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Why NMN is Called the Miracle Molecule for Aging
Introduction Nicotinamide Mononucleotide is a compound that can be used to make NAD+ - think of NAD+ as the energy currency of the mitochondria, much like how ATP is the cellular currency to get things done otherwise. We have all learnt by rote the phrase- ‘mitochondria is the powerhouse of the cell’, but what powers the mitochondria in turn? It is NAD+! Reserves of this compound begin to drop sharply once we hit our 30s. This is also when we notice more body aches and pains, more fatigue, brain fog and think that ‘Ah, I’m getting old, aren’t I?’ This could not be farther from the truth because if cells get enough energy, you will be back on top of everything at the end of a long day or work and everything else in between. How can you do that? By supplementing with NMN, duh! How NMN Slows Down The Aging Process Nicotinamide mononucleotide (NMN) has been known for a long while now since it was first discovered in 1963. Some more research then showed that this compound was super effective in activating the PARPs - which are polymerases responsible for DNA replication and ensuring integrity of the process itself. More recent research has shown that NMN is a good NAD+ precursor- which means it acts as a resource for cells to make more NAD+. With more NAD+ within cells, there is better control of cellular processes and DNA repair. In 2014, Dr. David Sinclair, a well known Australian researcher showed that regular supplementation with NMN on mice models lead to an increase in lifespan by reversing damage to DNA. The compound also helps reduce inflammation and improve blood circulation. Scientific research on NMN and aging has shown that NMN is made from vitamin B precursor molecules. It was found that NMN needed to be converted to another compound called NR - nicotinamide riboside for it to enter cells with ease. But, now scientists know that another receptor specific for NMN is coded for by the Slc12a8 gene. It is now known that NMN helps improve mitochondrial function in cells, which in turn means more cellular energy for all other activities to take place. The reduction in NAD+ by itself is a symptom of aging, but it also drives the aging process. The main pathway it helps activate is the sirtuins - key proteins which help keep cells safe from stress and other issues like inflammation and chronic illnesses. It helps improve heart and circulatory health, and NMN has shown some promise in treating heart failure too. Taking NMN helps in managing the well known hallmarks of aging- loss of lysosome activity, decreased autophagy, lipid peroxidation, decreasing chronic inflammation and improving brain and metabolic health. How To Use NMN For Anti-Aging Benefits? Simple! You need to begin supplementing with NMN on a daily basis. You can start with the lowest dose- maybe 250-500 mg once per day and then build it up to 1000 mg per day after a month of consistent use, provided you don’t notice any weird side effects. Gataca makes the best NMN supplements for anti-aging. All the ingredients used to formulate are vegan and GMT certified and the active ingredient that goes into making these supplements is at a 99.9% purity. Conclusion Nicotinamide mononucleotide is going to be a great buddy and help you achieve all the health goals you have in mind. Keep in mind though that NMN on its own will not work miracles, but will definitely help you a lot if you pay attention to your lifestyle, what you eat, learn different ways to reduce stress and get enough sleep. Animal studies have shown great results with NMN supplementation and clinical trials are now being done with NMN on healthy human volunteers to ascertain how helpful it could be for human use. While the FDA has banned NMN in the US and other regulatory organisations have followed suit, it is still available in India. Try it first, before you go dismissing NMN as another wonder pill which won’t really work for you. FAQs 1. What is NMN, and why is it called the 'miracle molecule' for aging? Nicotinamide mononucleotide is an NAD+ precursor, which means it is a starting material for NAD+ production. Since levels decrease naturally with advancing age, supplementing helps improve mitochondrial and cellular health over all- reducing aging related issues. 2. How does NMN work in the body to combat aging? Supplementing with NMN regularly can help cells repair themselves better and combat damage, increase NAD+ levels, markedly improve mitochondrial function and overall cellular health respectively. DNA damage is especially reduced due to the activation of important proteins called sirtuins. 3. What is the recommended dosage of NMN for anti-aging benefits? Research has shown that you can start taking NMN from 250 mg - 1000 mg per day, but not more than that. Higher amounts are not necessarily beneficial and may induce a lot of unwanted side effects too. To be safe, always begin with the lowest dose possible for the first month and then gradually increase as needed. 4. Are there any side effects associated with NMN supplementation? Some people may have to deal with headaches, nausea or diarrhoea, but in general, NMN is a very well tolerated supplement. It is important to stick to the right dosage to reduce the probability of having to deal with these side effects. 5. Who should consider taking NMN supplements? People who suffer from low energy levels, have brain fog or fatigue and want to improve their chances of aging healthily- these are the folks that sh0uld try NMN supplements. The ideal age group is above 30 years of age.
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What Happens to NAD+ After 30 and Why NMN Matters More Than Ever
What Happens To NAD+ Levels After 30? Okay, picture this: NAD+ is like the unsung stagehand at a big Bollywood production and it’s behind the curtains making sure the lights work, the actors don’t trip over the wires and the director’s chai is always hot. Now imagine after you turn 30, that stagehand starts skipping work more often when suddenly people forget their lines and the whole show feels a little off. That’s your body without optimal NAD+ levels. Scientifically speaking, NAD+ (short for nicotinamide adenine dinucleotide, a crucial coenzyme) begins to dip by as much as 65% by the age of 30-70 (Yikes!) which means less energy at a cellular level, sluggish DNA repair and a slower metabolism. Your mitochondria - the tiny engines of your cells, suddenly start running like old scooters instead of brand-new sports bikes. You’re still you, but just with a lot less vroom. Why NMN Is Important After Age 30 Enter NMN, or nicotinamide mononucleotide, which is basically the upgrade your cells didn’t know they needed. After 30, fuel levels drop. NMN swoops in like a premium fuel delivery service, topping up the tanks before things go off schedule. NMN acts as a precursor to NAD+, which means it helps your body produce more of this life-supporting molecule naturally and instead of patchy energy and slow recovery after a stressful day (or a killer HIIT session), your cells get the resources they need to function optimally. This obviously translates to better metabolic health, more consistent energy, faster recovery and even greater support for brain function overall. Signs Of NAD+ Deficiency In Adults Now, how do you even know if your NAD+ levels are waving the white flag? While you can get fancy lab tests, your body drops hints that are hard to ignore. Firstly, that unshakable fatigue despite mainlining three cups of filter coffee by noon? Classic sign. Then there’s the slower muscle recovery after a workout. It feels like you need a personal physio just to get off the sofa. Add to that a tendency to pick up every cold going around the office and a growing waistline despite no major changes in diet. Oh, and the new wrinkle that popped up overnight? That’s your skin telling you cellular repair isn’t what it used to be. NMN Supplements Benefits After 30 For starters, energy production improves at a cellular level and your mitochondria begin to function more efficiently, which means you don’t feel like your limbs are full of sand by 4 pm. Recovery from workouts or long days at work also speeds up dramatically because your cells have the resources to repair themselves faster and that translates to less muscle soreness and better resilience overall. Then there’s the impact on brain health. NAD+ is deeply involved in cognitive function, so better levels can mean sharper focus and memory. Your metabolism also gets a much-needed reboot. Think better fat utilisation and more stable blood sugar levels, which is pretty much the holy grail for anyone who wants to maintain a healthy weight without endless crash diets. Conclusion Here’s the thing, turning 30 isn’t some grand announcement that your energy and ambitions have packed their bags and left the building. It’s more like your body quietly tapping you on the shoulder and whispering that it might be time to give the engine room a little extra love, and when you choose to support your natural NAD+ production with NMN you’re essentially slipping your cells the tools they’ve been craving to fire on all cylinders again. NMN surely is NOT some magic bullet promising immortality but it is easily one of the most studied and genuinely promising ways to keep your energy, recovery and overall health humming as the years go by. FAQs 1. What is NAD+, and why is it important after age 30? NAD+ is a coenzyme found in every cell of your body and is essential for energy production, DNA repair and metabolism. After age 30, natural levels decline, which can lead to fatigue, slower recovery and accelerated ageing. Maintaining healthy NAD+ levels supports better energy and resilience. 2. Does NAD+ production really decline with age? Yes. Studies show NAD+ levels start to dip by your late twenties and can fall by up to 50 percent by mid-life. This decline impacts energy production and cellular health. Supporting your body’s NAD+ levels through lifestyle or supplements becomes more important after 30. 3. How does low NAD+ affect your body and energy levels? Low NAD+ can lead to constant fatigue, slower muscle recovery, brain fog, weakened immunity and even early signs of aging. Because NAD+ is vital for energy at a cellular level, its decline can affect nearly every aspect of physical and cognitive performance. 4. Can NMN supplements help restore NAD+ levels? Yes. NMN is a precursor to NAD+ and helps the body increase its natural levels. Consistent NMN supplementation may improve energy, metabolism, brain function and cellular repair, making it especially useful after 30 when natural NAD+ production begins to decline. 5. Is NMN safe to take after 30 for long-term health? Current research suggests NMN is safe for healthy adults when taken in recommended doses. It’s well tolerated, and since it supports natural processes in your body, it’s suitable for long-term use. Always consult your doctor before adding any supplement to your routine.
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The First Signs of Cellular Fatigue
Signs Of Cellular Fatigue There’s a kind of tiredness that doesn’t look like droopy eyelids or dramatic yawns, but rather feels like your body is wrapped in heavy fog and your mind is trudging through wet cement. And what makes it worse is the fact that you’re doing everything by the book- you sleep your full eight hours, you drink your water, you take your vitamins, you even pretend to enjoy meditation, yet somehow, you still wake up exhausted, wondering if your soul snuck out in the middle of the night and forgot to return. This isn’t your average fatigue that a nap or a weekend off can solve. This is cellular exhaustion. This is your mitochondria, those tiny little powerhouses inside your cells, quietly waving a white flag. How Chronic Stress Affects Cellular Health Picture your cells as tiny factories that are supposed to hum quietly and efficiently in the background, producing energy, repairing tissues, balancing hormones, and doing about a thousand other things without complaint. Now imagine you’ve flooded those factories with chaos. You’ve pulled out the wiring, overworked the machinery, fired the maintenance crew, and told them to “just keep going” while also cutting their supply chain and yelling at them through your thoughts. That’s what chronic stress does. It doesn’t just live in your mind. It floods your bloodstream with cortisol and adrenaline, messes with your blood sugar levels, disrupts your sleep cycle, and hijacks your immune system. Your poor mitochondria- those tiny energy producers- are left trying to function in a war zone. Over time, this stress wears down the very systems designed to keep you vibrant. Your digestion suffers. Your hormones misfire. Your brain slows down. How To Fix Cellular Fatigue It starts with sleep, and not just sleep that involves closing your eyes while doom-scrolling until your phone falls on your face, but actual deep, uninterrupted, circadian-respecting, melatonin-supported sleep that lets your brain clean itself out and your body recharge. You need to make bedtime sacred. Not optional. Not occasional. But definitely non-negotiable. Then there’s movement- not punishment, not panic-fuelled burpees, but calm, steady, mitochondria-loving exercise like zone 2 cardio or strength training. These aren’t just for aesthetics. They’re for metabolic resilience. They help your cells learn how to burn fat for fuel, build muscle, regulate blood sugar, and keep your mood in check. You’re not training for a six-pack. You’re training for long-lasting energy that doesn’t crash halfway through your to-do list. Cell Health Support Supplements are not magic pills, but they can be wonderful co-pilots when used with intention. When you’ve pushed your body to its limits, sometimes it needs a bit of targeted reinforcement, especially when food alone can’t keep up with the demands of modern living and the endless stressors that deplete your nutrient bank faster than you can refill it. Start with magnesium. It’s the mineral responsible for hundreds of cellular processes, and yet most people are deficient without even knowing it. It helps you sleep better, keeps blood sugar stable, calms an overactive nervous system, and smooths out that edgy, twitchy feeling that makes you want to cancel everything and live in a cave. And then there’s CoQ10- the quiet hero of the cellular world. It supports energy production directly at the mitochondrial level, and if you’ve been on medications like statins, or under prolonged stress, chances are your levels have quietly dipped. Supplementing with CoQ10 is like sending a power boost directly into your energy factories and asking them to please, kindly, turn the lights back on. Conclusion Your body wants to heal. Your cells are astonishingly resilient when given half a chance. You don’t need a full life overhaul. You just need to start paying attention - to the sleep you skip, the meals you rush and the stress you ignore. These are the signals that your body sends and you politely pretend not to hear. Vitality isn’t about perfection. It’s about presence. About creating the space where your biology can breathe again. You don’t have to keep dragging yourself through each week. You can restore, repair and reclaim your day. Because your energy isn’t gone. It’s just buried. And with the right support, it can come roaring back to life! FAQs- 1. What is the first site of fatigue in the body? Usually, the first signs of fatigue show up in the muscles and the brain. You may notice slower reaction times, heavy limbs, and difficulty concentrating. These subtle cues often appear before more noticeable physical exhaustion sets in. 2. What causes fatigue on a cellular level? At the cellular level, fatigue is caused by reduced mitochondrial function, which leads to decreased ATP (energy) production. Factors like chronic stress, poor nutrition, lack of sleep, and toxin exposure can impair these energy-producing organelles. 3. What is cellular fatigue? Cellular fatigue refers to a state where your cells can no longer produce energy efficiently. This can affect how your muscles function, how your brain processes information, and how your entire body recovers from stress or exertion. 4. What causes cells to lose energy over time? Cells lose energy due to age, oxidative stress, nutrient deficiencies, poor lifestyle habits, and inflammation. Mitochondrial damage builds up over time, especially without sufficient rest and nutritional support. 5. How can I tell if my mitochondria are underperforming? You may feel tired even after resting, experience brain fog, crave sugar for quick energy, notice slow exercise recovery, and fall sick frequently. These are all possible indicators of mitochondrial underperformance.
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FDA Re-Establishes NMN As A Dietary Supplement
In a landmark decision in September 2025, the U.S. Food and Drug Administration (FDA) officially removed restrictions on NMN (Nicotinamide Mononucleotide), restoring its status as a legal dietary supplement. This marks the end of a three-year regulatory saga that has shaped the future of NMN in the wellness and longevity industry. The journey began in May 2022, when the FDA approved NMN as a New Dietary Ingredient (NDI), paving the way for its legal sale as a dietary supplement. This was a significant moment for companies and consumers interested in NMN’s potential benefits for energy, metabolism, and healthy aging. However, in November 2022, the FDA reversed its stance. It ruled that NMN could not be sold as a supplement because it was under investigation as a pharmaceutical drug. This decision was based on the “drug preclusion” clause, which gives investigational drugs regulatory priority over supplements. The sudden restriction disrupted the NMN market and drew criticism from both industry stakeholders and consumers. In March 2023, the Natural Products Association (NPA) filed a formal petition urging the FDA to lift these restrictions, arguing that NMN had been marketed as a supplement well before drug investigations began. When this did not yield results, the NPA escalated the matter by filing a lawsuit in August 2024 against the FDA. Mounting public and legal pressure led the FDA to pause enforcement in October 2024, allowing NMN products back on shelves. Finally, in September 2025, the FDA permanently lifted its restrictions, marking a decisive victory for the supplement industry and NMN consumers. This resolution brings clarity to NMN’s regulatory status and paves the way for broader access and innovation in the longevity space.
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What to Stack With NMN for Results?
NMN Dosage by Weight Unlike a one-size-fits-all pill, NMN dosing requires a little more thought, because body weight, age, and lifestyle can influence how much is enough. While human trials have tested doses ranging from 250 mg to 1200 mg daily without major safety concerns, most experts now suggest a sweet spot of 500 mg to 1000 mg for those seeking longevity benefits, and here is where personal context matters the most. A person weighing 55 kg who leads a moderately active life may respond well to 400 or 500 mg, whereas someone closer to 75 or 80 kg, or someone dealing with higher oxidative stress from pollution, late nights, or metabolic concerns, might benefit from 800 mg or even 1000 mg per day. Should NMN Be Taken With Food? Picture NMN as a sprinter primed for the starting blocks- on an empty stomach it can dash straight into circulation, somewhat like an express train, quietly raising NAD+ levels without digestive friction, yet in the Indian context where every morning has its own culinary choreography of chai or coffee, paratha or pesarattu, and gentle spicing, sometimes a light breakfast or a smear of ghee gives the stomach what it needs to hold steady while NMN carries out its cellular mission. So the real trick is personalised timing: try it before the first sip of tea and see how your energy hums, or take it with your breakfast to see if your tummy prefers a softer drop. Best Supplements to Stack With NMN for Longevity NMN is the soloist, but the best routines are orchestras- and when it comes to longevity, several supporting agents help NMN shine: Resveratrol - the famed longevity polyphenol, activates sirtuins and makes NMN- driven NAD+ work harder and smarter; Quercetin and Fisetin - natural flavonoids from foods like onions and strawberries act as cleanup crew, clearing out cellular debris so NMN can dispatch maintenance crews more efficiently; Curcumin- a potent antioxidant and anti-inflammatory star found in turmeric, supports NAD+ pathways and soothes the body’s internal rhythm. NMN Stack for Boosting NAD+ Naturally Supplements may start the conversation, but your lifestyle writes the main story; elevating NAD+ requires habitual harmony: intermittent fasting- common in Indian households when meals run late or breakfast is delayed- naturally raises NAD+ and makes NMN’s impact smoother; daily movement- whether temple-going walks or yoga salutations- activates mitochondrial function; sleep aligned with your inner clock, resisting the urge for late-night screen binges - these activities ensure that NAD+ cycles in sync with natural rhythms. Lastly, it makes sense to eat NAD+ buddies like beans, avocado, broccoli, and leafy greens to support coenzyme synthesis overall, in the body. Conclusion Stacking NMN is not about complexity or chasing the most expensive bottle- it’s about thoughtful companionship and chemistry: NMN leads the NAD+ charge, while resveratrol, antioxidants, and supportive foods create a welcoming environment. Your lifestyle meanwhile- (fasting, movement, sleep, diet), is the conductor that ensures everything comes together in rhythm. So, start gently, feel deeply, and refine continuously, because aging gracefully is a dance, not a sprint, and NMN deserves to move with elegance, balance, and a touch of some very well known Indian sensibility. FAQs- 1.What to mix NMN powder with? The simplest option is water, as it ensures quick absorption, but many prefer to mix NMN powder into juices such as orange or amla to mask its slightly bitter taste. The key is to avoid very hot drinks, since heat may degrade NMN. 2.Can you take NMN and glutathione together? Yes, NMN and glutathione complement one another beautifully, because while NMN boosts NAD+ to improve energy metabolism and repair pathways, glutathione acts as a master antioxidant, clearing cellular waste and oxidative stress. Together they strengthen immunity, slow visible aging, and support skin clarity. 3.Can I mix NMN with coffee? You technically can, since NMN is water-soluble and coffee is a common morning ritual, but it is wise to test carefully. Start by taking NMN separately on an empty stomach, then if your system feels comfortable, try combining it with your morning coffee to suit your personal rhythm. 4.Can I take vitamin C with NMN? Absolutely, vitamin C adds an extra layer of defence by reducing oxidative stress, supporting collagen production, and boosting immunity, while NMN enhances NAD+ to fuel cellular repair. This combination is particularly useful for skin health and overall vitality, acting like a double shield against stressors. Taken together, they work as partners in wellness, and because both are safe and well-tolerated, many Indians include them in their daily stack. 5.Does NMN increase triglycerides? No evidence currently suggests that NMN raises triglycerides. In fact, some studies have shown that NMN may support better metabolic health, improve insulin sensitivity, and help regulate lipid profiles. Elevated triglycerides are often linked to poor diet, lack of exercise, and genetic factors, not to NMN itself.
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Nicotinamide vs. Niacinamide- Two Different Coins Or Are They One And The Same?
Introduction If you are a skincare enthusiast, then hunting for good products that work will take a lot of your time. This is because it was normal for us all to say - ‘I do skincare but my skin does NOT care’. Though it is more of a joke, it is important to understand that not all products work on everyone- and this is exactly illustrated by that skincare and skin DON’T care quote. Among all the options available in the skincare universe, none is more celebrated than niacinamide. Structurally similar to its sibling nicotinamide- both are derivatives of Vitamin B3- and they play different but highly specific roles within the body. These terms may appear more often than you realise in the ingredients list of your favourite skincare products. But, if they are structurally almost the same, why and how are they different? If this question bugs you pretty often, then we are here to help you decide once and for all- that both are good for you. No confusion needed at all! Nicotinamide or Niacinamide- Should I Really Overthink?Yep, totally. This is because structurally they are the same! It is a simple, water-soluble amide of Niacin (Vitamin B3). But with respect to usage for different aspects- the naming changes. When skincare is the point of focus- it is called niacinamide. When longevity and better health are major concerns- it is termed nicotinamide. This compound can be derived from niacin- which is Vitamin B3 (the parent compound). This is why it is important to understand that both niacin and niacinamide are different from each other. Niacin has been used to treat skin conditions like dermatitis or pellagra, from many centuries but an unfortunate side effect is present- excessive flushing of the skin is observed. This is why it is not such a great option for most people. Nicotinamide is a derivative of niacin sure, but it is not often used in skincare products because its role is more tailored to helping cells maintain their metabolism, while also providing them with energy in the form of NAD+ - which is a compound that all cells need to survive and function flawlessly. NAD+ levels plummet when someone gets older- so, it is in the interest of healthcare buffs to try to replenish reserves and to maintain health in the long run. However, it can be used in skincare too, as it will NOT give you the annoying flush. The principle here is that if you improve cellular health, you are improving your appearance and skin texture eventually, Niacinamide is another derivative of Vitamin B3 or niacin but is more commonly used in skincare products because it is oh-so-good for you! It is an excellent compound that will help your skin feel more lush and hydrated, works diligently on fine lines and wrinkles and is also great for treating acne breakouts- as it can calm your skin down due to its anti-inflammatory properties. It also works on dark spots or uneven skin tone and can work on redness and irritation. It helps protect against pollution and damage due to sun exposure as it has anti-oxidative properties. You could try creams or serums with 2-10% of nicotinamide or niacinamide in them. You don’t have to change any part of your skincare routine either, when you use this product, as it is not going to interfere much in any way at all. But, if you go any higher, you risk having to deal with unpleasant side effects like irritation. Another major positive with niacinamide is it is NOT like retinoids- which means it can be used during pregnancy or while breastfeeding too. Don’t Worry, It Is All Good For You! As we mentioned before, the different names may seem a little confusing, but you don’t need to overthink at all. This Vitamin B3 derivative is good for sensitive skin and can help retain or improve the skin barrier function, because of its pronounced anti-inflammatory and anti-oxidative properties. Be confident when you see ingredient labels with different terms.They will offer the same benefits as niacinamide containing products - because remember this- they are literally the SAME! If you are still worried, it makes sense to get serums or products that have a low percentage of the active ingredient present in them- like 2% which is the lowest. You can slowly build it up to 5 and 10% later, if you notice good results. Conclusion Niacinamide or nicotinamide is a celebrated ingredient in the skincare universe as it can help with a variety of concerns- like fine lines, wrinkles, hyperpigmentation, acne, and hydration, while strengthening the skin barrier by reinforcing collagen production. Thousand’s of studies have shown how efficient nicotinamide is for skincare- plus it does NOT give you the dreaded niacin flush just like its sibling niacinamide. It is not nicotinamide’s fault that it is used for other aspects of healthcare right? So, the next time you see a good deal on a nicotinamide based product, why don’t you try it out and see the goodness for yourself? Let us know if you loved it, liked it, hated it or just couldn’t be bothered with it- with some constructive feedback here! FAQs1. Is niacinamide the same as nicotinamide?Yes, they are the same type of Vitamin B3 derivative with different names. Niacinamide has been used in popular culture for skincare, while nicotinamide is used when the same vitamin is used for health and longevity related needs. 2. Is niacinamide a form of vitamin B3?Yes, they are the same- derived from Vitamin B3 or niacin. It is a versatile molecule that finds use in many sectors- skincare and healthcare especially. It is easily found in fruits and vegetables and animal based products, but when applied topically or taken as supplements in slightly higher percentages, it is very beneficial as it helps cells regain their functionality soon. 3. Does niacinamide cause skin flushing like niacin?Niacin can cause your skin to look red or flushed if applied topically as it is not well tolerated by most folk. But niacinamide has a different structure which makes it easier for your skin to absorb - and it is great for sensitive skin too. 4. Is nicotinamide better than niacin for health benefits?Nicotinamide is better for skin and the eyes as it is easily absorbed, when compared to niacin itself. Since Nicotinamide is needed to make NAD, your body handles it better than niacin alone. 5. Are there any side effects of using niacinamide in skincare?Some people may be allergic to it or react poorly if the active ingredient is present at a high percentage. You can also take it as a capsule - if better health is your goal.
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Can Supplements Really Help You Age Better?
Introduction David Sinclair is a very well known scientist who has been studying all about aging and its intricate mechanisms on the body. He recommends that taking supplements will greatly help you in the fight against aging. But is it really necessary to think of aging as a disease? Every cell has its own time limit etched within the DNA and forcing cells to live forever doesn’t really sound very realistic. However, if we think of aging as a phenomenon which can be controlled if we make the right choices everyday, then what is stopping you from enjoying what you do even after you retire? Let us try to understand why aging is an important part of life and that aging in the right way matters more than just racking up the years. Which Vitamins And Minerals Boost Longevity? Vitamins and minerals are easy to come by in your diet, if you tend to include a lot of variety with respect to fruits, vegetables and protein sources. Whole grains are good carbohydrate sources and they provide you with some vitamins and minerals too. You need all of them for your body to function well, but if longevity is your major health goal, then vitamins and minerals that help reduce oxidative damage and help regulate antiinflammatory pathways are the ones you should go for. Examples include the B group of vitamins, C, E, D, Magnesium, Calcium, iron, iodine, and zinc respectively. How Supplements Can Boost Energy And Slow Aging Aging is a collection of processes that involve damage to DNA, the shortening of the arms of the chromosomes (telomeres), the accumulation of mutations in DNA that cause it to be transcribed in the wrong way and other cellular pathways not working quite like they are supposed to. But, aging is inevitable and the only thing you can do is to try to age better- by ensuring that your cells stay healthy for longer. Making sustainable changes to your daily routine is one sure fire way to go about doing that, but when you do decide to add supplements, do so smartly. Adding those which help you improve energy levels, reduce oxidation and also aid your immune system in regulating inflammation will hence be useful. One sure fire way that works all the time is to go for supplements that mimic calorie restriction like resveratrol and also fasting in real life, few times in a month. Other supplements like epigallocatechin gallate (EGCG), curcumin from turmeric, collagen, CoQ10 which has antioxidant properties, NAD+ precursors and resveratrol have all been studied for their ability to promote healthy aging in cells. Does Taking NAD+ Supplements Help With Aging? NAD+ levels tend to decrease sharply once you are in your 30s. NAD+ is an important molecule that cells need to function well. But, NAD+ cannot be taken as a supplement all by itself because it is a huge molecule that cannot enter cells easily. Taking precursor molecules as supplements makes much more sense as cells like to make NAD+ from scratch- which is why NMN and NR are great options. Conclusion The supplement industry is a huge one with billions being invested into it. While most supplements can be helpful if taken in the right doses at the right times, there is no way they can prevent aging itself from occurring. So, instead of looking for magical solutions which won’t ever work, it is time you start paying attention to your daily routine and the food you eat. Supplements can be an assistive device but should never be used as a crutch for you to get through life. When you do want to include supplements to your routine, make sure you do your research- so you understand how they align with your specific health goals and then talk to your doctor about them. FAQs 1. Do anti-aging supplements actually work?Supplements in general cannot help you stop aging but if you take them, eat proper meals, get enough exercise and focus on getting a night’s sleep, then you are setting yourself up for better health and living for long. 2. Can collagen supplements really reduce wrinkles and improve skin elasticity?Yes, studies have shown that hydration of skin gets better, along with other parameters like elasticity, wrinkling and better texture. Collagen is also good for the muscles and joints. 3. How do NMN and resveratrol help with longevity?Both supplements help in increasing NAD+ levels in the body, which means more sirtuins get activated. SIRT1 is an important protein that helps cells in the body regulate aging, cell death and autophagy related pathways. They can work together and are generally well tolerated by most of the population. 4. Can taking antioxidants reverse signs of aging?Antioxidants in general help reduce DNA damage caused by the production of superoxide molecules- which are normal but toxic byproducts of metabolism. With respect to skin cells, there is an improvement in skin texture, hydration and elasticity and also protect them from damage caused due to sunlight and pollutants. Some common examples include carotenoids or those molecules that are responsible for giving vegetables and fruits their vivid colours, polyphenols and Vitamin C respectively. 5. Are there any risks or side effects of taking anti-aging supplements?You should always talk to your doctor about taking them in the right doses as high amounts can cause issues or interact unnecessarily with drugs you take on a regular basis.
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Why You Need To Care About Sleep Deprivation
IntroductionSleep is a biological imperative for a lot of organisms. Though much about sleep is shrouded in mystery, one thing is clear- it is very restorative and good for the body and the mind. A good night’s sleep can do wonders for tiredness, your lousy mood and help your body recover from a long day at work or school. Sleep is a finely regulated phenomenon- with the production of certain hormones and neurotransmitters that are made at specific times in the day. Melatonin is a very well known molecule that is produced by the pineal gland located deep in your forehead. It uses information from the eyes to check how much light is present and then synthesises melatonin accordingly. More is made at night in the absence of light, when compared to the day. This crucial hormone helps the brain synchronize its internal clock. Glycine is an amino acid that tells the brain to relax, along with GABA. When these molecules are not produced in the right amounts at the right time, you incur a sleep debt. Sleeping poorly can affect you systemically, so let’s look at 4 concerns in detail. How Does Sleep Deprivation Affect The Brain?Pulling all nighters regularly can get you closer to that promotion sooner but it is bad for your brain in the long run. The brain is always active, even when you are asleep- some areas in fact begin to work only when you are in deep sleep. Sleep is necessary for you to form new memories and to help you sharpen your problem solving skills. If you don’t sleep enough, you won’t be able to focus on work and you may not be able to exercise your decision making skills that accurately either. You will also feel annoyed and take that frustration out on others-which means your social skills are also impaired. Can Sleep Deprivation Lead To Poor Immunity?Yes, high levels of stress hormones can lead to greater chronic inflammation in the body. The immune system has to work overtime to take care of you in this case. This situation gets markedly worse when you don’t sleep enough. Can Sleep Deprivation Cause High Blood Pressure?Dealing with sleepless nights can leave you feeling more stressed than usual. This means you will have way more cortisol than is necessary, which can increase blood pressure. If you are always stressed, then you will probably have to deal with hypertension in the future. How Does Sleep Deprivation Affect Metabolism?Not sleeping at night can mean you will feel hungry at odd hours- more snackage than needed. Your blood glucose levels are not well regulated in such a scenario and this can lead to chronic inflammation. This is also how diabetes may begin. Changes in metabolism can cause the fat cells in your body to behave differently. You may have to deal with a dreaded ‘paunch’ too because your brain processes hunger cues more urgently. More of the ‘hunger’ hormone leptin is made and you don’t feel full as well, even if you have eaten properly. ConclusionThe lack of sleep and its impact on work performance has been well documented in many industries. For some. Loss of sleep is a genuine medical condition, in which case getting it treated immediately must be a priority. Some of you may have issues like sleep apnea, insomnia, eating disorders or may need to work at odd hours. All of this can contribute to massive changes in your daily routine. FAQs1. What are the immediate effects of not getting enough sleep?Your mood may be in the toilet, you can feel super tired and you may not be able to focus on work. Concentration may not be that great, so if you need to keep looking at minute details often, you may miss some. You will be a lot slower when you have to come up with solutions and you may not be able to exercise your decision making skills well. 2. How does sleep deprivation affect brain function and memory?You could forget more than before and you may not be able to process information like normal. Plus, being stressed about not getting enough sleep can ruin your mood for the day and make you feel pretty antisocial too. 3. Can lack of sleep cause weight gain or affect metabolism?Sleep deprivation can mess your hormones up big time, causing you to binge eat or snack at odd hours. Both of these factors need to be well within control and range for you to be able to have a decent metabolism and manage weight. 4. Can lack of sleep contribute to serious conditions like stroke or dementia?Dementia means to forget stuff and not sleeping enough can cause memories to not form properly, or even if they are present, you may not be able to retrieve them at the right time. Stroke risk is also higher in people who don’t sleep enough or sleep too much. So, sleeping just right needs to be on your agenda every night. 5. What are the best ways to recover from sleep debt and improve sleep quality?You should try to be super consistent about bedtime and wake up at the same time too every morning. You should try not to nap, use dim lights in the evening and eat well before sleeping, so you don’t stay up due to a full tummy. For melatonin to be produced, you need to get enough sunlight into your eyes, and try not to use your laptop or phone more than needed.
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Exploring NMN Human Trial Advancements
Unlocking the Potential of NMN: Is it the Anti-Aging Elixir We've Been Waiting For? NMN: The Fountain of Youth or Just Another Fad? In a world obsessed with staying youthful and vibrant, the quest for the elusive elixir of life has led us to some intriguing places. One such destination on this journey is Nicotinamide Mononucleotide (NMN). Over the past three years, NMN has been the subject of extensive human trials, and the results are nothing short of fascinating. These trials have not only confirmed its safety but have also unearthed its potential as an anti-aging supplement. Safety First: NMN's Clean Bill of Health One of the primary concerns when it comes to any supplement is safety. Can we trust it not to harm our bodies? Well, if the past three years of NMN trials are any indication, we can breathe a sigh of relief. NMN, the precursor to the essential NAD+ molecule, has undergone rigorous testing, and not once has it triggered adverse physiological effects. This verdict comes from a series of human trials, painting a reassuring picture of NMN's safety profile. NMN: A Beacon of Hope for Aging Bodies Now that we've established NMN's safety, let's dive into what truly sets it apart. The human trials have unveiled its remarkable benefits, particularly for aging adults. NMN seems to possess the power to enhance insulin sensitivity, an essential factor in maintaining stable blood sugar levels. This alone can be a game-changer for those battling age-related metabolic challenges. But that's not all NMN has up its sleeve. These trials also highlight its ability to bolster physical capacity in older individuals. The aging process often takes a toll on our muscles and overall physical performance, but NMN seems to push back against this decline. For those looking to stay active and vital as they age, this is welcome news indeed FDA Scrutiny and the Ongoing NMN Controversy While NMN's potential is captivating, it's important to address the elephant in the room: the FDA's stance on NMN. As of November 2022, the FDA authorized NMN for investigation as a new drug, effectively excluding its sale as a dietary supplement. However, this decision has not halted the fervent interest in NMN, with sales continuing unabated. For those who continue to purchase and consume NMN despite the FDA's ruling, as well as those waiting for a prescription, the question remains: what do the published NMN trials say about its safety and effectiveness as an anti-aging supplement? Let's take a closer look at the research that's shedding light on this enigmatic molecule. NMN Human Trials: A Closer Look A pivotal study published in Advances in Nutrition by Yang and colleagues from Hangzhou Normal University in China delves into the currently available data from NMN human trials. Their aim? To scrutinize NMN's safety and effectiveness, especially in combatting physiological deterioration during aging. The findings from these human trials paint a promising picture. NMN appears to confer a range of physical and metabolic benefits, particularly in older adults. However, a critical question remains unanswered: do the numerous advantages observed in aging rodents also apply to humans? While NMN's potential as an anti-aging therapeutic is evident, more extensive research is required to bridge the gap between rodent and human studies. The Safety Assurance: Keio University's Pioneering Study To understand why NMN has gained such momentum, we must revisit its safety profile. The journey began in 2016 when researchers at Keio University in Japan conducted the first study evaluating NMN's safety. Male participants were administered 100, 250, or 500 mg of NMN in the morning and closely monitored for five subsequent hours. The outcome was nothing short of reassuring. No harmful effects were observed, and crucial parameters like blood pressure, heart rate, blood oxygen saturation, and body temperature remained stable. Based on these results, Keio University researchers concluded that NMN, even at doses as high as 500 mg, is safe and well-tolerated. Building Confidence: Subsequent Human Trials Since the groundbreaking study at Keio University, seven other human trials, testing NMN's safety parameters with varying doses, have been carried out. The highest oral dose, a substantial 1,000 mg twice daily for 14 days, was administered in a Harvard study - all without any adverse side effects. These trials collectively send a resounding message: NMN is not only safe but also well-tolerated. NMN's Impact on Physical Performance Now, let's delve deeper into NMN's ability to enhance physical performance. Rodent studies have indicated positive findings related to physical capabilities, brain function, metabolism, and more. These promising results prompted researchers to explore whether NMN could counteract age-related physical decline in humans. The study led by Igarashi and colleagues demonstrated that NMN improves muscle motility, walking speed, grip strength, and the frequency of movements like standing and sitting in aged individuals. This data strongly suggests that NMN can significantly enhance physical performance in older adults. Another noteworthy study conducted by Liao and colleagues focused on trained runners. The results were equally impressive. NMN substantially improved aerobic capacity, a crucial factor for endurance athletes, as evidenced by increased blood oxygen consumption during exercise. Additionally, Huang and colleagues explored NMN's impact on walking endurance in adults aged 40 to 65 years. Using a six-minute walking endurance test, they discovered that NMN led to a sustained improvement. This finding underscores NMN's potential to enhance exercise capacity, even in middle-aged and older individuals. NMN and Metabolic Benefits NMN's benefits extend beyond physical performance. In one study involving postmenopausal women who were overweight or obese, NMN demonstrated its potential to combat prediabetes. The results indicated a substantial increase in muscle insulin sensitivity, along with improvements in insulin signaling. These findings suggest that NMN holds metabolic benefits, particularly for women dealing with prediabetes. The Sound of Youth: NMN and Hearing Capabilities Aging often takes a toll on our senses, including our hearing. NMN, however, may have something to say about that. Igarashi and colleagues found that NMN supplementation improved hearing capabilities in older men, particularly in the right ear. These findings provide a glimmer of hope that NMN could potentially restore hearing abilities in the elderly. Telomeres: The Key to Longevity? The ends of our chromosomes, known as telomeres, shorten with age, serving as a biological marker of the aging process. Niu and colleagues conducted a study that could hold the key to longevity. By supplementing with 300 mg of NMN per day, they nearly doubled telomere lengths in blood cells within just 90 days. These results suggest that NMN might exert its anti-aging effects at the molecular level. The Road Ahead: More Questions, More Research While NMN's potential is undeniable, there are still many unanswered questions. Do its benefits extend consistently across multiple organ systems in aging humans as they do in rodents? The relatively short durations of the studies, none lasting longer than three months, leave us wondering if NMN's effects are maximized over time and if there are any long-term side effects to consider. NMN and the FDA: An Ongoing Controversy Despite the FDA's decision to exclude NMN from the dietary supplement market, the molecule seems to hold significant promise. Human trials have not raised any red flags regarding its safety, and there is growing evidence of its potential anti-aging benefits. The fact that NMN is under investigation as a new drug underscores its potential as a game-changer in the world of anti-aging. In conclusion, NMN is a captivating molecule that has the potential to transform the way we age. It has cleared the safety hurdle with flying colors and has shown remarkable promise in improving physical performance, metabolic health, and even hearing capabilities in aging individuals. However, there is still much to uncover about its effects on multiple organ systems and its long-term implications. As research continues, NMN may yet prove to be the elixir of youth we've been searching for, challenging the controversy surrounding its accessibility and unlocking its true potential for humanity.
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