagen production internally. This gives your skin a natural, radiant lift from within. It’s not just about looking younger. It’s about aging better. Pro tip: Pair NMN with antioxidants and hydration for maximum glow. Your Journey Begins Here You, my smart and ambitious friend, have the power to make remarkable choices for your body and your future. You’re not just surviving time. You’re mastering it. With science on your side and NMN in your wellness toolkit, you’re one step closer to radiant skin, revitalized hair, and a more youthful you. So stay curious, stay radiant, and remember: The fountain of youth might not be a myth after all. Until next time,Team Gataca- Backed by science. Inspired by you.
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Indian Foods That Contain NMN
In India, many people are looking to enhance their NMN levels through dietary choices in order to lead healthier and longer lives. The remarkable benefits associated with NMN have piqued their interest, including increased energy, improved focus, enhanced fitness levels, weight loss, and the potential for extended life expectancy. However, supplements of NMN in India can be expensive, with prices reaching 1500 INR or more per bottle. As a result, individuals are considering whether incorporating NMN-rich foods into their diets can produce similar effects, providing a more affordable approach. NMN is naturally present in all living things and can be obtained from specific whole foods. NMN, a ribonucleotide and consists of a nicotinamide group, a ribose group, and a phosphate group. It serves as a direct precursor to nicotinamide adenine dinucleotide (NAD+), a vital molecule that plays a crucial role in supporting essential bodily functions such as cellular energy, DNA repair, and metabolic processes. Enzymes in mitochondria and sirtuins rely on NAD+ to maintain the proper functioning of these systems. With age, NAD+ levels decline, causing these systems to slow down and eventually cease functioning. This age-related NAD+ depletion occurs because our bodies struggle to produce enough NAD+ while simultaneously increasing their consumption to repair the wear and tear associated with aging. Boosting NAD+ levels in the body has the potential to slow down the aging process. While clinical evidence suggests that NMN supplements can promote the biosynthesis of NAD+ and combat the effects of aging. Taking supplements of NMN in India does not require a leap of faith due to their substantial benefits and efficacy, however, the costs can be prohibitive. Therefore, individuals are wondering if modifying their diet alone can yield similar results. Thankfully, NMN-rich foods can be found in a variety of fruits and vegetables that are part of the Indian dietFoods such as cabbage, cucumbers, avocados, broccoli, and edamame can give NMN levels a modest boost when incorporated into daily meals. However, it's important to note that the NMN levels in supplements are significantly higher than what can be obtained from a natural diet alone. Relying solely on a diet may not be sufficient to replicate the effects of NMN supplements To bridge the gap caused by age-related NAD+ decline, which often begins by the age of 40 with levels already reduced by half, relying solely on a diet may not be sufficient to replicate the effects of supplements. Consuming the right NMN-rich foods can still have a cumulative impact on NAD+ levels, slowing down the rate of decline and providing some minimal anti-aging effects. Among the NMN-rich foods, a 2016 study reported the following NMN levels: Cucumbers and cabbage: 0.25-1.88mg of NMN per 100g Fruits like avocado and tomato: 0.26 to 1.60mg per 100g Raw beef, meat, and shrimp: Approximately 0.06 to 0.42mg per 100g To clarify, to get a 500mg daily dose of NMN, you would need to eat a minimum of 26Kgs of Cucumber & cabbage 31 Kgs of avocado or tomato 119 Kgs of raw beef, meat, and shrimp Incorporating these foods into the diet can certainly boost NAD+ levels and help combat the effects of aging. However, it's essential to remember that maintaining a healthy diet provides numerous additional benefits that contribute to overall well-being and promote a youthful appearance. For a more significant impact, combining a balanced diet with regular exercise is recommended. This combination not only enhances NAD+ levels but also improves overall health and reduces vulnerability to various health risks that NMN aims to address. When considering NMN supplements, it's crucial to exercise caution. Most supplements contain between 100mg to 300mg of NMN per tablet, providing a significantly higher NMN intake than what can be achieved through diet alone. However, it's important to be aware that not all supplements of NMN in India are of equal quality. Due to the high cost, counterfeit or low-quality products may be present in the market, which could contain additional ingredients that are potentially harmful to health. If opting for the supplement route, it is wise to choose products with a proven track record and demonstrated effectiveness through independent studies. Nevertheless, maintaining a healthy diet with NMN-rich foods, particularly cabbage and cucumber which are commonly found in Indian cuisine, can help replenish NMN levels. For a substantial boost, combining a regular course of NMN supplements with a nutritious diet may be an effective approach, considering Indian sensibilities and preferences.
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NMN Reduces Weight, Cholesterol, and Blood Pressure in Overweight Adults: Harvard Study
Obesity has emerged as a global health crisis, affecting millions of people and increasing the risk of various chronic diseases. In India, the prevalence of obesity has been skyrocketing, with over 135 million individuals now considered obese. This alarming trend has spurred researchers to explore innovative solutions to tackle obesity and its associated health complications. In this quest for effective weight loss options, Human studies have shown that NMN (Nicotinamide Mononucleotide) supplementation has gained attention for its potential in boosting blood NAD+ levels in overweight or obese adults. NAD+ is a vital molecule involved in cellular energy production and plays a crucial role in metabolic processes. While previous studies have shown that NMN can increase NAD+ levels, the actual physiological benefits of this increase have been mixed and inconclusive. Enter Harvard Medical School researchers who sought to delve deeper into the potential benefits of NMN beyond just weight loss. Their groundbreaking study focused on a specific formulation of NMN called MIB-626 and its impact on overweight or obese adults. The findings of this study, published in the Journal of Clinical Endocrinology and Metabolism, shed new light on the potential of NMN as a metabolic stabilizer and cardiovascular health promoter. NMN Supplementation: More Than Just Weight Loss The study led by Bhasin and colleagues administered 1,000 mg of NMN twice daily to middle-aged and older overweight or obese adults for a duration of 28 days. The results were astonishing. Participants who received NMN experienced a significant decrease in body weight, averaging over 6 lbs., compared to those who did not receive NMN. This suggests that NMN supplementation indeed offers metabolic benefits, as reflected in the substantial reduction in body weight. But that's not all! The researchers went a step further to examine the effects of NMN on cardiovascular health. The results were equally promising. NMN supplementation led to a decrease in total cholesterol levels, including the notorious "bad" LDL cholesterol, known for its association with heart-related issues. Furthermore, NMN was found to have a positive impact on blood pressure, specifically reducing diastolic blood pressure, which is a critical factor in hypertension. Extending NMN Supplementation: Fighting Obesity Effectively While the results of this study are promising, it is essential to acknowledge its limitations. The relatively short duration of the study and the small number of participants (21 individuals) who received NMN warrant caution in drawing definitive conclusions. To truly understand the potential of NMN in reversing obesity and metabolic dysfunction, future clinical trials with larger sample sizes and longer durations are necessary. With India facing a growing obesity epidemic and associated cardiovascular risks, NMN supplementation could hold the key to combatting these challenges. Longer-term studies may uncover even more impressive anti-obesity effects of NMN and greater reductions in cholesterol and blood pressure levels. Additionally, exploring NMN's potential to enhance muscle performance when combined with exercise could revolutionize fitness approaches for overweight and obese individuals. India's Battle with Obesity and Cholesterol: A Wake-Up Call The obesity epidemic in India is reaching alarming levels, with approximately one in 16 women and one in 25 men now classified as obese. Obesity is a known risk factor for type 2 diabetes and cardiovascular diseases, making it a significant public health concern. Adding to the worrisome scenario, 6 out of 10 Indians exhibit abnormal levels of bad cholesterol, significantly contributing to heart disease risk. Genetic factors, sedentary lifestyles, and suboptimal dietary habits are some of the culprits behind this prevalent cholesterol problem. The Need for a Holistic Approach The promising findings from the study on NMN supplementation provide hope for those seeking effective weight loss solutions and improved cardiovascular health. However, it is crucial to recognize that NMN is not a magic bullet and a holistic approach to combating obesity and cholesterol issues is essential. Encouraging physical activity, adopting a balanced diet, and promoting lifestyle changes are integral to achieving long-term health goals. NMN supplementation, when combined with a comprehensive wellness plan, could pave the way for transformative results in the fight against obesity and cardiovascular disease. In conclusion, the study conducted by Harvard Medical School researchers highlights the remarkable potential of NMN supplementation in reducing body weight and improving cardiovascular health. While the results are encouraging, there is still much to explore in terms of the optimal dosing regimens and long-term effects of NMN. As India grapples with a growing obesity epidemic and cholesterol-related health risks, innovative solutions like NMN offer hope in shaping a healthier future. By embracing a holistic approach to wellness and furthering research in this area, we can unlock the full potential of NMN and transform the lives of millions.
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How is NMN manufactured? Read this before you start taking NMN
I think we have you figured out. You are the kid that took apart your dad’s Walkman or your mom’s microwave to figure out how each of those worked. Putting it back together was another story. It was not that important, right? If you were brilliant enough to put them back together, you are at the right place, researching the right molecule to not only enhance your overall cognition but also reclaim your child-like energy. I am not going to get into the benefits of NMN, because that’s not what you’re here to read. You can find that here: The Benefits of NMN There are 3 methods that are used to manufacture NMN. 1. Chemical synthesis – Expensive & Not environmentally friendly 2. Enzymatic production – Expensive & Slow 3. Fermentation – Not as easy as beer Let’s get into it Fermentation: As I said, it’s not easy as throwing in a few ingredients and letting it sit. It’s not as easy as making beer. Not that making beer is easy, but I’m sure it’s easier than fermenting this panacea into existence. If you don’t know what fermentation is, look it up. The gist – it involves the breaking up of organic matter by bacteria or yeast or other microorganisms. One of the ways of producing NMN is by yeast fermentation. NMN produced using this method is of high quality. However, the raw ingredients needed for this process end up costing much more than the yield of the NMN. NMN is found in small quantities in several avocados, broccoli, cabbage, edamame, cucumbers, etc. However, the quantity of NMN found in these is very low and requires a large amount of raw material to produce usable amounts of NMN. Additionally, the product stability is quite low. Enzymatic process: Enzymes are proteins that act as catalysts in all living beings. They speed up processes that are essential for digestion, liver function, and a multitude of other pathways/reactions in your body. Enzymes require certain conditions to function optimally. Alternations in these conditions result in the failure of the pathway/reaction and the process will have to be restarted again. NMN is produced from NAM (nicotinamide) with the help of the NAMPT (nicotinamide phosphoribosyltransferase) enzyme, where NMN attaches a phosphate called PRPP (5’-phosphoribosyl-1-pyrophosphate). NMN with high purity can be obtained through this process along with a high yield. The final product has a small molecular structure, low density, poor fluidity, and can be absorbed quite easily. One more thing, the purity of the final product and the yield is directly proportional to the purity of the enzyme that is used. Chemical process: This process, in addition to the enzymatic process, produces NMN with the highest purity. Like all other chemical reactions, each of the steps is controlled to ensure a high yield. NMN is produced through Zincke’s reaction. N-(2,4- dinitrophenyl)-3-carbamoylpyridinium chloride (compound A) and 2′,3′- O-isopropylidene-α/β-D-ribofuranosylamine (compound B) are the main two compound that takes place in the reaction The raw ingredients used in this process are not entirely safe for the environment. This limits the reliance on chemical processes to produce high-yield and high-purity NMN. What does each company use to produce NMN · Uthever – Enzymatic process · Wonderfeel: Enzymatic process. · Donotage: Enzymatic process · Decode age* – Enzymatic process · Fitness Veda – Unknown · Zaaz NMN – Fermentation with yeast
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Transforming Gut Health: New Study Shows NMN Fosters Beneficial Bacteria Growth
Unlocking the Gut's Potential: How NMN Shapes Beneficial Bacteria Growth and Nurtures Gut Health Understanding the Microbial World Within Us Our gastrointestinal tract, often referred to as the "gut," houses a diverse community of bacteria that play a crucial role in our overall health. These microorganisms impact everything from our immune system to blood glucose levels. Recent research from the Jiangsu Academy of Agricultural Sciences in China sheds light on how Nicotinamide Mononucleotide (NMN) influences the growth of gut bacteria, particularly its role in promoting beneficial species. NMN's Impact on Gut Bacteria Diversity The study conducted by Tang and colleagues involved testing stool samples from nine healthy volunteers, aiming to mimic the conditions of human intestines. The addition of 500 mg of NMN to the simulated intestines led to a reduction in species diversity after 24 hours of fermentation. The results suggest that NMN inhibits the growth of certain gut bacteria during this period. NMN and Bacteroides: A Symbiotic Relationship Tang and colleagues' findings reveal a fascinating aspect of NMN's impact on gut bacteria. After 24 hours, NMN was observed to increase the growth of beneficial bacteria, particularly Bacteroides. This genus, along with others, contributes to the production of a beneficial fat called propionate, a key metabolite that supports normal gut function. The Science Behind NMN's Influence on Gut Bacteria Diving deeper into the specifics, the researchers identified changes in different genera of bacteria. NMN was found to elevate the levels of Bacteroides and other genera associated with propionate production, while harmful bacteria were reduced. These observations suggest that NMN selectively promotes the growth of beneficial gut bacteria, creating a more favorable microbial environment. NMN and Short-Chain Fatty Acids (SCFAs): Nourishing the Gut When our gut bacteria ferment undigested carbohydrates, they produce short-chain fatty acids (SCFAs), crucial for maintaining normal gut function. Tang and colleagues discovered that NMN treatment increased the concentration of SCFAs, particularly propionate, in the artificially digested human stool. This implies that NMN has the potential to enhance the production of beneficial SCFAs, contributing to overall gut health. The Indian Perspective: Foods that Support Gut Health In India, where diverse culinary traditions prevail, several foods have long been recognized for their positive impact on gut health: Buttermilk (Chhaach): Available in various flavors, this traditional Indian drink aids in maintaining the body's fluid and salt levels, contributing to a well-balanced gut environment. Idli: A staple in South Indian cuisine, idli is a fermented food rich in plant-based protein, fiber, and micronutrients. Its consumption aligns with the principles of fostering a healthy gut. Curd: A probiotic-rich food widely consumed in Indian households, curd regulates bowel movements and provides a defense mechanism against infections, promoting a resilient gut. Ginger: A common spice in Indian cooking, ginger possesses natural laxative properties that aid in relieving constipation, supporting digestive health. Kefir: Although not traditionally Indian, incorporating probiotic-rich kefir into the diet can positively impact digestion, preventing bloating and flatulence. Turmeric: Widely used in Indian spices, turmeric's antioxidant and anti-inflammatory properties contribute to improved digestion, reducing gut spasms and flatulence. Timing Matters: Addressing the Duration of NMN Exposure While the study provides valuable insights into NMN's impact on gut bacteria, there are considerations regarding the duration of exposure. Human digestion typically takes 6 to 8 hours, and the study exposed the bacteria to NMN for a full 24 hours. This raises questions about the likelihood of such extended exposure in real-life scenarios. Additionally, NMN remained almost entirely intact after 6 hours in the simulated intestines, suggesting rapid absorption. Implications for NMN Supplementation in Humans Despite the timing discrepancy, the study suggests that some effects observed in the artificial setting may translate to humans upon oral NMN supplementation. However, the effects are likely to be less pronounced. Future studies focusing on gut bacteria in individuals, especially across different age groups, after NMN supplementation could provide valuable insights into the real-world impact of this promising compound. Nurturing Gut Health with NMN and Traditional Foods In conclusion, NMN emerges as a potential player in shaping a healthier gut environment. By selectively promoting the growth of beneficial bacteria and elevating the levels of propionate, NMN holds promise for enhancing gut health. As science continues to unravel the mysteries of our microbial companions, NMN stands as a noteworthy candidate in the quest for optimal gut health, complemented by the longstanding wisdom of traditional Indian foods that have supported digestive wellness for generations.
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Who is supplementing with NMN in India and Should You?
Unlocking the Potential of NMN: A New Age of Wellness in India In recent years, the world has witnessed a significant shift in the approach to health and wellness. India, too, has not remained untouched by this transformation. With the onset of the COVID-19 pandemic, the fitness industry in India underwent a complete makeover. As gyms closed and businesses digitized, a tech-driven fitness revolution emerged. Among the many innovations that gained traction, one intriguing compound began to draw attention: Nicotinamide Mononucleotide, or NMN. NMN is a precursor to NAD+, a molecule vital for various biological processes, and it has been linked to potential health benefits related to aging and cellular function. In this article, we delve into the new trend of NMN in India and explore how it may become a game-changer for health-conscious individuals. Seeking NAD+ Restoration: The Quest for Health and Longevity In the vibrant landscape of health and wellness in India, the relentless pursuit of health and longevity has taken a prominent role. With the age-related decline in Nicotinamide Adenine Dinucleotide (NAD+) levels becoming a growing concern, individuals across India are on a quest to restore and rejuvenate this essential molecule. NAD+, a linchpin in cellular processes, encompasses functions like energy production and DNA repair, but as the years progress, its levels diminish, potentially leading to organ dysfunction and metabolic issues. Amidst this quest, Nicotinamide Mononucleotide (NMN) emerges as a compelling solution. The Role of NMN in Age Prevention For those aged 35 and above, the quest for health and longevity often revolves around seeking ways to restore NAD+ levels. NAD+ (Nicotinamide Adenine Dinucleotide) plays a pivotal role in processes such as energy production and DNA repair. Unfortunately, as we age, NAD+ levels decline, leading to faltering organ function and metabolic problems. NMN has emerged as a potential solution to this problem, as it can boost NAD+ levels, offering hope for age prevention and overall health. The Pandemic-Driven Fitness Revolution The COVID-19 pandemic accelerated the adoption of technology in the fitness industry worldwide, and India was no exception. People started exploring new supplements, fitness apps, virtual workouts, and wellness counseling from the comfort of their homes. In this digital age of health and anti-aging, NMN has captured the attention of both fitness enthusiasts and those seeking age-related interventions. Understanding the NMN Enthusiasts in India Health, Fitness, Aging, Research, and Wellness Enthusiasts A significant portion of NMN enthusiasts in India falls under the category of health enthusiasts aged 35 and older. These proactive individuals are deeply invested in their well-being and often incorporate NMN into their wellness regimens. By increasing blood NAD+ levels, NMN helps them combat the effects of aging and maintain organ function. Age-Related Concerns People over 65 who are concerned about the challenges of aging form another group of potential NMN users. These individuals turn to NMN in the hope of staving off age-related frailty and organ decline. NMN's ability to restore NAD+ levels offers a promising strategy for maintaining health and vitality in their later years. Aging Fitness Buffs Aging fitness enthusiasts, who are keen on improving their endurance, muscle function, and recovery, are also showing interest in NMN. This supplement has found its way into the regimens of those who aim to enhance their physical fitness as they age. Avid Followers of Aging Research Trends The influence of prominent aging researchers like Harvard Professor David Sinclair has not gone unnoticed. NMN has garnered attention for its potential to extend health span—the number of years lived without disease. Those who closely follow such research trends are drawn to NMN as a means to counteract aging by increasing their blood NAD+ levels. Healthcare Practitioners and Wellness Professionals Healthcare practitioners and wellness professionals in India are increasingly recommending NMN to their clients and patients based on specific health goals. For instance, research suggests that NMN can improve insulin sensitivity in overweight adults with prediabetes, making it a valuable tool for those looking to improve their metabolic function and overall health. Potential Benefits Beyond Aging While the evidence is primarily anecdotal, there are studies suggesting that increasing NAD+ levels with NMN may alleviate cravings associated with addiction, as well as anxiety and depression. This opens up the possibility that individuals struggling with addiction or mood-related complications could also benefit from NMN, regardless of age or weight. However, further research is needed to confirm these potential benefits. Celebrities Embrace NMN In the world of celebrities, the use of NAD+ and NMN has gained prominence. Celebrities like Hailey Bieber, Kendall Jenner, Joe Rogan, and Andrew Huberman have openly discussed their use of NAD+ and NMN. Their endorsements have added to the growing interest in NMN as a means to combat aging and promote overall health. The rise of NMN in India in the health and wellness landscape signals a new era of proactive health maintenance. While NMN's potential as an anti-aging remedy is promising, it's important to remember that more research is needed to establish its long-term safety and efficacy. Nevertheless, the diverse group of NMN enthusiasts in India, spanning from health enthusiasts to aging fitness buffs and avid research followers, demonstrates the widespread curiosity and hope surrounding this intriguing compound. As the quest for health and longevity continues, NMN may play a significant role in shaping the future of wellness in India.
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The Anti-Aging Supplements Dr. David Sinclair Takes Besides NMN
Unlocking the Secrets of Dr. David Sinclair's Anti-Aging Regimen In the quest to extend the human lifespan, Harvard scientist Dr. David Sinclair stands as a prominent figure. He believes that we might already have individuals capable of living up to 150 years, thanks to the recent advances in anti-aging research. In a bid to slow down his own aging process, Dr. Sinclair has meticulously curated a daily supplement and drug regimen. He graciously shares this regimen, though without endorsing specific brands or offering personal advice. In this article, we will delve into Dr. Sinclair's regimen, exploring each component's potential anti-aging properties and the scientific evidence supporting their use. Resveratrol: Sipping from the Fountain of Youth Resveratrol, a polyphenol found in grapes, makes its appearance in Dr. Sinclair's daily regimen at a dosage of 1 gram. This compound activates sirtuin enzymes linked to longevity. Human studies have shown that resveratrol-enriched wine can reverse aging processes, hinting at its potential benefits for humans. In animal experiments, resveratrol has proven to delay heart and muscle aging, promote kidney health, and improve memory. https://gataca.in/products/trans-resveratrol Metformin: A Diabetes Drug Turned Anti-Aging Agent In the evening, Dr. Sinclair ingests 800 mg of Metformin, a drug primarily used to treat type 2 diabetes. Beyond its role in managing blood glucose, Metformin exhibits anti-aging properties. Animal studies have highlighted its ability to boost immune function, protect against organ deterioration, and even reverse intestinal aging. When combined with leucine, it prevents muscle atrophy, further emphasizing its potential in slowing down the aging process. Spermidine: Unveiling the Secrets of Wheat Germ Dr. Sinclair includes 1 mg of spermidine in his daily routine, a natural compound found in wheat germ and various foods. Spermidine induces autophagy, the body's cellular waste disposal system. In animals, spermidine has demonstrated benefits such as improved cardiovascular health, enhanced cancer immunity, reduced brain inflammation, and slowed liver aging. Amazon: https://tinyurl.com/bdfw2b4t Quercetin: The Senescence Fighter At 500 mg daily, quercetin takes a prominent spot in Dr. Sinclair's regimen. This polyphenol possesses senolytic properties, capable of removing senescent cells associated with aging. Studies often combine quercetin with dasatinib, a leukemia drug, for enhanced effects. Animal experiments have indicated potential benefits in muscle and bone regeneration, Alzheimer's treatment, heart function improvement, and blood sugar level reduction. Amazon: https://tinyurl.com/mr3be2tp Fisetin: The Lesser-Known Senolytic Fisetin, another polyphenol, makes its presence known with a daily dose of 500 mg. Like quercetin, fisetin has senolytic properties and can alleviate cognitive dysfunction, reduce depression-like behavior, and enhance kidney health. It also boosts muscle size and strength while extending lifespan in animal studies. Amazon: https://tinyurl.com/4mewc4p5 Vitamins D3 and K2: Building Stronger Bones and a Cancer Defense Dr. Sinclair adheres to recommended daily doses of 4,000 to 5,000 IUs of vitamin D3 and 180 to 360 mcg of vitamin K2. The combination of vitamin D3, omega-3s, and exercise has shown a 60% lower risk of cancer in older adults. Vitamin D3 activation of sirtuins is believed to slow colorectal cancer growth, and it also helps in arthritis management. Furthermore, vitamin D3 and K2 collaborate to enhance bone strength. Amazon: https://tinyurl.com/4sybkcej Low-Dose Aspirin: Balancing Cardiovascular Health Dr. Sinclair takes a daily dose of 83 mg of aspirin, a controversial choice for some. While the evidence on its cardiovascular benefits is mixed, Sinclair continues due to a perceived reduction in cancer risk. It's essential to note that aspirin's effectiveness in aging-related contexts remains a topic of ongoing research. Trimethylglycine (TMG): Safeguarding Methyl Groups To counteract the potential depletion of methyl groups caused by high nicotinamide levels, Dr. Sinclair includes 500 to 1,000 mg of TMG daily. Although he acknowledges uncertainty about its necessity, TMG provides a precautionary measure to replenish methyl groups, crucial for various bodily functions, including antioxidants. https://gataca.in/products/tmg-trimethylglycine Rapamycin: The Controversial Longevity Compound While Dr. Sinclair occasionally takes rapamycin, he hasn't disclosed the exact dosage. Rapamycin's effects are notable but come with caveats. It can extend the lifespan of animals significantly, reverse hair graying, prevent muscle weakness, and enhance immunity against the flu. However, taken too early in life, it may stunt growth and development. In closing, Dr. Sinclair's anti-aging regimen comprises a diverse array of compounds, each with unique potential benefits backed by scientific evidence. However, it's important to remember that most of these compounds have not undergone extensive testing in humans for their anti-aging effects. Dr. Sinclair's regimen serves as an intriguing experiment, a testament to the ongoing pursuit of longevity. While we await more robust human studies, it's wise to consult with a healthcare professional before embarking on a similar journey to unlock the secrets of a longer, healthier life. Nicotinamide Mononucleotide (NMN): The Elixir of Youth Dr. Sinclair starts his day with 1 gram of Nicotinamide Mononucleotide (NMN). NMN acts as a precursor to nicotinamide adenine dinucleotide (NAD+), a molecule vital for cellular energy production. Declining NAD+ levels are associated with aging, and NMN aims to counter this decline. Extensive clinical trials suggest NMN's potential to enhance physical performance, sleep quality, insulin sensitivity, and even skin aging. Furthermore, it exhibits positive effects on cardiovascular and neurological health, showcasing promise as a potent anti-aging compound. https://gataca.in/products/nmn-500-india-s-purest-nmn-anti-aging-supplement-for-enhanced-cellular-energy-dna-repair
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Best NMN Supplements In India: A Review Of The Top 7 - Aug 2023
Smarty pants! Good job on discovering the panacea that can help you live a long, long time. You must already know all the benefits of NMN and you are about to quickly scroll down to glance at the top 5 list before you make a decision. Do that! Cause I am going to write a little about NMN and its benefits etc, such that Google Baba will show my article on page 1. Go on, scroll down to the information you are here to read. Benefits of NMN: Are you still reading this? This will be a brief version of the benefits of NMN, you can click through our more detailed article for a breakdown on how NMN works and why you should start taking it. NMN was discovered in 1963 by Chambon, Weill, and Mandel who reported that it provided cellular energy for an important nuclear enzyme called PARP. PARP is implicated in several cellular processes such as DNA repair, programmed cell death, genomic stability, lifespan, and much more. NMN does this by increasing the NAD+ levels. NAD+ energizes PARP. PARP protects the genome. YOU LIVE LONGER! David Sinclair and his team, in 2014, demonstrated that NMN can extend the lifespan of mice. Since this discovery, NMN has been implicated to benefit a wide range of conditions. From increasing insulin sensitivity in diabetics to anecdotal demonstrations of improvement in fertility, NMN is truly a panacea. NMN can Improve brain function Restore blood vessel health Improve muscle function Promote heart health Protect against obesity Protect against diabetes Improve vision Improve organ health Improve fertility & much more What to look for when buying NMN The color should be light grey or white Should taste like burnt popcorn Ideally Manufactured under GMP (Good Manufacturing Processes) Reputable brand names The Top 7 Brands of NMN in India GATACA Of course we are going to put ours first. But hear us out! You will definitely prefer our product once you’ve read this and tried us out.A majority of the brands in India are using Uthever. Specifically for our NMN, we went another route. We’ve comprehensively tested suppliers and our manufacturer came out on top. We were surprised too! Our supplier is among the first to figure out the process of manufacturing NMN on a large scale and claims to supply to David Sinclair’s lab too! All of these put together made us pick this manufacturer. How they make it: Enzymatic Process Contains: NMN only Available Doses: 500 mg, 1000 mg Form: Capsules Claimed Purity: 99.9% GMP: Yes Manufacturer: Secret :) Website price: ₹1599 | ₹2999 Shipping: Free link: https://tinyurl.com/m4e3emh5 Decode Age Decode Age not only uses the same vendor as the market leader Do Not Age but has also established itself as the most reputable brand in India in a short period of time. While they offer NMN in India as a single ingredient, their marketing focus is primarily on their formulations Longevit, Sinevit, etc. which are severely underdosed with NMN. This is not a comment on the effectiveness of their formulations, merely an observation about the dosing of NMN in these formulations. The manufacturer of Decode Age, Uthever, uses the Enzymatic process to manufacture NMN. NMN as a single ingredient is offered in three doses on Decode Age. How they make it: Enzymatic Process Contains: NMN only Available Doses: 250 mg, 500 mg, 1000 mg Form: Capsules Claimed Purity: 99% GMP: Yes Manufacturer: Uthever Website price: ₹990 | ₹1800 | ₹3400 (subscribe to save) Amazon Price: ₹921 | ₹1674 | ₹3248 Shipping: Free Amazon link: https://tinyurl.com/2mt3uy2f Fitness Veda: The only company we found that makes NMN in India. If the “Make in India” tag is important to you, we highly recommend you buy your NMN for Fitness Veda. However, if you are looking for the best NMN in India, we are unable to comment on this as their manufacturing process is not listed on public sources of information. We have reached out to them to understand their manufacturing process but have not received any comment. How they make it: Unknown Contains: NMN Pro+ Available Doses: 300 mg | 600mg | 1000 mg Form: Capsules Claimed Purity: 99% GMP: Yes Manufacturer: Made In India Website price: ₹2475 | ₹3499 | ₹3999 Amazon Price: ₹2999 | ₹3999 | ₹4400 Shipping: Free Amazon link: https://tinyurl.com/3hfv4y2m Leap Life One of the newer entrants into the sales of NMN in India, Leap life has its pricing on point. One month's supply of NMN comes at a sticker price of ₹1699. Information about their manufacturing process and their supplier is sparse. They claim to be vegan if that’s important for you. How they make it: Unknown Contains: NMN Available Doses: 500 mg Form: Capsules Claimed Purity: Unknown GMP: Yes Manufacturer: Unknown Website price: ₹1699 Amazon Price: ₹1699 Shipping: Free Amazon link: https://tinyurl.com/2twvcxxv Nutrija NMN Another new entrant into the NMN supplements space in India, Nutrija NMN claims a purity of 99.8%. We honestly have not come across any manufacturer who claims this level of purity. Nutirja must have figured out a great supplier or a process. They claim to have their ingredients imported from the US while the origin of the NMN is India. How they make it: Special Unknown Process Contains: NMN Available Doses: 500 mg Form: Slow Release Capsules Claimed Purity: 99.8% GMP: Yes Manufacturer: Self Website price: ₹1250 Amazon Price: ₹2698 Shipping: Free Amazon link: https://tinyurl.com/5as4tnp2 ProHealth This is not an Indian company. Their NMN, seemingly, is distributed by the same company that launched Centrum in India. Prohealth offers NM in two forms, as capsules, and as lozenges. It is the only option for lozenges. The Price for both forms is too high. If you are looking for a cost-effective solution, this is not an option. However, if you are looking for lozenges, this is your only option as of now. By the way, they use the same manufacturer as Decode Age and Do Not Age. How they make it: Enzymatic Process Contains: NMN Only Available Doses: 250 mg | 300 mg | 500 mg | 1000 mg Form: Powder, Capsules & Lozenges Claimed Purity: 99% GMP: Yes Manufacturer: Uthever Website price: $29 - $115 (price varies on form) Amazon Price: ₹5000 (price varies on form) Shipping: Free from Amazon Amazon link: https://tinyurl.com/bwuhup6u Livest: Really! ₹999 for 100mg. This is the most expensive product/gram. We are guessing this product was either launched in a hurry to catch the NMN wave or was released before the NMN wave caught up in India. Livest does claim that their NMN has high bioavailability, however, they do not explain how they have achieved this. How they make it: Unknown Contains: NMN only Available Doses: 100 mg Form: Powder, Capsules Claimed Purity: Unknown GMP: Unknown Manufacturer: RGS Formulations Website price: ₹999 Amazon Price: ₹999 Shipping: Free Amazon link: https://tinyurl.com/4uaatu9z StemRx Biosciences This is a formulation of NMN and NAD. The only company that has NAD available in any form. NAD is not necessarily a better alternative to its precursors. The dosing is surprisingly lower than necessary. How they make it: Unknown Contains: NMN & NAD Available Doses: 150 mg Form: Powder, Capsules Claimed Purity: Unknown GMP: Yes Manufacturer: Vitagenics Lifesciences Website price: ₹3499 Amazon Price: ₹3299 Shipping: Free Amazon link: https://tinyurl.com/3rhfran9
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NMN Delivers Stronger Bones: An Australian Study Shows
NMN: Pioneering a Paradigm Shift in Osteoporosis Treatment Decoding Osteoporosis: A Stealthy Bone Marauder Osteoporosis, the silent killer of bone integrity, steadily depletes bone density, rendering it fragile and susceptible to fractures. This affliction gains prominence with age, predominantly among women, making it a covertly menacing health concern. Astonishingly, the risk of a 50-year-old woman succumbing to hip fractures parallels that of breast cancer, making osteoporosis an underestimated global pandemic. Often latent in its onset, the true gravity of this condition only surfaces when a fracture occurs, frequently inflicting substantial health consequences or even fatality. India, in particular, grapples with a considerable prevalence of this ailment. Based on analyses of bone mineral density (BMD) data obtained from Western populations, it is noteworthy that osteopenia, a precursor to osteoporosis characterized by a lower degree of bone density, affects more than 70% of Indian men aged over 50 and approximately 48% of post-menopausal Indian women. Furthermore, osteoporosis, which represents a more severe state of compromised bone density, is diagnosed in approximately 18% of men and 25% of women in India. These statistics underscore the substantial prevalence of bone health issues in the Indian population. The roots of this malady delve into lifestyle choices and genetic predisposition. A Promising Therapeutic Frontier In a recent scientific revelation documented in The Journals of Gerontology: Series A, scholars hailing from the University of Sydney in Australia have unraveled the profound potential of NMN (Nicotinamide Mononucleotide) as a pivotal agent in the battle against osteoporosis. These findings have opened up a new frontier in healthcare and underscore NMN as a transformative prospect. The Erosion of Bone Fortitude Osteoporosis, essentially the debilitation of bone strength and density, begets brittle bones that are highly vulnerable to fractures. While the etiology of this ailment remains somewhat enigmatic, it is postulated that diminished levels of NAD+ (Nicotinamide Adenine Dinucleotide) play a significant role. A Rejuvenating Elixir for Bone Regeneration As we advance in age, the bone-forming cells, essential for generating fresh bone tissue, wither and degenerate. This phenomenon is partly attributed to the transformation of these bone cells into senescent entities. Senescent cells lose their ability to produce new bone, contributing to the development of osteoporosis. To address this fundamental issue, scientists embarked on a series of experiments to ascertain NMN's efficacy. NMN Mitigates Senescence in Bone-Forming Cells Within their laboratory, researchers intentionally induced senescence in bone-forming cells by subjecting them to TNF-⍺, a pro-inflammatory factor. This orchestrated aging process resulted in a notable surge in cell senescence. Nevertheless, the introduction of NMN effectively acted as a fountain of youth for these aged cells, mitigating senescence by a factor approaching threefold. This compelling outcome implies that NMN possesses the potential to combat the senescence of bone-forming cells, a critical contributor to osteoporosis. NMN Catalyzes Bone Formation Moreover, the researchers discovered that NMN plays a pivotal role in stimulating bone growth. This is of paramount significance as new bone formation is the cornerstone of skeletal strength. The researchers found that NMN amplified the population of these vigorous, nascent bone cells. This robust evidence further emphasizes NMN's capacity to facilitate bone formation and potentially reverse the hallmarks of osteoporosis. Hope Arises from Animal Trials The potential of NMN isn't confined to petri dishes and laboratory settings; it extends into living organisms, including mice. By surgically removing the ovaries of female mice and fracturing their femur bones, the scientists created a scenario of diminished bone volume, a telltale sign of osteoporosis. However, when NMN was administered to these osteoporotic mice over two months, the outcome was nothing short of revelatory. Their bone volume witnessed a substantial increase, suggesting NMN's potential to ameliorate osteoporosis in living beings. Looking Forward: A Ray of Optimism in Osteoporosis Treatment While the majority of research has been centered on animal models, the outcomes are undeniably encouraging. Previous animal studies have also pointed to NMN's potential to bolster bone stem cells, pivotal in bone formation, and invigorate various bone cells in the process of bone formation. Despite the absence of direct evidence for NMN's effectiveness in human osteoporosis patients, the horizon is replete with promise. It holds the tantalizing prospect that NMN may stand as a prophylactic bulwark against age-related bone loss. In summation, NMN, an exceptional agent, offers immense promise in the battle against osteoporosis. By mitigating the presence of senescent bone cells and stimulating the emergence of fresh, robust bone cells, it holds the key to a healthier skeletal structure and a better quality of life. As our exploration of NMN's capabilities deepens increasingly, it holds the promise of becoming a formidable asset in the ongoing battle against osteoporosis, potentially leading to significant improvements in both bone health and overall quality of life for the whole world.
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