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Transforming Gut Health: New Study Shows NMN Fosters Beneficial Bacteria Growth
Unlocking the Gut's Potential: How NMN Shapes Beneficial Bacteria Growth and Nurtures Gut Health Understanding the Microbial World Within Us Our gastrointestinal tract, often referred to as the "gut," houses a diverse community of bacteria that play a crucial role in our overall health. These microorganisms impact everything from our immune system to blood glucose levels. Recent research from the Jiangsu Academy of Agricultural Sciences in China sheds light on how Nicotinamide Mononucleotide (NMN) influences the growth of gut bacteria, particularly its role in promoting beneficial species. NMN's Impact on Gut Bacteria Diversity The study conducted by Tang and colleagues involved testing stool samples from nine healthy volunteers, aiming to mimic the conditions of human intestines. The addition of 500 mg of NMN to the simulated intestines led to a reduction in species diversity after 24 hours of fermentation. The results suggest that NMN inhibits the growth of certain gut bacteria during this period. NMN and Bacteroides: A Symbiotic Relationship Tang and colleagues' findings reveal a fascinating aspect of NMN's impact on gut bacteria. After 24 hours, NMN was observed to increase the growth of beneficial bacteria, particularly Bacteroides. This genus, along with others, contributes to the production of a beneficial fat called propionate, a key metabolite that supports normal gut function. The Science Behind NMN's Influence on Gut Bacteria Diving deeper into the specifics, the researchers identified changes in different genera of bacteria. NMN was found to elevate the levels of Bacteroides and other genera associated with propionate production, while harmful bacteria were reduced. These observations suggest that NMN selectively promotes the growth of beneficial gut bacteria, creating a more favorable microbial environment. NMN and Short-Chain Fatty Acids (SCFAs): Nourishing the Gut When our gut bacteria ferment undigested carbohydrates, they produce short-chain fatty acids (SCFAs), crucial for maintaining normal gut function. Tang and colleagues discovered that NMN treatment increased the concentration of SCFAs, particularly propionate, in the artificially digested human stool. This implies that NMN has the potential to enhance the production of beneficial SCFAs, contributing to overall gut health. The Indian Perspective: Foods that Support Gut Health In India, where diverse culinary traditions prevail, several foods have long been recognized for their positive impact on gut health: Buttermilk (Chhaach): Available in various flavors, this traditional Indian drink aids in maintaining the body's fluid and salt levels, contributing to a well-balanced gut environment. Idli: A staple in South Indian cuisine, idli is a fermented food rich in plant-based protein, fiber, and micronutrients. Its consumption aligns with the principles of fostering a healthy gut. Curd: A probiotic-rich food widely consumed in Indian households, curd regulates bowel movements and provides a defense mechanism against infections, promoting a resilient gut. Ginger: A common spice in Indian cooking, ginger possesses natural laxative properties that aid in relieving constipation, supporting digestive health. Kefir: Although not traditionally Indian, incorporating probiotic-rich kefir into the diet can positively impact digestion, preventing bloating and flatulence. Turmeric: Widely used in Indian spices, turmeric's antioxidant and anti-inflammatory properties contribute to improved digestion, reducing gut spasms and flatulence. Timing Matters: Addressing the Duration of NMN Exposure While the study provides valuable insights into NMN's impact on gut bacteria, there are considerations regarding the duration of exposure. Human digestion typically takes 6 to 8 hours, and the study exposed the bacteria to NMN for a full 24 hours. This raises questions about the likelihood of such extended exposure in real-life scenarios. Additionally, NMN remained almost entirely intact after 6 hours in the simulated intestines, suggesting rapid absorption. Implications for NMN Supplementation in Humans Despite the timing discrepancy, the study suggests that some effects observed in the artificial setting may translate to humans upon oral NMN supplementation. However, the effects are likely to be less pronounced. Future studies focusing on gut bacteria in individuals, especially across different age groups, after NMN supplementation could provide valuable insights into the real-world impact of this promising compound. Nurturing Gut Health with NMN and Traditional Foods In conclusion, NMN emerges as a potential player in shaping a healthier gut environment. By selectively promoting the growth of beneficial bacteria and elevating the levels of propionate, NMN holds promise for enhancing gut health. As science continues to unravel the mysteries of our microbial companions, NMN stands as a noteworthy candidate in the quest for optimal gut health, complemented by the longstanding wisdom of traditional Indian foods that have supported digestive wellness for generations.
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Who is supplementing with NMN in India and Should You?
Unlocking the Potential of NMN: A New Age of Wellness in India In recent years, the world has witnessed a significant shift in the approach to health and wellness. India, too, has not remained untouched by this transformation. With the onset of the COVID-19 pandemic, the fitness industry in India underwent a complete makeover. As gyms closed and businesses digitized, a tech-driven fitness revolution emerged. Among the many innovations that gained traction, one intriguing compound began to draw attention: Nicotinamide Mononucleotide, or NMN. NMN is a precursor to NAD+, a molecule vital for various biological processes, and it has been linked to potential health benefits related to aging and cellular function. In this article, we delve into the new trend of NMN in India and explore how it may become a game-changer for health-conscious individuals. Seeking NAD+ Restoration: The Quest for Health and Longevity In the vibrant landscape of health and wellness in India, the relentless pursuit of health and longevity has taken a prominent role. With the age-related decline in Nicotinamide Adenine Dinucleotide (NAD+) levels becoming a growing concern, individuals across India are on a quest to restore and rejuvenate this essential molecule. NAD+, a linchpin in cellular processes, encompasses functions like energy production and DNA repair, but as the years progress, its levels diminish, potentially leading to organ dysfunction and metabolic issues. Amidst this quest, Nicotinamide Mononucleotide (NMN) emerges as a compelling solution. The Role of NMN in Age Prevention For those aged 35 and above, the quest for health and longevity often revolves around seeking ways to restore NAD+ levels. NAD+ (Nicotinamide Adenine Dinucleotide) plays a pivotal role in processes such as energy production and DNA repair. Unfortunately, as we age, NAD+ levels decline, leading to faltering organ function and metabolic problems. NMN has emerged as a potential solution to this problem, as it can boost NAD+ levels, offering hope for age prevention and overall health. The Pandemic-Driven Fitness Revolution The COVID-19 pandemic accelerated the adoption of technology in the fitness industry worldwide, and India was no exception. People started exploring new supplements, fitness apps, virtual workouts, and wellness counseling from the comfort of their homes. In this digital age of health and anti-aging, NMN has captured the attention of both fitness enthusiasts and those seeking age-related interventions. Understanding the NMN Enthusiasts in India Health, Fitness, Aging, Research, and Wellness Enthusiasts A significant portion of NMN enthusiasts in India falls under the category of health enthusiasts aged 35 and older. These proactive individuals are deeply invested in their well-being and often incorporate NMN into their wellness regimens. By increasing blood NAD+ levels, NMN helps them combat the effects of aging and maintain organ function. Age-Related Concerns People over 65 who are concerned about the challenges of aging form another group of potential NMN users. These individuals turn to NMN in the hope of staving off age-related frailty and organ decline. NMN's ability to restore NAD+ levels offers a promising strategy for maintaining health and vitality in their later years. Aging Fitness Buffs Aging fitness enthusiasts, who are keen on improving their endurance, muscle function, and recovery, are also showing interest in NMN. This supplement has found its way into the regimens of those who aim to enhance their physical fitness as they age. Avid Followers of Aging Research Trends The influence of prominent aging researchers like Harvard Professor David Sinclair has not gone unnoticed. NMN has garnered attention for its potential to extend health span—the number of years lived without disease. Those who closely follow such research trends are drawn to NMN as a means to counteract aging by increasing their blood NAD+ levels. Healthcare Practitioners and Wellness Professionals Healthcare practitioners and wellness professionals in India are increasingly recommending NMN to their clients and patients based on specific health goals. For instance, research suggests that NMN can improve insulin sensitivity in overweight adults with prediabetes, making it a valuable tool for those looking to improve their metabolic function and overall health. Potential Benefits Beyond Aging While the evidence is primarily anecdotal, there are studies suggesting that increasing NAD+ levels with NMN may alleviate cravings associated with addiction, as well as anxiety and depression. This opens up the possibility that individuals struggling with addiction or mood-related complications could also benefit from NMN, regardless of age or weight. However, further research is needed to confirm these potential benefits. Celebrities Embrace NMN In the world of celebrities, the use of NAD+ and NMN has gained prominence. Celebrities like Hailey Bieber, Kendall Jenner, Joe Rogan, and Andrew Huberman have openly discussed their use of NAD+ and NMN. Their endorsements have added to the growing interest in NMN as a means to combat aging and promote overall health. The rise of NMN in India in the health and wellness landscape signals a new era of proactive health maintenance. While NMN's potential as an anti-aging remedy is promising, it's important to remember that more research is needed to establish its long-term safety and efficacy. Nevertheless, the diverse group of NMN enthusiasts in India, spanning from health enthusiasts to aging fitness buffs and avid research followers, demonstrates the widespread curiosity and hope surrounding this intriguing compound. As the quest for health and longevity continues, NMN may play a significant role in shaping the future of wellness in India.
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The Anti-Aging Supplements Dr. David Sinclair Takes Besides NMN
Unlocking the Secrets of Dr. David Sinclair's Anti-Aging Regimen In the quest to extend the human lifespan, Harvard scientist Dr. David Sinclair stands as a prominent figure. He believes that we might already have individuals capable of living up to 150 years, thanks to the recent advances in anti-aging research. In a bid to slow down his own aging process, Dr. Sinclair has meticulously curated a daily supplement and drug regimen. He graciously shares this regimen, though without endorsing specific brands or offering personal advice. In this article, we will delve into Dr. Sinclair's regimen, exploring each component's potential anti-aging properties and the scientific evidence supporting their use. Resveratrol: Sipping from the Fountain of Youth Resveratrol, a polyphenol found in grapes, makes its appearance in Dr. Sinclair's daily regimen at a dosage of 1 gram. This compound activates sirtuin enzymes linked to longevity. Human studies have shown that resveratrol-enriched wine can reverse aging processes, hinting at its potential benefits for humans. In animal experiments, resveratrol has proven to delay heart and muscle aging, promote kidney health, and improve memory. https://gataca.in/products/trans-resveratrol Metformin: A Diabetes Drug Turned Anti-Aging Agent In the evening, Dr. Sinclair ingests 800 mg of Metformin, a drug primarily used to treat type 2 diabetes. Beyond its role in managing blood glucose, Metformin exhibits anti-aging properties. Animal studies have highlighted its ability to boost immune function, protect against organ deterioration, and even reverse intestinal aging. When combined with leucine, it prevents muscle atrophy, further emphasizing its potential in slowing down the aging process. Spermidine: Unveiling the Secrets of Wheat Germ Dr. Sinclair includes 1 mg of spermidine in his daily routine, a natural compound found in wheat germ and various foods. Spermidine induces autophagy, the body's cellular waste disposal system. In animals, spermidine has demonstrated benefits such as improved cardiovascular health, enhanced cancer immunity, reduced brain inflammation, and slowed liver aging. Amazon: https://tinyurl.com/bdfw2b4t Quercetin: The Senescence Fighter At 500 mg daily, quercetin takes a prominent spot in Dr. Sinclair's regimen. This polyphenol possesses senolytic properties, capable of removing senescent cells associated with aging. Studies often combine quercetin with dasatinib, a leukemia drug, for enhanced effects. Animal experiments have indicated potential benefits in muscle and bone regeneration, Alzheimer's treatment, heart function improvement, and blood sugar level reduction. Amazon: https://tinyurl.com/mr3be2tp Fisetin: The Lesser-Known Senolytic Fisetin, another polyphenol, makes its presence known with a daily dose of 500 mg. Like quercetin, fisetin has senolytic properties and can alleviate cognitive dysfunction, reduce depression-like behavior, and enhance kidney health. It also boosts muscle size and strength while extending lifespan in animal studies. Amazon: https://tinyurl.com/4mewc4p5 Vitamins D3 and K2: Building Stronger Bones and a Cancer Defense Dr. Sinclair adheres to recommended daily doses of 4,000 to 5,000 IUs of vitamin D3 and 180 to 360 mcg of vitamin K2. The combination of vitamin D3, omega-3s, and exercise has shown a 60% lower risk of cancer in older adults. Vitamin D3 activation of sirtuins is believed to slow colorectal cancer growth, and it also helps in arthritis management. Furthermore, vitamin D3 and K2 collaborate to enhance bone strength. Amazon: https://tinyurl.com/4sybkcej Low-Dose Aspirin: Balancing Cardiovascular Health Dr. Sinclair takes a daily dose of 83 mg of aspirin, a controversial choice for some. While the evidence on its cardiovascular benefits is mixed, Sinclair continues due to a perceived reduction in cancer risk. It's essential to note that aspirin's effectiveness in aging-related contexts remains a topic of ongoing research. Trimethylglycine (TMG): Safeguarding Methyl Groups To counteract the potential depletion of methyl groups caused by high nicotinamide levels, Dr. Sinclair includes 500 to 1,000 mg of TMG daily. Although he acknowledges uncertainty about its necessity, TMG provides a precautionary measure to replenish methyl groups, crucial for various bodily functions, including antioxidants. https://gataca.in/products/tmg-trimethylglycine Rapamycin: The Controversial Longevity Compound While Dr. Sinclair occasionally takes rapamycin, he hasn't disclosed the exact dosage. Rapamycin's effects are notable but come with caveats. It can extend the lifespan of animals significantly, reverse hair graying, prevent muscle weakness, and enhance immunity against the flu. However, taken too early in life, it may stunt growth and development. In closing, Dr. Sinclair's anti-aging regimen comprises a diverse array of compounds, each with unique potential benefits backed by scientific evidence. However, it's important to remember that most of these compounds have not undergone extensive testing in humans for their anti-aging effects. Dr. Sinclair's regimen serves as an intriguing experiment, a testament to the ongoing pursuit of longevity. While we await more robust human studies, it's wise to consult with a healthcare professional before embarking on a similar journey to unlock the secrets of a longer, healthier life. Nicotinamide Mononucleotide (NMN): The Elixir of Youth Dr. Sinclair starts his day with 1 gram of Nicotinamide Mononucleotide (NMN). NMN acts as a precursor to nicotinamide adenine dinucleotide (NAD+), a molecule vital for cellular energy production. Declining NAD+ levels are associated with aging, and NMN aims to counter this decline. Extensive clinical trials suggest NMN's potential to enhance physical performance, sleep quality, insulin sensitivity, and even skin aging. Furthermore, it exhibits positive effects on cardiovascular and neurological health, showcasing promise as a potent anti-aging compound. https://gataca.in/products/nmn-500-india-s-purest-nmn-anti-aging-supplement-for-enhanced-cellular-energy-dna-repair
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Best NMN Supplements In India: A Review Of The Top 7 - Aug 2023
Smarty pants! Good job on discovering the panacea that can help you live a long, long time. You must already know all the benefits of NMN and you are about to quickly scroll down to glance at the top 5 list before you make a decision. Do that! Cause I am going to write a little about NMN and its benefits etc, such that Google Baba will show my article on page 1. Go on, scroll down to the information you are here to read. Benefits of NMN: Are you still reading this? This will be a brief version of the benefits of NMN, you can click through our more detailed article for a breakdown on how NMN works and why you should start taking it. NMN was discovered in 1963 by Chambon, Weill, and Mandel who reported that it provided cellular energy for an important nuclear enzyme called PARP. PARP is implicated in several cellular processes such as DNA repair, programmed cell death, genomic stability, lifespan, and much more. NMN does this by increasing the NAD+ levels. NAD+ energizes PARP. PARP protects the genome. YOU LIVE LONGER! David Sinclair and his team, in 2014, demonstrated that NMN can extend the lifespan of mice. Since this discovery, NMN has been implicated to benefit a wide range of conditions. From increasing insulin sensitivity in diabetics to anecdotal demonstrations of improvement in fertility, NMN is truly a panacea. NMN can Improve brain function Restore blood vessel health Improve muscle function Promote heart health Protect against obesity Protect against diabetes Improve vision Improve organ health Improve fertility & much more What to look for when buying NMN The color should be light grey or white Should taste like burnt popcorn Ideally Manufactured under GMP (Good Manufacturing Processes) Reputable brand names The Top 7 Brands of NMN in India GATACA Of course we are going to put ours first. But hear us out! You will definitely prefer our product once you’ve read this and tried us out.A majority of the brands in India are using Uthever. Specifically for our NMN, we went another route. We’ve comprehensively tested suppliers and our manufacturer came out on top. We were surprised too! Our supplier is among the first to figure out the process of manufacturing NMN on a large scale and claims to supply to David Sinclair’s lab too! All of these put together made us pick this manufacturer. How they make it: Enzymatic Process Contains: NMN only Available Doses: 500 mg, 1000 mg Form: Capsules Claimed Purity: 99.9% GMP: Yes Manufacturer: Secret :) Website price: ₹1599 | ₹2999 Shipping: Free link: https://tinyurl.com/m4e3emh5 Decode Age Decode Age not only uses the same vendor as the market leader Do Not Age but has also established itself as the most reputable brand in India in a short period of time. While they offer NMN in India as a single ingredient, their marketing focus is primarily on their formulations Longevit, Sinevit, etc. which are severely underdosed with NMN. This is not a comment on the effectiveness of their formulations, merely an observation about the dosing of NMN in these formulations. The manufacturer of Decode Age, Uthever, uses the Enzymatic process to manufacture NMN. NMN as a single ingredient is offered in three doses on Decode Age. How they make it: Enzymatic Process Contains: NMN only Available Doses: 250 mg, 500 mg, 1000 mg Form: Capsules Claimed Purity: 99% GMP: Yes Manufacturer: Uthever Website price: ₹990 | ₹1800 | ₹3400 (subscribe to save) Amazon Price: ₹921 | ₹1674 | ₹3248 Shipping: Free Amazon link: https://tinyurl.com/2mt3uy2f Fitness Veda: The only company we found that makes NMN in India. If the “Make in India” tag is important to you, we highly recommend you buy your NMN for Fitness Veda. However, if you are looking for the best NMN in India, we are unable to comment on this as their manufacturing process is not listed on public sources of information. We have reached out to them to understand their manufacturing process but have not received any comment. How they make it: Unknown Contains: NMN Pro+ Available Doses: 300 mg | 600mg | 1000 mg Form: Capsules Claimed Purity: 99% GMP: Yes Manufacturer: Made In India Website price: ₹2475 | ₹3499 | ₹3999 Amazon Price: ₹2999 | ₹3999 | ₹4400 Shipping: Free Amazon link: https://tinyurl.com/3hfv4y2m Leap Life One of the newer entrants into the sales of NMN in India, Leap life has its pricing on point. One month's supply of NMN comes at a sticker price of ₹1699. Information about their manufacturing process and their supplier is sparse. They claim to be vegan if that’s important for you. How they make it: Unknown Contains: NMN Available Doses: 500 mg Form: Capsules Claimed Purity: Unknown GMP: Yes Manufacturer: Unknown Website price: ₹1699 Amazon Price: ₹1699 Shipping: Free Amazon link: https://tinyurl.com/2twvcxxv Nutrija NMN Another new entrant into the NMN supplements space in India, Nutrija NMN claims a purity of 99.8%. We honestly have not come across any manufacturer who claims this level of purity. Nutirja must have figured out a great supplier or a process. They claim to have their ingredients imported from the US while the origin of the NMN is India. How they make it: Special Unknown Process Contains: NMN Available Doses: 500 mg Form: Slow Release Capsules Claimed Purity: 99.8% GMP: Yes Manufacturer: Self Website price: ₹1250 Amazon Price: ₹2698 Shipping: Free Amazon link: https://tinyurl.com/5as4tnp2 ProHealth This is not an Indian company. Their NMN, seemingly, is distributed by the same company that launched Centrum in India. Prohealth offers NM in two forms, as capsules, and as lozenges. It is the only option for lozenges. The Price for both forms is too high. If you are looking for a cost-effective solution, this is not an option. However, if you are looking for lozenges, this is your only option as of now. By the way, they use the same manufacturer as Decode Age and Do Not Age. How they make it: Enzymatic Process Contains: NMN Only Available Doses: 250 mg | 300 mg | 500 mg | 1000 mg Form: Powder, Capsules & Lozenges Claimed Purity: 99% GMP: Yes Manufacturer: Uthever Website price: $29 - $115 (price varies on form) Amazon Price: ₹5000 (price varies on form) Shipping: Free from Amazon Amazon link: https://tinyurl.com/bwuhup6u Livest: Really! ₹999 for 100mg. This is the most expensive product/gram. We are guessing this product was either launched in a hurry to catch the NMN wave or was released before the NMN wave caught up in India. Livest does claim that their NMN has high bioavailability, however, they do not explain how they have achieved this. How they make it: Unknown Contains: NMN only Available Doses: 100 mg Form: Powder, Capsules Claimed Purity: Unknown GMP: Unknown Manufacturer: RGS Formulations Website price: ₹999 Amazon Price: ₹999 Shipping: Free Amazon link: https://tinyurl.com/4uaatu9z StemRx Biosciences This is a formulation of NMN and NAD. The only company that has NAD available in any form. NAD is not necessarily a better alternative to its precursors. The dosing is surprisingly lower than necessary. How they make it: Unknown Contains: NMN & NAD Available Doses: 150 mg Form: Powder, Capsules Claimed Purity: Unknown GMP: Yes Manufacturer: Vitagenics Lifesciences Website price: ₹3499 Amazon Price: ₹3299 Shipping: Free Amazon link: https://tinyurl.com/3rhfran9
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NMN Delivers Stronger Bones: An Australian Study Shows
NMN: Pioneering a Paradigm Shift in Osteoporosis Treatment Decoding Osteoporosis: A Stealthy Bone Marauder Osteoporosis, the silent killer of bone integrity, steadily depletes bone density, rendering it fragile and susceptible to fractures. This affliction gains prominence with age, predominantly among women, making it a covertly menacing health concern. Astonishingly, the risk of a 50-year-old woman succumbing to hip fractures parallels that of breast cancer, making osteoporosis an underestimated global pandemic. Often latent in its onset, the true gravity of this condition only surfaces when a fracture occurs, frequently inflicting substantial health consequences or even fatality. India, in particular, grapples with a considerable prevalence of this ailment. Based on analyses of bone mineral density (BMD) data obtained from Western populations, it is noteworthy that osteopenia, a precursor to osteoporosis characterized by a lower degree of bone density, affects more than 70% of Indian men aged over 50 and approximately 48% of post-menopausal Indian women. Furthermore, osteoporosis, which represents a more severe state of compromised bone density, is diagnosed in approximately 18% of men and 25% of women in India. These statistics underscore the substantial prevalence of bone health issues in the Indian population. The roots of this malady delve into lifestyle choices and genetic predisposition. A Promising Therapeutic Frontier In a recent scientific revelation documented in The Journals of Gerontology: Series A, scholars hailing from the University of Sydney in Australia have unraveled the profound potential of NMN (Nicotinamide Mononucleotide) as a pivotal agent in the battle against osteoporosis. These findings have opened up a new frontier in healthcare and underscore NMN as a transformative prospect. The Erosion of Bone Fortitude Osteoporosis, essentially the debilitation of bone strength and density, begets brittle bones that are highly vulnerable to fractures. While the etiology of this ailment remains somewhat enigmatic, it is postulated that diminished levels of NAD+ (Nicotinamide Adenine Dinucleotide) play a significant role. A Rejuvenating Elixir for Bone Regeneration As we advance in age, the bone-forming cells, essential for generating fresh bone tissue, wither and degenerate. This phenomenon is partly attributed to the transformation of these bone cells into senescent entities. Senescent cells lose their ability to produce new bone, contributing to the development of osteoporosis. To address this fundamental issue, scientists embarked on a series of experiments to ascertain NMN's efficacy. NMN Mitigates Senescence in Bone-Forming Cells Within their laboratory, researchers intentionally induced senescence in bone-forming cells by subjecting them to TNF-⍺, a pro-inflammatory factor. This orchestrated aging process resulted in a notable surge in cell senescence. Nevertheless, the introduction of NMN effectively acted as a fountain of youth for these aged cells, mitigating senescence by a factor approaching threefold. This compelling outcome implies that NMN possesses the potential to combat the senescence of bone-forming cells, a critical contributor to osteoporosis. NMN Catalyzes Bone Formation Moreover, the researchers discovered that NMN plays a pivotal role in stimulating bone growth. This is of paramount significance as new bone formation is the cornerstone of skeletal strength. The researchers found that NMN amplified the population of these vigorous, nascent bone cells. This robust evidence further emphasizes NMN's capacity to facilitate bone formation and potentially reverse the hallmarks of osteoporosis. Hope Arises from Animal Trials The potential of NMN isn't confined to petri dishes and laboratory settings; it extends into living organisms, including mice. By surgically removing the ovaries of female mice and fracturing their femur bones, the scientists created a scenario of diminished bone volume, a telltale sign of osteoporosis. However, when NMN was administered to these osteoporotic mice over two months, the outcome was nothing short of revelatory. Their bone volume witnessed a substantial increase, suggesting NMN's potential to ameliorate osteoporosis in living beings. Looking Forward: A Ray of Optimism in Osteoporosis Treatment While the majority of research has been centered on animal models, the outcomes are undeniably encouraging. Previous animal studies have also pointed to NMN's potential to bolster bone stem cells, pivotal in bone formation, and invigorate various bone cells in the process of bone formation. Despite the absence of direct evidence for NMN's effectiveness in human osteoporosis patients, the horizon is replete with promise. It holds the tantalizing prospect that NMN may stand as a prophylactic bulwark against age-related bone loss. In summation, NMN, an exceptional agent, offers immense promise in the battle against osteoporosis. By mitigating the presence of senescent bone cells and stimulating the emergence of fresh, robust bone cells, it holds the key to a healthier skeletal structure and a better quality of life. As our exploration of NMN's capabilities deepens increasingly, it holds the promise of becoming a formidable asset in the ongoing battle against osteoporosis, potentially leading to significant improvements in both bone health and overall quality of life for the whole world.
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NMN Lowers Blood Pressure in Patients with Hypertension: Latest Human Trial
Unlocking the Potential of NMN: A Promising Breakthrough in Hypertension Treatment High blood pressure, or hypertension, is a looming menace that has been and is affecting millions of people in India and across the globe. It's surprising to learn that even the younger generation, aged 15 to 49, is grappling with this health issue, thanks to their hectic and stressful lifestyles. In India, the numbers are staggering, with approximately 234 million people dealing with high blood pressure. But there's hope on the horizon, and it comes in the form of NMN. The Subdued Onslaught of Hypertension in India The surge of hypertension has emerged as a prevailing contributor to cardiovascular ailments in India, exerting its influence on approximately 30% of the adult population. What is undeniably disquieting is its pivotal role in contributing to nearly 63% of the overall mortalities within the nation, with a substantial 27% ascribed directly to cardiac complications. However, the truly astonishing facet of this dilemma lies in the revelation that an overwhelming 45% of individuals aged 40 to 69 in India grapple with cardiovascular disorders. This pervasive prevalence of hypertension could be likened to a latent time bomb, poised to detonate. Nevertheless, amidst this conundrum, there arises a glimmer of hope - a beacon of potential progress in our quest for healthier hearts. New Insight: The Burden of Economic Costs Beyond the formidable health challenges posed by hypertension in India, there is an additional layer of concern that often remains obscured. The economic toll imposed by this silent epidemic is substantial. A study conducted by the Indian Heart Association estimated that the direct and indirect costs of treating hypertension in India amounted to a staggering 30 billion dollars annually. These costs encompass medical expenses, lost productivity, and the financial burden on families affected by hypertension-related complications. Thus, in our pursuit of mitigating the effects of hypertension, we are also confronted with the imperative need to alleviate its profound economic impact. NMN: A Ray of Hope for Hypertension Patients A recent study published in Signal Transduction and Target Therapy has set the scientific community buzzing with excitement. Led by Tao and associates from the First Affiliated Hospital of Sun Yat-sen University in China, this investigation has elucidated the promise of Nicotinamide Mononucleotide (NMN) as a paradigm-shifting remedy for hypertension. Unveiling the Power of NMN The researchers began by studying 19 adults aged 18 to 80, all dealing with mild hypertension. These individuals underwent lifestyle changes, including adopting a low-salt, high-fiber diet and engaging in regular aerobic exercise. However, the real breakthrough came when nine of them supplemented their lifestyle changes with 800 mg of NMN daily for six weeks, while the remaining 10 participants relied solely on lifestyle modifications. The results were nothing short of astounding. The group taking NMN showed a significant drop in systolic blood pressure, a crucial indicator of hypertensive blood pressure. This discovery suggests that NMN can genuinely help lower blood pressure in people with hypertension. Unlocking the NAD+ Connection To unravel the underlying mechanisms at play, Tao and colleagues delved deep into the world of cellular biology. They uncovered that hypertension patients had significantly lower levels of blood cell NAD+ compared to healthy adults. However, when NMN was introduced alongside lifestyle changes, NAD+ levels in hypertensive patients shot up by approximately 43%. This incredible finding indicates that NMN might have the potential to restore NAD+ levels in hypertension patients. But the story doesn't end there. The researchers also explored the role of the NAD+ consuming enzyme CD38 in endothelial cells. Surprisingly, they found that CD38 levels were over twice as high in hypertension patients compared to their healthy counterparts. This increased CD38 activity appears to be a contributing factor to the lower NAD+ levels in hypertension patients. Consequently, inhibiting CD38 could be a promising avenue for increasing NAD+ levels and mitigating high blood pressure. A New Dawn for Hypertension Treatment In the words of Tao and colleagues, "Hypertension is recognized as an age-related disease, and NAD+ supplementation may be a promising clinical strategy as an aging-targeted intervention for hypertension." This study presents the first human trial evidence showing that NMN can effectively lower blood pressure in patients with hypertension. Furthermore, it sheds light on the previously unexplored connection between falling NAD+ levels and hypertension. The implications of this research are profound. NMN, known for its safety profile, may hold the key to transforming hypertension treatment. Additionally, the study suggests that CD38 inhibitors, like the pharmaceutical agent 78c, could play a pivotal role in hypertension management in the future, although they are currently available only for laboratory use. As we grapple with the increasing surge of hypertension in India and globally, the research carried out by Tao and colleagues presents a glimmer of optimism. The potential of NMN to diminish blood pressure and reinstate NAD+ levels in individuals with hypertension is a hopeful stride towards more efficient treatments. While additional investigation is essential, these discoveries have unveiled fresh pathways for addressing this silent threat and enhancing the well-being of millions. In conclusion, elevated blood pressure poses a critical health concern in India, impacting individuals across all age brackets, including the younger generation. The pioneering exploration into NMN's influence on hypertension sparks a glint of optimism for superior hypertension management. With sustained research and inventive solutions, we stand at the brink of a new era in the battle against hypertension, with the potential to save numerous lives.
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NMN vs NR: Scientists Rejuvenate COVID-19 Infected Cells
Understanding the Role of NAD+ and NO in COVID-19 Cardiovascular Risks In the wake of the COVID-19 pandemic, the world has been grappling with the virus's lingering impact on survivors. One particularly concerning trend that has emerged is the increased risk of cardiovascular disease (CVD) among COVID-19 survivors. Recent research from the University of Colorado Boulder sheds light on this issue and offers a potential solution – replenishing NAD+. The Cardiovascular Connection COVID-19 has evolved into one of the leading causes of death worldwide. What's intriguing, however, is the link between COVID-19 severity and the subsequent risk of cardiovascular disease. This link became the focus of a study conducted by Freeberg and colleagues, as reported in Nitric Oxide. While India's medical research body, the Indian Council of Medical Research (ICMR), continues to investigate the connections between heart attacks and both COVID recovery and vaccination, international studies have been yielding noteworthy insights. These studies suggest a concrete association between COVID-19 and a heightened likelihood of heart attacks. Even individuals who experience a less severe COVID-19 infection and recover may face increased prospects of developing heart-related issues or encountering early-onset cardiovascular challenges. A study based in Italy, for instance, highlights the alarming risk of acute myocardial infarction, which was found to be 93 percent higher among COVID-19-recovered individuals when compared to the general population. Furthermore, even those who had experienced mild forms of the disease seem to remain at an elevated risk of heart problems up to a year after their initial infection, as indicated by one of the largest investigations into the long-term cardiovascular consequences of COVID-19. These findings underscore the importance of comprehending the potential impacts of the virus on heart health, even in cases where the infection is relatively mild. The severity of COVID-19 infection correlates with a higher risk of cardiovascular complications. To investigate this connection, researchers examined the effect of the virus on human aorta endothelial cells (HAECs), the innermost layer of the body's largest artery, the aorta. These cells play a pivotal role in producing nitric oxide (NO), a critical signaling molecule that dilates blood vessels. The Oxidative Stress Dilemma Upon infecting HAECs with the SARS-CoV-2 virus, researchers observed a concerning phenomenon. COVID-19-infected HAECs displayed elevated levels of reactive oxygen species (ROS), which are known to cause cellular damage – a condition referred to as oxidative stress. Additionally, these infected cells produced less NO and had reduced levels of NAD+, a coenzyme involved in various cellular processes. The key takeaway here is that low NAD+ levels are closely associated with blood vessel dysfunction in the context of COVID-19 infection. NAD+ Precursors to the Rescue In their quest to rejuvenate COVID-19-affected HAECs, Freeberg and colleagues turned to NAD+ precursors. Specifically, they treated these cells with nicotinamide riboside (NR), a compound that boosts NAD+ levels. The results were promising – NR successfully restored NO and ROS levels to normal. This suggests that NR has the potential to rejuvenate COVID-19-affected HAECs. However, NR wasn't the only contender in this fight. Another NAD+ precursor, nicotinamide mononucleotide (NMN), was also put to the test. NMN exhibited remarkable results, almost completely restoring NO production to normal levels and significantly reducing ROS production. The implication is clear: NMN can rejuvenate COVID-19-affected HAECs just as effectively as NR. A Promising Approach for Cardiovascular Health In summary, the findings of Freeberg and colleagues open a promising avenue in the battle against COVID-19-related cardiovascular risks. Replenishing NAD+ through precursors like NR and NMN can effectively combat oxidative stress and the depletion of NO in COVID-19-affected HAECs. This, in turn, may help prevent cardiovascular dysfunction and disease in survivors of the virus. NMN's Unique Potential A separate study highlighted the remarkable capabilities of NMN. Not only did NMN reduce ROS levels in human endothelial cells, but it also addressed senescence, a pro-inflammatory state associated with aging. This suggests that NMN might have broader health benefits beyond COVID-19-related concerns. NMN vs. NR: The Ongoing Debate The question remains: is NMN or NR the superior NAD+ precursor? While NMN came very close to restoring NO levels to normal, statistical differences were noted. This discrepancy could be attributed to the number of cells tested for each precursor. More cells were treated with NMN, potentially resulting in more statistically accurate results. Comparative studies between NMN and NR in humans are still relatively scarce. However, some research has suggested similar metabolic improvements with both compounds in healthy adults. Bryan Johnson's walking longevity experiment also yielded comparable results for NMN and NR. Until more studies emerge to definitively compare these NAD+ precursors, it's premature to conclude that one is superior to the other. In conclusion, the intricate dance between NAD+ and NO, alongside the havoc wreaked by ROS in human artery cells infected with SARS-CoV-2, unveils a profound story of cellular resilience. NR, acting as a shield, steps in to thwart the loss of NO production and the surge in ROS levels, effectively combating oxidative stress. Meanwhile, NMN takes on the role of a vigilant guardian, preventing the dangerous elevation of ROS and almost single-handedly rescuing NO production from its COVID-19-induced decline. These revelations not only offer a glimmer of hope in the fight against COVID-19-related cardiovascular complications but also shed light on a broader path toward fortifying our cardiovascular health in the face of viral adversaries.
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Latest Japanese Clinical Study Demonstrates NMN’s Insulin-Promoting Effect
In recent years, scientific research has been shedding light on the potential health benefits of NMN (nicotinamide mononucleotide) supplementation. From improved metabolic, cardiovascular, and neurological health to enhanced physical performance, NMN has captured the attention of health enthusiasts and researchers alike. Among those exploring its impact, Uchiyama and colleagues from Osaka University in Japan have made significant strides in unraveling the effects of NMN on human metabolism. In their groundbreaking study published in Clinical Nutrition ESPEN, they revealed some intriguing findings that could pave the way for better health management and even diabetes prevention. NMN and Insulin: A Vital Connection Insulin, a hormone responsible for regulating blood sugar levels, plays a pivotal role in our overall health. The researchers began their investigation by measuring insulin levels in blood serum, which was done after removing clotting factors to get a clearer picture. At the start of the research, the scientists examined the average amount of insulin present in the blood, which was measured at 6.95 microunits per milliliter (µIU/mL). To better understand what a microunit (µIU) represents, let's delve into the concept:A microunit, denoted by µIU, is a tiny unit used in medical measurements to express the concentration of certain substances in the body. In this case, it refers to the concentration of insulin, a vital hormone that helps regulate the levels of sugar (glucose) in our blood.Remarkably, after two months of NMN supplementation at a modest dose of 250 mg daily, insulin levels skyrocketed fivefold to 39.2 µIU/mL. However, it's important to note that insulin levels gradually tapered off to 28.1 µIU/mL by the third month of NMN intake. This intriguing discovery suggested that NMN could positively influence insulin levels, especially after meals when blood glucose levels rise. Boosting NAD+ Levels for Improved Metabolic Health Another exciting aspect of the study focused on NAD+ levels, a coenzyme critical for various cellular processes. NMN has been linked to increased NAD+ levels, and the researchers sought to confirm this effect in human subjects. Over the course of the study, blood plasma NAD+ levels increased over fivefold after just one month of NMN supplementation. However, as the supplementation continued for two and three months, the NAD+ levels showed signs of tapering off. This suggests that NMN could be instrumental in raising NAD+ levels, but the impact might wane over prolonged usage. NMN Concentrations and Individual Variations Interestingly, the researchers delved into the dynamics of NMN concentrations within the blood plasma. They discovered that NMN levels more than doubled during the NMN supplementation regimen but returned to baseline levels a month after discontinuation. Additionally, they observed considerable variations in NMN absorption across the study's participants. This individual variability indicates that some individuals might benefit more from NMN supplementation than others. Moreover, an intriguing discovery emerged from the study regarding NMN concentrations in the bloodstream. The researchers observed that NMN levels were notably higher in the plasma, which is the liquid component of blood without blood cells, as compared to the concentration found in whole blood. This finding indicates that blood cells may play a significant role in metabolizing NMN, possibly accounting for the disparity in concentrations between plasma and whole blood. A Pathway to Prevent Diabetes One of the most significant implications of the study's findings lies in the potential of NMN to prevent diabetes, a metabolic condition characterized by low insulin and insulin insensitivity. The substantial increase in postprandial (after a meal) insulin levels with NMN supplementation could be a key mechanism in improving insulin sensitivity, particularly in prediabetic individuals. By fostering better insulin utilization, NMN holds promise as a preventive measure against diabetes.The study conducted by Uchiyama and colleagues highlights the profound impact NMN supplementation can have on metabolic health. From its role in increasing insulin levels and enhancing insulin sensitivity to elevating NAD+ levels for cellular functions, NMN presents an exciting avenue for potential health benefits. Although the current research on NMN supplementation is in its initial phases, the findings from these studies hold great promise and underscore the need for deeper exploration. The profound impact of these discoveries reaches well beyond the scope of the present research, as they possess the potential to revolutionize our perception and approach toward metabolic well-being. Furthermore, they present exciting new possibilities for enhancing overall well-being through innovative approaches.As we navigate the early stages of NMN research, it becomes evident that this compound has the capacity to profoundly impact various aspects of human health. From its demonstrated ability to elevate insulin levels and enhance insulin sensitivity, particularly after meals, to its role in significantly increasing NAD+ concentrations, NMN emerges as a potent agent in promoting metabolic health.As we move forward, it is crucial to approach NMN supplementation with caution, understanding that individual responses may vary. Consulting with healthcare professionals and staying informed about the latest research will be essential in harnessing the full potential of NMN for our health and longevity. Through continuous research and a more profound comprehension of its impacts, NMN has the capacity to truly transform the manner in which we tackle metabolic health, forging a path toward a healthier and more dynamic future for everyone.
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Newest Study Indicates NMN Reduces Inflammation and Restores Cognitive Function
Our immune system, the shield that protects us from infections, is a marvel of nature. It tirelessly battles pathogens, keeping us healthy and safe. Yet, sometimes, this protective mechanism can become overly zealous or unbalanced, mistakenly attacking our own organs, and leading to severe damage. Even our precious brain, the core of our identity and intelligence, is not immune to these potential hazards. When inflammation takes over the brain, it can cause cognitive impairments, affecting our memory and learning abilities.But hold on to hope! In a groundbreaking research discovery from the Naval Medical University in China, scientists have unearthed a remarkable solution to combat this memory-hindering brain inflammation. Meet NMN (nicotinamide mononucleotide), an extraordinary compound showing great promise in counteracting brain inflammation and enhancing cognitive function. The Connection Between NMN and Brain Inflammation Published in the esteemed scientific journal Redox Biology, a study led by Li and colleagues delved into the interplay between NMN and the immune system's inflammatory response. The researchers unveiled NMN's ability to activate a critical enzyme called SIRT1, playing a pivotal role in regulating the immune system's response to inflammation and oxidative stress.In a series of experiments on mice afflicted with a life-threatening infection known as sepsis, the team observed that NMN brought about increased levels of NAD+ and SIRT1 in a crucial brain region called the hippocampus. This finding is of paramount importance as the hippocampus governs memory and learning processes. Putting NMN to the Test To gauge the cognitive abilities of the septic mice, the scientists employed the Morris water maze test. In this challenging test, the infected mice faced navigation hurdles, exhibiting memory deficits by taking longer to find an escape platform and making more errors compared to their healthy counterparts. Yet, when NMN was administered to the septic mice, their cognitive performance underwent a remarkable improvement, indicating NMN's potential to enhance cognition. NMN: Easing Inflammation and Oxidative Stress Delving deeper into NMN's effects on the septic mice's cognition, the researchers examined inflammation and oxidative stress levels in the hippocampus. Oxidative stress arises when harmful reactive oxygen species (ROS) accumulate, causing damage to cellular components like proteins, lipids, and DNA. Importantly, inflammation is a known trigger of oxidative stress.In the septic mice, the hippocampus showed elevated levels of proinflammatory molecules, including the notorious IL-6, alongside ROS. Nevertheless, NMN administration led to a significant reduction in both inflammatory molecules and ROS, highlighting NMN's prowess in effectively countering inflammation and oxidative stress in the brain. SIRT1: The Longevity-Boosting Enzyme Aiding NMN's potent effects, SIRT1 acts like an engine fueled by a molecule called NAD+. Sufficient NAD+ supply, generated through NMN metabolism, sets SIRT1 in motion, initiating a cascade of processes associated with longevity and overall health. Interestingly, previous studies have demonstrated that over-activating SIRT1 in the brain can extend the lifespan of mice.To solidify the connection between NMN and SIRT1 in alleviating brain inflammation, the researchers performed additional experiments by blocking SIRT1 using a specific drug. The results were clear: inhibiting SIRT1 undermined NMN's cognitive-enhancing, anti-oxidative, and anti-inflammatory effects in the septic mice, underscoring that NMN's benefits stem from its activation of SIRT1. NMN is a Potent Anti-Inflammatory Agent The impact of this research extends beyond sepsis-induced inflammation, with NMN demonstrating potential in various inflammation-related conditions, including aging and chronic diseases such as neurodegenerative and cardiovascular disorders. Inflammation can be triggered by factors like injury, aging, and even certain foods or environmental toxins.NMN's positive influence goes beyond the brain, as it exhibits anti-inflammatory properties in other organs like the skin, gut, lungs, and fat tissue, as seen in animal studies. NMN's activation of SIRT1 and subsequent increase in NAD+ levels enhance the health of cellular powerhouses known as mitochondria, reducing harmful ROS production. Additionally, elevated NAD+ levels in immune cells contribute to restoring balance in a dysregulated immune system, effectively reducing inflammation.The exciting discoveries emerging from the Naval Medical University's research shed a beacon of light on NMN's immense potential in combating brain inflammation and enhancing cognitive function. This extraordinary compound, through its activation of the longevity-promoting enzyme SIRT1, offers a promising path toward addressing inflammation-induced memory impairments.The wonders of NMN extend far beyond the brain, presenting a holistic impact on overall health by taming inflammation in multiple organs. As researchers continue their journey, we might witness NMN emerging as a powerful ally in the battle against inflammation-related health challenges, fostering hope for a brighter future of improved cognitive function and enhanced well-being. Let us remain eager as the quest for better brain health and longevity unfolds before our eyes.
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